Rhodium(III)-catalyzed enantioselective C-H indolylization of isoquinolines was developed.The C-H coupling reactions between 1-aryl isoquinoline derivatives and 3-indolylphenyliodonium salts proceeded smoothly in the ...Rhodium(III)-catalyzed enantioselective C-H indolylization of isoquinolines was developed.The C-H coupling reactions between 1-aryl isoquinoline derivatives and 3-indolylphenyliodonium salts proceeded smoothly in the presence of a modified chiral cyclopentadienyl-Rh(III)complex,affording a series of axially chiral indolylated biaryl products in excellent yields and enantioselectivity(up to 98%yield and 95%ee).展开更多
基金We thank the National Key R&D Program of China(2021YFA1500100)National Natural Science Foundation of China(21821002,92256302,22071260)Science and Technology Commission of Shanghai Municipality(21520780100)for generous financial support.S.-L.Y.thanks the supports from the New Cornerstone ScienceFoundation.
文摘Rhodium(III)-catalyzed enantioselective C-H indolylization of isoquinolines was developed.The C-H coupling reactions between 1-aryl isoquinoline derivatives and 3-indolylphenyliodonium salts proceeded smoothly in the presence of a modified chiral cyclopentadienyl-Rh(III)complex,affording a series of axially chiral indolylated biaryl products in excellent yields and enantioselectivity(up to 98%yield and 95%ee).
