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The Synthesis of 3-(2'-Hydroxybutyl) isobenzofuran-1 (3H)-one 被引量:2
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作者 Guo Xin WANG Guo HSO XIE +1 位作者 Yuan Liu WU Xin Fu PAN(Laboratory of Applled Organic Chemistry,Institute of Organlc Chemistry. Lanzhou University,Lanzhou,730000)(Instltute ofMateria Medica, Chinese Academy of Medical Science,Beijing 100050)(Department of 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第1期21-22,共2页
The synthesis of 3-(2'-hydroxybutyl)isobenzofuran-1(3H)-onel from phthalicanhydride via the intermediate 3-(2'-oxoethyl) isobenzofuran-1(3H)-one 6 was described.
关键词 SYNThESIS 3-(2'-hydroxybutyl)lsobenzofuran-1(3h)-one
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Highly efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropoly acids in water 被引量:6
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作者 YingXiao Zong Yan Zhao +3 位作者 WenCai Luo Xing Hai Yu Jun Ke Wang Yi Pan 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第7期778-781,共4页
Heteropoly acids efficiently catalyzed the cyclocondensation reaction of anthranilamide with aldehydes in water at ambient temperature and afforded the corresponding 2,3-dihydro-4(1H)-quinazolinones compounds in goo... Heteropoly acids efficiently catalyzed the cyclocondensation reaction of anthranilamide with aldehydes in water at ambient temperature and afforded the corresponding 2,3-dihydro-4(1H)-quinazolinones compounds in good to excellent yields.This method provides mild reaction conditions and clean reaction profiles,using a small quantity of catalyst and a simple workup procedure. 展开更多
关键词 heteropoly acid 2 3-Dihydroquinazolin-4(1h)-ones WATER
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Synthesis,Bioactivity and Crystal Structure Analysis of Novel Benzo[d]isothiazol-3(2H)-ones 被引量:7
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作者 王向辉 林强 +2 位作者 尹学琼 游诚航 杨建新 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第8期1170-1174,共5页
Two compounds,3-oxo-N-o-tolylbenzo[d]isothiazole-2(3H)-carboxamide (1) and N-(2-methoxyphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide (2),were synthesized from the initial compound benzo[d]isothiazol-3... Two compounds,3-oxo-N-o-tolylbenzo[d]isothiazole-2(3H)-carboxamide (1) and N-(2-methoxyphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide (2),were synthesized from the initial compound benzo[d]isothiazol-3(2H)-one (BIT) and characterized by 1 H NMR,IR and elemental analysis,respectively.The single crystals of compounds 1 and 2 were obtained and determined by X-ray diffraction analysis.The preliminary results of biological activity experiment show that some of the title compounds exhibited a favorable antimicrobial activity. 展开更多
关键词 benzo[d]isothiazol-32h)-one (BIT) crystal structure antimicrobial activity
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Synthesis and Crystal Structure of 2-Ethoxy-3-n-butyl-benzofuro [2,3-d]pyrimidin-4(3H)-one 被引量:3
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作者 胡扬根 丁明武 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2008年第1期21-24,共4页
The crystal structure of the new title compound 2-ethoxy-3-n-butyl- benzofuro[2,3d]pyrimidin-4(3H)-one (C16H18N2O3, Mr = 286.32) has been prepared and determined by singlecrystal X-ray diffraction. The crystal is ... The crystal structure of the new title compound 2-ethoxy-3-n-butyl- benzofuro[2,3d]pyrimidin-4(3H)-one (C16H18N2O3, Mr = 286.32) has been prepared and determined by singlecrystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 13.7167(14), b = 13.113(1), c = 8.378(1) A, β = 98.992(2)^o, V = 1488.4(3) A^3, Z = 4, Dc = 1.278, F(000) = 608, μ = 0.089 mm^-1, MoKa radiation (2 = 0.71073), R = 0.0498, wR = 0.1238 for 2336 observed reflections with I 〉 2σ(I). X-ray diffraction analysis reveals that all ring atoms in the benzo[4, 5]furo [2,3-d] pyrimi- dinone moieties are almost coplanar. 展开更多
