Complexation of benzhexol and β-cyclodextrin was studied in aqueous medium. The formation of inclusion complex and its stoichiometry were determined by NMR titration method. ROESY spec-trum, recorded with a mixing ti...Complexation of benzhexol and β-cyclodextrin was studied in aqueous medium. The formation of inclusion complex and its stoichiometry were determined by NMR titration method. ROESY spec-trum, recorded with a mixing time of 0.5 s in few minutes, displayed crosspeaks between phenyl ring of benzhexol and β-cyclodextrin cavity protons established the inclusion of phenyl ring into the cavity. No inference about the distances between interacting protons could be drawn due to spin diffusion. However, analysis of peak intensity ratios of intermolecular crosspeaks suggested partial penetration of phenyl ring from wider side. Molecular mechanics studies supported these conclusions and the lowest energy conformation was proposed as the probable structure of 1:1 benzhexol-β-cyclodextrin complex.展开更多
目的 探讨盐酸乙哌立松治疗痉挛性脑瘫患儿的临床效果。方法 选取84例痉挛性脑瘫患儿作为研究对象,按照随机数字表法分为Ⅰ组(盐酸乙哌立松治疗组)、Ⅱ组(盐酸苯海索治疗组)、Ⅲ组(氯硝西泮治疗组),对比各组治疗效果、肌张力缓解情况以...目的 探讨盐酸乙哌立松治疗痉挛性脑瘫患儿的临床效果。方法 选取84例痉挛性脑瘫患儿作为研究对象,按照随机数字表法分为Ⅰ组(盐酸乙哌立松治疗组)、Ⅱ组(盐酸苯海索治疗组)、Ⅲ组(氯硝西泮治疗组),对比各组治疗效果、肌张力缓解情况以及药物不良反应发生率。结果 Ⅰ组治疗效果显著优于Ⅱ组和Ⅲ组( P <0.05);治疗前, 3组肌张力水平无显著差异( P >0.05),治疗后, 3组患儿肌张力均有所好转,但Ⅰ组和Ⅲ组的肌张力评分显著低于Ⅱ组( P <0.05);治疗期间,Ⅲ组不良反应发生率最高,Ⅰ组不良反应发生率最低,组间差异显著( P <0.05)。结论 采用盐酸乙哌立松治疗小儿痉挛性脑性瘫痪效果佳,不仅能有效改善患儿肌张力障碍,而且具有较高的安全性。展开更多
文摘Complexation of benzhexol and β-cyclodextrin was studied in aqueous medium. The formation of inclusion complex and its stoichiometry were determined by NMR titration method. ROESY spec-trum, recorded with a mixing time of 0.5 s in few minutes, displayed crosspeaks between phenyl ring of benzhexol and β-cyclodextrin cavity protons established the inclusion of phenyl ring into the cavity. No inference about the distances between interacting protons could be drawn due to spin diffusion. However, analysis of peak intensity ratios of intermolecular crosspeaks suggested partial penetration of phenyl ring from wider side. Molecular mechanics studies supported these conclusions and the lowest energy conformation was proposed as the probable structure of 1:1 benzhexol-β-cyclodextrin complex.
文摘目的 探讨盐酸乙哌立松治疗痉挛性脑瘫患儿的临床效果。方法 选取84例痉挛性脑瘫患儿作为研究对象,按照随机数字表法分为Ⅰ组(盐酸乙哌立松治疗组)、Ⅱ组(盐酸苯海索治疗组)、Ⅲ组(氯硝西泮治疗组),对比各组治疗效果、肌张力缓解情况以及药物不良反应发生率。结果 Ⅰ组治疗效果显著优于Ⅱ组和Ⅲ组( P <0.05);治疗前, 3组肌张力水平无显著差异( P >0.05),治疗后, 3组患儿肌张力均有所好转,但Ⅰ组和Ⅲ组的肌张力评分显著低于Ⅱ组( P <0.05);治疗期间,Ⅲ组不良反应发生率最高,Ⅰ组不良反应发生率最低,组间差异显著( P <0.05)。结论 采用盐酸乙哌立松治疗小儿痉挛性脑性瘫痪效果佳,不仅能有效改善患儿肌张力障碍,而且具有较高的安全性。
