Evolutionary trend analysis and knowledge structure mapping of endothelial dysfunction in sepsis:a bibliometrics study

BACKGROUND:A pathophysiological feature of septic organ failure is endothelial dysfunction in sepsis(EDS).The physiological and pathological mechanism of sepsis is considered to be vascular leakage caused by endothelial dysfunction.These pathological changes lead to systemic organ injury.However,an analysis using bibliometric methods has not yet been conducted in the field of EDS.This study was conducted to provide an overview of knowledge structure and research trends in the fi eld of EDS.METHODS:Based on previous research,a literature search was performed in the Web of Science Core Collection(WoSCC)for publications associated with EDS published between the year 2003 and 2023.Various types of data from the publications,such as citation frequency,authorship,keywords and highly cited articles,were extracted.The"Create Citation Report"feature in the WoSCC was employed to calculate the Hirsch index(h-index)and average citations per item(ACI)of authors,institutions,and countries.To conduct bibliometric and visualization analyses,three bibliometric tools were used,including R-bibliometrix,CiteSpace(co-citation analysis of references),and VOSviewer(co-authorship analysis of institutions,co-authorship analysis of authors,co-occurrence analysis of keywords).RESULTS:After excluding invalid records,the study finaly included 4,536 publications with 135,386 citations.Most of these publications originated in the USA,China,Germany,Canada,and Japan.Harvard University emerged as the most prolifi c institution,while professor Jong-Sup Bae and his research team at Kyungpook National University emerged as authors with the greatest infl uence.The"protein C","tissue factor","thrombin","glycocalyx",“acute kidney injury”,“syndecan-1”and“biomarker”were identifi ed as prominent areas of research.Future research may focus on molecular mechanisms(such as as vascular endothelial[VE]-cadherin regulation)and therapeutic interventions to enhance endothelial repair and function.CONCLUSION:Our findings show a growing interest in EDS research.Key areas for future research include signaling pathways,molecular mechanisms,endothelial repair,and interactions between endothelial cells and other cell types in sepsis.

Bibliometrics analysis based on the Web of Science:Current trends and perspective of gastric organoid during 2010-2023

BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy testing.The use of gastric organoid models holds significant promise for advancing personalized medicine research.However,a comprehensive bibliometric review of this burgeoning field has not yet been published.AIM To analyze and understand the development,impact,and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection(WoSCC)database.METHODS This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023,as indexed in the WoSCC.CiteSpace and VOSviewer were used to depict network maps illustrating collaborations among authors,institutions and keywords related to gastric organoid.Citation,co-citation,and burst analysis methodologies were applied to assess the impact and progress of research.RESULTS A total of 656 relevant studies were evaluated.The majority of research was published in gastroenterology-focused journals.Globally,Yana Zavros,Hans Clevers,James M Wells,Sina Bartfeld,and Chen Zheng were the 5 most productive authors,while Hans Clevers,Huch Meritxell,Johan H van Es,Marc Van de Wetering,and Sato Toshiro were the foremost influential scientists in this area.Institutions from the University Medical Center Utrecht,Netherlands Institute for Developmental Biology(Utrecht),and University of Cincinnati(Cincinnati,OH,United States)made the most significant contributions.Currently,gastric organoids are used mainly in studies investigating gastric cancer(GC),Helicobacter pylori-infective gastritis,with a focus on the mechanisms of GC,and drug screening tests.CONCLUSION Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques.Major contributions from renowned academic institutions highlight this field’s dynamic growth.

Research Progress of Different Fertilization Models in Farmland Based on Bibliometrics

In order to grasp the research status of different fertilization modes in China s farmland more comprehensively, with papers in core journals of Chinese Peking University collected in CNKI database from 2003 to 2022 as the main research object, this paper analyzed the research status of different fertilization modes from the perspectives of annual number of published papers, published journals, keywords and highly cited papers applying the bibliometrics research method. This study provides reference for the research in this field.

Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index Expanded.Using CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research trends.Results:This investigation yielded a total of 336 relevant papers.China is the most productive country.Shanghai University of Traditional Chinese Medicine is the leading institution.The journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative Medicine.The author with the most citations and centrality is Lin JM.The terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness centrality.Conclusion:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment investigations.In recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and invasion.However,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

Bibliometrics-based Research Hotspots and Development Trends in Eco-hydrology of Dammed Rivers

Water conservation initiatives satisfy the demand for water supply,electricity generation,irrigation,and flood control.While helping humanity,they have also altered the ecosystem of natural rivers,impacted river ecology,disrupted river continuity,and jeopardized the existence of aquatic creatures in rivers.Studying the impacts of dam construction on rivers can enhance our knowledge of river ecological and environmental concerns and help sustain the health of river ecosystems,thereby realizing the harmony between humans and water in both theoretical and practical aspects.This study used bibliometrics and constructed an author-keyword 2-mode matrix network using Co-Occurrence software to identify the hotspots and research trend in eco-hydrology of dammed rivers.We identified‘FLOW’‘SEDIMENT’‘QUALITY’and‘MODEL’as the research hotspots in the ecological impact of dammed rivers,and combined the related literatures,we highlight the research progress in the four directions.Then the research shortcomings and prospect were discussed,including strengthening the monitoring and analysis of critical ecological variables,enhancing the hydrological monitoring density for small rivers,strengthening the research of relationship between eutrophication and zooplankton,establishing multiscale approaches,and combining multi-sources information technologies to improve parameter accuracy in the model research.

Bibliometrics Is Valuable Science.Why Do Some Journals Seem to Oppose It?

Of all forms of research that can be accepted as valuable investigations,bibliometrics is often thought to be one of the most accessible to the widest number of researchers.Qualitative methods like interviewing and ethnography require extensive training,time,and often need ethical approval.Even basic quantitative methods like using questionnaires require significant drafting,mastery of language,and ethical review.Bibliometrics,being based on the analysis of publicly-available bibliographic data,does not have these requirements.Unlike with these other research approaches,where the top software(e.g.,SPSS,NVIVO)are expensive for researchers to afford.

Historical Bibliometrics Using Google Scholar: The Case of Roman Law, 1727–2016

Purpose: The purpose of this study is to investigate the historical and linguistic coverage of Google Scholar, using publications in the field of Roman law as an example.Design/methodology/approach: To create a dataset of Roman law publications, we retrieved a total of 21,300 records of publications, published between years 1500 and 2016, with title including words denoting "Roman law" in English, French, German, Italian, and Spanish. Findings: We were able to find publications dating back to 1727. The largest number of publications and authors date to the late 19th century, and this peak might be explained by the role of Roman law in French legal education at the time. Furthermore, we found exceptionally skewed concentration of publications to authors, as well as of citations to publications. We speculate that this could be explained by the long time-frame of the study, and the importance of classic works. Research limitation: Major limitations, and potential future work, relate to data quality, and cleaning, disambiguation of publications and authors, as well as comparing coverage with other data sources. Practical implications: We find Google Scholar to be a promising data source for historical bibliometrics. This approach may help bridge the gap between bibliometrics and the "digital humanities".Originality/value: Earlier studies have focused mainly on Google Scholar's coverage of publications and citations in general, or in specific fields. The historical coverage has, however, received less attention.

Analysis of the hotspots and trends in traditional Chinese medicine immunomodulation research based on bibliometrics

Objective To analyze the intellectual structure,hotspots and trends of traditional Chinese medicine(TCM)in immune regulation research.Methods The data were extracted from the Web of Science Core Collection(WoSCC)and the China National Knowledge Infrastructure(CNKI)and verified by two experienced TCM researchers.The time of literature retrieval is up to 2020.CiteSpace 5.7.R1 and Microsoft Excel 2016 were used for the statistical analysis and bibliometric diagrams,including the co-occurrence network of authors,institutions,countries,keywords,references,dual-map overlays of journals and citation bursts,etc.Results A total of 12270 publications related to TCM in immune regulation were included.The annual number of publications has increased in this field.There was close cooperation of countries and institutions,while the distribution of scholars was scattered.China was the core of the cooperation network.The dual-map overlays analysis of journals showed that core and marginal fields had increased.The keywords and references analysis showed that network pharmacology,metabolism and cancer were the most high-frequency keywords with high-intensity bursts.Conclusion TCM in immune regulation has attracted wider attention,with multi-country,multi-field,multi-disciplinary and multi-level research developing toward informatization.Network pharmacology,metabolism and cancer may be the focus of future research in this field.