关键词 crystal structure benzo[4 5]furo[2 3-d]pyrimidin-4(3h)-one aza-Wittig reaction synthesis
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Synthesis and Crystal Structure of 1-(4-Fluorophenyl)-2-hexylthiobenzo[4,5]-furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5(1H)-one 被引量:4
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作者 胡扬根 杜士明 +1 位作者 李清 丁明武 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2011年第1期75-78,共4页
The crystal structure of the title compound 1-(4-fluorophenyl) -2-hexylthio-benzo [4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5(1H) -one(C23H21FN4O2S,Mr = 436.5) has been prepared and determined by single-cr... The crystal structure of the title compound 1-(4-fluorophenyl) -2-hexylthio-benzo [4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5(1H) -one(C23H21FN4O2S,Mr = 436.5) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic,space group P21/n with a = 13.9854(3) ,b = 17.2678(4) ,c = 18.1828(5)A,β = 99.364(2) °,V = 4332.58(18) A^3,Z = 4,Dc = 1.338,F(000) =1824,μ = 0.185 mm^-1,MoKa radiation(λ = 0.71073) ,R = 0.0538 and wR = 0.1162 for 4728 observed reflections with I 〉 2σ(I) . X-ray diffraction analysis reveals the fused rings of benzo[4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a] pyrimidin-5(1H) -one system are nearly coplanar. The crystal packing is mainly stabilized by weak intermolecular C-H···O hydrogen bond and π-π interactions. 展开更多
关键词 SYNThESIS crystal structure 1-(4-fluorophenyl)-2-hexylthio-benzo[4 5]furo[3 2-d]-1 2 4-triazolo[1 5-a]pyrimidin-5(1h)-one
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Synthesis of some new bis-3,4-dihydropyrimidin-2(1H)-ones by using silica-supported tin chloride and titanium tetrachloride 被引量:1
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作者 Khodabakhsh Niknam Alireza Hasaninejad Madihe Arman 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第4期399-402,共4页
Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as ... Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as the catalysts for the synthesis of bisdihydropyrimidin -2(1H)-ones from aromatic dialdehydes,1,3-dicarbonyl compounds and urea at 90℃under solvent-free conditions. 展开更多
关键词 Silica-supported tin chloride Silica-supported titanium tetrachloride Bis-3 4-dihydropyrimidin-2(1h)-one SOLVENT-FREE 1 3-Dicarbonyl compounds
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A Selective Synthesis of 2-Alkylamino-5, 6, 7, 8-tetrahydro-benzothieno[2, 3-d]pyrimidin-4(3H)-ones 被引量:1
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作者 MingWuDING RuiJunXU JingXU YunFengCHEN 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第2期189-192,共4页
Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno [2, 3-d] pyrimidin-4(3H)-ones 7 weresynthesized by a new selective synthetic method, which includes aza-Wittig reaction of imino-phosphorane 4 with aromatic isocynate to giv... Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno [2, 3-d] pyrimidin-4(3H)-ones 7 weresynthesized by a new selective synthetic method, which includes aza-Wittig reaction of imino-phosphorane 4 with aromatic isocynate to give carbodiimide 5 and subsequent reaction of 5 withvarious aliphatic primary amine in the presence of EtO-Na+. 展开更多
关键词 Benzothieno[2 3-d]pyrimidin-4(3h)-ones aza-Wittig reaction iminophosphorane carbodiimide synthesis.
