Preparation of Ni2P/Al-SBA-15 catalyst and its performance for benzofuran hydrodeoxygenation

The Al-doped Ni_2P/Al-SBA-15 catalyst with high hydrodeoxygenation(HDO) activity was synthesized by temperature programmed reduction at a relatively low reduction temperature of 400 °C. The as-prepared catalyst was characterized by X-ray diffraction(XRD), H_2 temperature-programmed reduction(H_2-TPR), X-ray photoelectron spectroscopy(XPS), transmission electron microscope(TEM), NH3 temperature programmed desorption(NH_3-TPD), N_2 adsorption–desorption and CO uptake. The effect of Al on benzofuran(BF) HDO performance was investigated. The result indicates that the incorporation of Al into the SBA-15 support can promote the formation of much uniform, smaller, highly dispersed Ni_2 P particles on the catalyst. The Al also contributes to suppress the enrichment of P and promote more exposed Ni sites on the surface. In addition, the incorporation of Al can enhance the acid strength. The total deoxygenated product yield over Ni_2P/Al-SBA-15 reached 90.3%, which is an increase of 19.4%, when compared with that found for Ni_2P/SBA-15(70.9%).

In vitro antiplasmodial activity of Spiro benzofuran compound from mangrove plant of Southern India

Objective:To find out the in vitro antipalsmodial activities of mangrove leaf extracts.Methods: In vitro antiplasmodial assay was carried out with 13 different mangrove plants.Column chromatography was performed with the most potent Agecerious corniculatum（A.corniculatum） by using various solvent extractions.GC-MS was also preformed with the most potent ethanolic fraction of the A.corniculatum extract.Results:Of the 13 mangroves plants, A.corniculatum showed maximum percentage of parasitemia suppression（94.98±1.16）%.Column chromatography was performed with A.corniculatum with different solvents and the methanolic extract showed maximum percentage（99.73±1.63）%of parasitemia inhibition at 150μg/mL concentration with the IC50 value of（29.28±3.23）μg/mL concentration.The results of the GC-MS analysis observed that,the most potent methanolic extract showed maximum retention time（30.687 RT） and the chemical class was identified as Spiro[benzofuran-2（3 H）,1’-（3 cyclohexane）-2’,3- dione,7-chloro-4’,6]which was responsible for the antiplasmodial activity.Conclusions:It is concluded from the present study that,the chemical constituents of A.corniculatum collected from Pichavaram mangrove forest can be used as a putative antiplasmodial drugs in future.

A New Isopropenyl Benzofuran-type Tetramer from Ligularia stenocephala

A new isopropenyl benzofuran-type tetramer was isolated from the roots of ligularia stenocephala and its structure was established by spectroscopic methods.

Unexpected Synthesis of 2,2'-[1-(4-Methoxyphenoxy)propane-2,2-diyl]bis(5-methoxy-3-methylbenzofuran)

A new bisbenzofuran analogue Ⅶ was achieved unexpectedly in one step procedure from 1-（4-methoxyphenoxy）acetone Ⅰ by using Amberlyst 15 resin as catalyst in excellent yield. The structure was elucidated by spectroscopy analysis including ^1H-NMR, ^13C-NMR, DEPT, ESI-MS, element analysis.

Two New Benzofuran Derivatives from Ligularia stenocephala

Two new benzofuran derivatives were isolated from the roots of Ligularia stenocephala. Their structures were established by spectroscopic methods and 2D NMR experiments.

THE SYNTHESES OF BENZOFURAN DERIVATIVES

Two benzofuran derivatives were synthesized from 3,4-bis(trimethylsilyl) furan after a series of reactions. Their structures were identified by 1H NMR, 13C NMR, MS and EA.

Synthesis and Crystal Structure of (5-Hydroxy-6-methoxybenzofuran-3-yl)-(4-methoxyphenyl)methanone

Compound 1 （5-hydroxy-6-methoxybenzofuran-3-yl）（4-methoxyphenyl）metha- none, C17H1405, as a potential anti-breast cancer agent has been synthesized under microwave irradiation, which was further converted to （5,6-dihydroxybenzofuran-3-yl）（4-methoxyphenyi）me- thanone （2）. The compounds were characterized by MS and NMR spectra. Meanwhile, the crystal of 1 was obtained and determined by X-ray single-crystal diffraction. Crystal data： monoclinic system, space group P2/n, a = 8.908（6）, b = 10.505（7）, c = 15.452（11） A, β = 105.043（9）, V = 1396.4（16） A3, Z = 4, F（000） = 624, Dc = 1.419 g/cm3, p = 0.105 mm-1, R = 0.0513 and wR = 0.1246 for 14459 independent reflections （Rint = 0.0647） and 2488 observed ones （I〉 2σ（/））. lntermolecular O-H...O and π-π stacking interactions contributed to the stability of the structure.