The bibliometrics survey of ecological economic research:A knowledge mapping analysis based on the SCI and SSCI database

Based on bibliometrics and knowledge mapping analysis method,this paper uses CiteSpace,a visual literature analysis tool,to analyze 3794 related documents with the theme of“economic economy”in SCI and SSCI databases from 2010 to 2020,including authors,institutions,subject headings and literature co-citation,so as to reveal the development and hot spots of ecological economic research.The results show that in recent years,the number of documents on ecological economic research has been increasing,and developed countries are dominant.China’s research in this field has developed rapidly and has certain advantages in terms of quantity and quality.The institution with the largest number of papers is Chinese Academy Science,followed by Beijing Normal University,University of Chinese Academy of Sciences,Peking University and Universitat autonomy de Barcelona;research hotspots in recent 10 years include“sustainability”,“management”,“climate change”,“impact”,“economy”,“china”,“conservation”,“ecosystem service”,etc.The top three journals are Sustainability,Journal of Cleaner Production,and Ecological Economics,accounting for about 10%of the total number of papers published.The hot spots of ecological economic research in 2010-2020 can be divided into three stages,with different theme words emerging in each stage.From 2018 to 2020,the theme word of high-strength emergence is“anthropocene”,which indicates that“anthropocene”may be the focus of future research.

Bibliometrics study on the Journal of American College Health： 1994-2014

Objective： To help readers around the world comprehensively understand the development of the journal and evolution of cooperation study, we employed a bibliometrics analysis for the Journal of American College Health. Methods： One-thousand-one-hundred-forty-three articles published in this journal from 1994 were analyzed using the bibliometrics and visualization software CiteSpace. Results： The annual number of published articles and cited studies increased. The published studies by RP Keeling and H Wechsler were at the forefront. ＂College student＂ and ＂alcohol＂ were prevalent key- words. University of Wisconsin and Harvard University were the institutional leaders of contributions. Conclusions： This journal provides an important platform for sharing research achievements and promoting cooperation in this field. The level of articles published is continually improving. A research cooperative network promoted by famous scholars and institutions is developing. However, crossregional and international cooperation is relatively limited.

Visualization analysis of the research status of FU Qingzhu’s Obstetrics and Gynecology based on bibliometrics

