Synthesis and Fungicidal Activity of 2-Acetyl-6-（un）substituted-1 H-benzimidazole Oxime-ethers

Twelve novel compounds of 2-acetyl-lH-benzimidazole oxime-ethers and 2-acetyl-6-chloro-1H-benzimidazole oxime-ethers were synthesized with o-phenylenediamine （or 4-chloro-o-phenylenediamine）, 2-hydroxypropyl acid, alkoxy （or benzyloxy） amines hydrochloride as starting materials. The structures of the target compounds were characterized by IR, 1H NMR spectra and elemental analyses. The in vitro fungicidal activities against Botrytis cinerea Pers and Alternaria alternata were also evaluated by mycelium growth rate method. The results indicate that the compounds 3b, 3c, 3f, 3g and 3h exhibit good activities against Botrytis cinerea Pers, while 3b and 3f possess excellent activities against Alternaria alternate, and their fungicidal activities are all higher than that of carbendazim.

含1H-吡唑和咪唑的新型双杂环化合物的合成与生物活性

1-甲基-3-乙基-4-取代-5-吡唑甲酰氯与含氮杂环反应,合成了8个新型结构的双杂环化合物。其结构经1HNMR,IR,MS和元素分析表征。初步生物活性实验结果表明:在500μg·mL-1,部分化合物对稻黑尾叶蝉的抑制活性达到53.57%。

二（2—苯并咪唑亚甲基）胺合Zn（Ⅱ）配合物晶体和电子结构研究及生物活性测定

合成了二(2-苯并咪唑亚甲基)胺合Zn(Ⅱ)高氯酸盐配合物[C16H15N5Zn@(C1O4)2@3H2O和C32H30N10Zn@(ClO4)2@C2H5OH],进行了元素分析、红外和紫外表征.对后者采用X射线方法测定了晶体结构,并采用G94W程序进行了量子化学计算.利用邻苯三酚自氧化法测定了所合成配合物的生物活性.

新型苯并咪唑衍生物的合成及其生物活性

以香草醛为原料,经2步反应制得中间体——2-(4-羟基-3-甲氧基苯基)-1-氢-苯并咪唑(3);3分别与取代苯甲酰氯,取代苯乙酰氯和取代苯磺酰氯反应,合成了13个新型的苯并咪唑衍生物(7a^7g,8a,8d,8g,9a,9d和9g),其结构经~1H NMR,IR和HR-ESI-MS表征。分别用菌丝生长速率法和曹坳程法测试了7~9的抑菌活性和除草活性。结果表明:c=100 mg·L^(-1)时,7~9对番茄灰霉病菌,油菜菌核病菌和稻瘟病菌的抑制率分别为13.79%~65.38%,13.88%~63.78%和34.22%~58.79%;c=300 mg·L^(-1)时,7g对稗草和反枝苋的芽长抑制率分别为40.20%和80.84%。