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Mannich Base Derivatives of 1,2-Benzisothiazolin-3-one: Syntheses, Crystal Structures and Bioactivities 被引量:1
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作者 王向辉 邵艳东 +1 位作者 伍媛媛 林强 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2014年第9期1395-1400,共6页
Twelve Mannich base derivatives of 1,2-benzisothiazolin-3-one were synthesized by the reaction of 1,2-benzisothiazol-3(2H)-one (BIT) with different amines and formaldehyde. All the compounds were characterized by ... Twelve Mannich base derivatives of 1,2-benzisothiazolin-3-one were synthesized by the reaction of 1,2-benzisothiazol-3(2H)-one (BIT) with different amines and formaldehyde. All the compounds were characterized by elemental analysis, IR spectroscopy, MS and 1H NMR. The crystal structure for 2,2'-methylenebis(benzo[d]isothiazol-3(2H)-one) (3) has been determined by X-ray single-crystal structure analysis. Compound 3 (C15HIoN202S2) crystallizes in the monoclinic system, space group C2/c with a = 25.052(8), b = 4.510(1), c = 11.948(4) A, β = 100.992(4)°, V= 1325.2(7) A3, Mr = 314.37, Dc = 1.576 Mg.m-3, p = 0.25 mm-1, F(000) = 648, Z = 4, R = 0.034 and wR = 0.087. The preliminary biological test indicated that the compounds (2b, 2c) showed growth inhibitory activity against the gram-positive and gram-negative bacteria. 展开更多
关键词 1 2-benzisothiazol-3(2h)-one SYNThESES crystal structure bioactivity
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Synthesis and Crystal Structure of 2-Ethoxycarbonylmethyl-8-chloro-3a,4-dihydro-3a-methyl-chromeno[4,3-c]pyrazol-3(2H)-one 被引量:1
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作者 赵培亮 周中振 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第8期1280-1283,共4页
The crystal structure of the title compound 2-ethoxycarbonylmethyl-8-chloro-3a,4-dihydro-3a-methyl-chromeno[4,3-c]pyrazol-3(2H)-one(C15H15ClN2O4,Mr = 322.74) has been prepared and determined by single-crystal X-ra... The crystal structure of the title compound 2-ethoxycarbonylmethyl-8-chloro-3a,4-dihydro-3a-methyl-chromeno[4,3-c]pyrazol-3(2H)-one(C15H15ClN2O4,Mr = 322.74) has been prepared and determined by single-crystal X-ray diffraction.The crystal is of orthorhombic,space group Pccn with a = 16.7246(10),b = 19.6626(12),c = 9.3013(6) ,V = 3058.7(3) 3,Z = 8,Dc = 1.402 g/cm3,μ = 0.269 mm-1,F(000) = 1344,the final R = 0.0506 and wR = 0.1464 for 2568 reflections with I 〉 2σ(I).In addition,disordered C(14) and C(15) atoms exist in the crystal structure. 展开更多
关键词 chromeno[4 3-c]pyrazol-32h)-one SYNThESIS insecticidal activity crystal structure structural disorder
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Synthesis and Crystal Structure of 2-(4’-Methylphenoxy)-5,8,9-trimethyl-3-phenyl Thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4-(3H)-one Hydrochloride 被引量:1
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作者 LIU Jian-Chao HE Hong-Wu DING Ming-Wu 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第5期577-581,共5页
The title compound 2-(4'-methylphenoxy)-5,8,9-trimethyl-3-phenyl thieno[3',2':5,6] pyrido[4,3-d]pyrimidin-4(3H)-one hydrochloride (C26H23Cl4N3O2S, Mr = 583.33) has been determined by single-crystal X-ray dif... The title compound 2-(4'-methylphenoxy)-5,8,9-trimethyl-3-phenyl thieno[3',2':5,6] pyrido[4,3-d]pyrimidin-4(3H)-one hydrochloride (C26H23Cl4N3O2S, Mr = 583.33) has been determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/c with a = 14.8442( 11 ), b = 11.5131 (8), c = 17.2010(13) A, β = 113.7250(10)°, V = 2691.3(3) ,A^3, Z = 4, Dc = 1.440 g/cm^3, S = 1.094,μ = 0.547 mm^-1, F(000) = 1200, the final R = 0.0571 and wR = 0.1458. X-ray analysis reveals that the title compound combines with a molecule of dichloromethane by an intramolecular hydrogen bond. The thienopyridine ring is almost coplanar, and the dihedral angle between the thiophene plane and the pyridine plane is 0.6°. 展开更多
关键词 thieno[3 2':5 6]pyrido[4 3-d]pyrimidin-4(3h)-one triphenylphosphine IMINOPhOSPhORANE crystal structure