Objective This study examined the research status and development process of FU Qingzhu’s Obstetrics and Gynecology(Fu Qing Zhu Nv Ke,《傅青主女科》,FQZNK)in the past 40 years with bibliometrics and visual analysis.Methods Retrieved all related literature in the research field of FQZNK from the domestic and foreign databases:China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Database,and Web of Science(WOS)core database,including Science Citation Index Expanded(SCIE),Social Sciences Citation Index(SSCI),and Arts&Humanities Citation Index(A&HCI).The search range was from January 1,1980 to March 10,2021.In addition,bibliometrics and CiteSpace 5.7.R2 software were used to analyze literature types,published journals,cited literature,the number of author publica-tions,co-author networks,co-institution networks,keyword co-occurrence networks,keyword clusters,and keyword bursts.Results A total of 678 valid records were included in the final dataset.Literature types,high publication journals,highly cited literature,high-yield institutions,high-yield research teams,and high-productivity scholars in this research field were found through bibliometrics.Liter-ature types can be divided into four categories,among which 451 are theoretical studies on academic thoughts of FQZNK,accounting for 66.5%of the included journals.The Journal of Shanxi Traditional Chinese Medicine had the largest volume of published articles(61),ac-counting for 9.0%of the total number of the included journals.The most cited literature was ZHOU Mingxin’s article“Using the quantitative method to discuss author’s authenticity and formula characteristics of FU Qingzhu’s Obstetrics and Gynecology”,which was cited 94 times.Hunan University of Chinese Medicine,the institution with the most publications,published 45 articles,and YOU Zhaoling,the most published author,published 33 articles.Moreover,it was found that most high-yield researchers came from high-yield institutions and that Hun-an University of Chinese Medicine had the most research on FQZNK.Keyword co-occur-rence analysis revealed that the keyword“FQZNK”had the highest frequency(597 times)and the highest centrality(1.00).Keyword cluster analysis used the Log-Likelihood Ratio(LLR)al-gorithm to form eleven important clusters:#0 treatment aiming at its root causes,#1 gynecopathy,#2 Siwu Decoction(四物汤),#3 FU Qingzhu,#4 post-partum,#5 infertility,#6 dysmenorrhea,#7 sterility,#8 coordinate the heart and kidney,#9 Danggui Buxue Decoction(当归补血汤),and#10 treatment.It was found that the prescriptions of FQZNK were studied mainly before 2000,the theoretical studies were mainly conducted before 2010,and its clinic-al application was mainly explored from 2010 until now.Diseases such as dysmenorrhea,morbid vaginal discharge,infertility,metrorrhagia,and polycystic ovarian syndrome(PCOS)have recently become popular topics in this field.Conclusion The current study provides more scientific,accurate,and comprehensive sci-entific support for further research and development of traditional Chinese medicine(TCM)in FQZNK.With this foundation,people can use burst detection to ascertain the current hot-spots in research,get their development trends,and forecast future research directions.In ad-dition,infertility,morbid vaginal discharge,flooding,and PCOS treatments based on TCM syndrome differentiation are currently popular research topics for FQZNK.

Sustainability in Higher Education Institutions(HEI):Merging the Study Systematic Review,Analysis Content and Bibliometrics

This study aims to explore how the topic of sustainability in Higher Education Institutions(HEI)has been addressed in the scientific literature.It presents a systematic literature review of peer-reviewed journal articles published between 1975 and 2019.After that,bibliometric and content analyses were performed in order to identify the behavior and evolution of the literature and identify the frequency with which they appear in the text,making it possible to raise replicable and valid inferences to the data.The results of this study indicate that the theme is emerging since the year 2010 and with a strong focus on qualitative studies,focused on critical theory.The results indicate that although studies involve the tripod environment,economy,and society,there is still a gap in studies that deal with specific issues to solve practical problems and that analyze the impacts from a more holistic perspective.The combination of methods made it possible to identify and interpret the articles in the selected sample,but based on results reported by other authors,with little room for quality control and integrity.

Comparative Study of Trace Metrics between Bibliometrics and Patentometrics

Purpose： To comprehensively evaluate the overall performance of a group or an individual in both bibliometrics and patentometrics. Design/methodology/approach： Trace metrics were applied to the top 30 universities in the2014 Academic Ranking of World Universities（ARWU） — computer sciences, the top 30 ESI highly cited papers in the computer sciences field in 2014, as well as the top 30 assignees and the top 30 most cited patents in the National Bureau of Economic Research（NBER） computer hardware and software category.Findings： We found that, by applying trace metrics, the research or marketing impact efficiency, at both group and individual levels, was clearly observed. Furthermore, trace metrics were more sensitive to the different publication-citation distributions than the average citation and h-index were.Research limitations： Trace metrics considered publications with zero citations as negative contributions. One should clarify how he/she evaluates a zero-citation paper or patent before applying trace metrics.Practical implications： Decision makers could regularly examinine the performance of their university/company by applying trace metrics and adjust their policies accordingly.Originality/value： Trace metrics could be applied both in bibliometrics and patentometrics and provide a comprehensive view. Moreover, the high sensitivity and unique impact efficiency view provided by trace metrics can facilitate decision makers in examining and adjusting their policies.

