AIM: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).
patients with multiple myeloma (MM) were investigated for lymphocyte subsets using APAAP (Alkaline Phosphastase Anti-Alkaline Phosphatase) technique and a panel of monoclonal antibodies.Radioimmunoassay was used to ex...patients with multiple myeloma (MM) were investigated for lymphocyte subsets using APAAP (Alkaline Phosphastase Anti-Alkaline Phosphatase) technique and a panel of monoclonal antibodies.Radioimmunoassay was used to examine serum beta-2-microglobulin (Sβ2-MG).The results showed that OKT3, OKT4 positive cells and OKT4/OKT8 ratio reduced significantly. OKT8 positive cells increased sharply in MM. We conclude that,in MM,all patients have severe abnormalities in the number and proportion of T cells.The level of S β2-MG increased significantly, especially in the initial and relapsing patients.But,we did not find the relationship between Sβ2-MG and T subsets.展开更多
目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标...目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标,检测相关代谢血生化指标,采用酶联免疫吸附实验(ELISA)法测定空腹血清Betatrophin水平,采用直线相关分析研究betatrophin与胰岛β细胞功能、体测及代谢指标的相关关系。结果观察组血清Betatrophin水平(422.5±247.60)pg/m L明显高于对照组(316.3±293.30)pg/m L,差异有统计学意义(P<0.05);相关性分析提示Betatrophin与腰臀比、HOMA-IR、FPG、2 h PG、HbA1c、FINS、TG呈正相关(r=0.215、0.216、0.249、0.447、0.338、0.452、0.470,P<0.01),与HDL-C、HOMA-β成负相关(r=-0.256、-0.363,P<0.05),差异有统计学意义(P<0.05)。结论初诊肥胖2型糖尿病患者的血清betatrophin水平较NGT组明显升高,并且与胰岛β细胞功能密切相关,推测其参与了糖尿病的发生。展开更多
文摘AIM: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).
文摘patients with multiple myeloma (MM) were investigated for lymphocyte subsets using APAAP (Alkaline Phosphastase Anti-Alkaline Phosphatase) technique and a panel of monoclonal antibodies.Radioimmunoassay was used to examine serum beta-2-microglobulin (Sβ2-MG).The results showed that OKT3, OKT4 positive cells and OKT4/OKT8 ratio reduced significantly. OKT8 positive cells increased sharply in MM. We conclude that,in MM,all patients have severe abnormalities in the number and proportion of T cells.The level of S β2-MG increased significantly, especially in the initial and relapsing patients.But,we did not find the relationship between Sβ2-MG and T subsets.
基金Supported by the National Natural Science Foundation of China(No.51572232,No.51561135015)Key Technology Research and Development Program of Ningbo(No.2011B1001)
文摘目的探讨初诊肥胖2型糖尿病患者血清Betatrophin水平与胰岛β细胞功能的关系。方法方便选择2014年1月—2015年1月初诊肥胖2型糖尿病患者100例为研究对象(观察组),另选择同期该院体检健康者(NGT)者100名为对照观察(对照组)。测量人体指标,检测相关代谢血生化指标,采用酶联免疫吸附实验(ELISA)法测定空腹血清Betatrophin水平,采用直线相关分析研究betatrophin与胰岛β细胞功能、体测及代谢指标的相关关系。结果观察组血清Betatrophin水平(422.5±247.60)pg/m L明显高于对照组(316.3±293.30)pg/m L,差异有统计学意义(P<0.05);相关性分析提示Betatrophin与腰臀比、HOMA-IR、FPG、2 h PG、HbA1c、FINS、TG呈正相关(r=0.215、0.216、0.249、0.447、0.338、0.452、0.470,P<0.01),与HDL-C、HOMA-β成负相关(r=-0.256、-0.363,P<0.05),差异有统计学意义(P<0.05)。结论初诊肥胖2型糖尿病患者的血清betatrophin水平较NGT组明显升高,并且与胰岛β细胞功能密切相关,推测其参与了糖尿病的发生。