Crystal and Molecular Structure of N-[2-(6-Methoxy-2-oxo-2H-Chromen-4-yl-Benzofuran-3-yl]- Benzamide

The crystal structure of the potential active N-[2-(6-Methoxy-2-oxo-2H-chromen-4-yl)-benzofuran-3-yl]-benzamide (C25H17NO5) (I) has been determined from single crystal X-ray diffraction data. The title compound crystallizes in the monoclinic space group P 21/n, with a = 12.0551(11), b = 9.7853(8), c = 16.6517(16) , β = 90.092(4)o, V = 1964.28(3) 3, Dcalc = 1.391 Mg/m3, Z = 4. In the structure, intermolecular H-bonds lead to the formation of a centrosymmetric dimer of the molecule. There is an intramolecular C7—H7…N1 hydrogen bond forming a closed seven membered ring. There are also intramolecular π-π interactions presented between the 3,6-Dihydro-2H-pyran ring of the chromen moiety [Cg2…Cg2 distance = 3.5812(13) ]. The packing structure is stabilized by these C—H…N, N—H…O hydrogen bonds, C—H… π and π…π interactions.

Synthesis, Crystal Structure and Biological Activity of 2-((2,2-Dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-(3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-yl)acetamide

The title compound 2-（（2,2-dimethyl-2,3-dihydrobenzofuran-7-yl）oxy）-N-（3-（furan-2-yl）-1-phenyl-1H-pyrazol-5-yl） acetamide（C25H23N3O4, Mr = 429.46） has been synthesized, and its structure was characterized by 1H-NMR, 13C-NMR, H RMS, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/c with a = 20.6205（18）, b = 5.2930（5）, c = 18.9282（17） A, β = 94.089（2）°, V = 2060.6（3） A^3, Z = 4, Dc = 1.384 g/cm^3, μ（Mo Ka） = 0.71073 mm^-1, F（000） = 904, R = 0.0345 and w R = 0.0930. The intramolecular hydrogen bond at N（1）–H（1）…O（2）, intermolecular weak interactions at O（3）…H（4） and weak π-π interactions connected the molecules to lead to one-dimensional tapes. Bioassay results indicated that the title compound had moderate herbicidal and fungicidal activities.

Two new benzofuran lignan glycosides from Gelsemium elegans

二新 benzofuran lignan glycosides， gelsemiunoside A 和 B，从 Gelsemium elegans Benth 的整个植物被孤立。他们的结构根据分光镜的证据被阐明。而且， gelsemiunoside A 和 B 被看一个有势力由压制 A375-S2 房间的增长的细胞毒素的活动。

An efficient synthesis of benzofuran derivatives under conventional/non-conventional method

1-Methyl-3-ethyl imidazolium 溴化物[meim ] Br/basic 氧化铝(Al2O3 ) 被发现了与 salicylaldehydes 支持 chloroacetone/chloroethyl 醋酸盐的 cyclocondensation 在下面象到收益 benzofuran 衍生物的微波照耀一样常规。

Synthesis,nematicidal evaluation,and SAR study of benzofuran derivatives containing 2-carbonyl thiophene

Plant-parasitic nematodes are major threat for crop protection.The lack of nematicides with new mode of action and increasing resistance raises the need for novel nematicides.In order to seek new nematicidal lead,originating from the structure of chalcone,a series of fused ring compounds was obtained by ring closure design strategy.These compounds were modified further.The nematicidal activity against M.incognita of synthesized compounds was evaluated.The bioassay showed that compound 3 and some of its derivatives such as compounds 18,19,21,22,23,24 and 26 exhibited excellent nematicidal activity.Among them,compound 23 exhibited significant bioactivity.The LC50/72 hvalue reached 3.20 mg/L in vitro and the inhibition rate was 100.00%at 40 mg/L in the matrix.The structure-activity relationship of synthesized compounds was discussed in details.The influence of compound 23 on egg hatching,motility,and feeding behavior of C.elegans was also evaluated.

Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole/benzofuran-chromanone]s through organocatalytic inter-/intramolecular Michael cycloaddition

A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromoneoxindole/benzofuranone synthons with 3-substituted methylenebenzofuranones has been established,which constructed enantiomerically pure bispiro[benzofuran-oxindole/benzofuran-chromanone]s bearing five consecutive stereocenters including two spiro quaternary carton centers in good yields(up to 93%) with high diastereoselectivities(up to>20:1 dr) and good enantioselectivities(up to>99% ee).Moreover,this is the first example of bifunctional chromone-benzofuranone synthon directed organocatalytic tandem reaction,and also the first example of the bispiro[benzofuran-oxindole] and bispirobenzofuranone,potentially useful in medicinal chemistry.