Research hotspots and trends in Chinese minority traditional medicine during 2021:a visual bibliometrics analysis

Background:Chinese minority traditional medicine(CMTM)is an important component of Chinese traditional culture and medicine that has contributed to the health and prosperity of Chinese people of all ethnic groups.Although this type of medicine has attracted interest,its developmental trends and research status remain unclear.Therefore,we used literature metrology to evaluate the publications on CMTM during 2021 and explore hotspots and frontier areas.Methods:Reports associated with CMTM published between January 1,2021,and December 31,2021,were downloaded from the Web of Science database.The authors,institutions,countries,journals,keywords,and other standard bibliometric indicators were analyzed and visualized using CiteSpace,and research hotspots and trends were identified.Results:We retrieved 152 CMTM-related publications,among which Tibetan medicine attracted the most interest.Journals covering alternative and complementary medicine topics were the most prevalent sources of reports about CMTM,particularly the Journal of Ethnopharmacology.Most research in this field was conducted in China and frequently published by traditional Chinese medicine colleges and universities.One author,Yi Zhang,has extensively investigated Tibetan and Korean medicine.The keyword co-occurrence network revealed that investigations into ethnic groups mainly focused on the pharmacological activities and phytochemical components of ethnic medicines.The keywords of gut microbiota and autophagy in some publications reflect the direction of future CMTM investigations.Conclusion:Our findings showed the current status and trends in CMTM investigations.This information will help identify new research directions and hotspots in this field.

Bibliometrics and social network analysis of clinical researches on acupuncture and moxibustion

Objective:In order to explore the development trend and research hotspots of clinical researches of acupuncture and moxibustion and provide some insight into the key research direction for researchers.Methods:The clinical studies of acupuncture and moxibustion were searched in PubMed.Using the method of bibliometry,the year,country,journals,authors were analyzed.The cluster analysis was used to analyze subject terms by the social network analysis.Results:A total of 4237 literature were retrieved,published in 617 journals.The number of clinical studies on acupuncture and moxibustion has been increased substantially since 2006.The clinical researches on acupuncture and moxibustion have been conducted worldwide,specifically in China,the United States,Britain,Sweden,etc.Three major author cooperation networks(China,South Korea and European and North American countries)has been formed.The cluster analysis based on 53 high-frequency theme words indicates that the clinical researches on acupuncture and moxibustion are mainly concerned about acupoint selection associated with pain,stroke,knee osteoarthritis and other diseases in different age groups,blind,treatment outcomes,time factor of acupuncture,etc.Conclusion:Clinical researches on acupuncture and moxibustion have been widely concerned by international medicine.The research direction is clear,Thematic is concentrate,and research paradigm has been formed.However,international influence is still limited academically.The cooperation between different authors or teams is insufficient.The core research hotspots include the selection of acupoint,acupuncture and moxibustion tools,research design,treatment outcome,blind,time factor,follow-up,placebo,clinical protocol,quality of life,patient satisfaction and so on.

Research progress and prospect of grassland degradation based on bibliometrics analysis during 1970–2020

To understand the research trends and areas of focus on the grassland degradation(GD),a bibliometric study based on the Science Citation Index-Expanded(SCI-E)was performed.This study presented a comprehensive overview of the field based on the annual papers,research areas,temporal trends in keywords,marked journals,institutions,and authors.In the SCI-E database,GD publications first appeared in1970.Thus,we chose the study period between 1970 and 2020.The results showed that the annual number of publications increased in exponential model,with an especially rapid increase after 2009.Dong S.K.,Wang S.P.,and Liu S.L.were the most competitive authors based on their large numbers of papers and citations.A keyword analysis indicated that“grazing,alpine grassland,soil carbon and nitrogen,plant diversity,vegetation restoration”was the most popular study area.The institution with the greatest research publications and most citations was the Chinese Academy of Sciences.Journal of Arid Environments was one of the most popular journals for researchers to publish their research and had greater influence in the field with larger citations than other journals.Environmental science and ecology,soil science,plant science,biodiversity protection,geoscience,and water resources were the most popular Web of Science research areas.The keywords knowledge map mainly divides into four clusters,which are“vegetation”,“soil carbon”,“climate change”,and“grazing”.The ten clusters of the author’s co-occurrence analysis showed that the research areas of GD mainly concentrate on alpine grassland of Qinghai Tibetan Plateau and temperate steppe of Inner Mongolia.Especially under global climate change and the increasing human activities,they were continually increasing close attention to the present.The research methods are mainly in the combination of micro and macro view,such as high-throughput sequencing of the microbial community,remote sensing,quantitative analysis of models,etc.The current international research frontiers are alpine meadow degradation and the assessment of ecosystem service in degraded grassland.To distinguish human activities and climate change to the GD rate is also a new research hotspot in recent years.As the first bibliometrics paper in GD,this paper presents an attempt to better understanding of the progress on GD research.