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Synthesis, Crystal Structure and Antibacterial Activity of 1-((2-Chloroquinolin-3-yl)-methyl)-pyridin-2(1H)-one 被引量:1
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作者 S. Mohana Roopan Venkatesha R. Hathwar +1 位作者 F. Nawaz Khan Atul Kumar Kushwaha 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第11期1612-1617,共6页
On the basis of the interesting structures and biological activities exhibited by several heterocyclic systems possessing the pyridone nucleus such as mappcine and camptothecin, we have planed to design the synthesis,... On the basis of the interesting structures and biological activities exhibited by several heterocyclic systems possessing the pyridone nucleus such as mappcine and camptothecin, we have planed to design the synthesis, crystal studies and antibacterial activity of the new 1-((2- chloroquinolin-3yl)-methyl)-pyridine-2(1H)-one building block. An X-ray analysis has provided valuable insight into the effect of steric factors on the three-dimensional shape of this compound which serves as a useful advanced intermediate in the synthesis of these biologically active molecules. A multistep synthesis of camptothecin (5) has been designed by retrosynthetic analysis as part of an ongoing program on lead anticancer drug. 展开更多
关键词 crystal structure 1-((2-chloroquinolin-3yl)-pyridine-2(1h)-one
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Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5
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作者 Xing Zhou Li Xian Ping Dai +3 位作者 Kang Ying Lai Li Li Wang Zhi Bing Zheng Song Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第4期379-382,共4页
A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones,as ALK5 inhibitors,were desigened,synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1μmol/L and display... A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones,as ALK5 inhibitors,were desigened,synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1μmol/L and displayed no significant cytotoxicities at 30μmol/L. 展开更多
关键词 Activin-like kinases5(ALK5) Kinase inhibitors 1h-Pyrazol-32h)-ones
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H_3PMo_(12)O_(40) catalyzed three-component one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions
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作者 Zeinab Pourghobadi Fatemeh Derikvand 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第3期269-272,共4页
4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophe-none derivatives,aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amou... 4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophe-none derivatives,aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of HPMoOunder solvent-free conditions. 展开更多
关键词 4 6-Diarylpyrimidin-2(1h)-ones h_3PMo_(12)O_(40) Solvent-less reactions Biginelli like reactions hETEROPOLYACIDS
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Synthesis and Crystal Structure of a New Quinazolinone Compound 2,3-Dihydro-2-(2-hydroxyphenyl)-3-phenyl-quinazolin-4(1H)-one
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作者 ZHANGGai LIANGYong-Qing ZHANGRong-Lan ZHANGWei-Hai ZHAOJian-She GUOZhi-An 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2005年第7期783-788,737,共7页
A new quinazolinone compound 2,3-dihydro-2-(2-hydroxyphenyl)-3-phenyl- quinazolin-4(1H)-one 3 ([C20H16O2N2]?C2H5OH, Mr = 362.42) and compound 2-(2-hydroxy- benzylidene-amino)-N-phenyl-benzamide 2 (C20H16O2N2, Mr = 316... A new quinazolinone compound 2,3-dihydro-2-(2-hydroxyphenyl)-3-phenyl- quinazolin-4(1H)-one 3 ([C20H16O2N2]?C2H5OH, Mr = 362.42) and compound 2-(2-hydroxy- benzylidene-amino)-N-phenyl-benzamide 2 (C20H16O2N2, Mr = 316.34) were prepared from a precursor of 2-amino-N-phenyl-benzamide 1 (C13H12ON2, Mr = 212.25). Compound 3 was characterized by single-crystal X-ray diffraction analysis. The crystal belongs to orthorhombic, space group Pbca with a = 1.2889(11), b = 1.6170(14), c = 1.7729(15) nm, V = 3.695(6) nm3, Z = 8, F(000) = 1536, Mr = 362.42, Dc = 1.303 g/cm3, μ(MoKα) = 0.087 mm-1, R = 0.0447 and wR = 0.0879. The crystal structure analysis indicates that the title compound has a two-dimensional network structure formed by hydrogen bonds and electrostatic interactions. 展开更多
