A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-c...A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical cou-pling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclicα-halides andα-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions.With multi distinct sites for structural modification,a di-verse pool of chiral N,N,P-ligands is readily accessed,allowing for rapid optimization of the ligand structure for a specific substrate.Notably,the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.展开更多
Functionalized benzylic zinc halides reacted with benzaldehydes in the presence of Lewis acid Me3SiCl giving high yields of trans-stilbenes under the catalysis of Co(PPh3)3Cl.
A novel type of palladium-catalyzed cascade cyclization-coupling reaction has been found. Reaction of N, N-diallylbenzoylamide 1 with benzyl halides 2 afforded the corresponding dihydropyrroles 3 in moderate to excel...A novel type of palladium-catalyzed cascade cyclization-coupling reaction has been found. Reaction of N, N-diallylbenzoylamide 1 with benzyl halides 2 afforded the corresponding dihydropyrroles 3 in moderate to excellent yields.展开更多
The visible‐light photoredox‐catalyzed carboxylation of benzyl chlorides and bromides with CO_(2) has been reported.With inexpensive organic dyes as photocatalysts and amines as electron donors,this carboxylation pr...The visible‐light photoredox‐catalyzed carboxylation of benzyl chlorides and bromides with CO_(2) has been reported.With inexpensive organic dyes as photocatalysts and amines as electron donors,this carboxylation proceeds well in the absence of sensitive organometallic reagents,transition metal catalysts,or metallic reductants.A wide range of commercially available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids,including several pharmaceutical molecules and drug precursors,in moderate to high yields.Moreover,this reaction features mild reaction conditions(one atmospheric pressure of CO_(2) and room temperature),broad substrate scope,good functional group tolerance,easy scalability,and low catalyst loading,thus providing an efficient approach for the assembly of aryl acetic acids.展开更多
The title compound was prepared from the mixture of cobalt ( Ⅱ ) acetate, chromium trioxide and pyridine in an aqueous solution, and its structure was determined by X-ray single crystal diffraction method. A number o...The title compound was prepared from the mixture of cobalt ( Ⅱ ) acetate, chromium trioxide and pyridine in an aqueous solution, and its structure was determined by X-ray single crystal diffraction method. A number of alcohols, benzyl halides and benzy-lamines can be oxidized by this oxidant to the corresponding aldehydes in high yields.展开更多
基金We are grateful to the National Natural Science Foundation of China(Nos.22071073,21772218 and 21821002)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences and Central China Normal University(CCNU).
文摘A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)-benzoic acid were developed.Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical cou-pling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclicα-halides andα-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions.With multi distinct sites for structural modification,a di-verse pool of chiral N,N,P-ligands is readily accessed,allowing for rapid optimization of the ligand structure for a specific substrate.Notably,the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.
基金This work was supported by the National Natural Science Foundation of China and the Northwest Normal University Science and Technology Devolopment Foundation of China.
文摘Functionalized benzylic zinc halides reacted with benzaldehydes in the presence of Lewis acid Me3SiCl giving high yields of trans-stilbenes under the catalysis of Co(PPh3)3Cl.
文摘A novel type of palladium-catalyzed cascade cyclization-coupling reaction has been found. Reaction of N, N-diallylbenzoylamide 1 with benzyl halides 2 afforded the corresponding dihydropyrroles 3 in moderate to excellent yields.
文摘The visible‐light photoredox‐catalyzed carboxylation of benzyl chlorides and bromides with CO_(2) has been reported.With inexpensive organic dyes as photocatalysts and amines as electron donors,this carboxylation proceeds well in the absence of sensitive organometallic reagents,transition metal catalysts,or metallic reductants.A wide range of commercially available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids,including several pharmaceutical molecules and drug precursors,in moderate to high yields.Moreover,this reaction features mild reaction conditions(one atmospheric pressure of CO_(2) and room temperature),broad substrate scope,good functional group tolerance,easy scalability,and low catalyst loading,thus providing an efficient approach for the assembly of aryl acetic acids.
文摘The reaction of benzyl alcohol and ethanol cannot take place with quaternary ammonium salt,but will be carried out smoothly if benzyl halide is added.
文摘The title compound was prepared from the mixture of cobalt ( Ⅱ ) acetate, chromium trioxide and pyridine in an aqueous solution, and its structure was determined by X-ray single crystal diffraction method. A number of alcohols, benzyl halides and benzy-lamines can be oxidized by this oxidant to the corresponding aldehydes in high yields.