A Novel and Facile Synthesis of 2-（Benzofuran-2-yl）benzo[h]- quinoline-3-carboxylic Acid Derivatives

A simple and concise approach for the synthesis of a series of new heterocyclic systems of 2-（benzofuran-2-yl）- benzo[h]quinoline-3-carboxylic acid derivatives （3a--3g） is described. The synthetic strategy features the one-pot reaction of ethyl 2-（chloromethyl）benzo[h]quinoline-3-carboxylate （2） with various substituted salicylaldehydes as well as 2-hydroxy-l-naphthaldehyde as a key step. The substrate 2 was prepared in good yield by a mild, efficient and direct reaction of 1-naphthylamine （1） with Vilsmeier-Haack reagent. The structures of all the new compounds were identified by spectral data and elemental analysis.

Benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids:Design,synthesis and in vitro anti-mycobacterial activity evaluation

A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.

High-efficiency all-small-molecule organic solar cells based on an organic molecule donor with an asymmetric thieno[2,3-f]benzofuran unit

Two p-type small molecules BDTT-TR and TBFT-TR with benzo[1,2-b′:4,5-b′]dithiophene(BDT)and thieno[2,3-f]benzofuran(TBF)as central core units are synthesized and used as donors in all-small-molecule organic solar cells(all-SMOSCs)with a narrow-bandgap small molecule Y6(2,2′-((2 Z,2′Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,3’′:4’,5′]thieno[2′,3′:4,5]pyrrolo[3,2-g]thieno[2′,3′:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1 H-indene-2,1-diylidene))dimalononitrile)as the acceptor.In comparison to BDTT-TR with centrosymmetric BDT as the central unit,TBFT-TR with asymmetric TBF as the central unit shows red-shifted absorption,higher charge-carrier mobility and better charge pathway in blend films.The power conversion efficiency(PCE)of the all-SMOSCs based on TBFT-TR:Y6 reaches 14.03%with a higher short-circuit current density of 24.59 m A cm-2 and a higher fill factor of72.78%compared to the BDTT-TR:Y6 system.The PCE of 14.03%is among the top efficiencies of all-SMOSCs reported in the literature to date.

One-Pot Three-Component Synthesis of 2-Methyl-3-aminobenzofurans Using Calcium Carbide as a Concise Solid Alkyne Source

A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source,and salicylaldehydes and secondary amines as starting materials is described.This protocol has salient feature of the use of inexpensive,abundant and easy-to-handle alkyne source,avoiding the use of inflammable and explosive acetylene gas as an original alkyne source.In addition,step economy,satisfactory yield,and simple work-up procedure are also advantages of this route.

噻吩[3,2-b:4,5-b′]双苯并呋喃类化合物的合成及光物理性质研究

噻吩[3,2-b:4,5-b′]双苯并呋喃稠杂环化合物是一类重要的用于有机光电材料的并五苯的衍生物,该类稠杂环化合物的合成具有十分重要的意义。以廉价的2-碘苯甲醚、4-叔丁基-2-碘苯甲醚或2,4-二叔丁基-2-碘苯甲醚为原料,通过经典的Sonogashira偶联反应、脱保护基反应、Glaser-Hay偶联反应、碘亲电环化反应和噻吩合成反应五步反应成功合成了一类结构新颖的稠合杂环类化合物噻吩[3,2-b:4,5-b′]双苯并呋喃。关键的中间体双苯并呋喃二碘化合物(6a)和噻吩[3,2-b:4,5-b′]双苯并呋喃化合物(1a)均由单晶衍射分析确认了结构。该反应路线原料成本低,反应操作简单,总收率较高(1a:54%;1b:40%;1c:47%)。该合成策略为获得这类稠杂环化合物提供了一种有效的合成方法,所制备的化合物具有优异的光物理性质,有望用于光电材料领域。

伯醇对镍基催化剂在转移氢化反应中的抑制作用研究

本文研究了在转移加氢条件下,不同类型醇作为氢供体对镍基催化剂在苯并呋喃加氢反应中的活性影响.结果表明,使用异丙醇作为氢供体时,苯并呋喃的加氢过程为底物先发生脱芳构化,然后再进行脱氧反应.然而,当使用伯醇如甲醇、乙醇和正丙醇作为氢供体时,会导致镍基催化剂的不可逆失活.针对这一现象,进一步研究了伯醇使镍基金属催化剂失活的机理.结果表明,在250°C条件下,催化剂与伯醇的相互作用会导致形成非活性的碳化物Ni_(3)C,并且镍金属颗粒在氧化铝载体表面会发生烧结和偏析.