关键词 2 3-dihydro-2-(2-hydroxyphenyl)-3-phenylquinazolin-4(1h)-one synthesis crystal structure conversion mechanism of the structure
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Enamine Configuration of 5-Methyl-2-phenyl-4- [(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one
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作者 QIAO Yu-Qin Lü Xing-Qiang +1 位作者 BAO Feng KANG Bei-Sheng 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2005年第8期957-961,共5页
Compound 5-methyl-2-phenyl-4-[(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one (C24H21N3O) crystallizes in the triclinic system, space group P1, with a = 9.267(3), b = 9.904(4),c = 12.035(4) A°, α ... Compound 5-methyl-2-phenyl-4-[(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2H)-one (C24H21N3O) crystallizes in the triclinic system, space group P1, with a = 9.267(3), b = 9.904(4),c = 12.035(4) A°, α = 97.896(6), β = 103.865(6), γ = 107.950(6)°, Mr= 367.44, Z = 2, V = 993.2(6)A°^3,Dc = 1.229 g/cm^3,μ(MoKa) = 0.077 mm^-1 and F(000) = 388. The structure was refined to R =0.0444 and wR = 0.1199 for 2903 observed reflections (I 〉 2σ(I)). The results of ^1H NMR and single-crystal X-ray diffraction studies showed the enamine character of the compound. The strong intramolecular hydrogen bonds in the large conjugate system, together with weak intermolecular C-H……π hydrogen bonding and π……π stacking, lead to the formation of a multi-dimensional supramolecular network. 展开更多
关键词 5-methyl-2-phenyl-4-[(Z)-3-tolylamino-phenylmethylene]pyrazol-3(2h)-one enamine weak interaction snpramolecnlar network
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Synthesis and Crystal Structure of 4-Bromo-5-ethoxy-3-methyl-5- (naphthalen-1-yl)-1-tosyl-1H-pyrrol-2(5H)-one
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作者 沈如伟 杨誉竹 +2 位作者 曹剑 吴露玲 黄宪 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第12期1505-1508,共4页
The title compound 4-bromo-5-ethoxy-3-methyl-5-(naphthalen-l-yl)-l-tosyl-lH- pyrrol-2(5H)-one 1 (C24H22BrNO4S, Mr = 500.40) has been synthesized and its crystal structure was determined by single-crystal X-ray d... The title compound 4-bromo-5-ethoxy-3-methyl-5-(naphthalen-l-yl)-l-tosyl-lH- pyrrol-2(5H)-one 1 (C24H22BrNO4S, Mr = 500.40) has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in monoclinic, space group P21/n with a = 8.8562(15), b = 18.118(3), c = 14.055(2)A, β = 99.855(3)^o, V= 2221.9(6)A3, Z = 4, Dc = 1.496 g/cm^3,μ= 1.975 mm^-1, 2 = 0.71073A, F(000) = 1024, R = 0.0607 and wR = 0.1371. 展开更多
关键词 4-bromo-5-ethoxy-3-methyl-5-(naphthalen-1-y1)-1-tosyl-1h-pyrrol-2(5h)-one synthesis crystal structure
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Synthesis, Bioactivity and Crystal Structure Analysis of 2-(Benzo[d]isothiazol-3-yloxy)-N-(3-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl) Acetamide 被引量:2
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作者 于鹏 李溪 +1 位作者 胡俊 徐炎华 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2014年第9期1375-1382,共8页
A novel benzisothiazolin-3-one derivative, 2-(benzo[d]isothiazol-3-yloxy)-N-(3- cyano-l-(4-fluorophenyl)-lH-pyrazol-5-yl) acetamide (8), was synthesized from the initial compound benzo[d]isothiazol-3(2H)-one... A novel benzisothiazolin-3-one derivative, 2-(benzo[d]isothiazol-3-yloxy)-N-(3- cyano-l-(4-fluorophenyl)-lH-pyrazol-5-yl) acetamide (8), was synthesized from the initial compound benzo[d]isothiazol-3(2H)-one (BIT) 1 and 4-fluoroaniline 3. The structure of the target compound 8 was determined by elemental analyses, IR and 1H NMR. The single crystals of intermediate compound 6 and the target compound 8 were obtained and determined by X-ray diffraction analysis. The preliminary biological activity was also evaluated and the results showed tile target compound exhibited a good anti-microbial activity. 展开更多
