期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
Palladium‐catalyzed enantioselective linear allylic alkylation of vinyl benzoxazinanones:An inner‐sphere mechanism
1
作者 Kai Wang Binli Wang +3 位作者 Xianghui Liu Hongjun Fan Yan Liu Can Li 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2021年第7期1227-1237,共11页
Palladium‐catalyzed asymmetric allylic alkylation(AAA)of vinyl benzoxazinanones has become an important strategy for the synthesis of chiral nitrogen‐containing heterocycle compounds.However,the asymmetric synthesis... Palladium‐catalyzed asymmetric allylic alkylation(AAA)of vinyl benzoxazinanones has become an important strategy for the synthesis of chiral nitrogen‐containing heterocycle compounds.However,the asymmetric synthesis of linear‐selective products has rarely been reported.The simultaneous control of regio‐,E/Z‐and enantioselectivities constitutes a major challenge and inhibits the advancement of this chemistry.Herein,we present a palladium‐catalyzed AAA of vinyl benzoxazinanones withα‐thiocyanato ketones,affording various chiral thiocyanates characterized with high linear‐,E‐and stereoselectivities.The reaction has a broad substrate scope and the chiral thiocyanates can be transformed to useful heterocycles.Experimental and computational studies suggest an inner‐sphere mechanism for AAA process,which results from the acidic and coordination effect of the nucleophilic substrates with palladium catalyst. 展开更多
关键词 Pd catalysis Asymmetric catalysis Allylic alkylation Vinyl benzoxazinanones Inner‐sphere mechanism
下载PDF
Cooperative Dual Organocatalytic Asymmetric Decarboxylative[4+3]Annulations with Benzoxazinanones
2
作者 Ling Zhu Teng Xie +1 位作者 Jin Song Liu-Zhu Gong 《Precision Chemistry》 2023年第4期241-247,共7页
The cooperative catalysis of an achiral Lewis base and a chiral N-heterocyclic carbene(NHC)enables a highly enantioselective[4+3]annulation of benzoxazinanones with isatin-derived enals.DMAP serves as a nucleophilic L... The cooperative catalysis of an achiral Lewis base and a chiral N-heterocyclic carbene(NHC)enables a highly enantioselective[4+3]annulation of benzoxazinanones with isatin-derived enals.DMAP serves as a nucleophilic Lewis base to promote decarboxylation of benzoxazinanones,which leads to azaortho-xylylene intermediates that undergo[4+3]annulations with NHC-bound homoenolates.This method breaks the substrate scope limitation of transition-metal-catalyzed variants,thus a broader range of benzoxazinanones are tolerated,and provides a straightforward entry to enantioenriched spirooxindoles in high structural diversity. 展开更多
关键词 cooperative catalysis chiral N-heterocyclic carbene [4+3]annulation benzoxazinanones spirobenzazepinone
原文传递
Diastereo-and enantioselective palladium-catalyzed dearomative [4+2] cycloaddition of 3-nitroindoles 被引量:1
3
作者 Jia-Jia Suo Juan Du +3 位作者 Yang-Jie Jiang Di Chen Chang-Hu Ding Xue-Long Hou 《Chinese Chemical Letters》 SCIE CAS CSCD 2019年第8期1512-1514,共3页
A Pd-catalyzed asymmetric decarboxylative[4+2]cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach.The reaction provides an efficient protocol for constructing a s... A Pd-catalyzed asymmetric decarboxylative[4+2]cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach.The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and with excellent diastereo-and enantioselectivities. 展开更多
关键词 PALLADIUM [4+2]cycloaddition Asymmetric CATALYSIS 3-Nitroindole VINYL benzoxazinanone
原文传递
Pd-Catalyzed enantioselective synthesis of 2-methyl-3-methyleneindoline 被引量:1
4
作者 Chun-Hua Lu Sima Darvishi +1 位作者 Vahid Khakyzadeh Changkun Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期405-407,共3页
A Pd-catalyzed enantioselective synthesis of 2-methyl-3-methyleneindoline in up to 89% yield and 84% ee from racemic vinyl benzoxazinanones has been developed with the help of(R,R)-BenzP*ligand.Mechanism studies suppo... A Pd-catalyzed enantioselective synthesis of 2-methyl-3-methyleneindoline in up to 89% yield and 84% ee from racemic vinyl benzoxazinanones has been developed with the help of(R,R)-BenzP*ligand.Mechanism studies support the formation of palladacyclobutane as the key intermediate via C2 attack to π-allyl Pd complex.The β-hydride elimination provides a new reaction pathway for the palladacyclobutane. 展开更多
关键词 Palladium Asymmetric catalysis Vinyl benzoxazinanone 2-Methyl-3-methyleneindoline Palladacyclobutane
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部