The title compound 2-[(4-methoxy-6-methylthio-2-pyrimidinyl)aminocarbonyl- aminosulfonyl]benzoic acid methyl ester (C15H16N4O6S2, Mr = 412.44) was obtained by the reaction of (4-methoxy-6-methylthio-2-pyrimidinyl)amin...The title compound 2-[(4-methoxy-6-methylthio-2-pyrimidinyl)aminocarbonyl- aminosulfonyl]benzoic acid methyl ester (C15H16N4O6S2, Mr = 412.44) was obtained by the reaction of (4-methoxy-6-methylthio-2-pyrimidinyl)amine with 2-methoxylcarbonylbenzene-sulfonylisocya- nate. The crystal is of monoclinic, space group P21/c with a =11.169(3), b = 9.508(3), c = 17.690(5) ? b = 91.593(5), Z = 4, V = 1877.9(10) 3, Dc = 1.459 g/cm3, F(000) = 856, m(MoKa) = 0.324 mm-1, R = 0.0690 and wR = 0.1368 for 3301 observed reflections (I > 2s(I)). The N(1)H…N(3) and N(2)H…O(4) hydrogen bonds can be observed. In the molecule the phenyl plane(I), pyrimi- din-2-yl-urea bridge plane(Ⅱ) and ester plane(Ⅲ) form three conjugated systems.展开更多
Three tetraacetyl glucosyl esters of the ferrocenyl benzoic acids(compounds Ⅱ o,Ⅱ m,Ⅱ p) have been synthesized using a phase transfer catalyst(CTAB) in dichloroethane/water at 50 ℃. Their structures have been conf...Three tetraacetyl glucosyl esters of the ferrocenyl benzoic acids(compounds Ⅱ o,Ⅱ m,Ⅱ p) have been synthesized using a phase transfer catalyst(CTAB) in dichloroethane/water at 50 ℃. Their structures have been confirmed by elemental analysis, IR, 1H NMR and MS. The compounds were found to have antianemic activity. The RBC and HB values of the tested anemic rats were increased by 72 0% and 126 4%, respectively after abdomen injection.展开更多
基金The project was supported by the National Natural Science Foundation of China (20372021) and Natural Science Foundation of Hunan Province (03JJY3018)
文摘The title compound 2-[(4-methoxy-6-methylthio-2-pyrimidinyl)aminocarbonyl- aminosulfonyl]benzoic acid methyl ester (C15H16N4O6S2, Mr = 412.44) was obtained by the reaction of (4-methoxy-6-methylthio-2-pyrimidinyl)amine with 2-methoxylcarbonylbenzene-sulfonylisocya- nate. The crystal is of monoclinic, space group P21/c with a =11.169(3), b = 9.508(3), c = 17.690(5) ? b = 91.593(5), Z = 4, V = 1877.9(10) 3, Dc = 1.459 g/cm3, F(000) = 856, m(MoKa) = 0.324 mm-1, R = 0.0690 and wR = 0.1368 for 3301 observed reflections (I > 2s(I)). The N(1)H…N(3) and N(2)H…O(4) hydrogen bonds can be observed. In the molecule the phenyl plane(I), pyrimi- din-2-yl-urea bridge plane(Ⅱ) and ester plane(Ⅲ) form three conjugated systems.
文摘Three tetraacetyl glucosyl esters of the ferrocenyl benzoic acids(compounds Ⅱ o,Ⅱ m,Ⅱ p) have been synthesized using a phase transfer catalyst(CTAB) in dichloroethane/water at 50 ℃. Their structures have been confirmed by elemental analysis, IR, 1H NMR and MS. The compounds were found to have antianemic activity. The RBC and HB values of the tested anemic rats were increased by 72 0% and 126 4%, respectively after abdomen injection.