关键词 benzisothiazol-32h)-one PYRAZOL SYNThESIS bioactivity crystal structure
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布朗斯特酸性离子液体[DC2O2IM][p-CH3PhSO3]催化Biginelli三组分反应的研究
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作者 张海燕 李贺 刘晨江 《有机化学研究》 2018年第2期61-68,共8页
本文报道了布朗斯特酸性离子液体1,3-二羧甲基咪唑对甲苯磺酸盐作为一种绿色、环境友好的催化剂,成功地催化Biginelli三组分反应合成了一系列3,4-二氢嘧啶-2(1H)-酮或硫酮化合物。该方法具有条件温和、产率高、反应时间短的优点。此外,... 本文报道了布朗斯特酸性离子液体1,3-二羧甲基咪唑对甲苯磺酸盐作为一种绿色、环境友好的催化剂,成功地催化Biginelli三组分反应合成了一系列3,4-二氢嘧啶-2(1H)-酮或硫酮化合物。该方法具有条件温和、产率高、反应时间短的优点。此外,催化剂离子液体可循环使用五次且催化活性没有明显降低。 展开更多
关键词 离子液体 催化 BIGINELLI反应 3 4-二氢嘧啶-2(1h)-酮/硫酮 Ionic Liquid Catalysis BIGINELLI Reaction 4-Dihydropyrimidin-2(1h)-ones/Thiones
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A Facile Synthesis of 9,10-Dimethoxybenzo[6,7]- ox-epino[3,4-<i>b</i>]quinolin-13(6<i>H</i>)-one and Its Derivatives
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作者 Dingqiao Yang Xiuli Liang +1 位作者 Xiongjun Zuo Yuhua Long 《International Journal of Organic Chemistry》 2013年第2期119-124,共6页
A concise and efficient method for the synthesis of novel 9,10-imethoxybenzo[6,7]oxepino[3,4-b]quinolin13(6H)-one and its derivatives 7a-p has been developed via the intramolecular Friedel-Crafts acylation reactions o... A concise and efficient method for the synthesis of novel 9,10-imethoxybenzo[6,7]oxepino[3,4-b]quinolin13(6H)-one and its derivatives 7a-p has been developed via the intramolecular Friedel-Crafts acylation reactions of 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic acids 6a-p with polyphosphoric acid (PPA) as catalyst and solvent under mild conditions. The key intermediates 6a-p were prepared through the in situ formation of ethyl 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylates 5a-p followed by hydrolysis with aqueous ethanolic sodium hydroxide solution. The novel synthetic method has the advantages of good yields, easy work-up, and environmentally friendly character, which may provide a novel highly efficient process for making quinoline and related azaheterocycle libraries. 展开更多
关键词 The Intramolecular Friedel-Crafts Acylation Reaction: 9 10-Dimethoxybenzo [6 7]oxepino[3 4-b]quinolin-13(6h)-one and Its DERIVATIVES 6 7-Dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic Acid: Ethyl 7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylate: PPA
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Multicomponent cascade reaction of 3-formylchromones:Highly regioselective synthesis of functionalized pyridin-2(1H)-ones
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作者 Xinghan Yun Li Chen +3 位作者 Ying Lv Zihan Lu Kun Huang Shengjiao Yan 《Green Synthesis and Catalysis》 2023年第3期231-239,共9页
A novel protocol was developed for the construction of highly functionalized pyridin-2(1H)-ones from 3-formylchromones,ethyl 2-(pyridin-2-yl)acetate derivatives and amines via a complex multicomponent cascade reaction... A novel protocol was developed for the construction of highly functionalized pyridin-2(1H)-ones from 3-formylchromones,ethyl 2-(pyridin-2-yl)acetate derivatives and amines via a complex multicomponent cascade reaction involving targeted duplicated ring-opening and duplicated cyclization reactions which form skeleton-reorganized target compounds.A series of pyridin-2(1H)-ones were produced by this reaction accompanied by the formation of three bonds(one C–N and two C–C bonds)and the cleavage of one bond in one step.This protocol can be used in combinatorial and parallel syntheses of various pyridin-2(1H)-ones with potent biological activity.The advantages of this approach include simple and practical operation(multicomponent one-pot),high yields(up to 91%),and products with potential biological activity. 展开更多
关键词 Pyridin-2(1h)-ones Cascade reaction Selective synthesis 3-Formylchromones
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