Bibliometrics analysis of psychological intervention in breast cancer patients

Background:In order to provide some references and direction for further research on psychological intervention for breast cancer patients,we analyzed the breast cancer patients,learned its research status,and found out the existing problems.Methods:We retrieved relevant literatures on psychological intervention for breast cancer patients from databases such as CNKI,Wanfang data,VIP and CBM.Note Express 3.2 was used for bibliometric analysis.Results:A total of 60 articles were included.We found that the research institutions were mainly hospitals.There was a lack of attention to special breast cancer patients,efficacy comparison trials of different intervention and cooperation during institutions.Research design was not rigorous enough:lack of pertinence of populations,unclear and short intervention interval,low repeatability of research trials,low transparency of intervention,and defects in intervention quality control.Conclusion:Clinical trials on psychological intervention for breast cancer patients should pay more attention to special breast cancer populations.Researchers should correctly grasp related research trends,seek cooperation opportunities with other institutions,and improve the quality of their own research and ensure the innovation and scientificity of trial design.Meanwhile,researchers can further explore the psychological intervention methods for special breast cancer populations,and conduct comparative studies on the efficacy of different intervention measures.

Bibliometrics analysis of Jean Waston’s Human caring theory in China in the past 10 years

Aims:To analyze the research status and development trend of human caring theory in the field of nursing in China,and to provide better reference for theory and research.Methods:All articles related to human caring theory were searched in the China national knowledge infrastructure(CNKI),Wanfang Data and VIP database which were published in the past year was searched.NoteExpress document management software and Excel software were used to conduct bibliometrics analysis on the annual distribution,regional distribution,journal distribution,fund support and research content of the documents.The search time was from 1 January 2009 to 31 December 2009.Results:A total of 113 articles were included in the literature.The total number of published articles showed a slow and tortuous trend.After 2013,the volume of publications was relatively stable.The core journals accounted for 17.7%of the total number of articles,and most of them came from hospitals.The research covers clinical applications,nursing education,nursing management and other fields.Conclusion:Human caring theory is an important part of nursing theory,Nursing researchers in China can conduct clinical research,nursing management and nursing education research based on their theoretical connotation,combined with clinical and teaching environment.

Bibliometrics of stem cell effects on aging in the last decade based on the Web of Science database

Objective:To summarize the recent 10 years of related literature on stem cell effect on aging and explore the research results and hot topics.Methods:Based on the core databaseof Web of Science,all relevant literature from January 1,2012,to December 31,2021,was screened,and CiteSpace 6.1.R2 software was used to show the intrinsic value of literature.The number of publications,research institutions,research countries,co-cited literature,and keywords was analyzed and visualized.Results:In the past 10 years,the total number of articles published showed an upward trend.The number of articles published by relevant countries was 3,911,and the United States had the most significant number of articles published and the highest centrality.The research institutions were mainly universities,supplemented by research centers,and the quality of articles published by famous foreign universities in this field was high.The most co-cited literature is“Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan”by Darren J Baker,which clarifies the feasibility of cell therapy for aging.The high-frequency keywords are stem cell,senescence,expression,etc.,and the most central ones are cancer cell,migration and DNA repair,etc.In addition,emergent words and clustering show that research hotspots are mainly in the aging mechanism.There are many research entry points,and the pathogenesis and development of senescence,therapeutic targets of ion channels in senescent cells,and their effects on exosomes are the main focus of current research.Conclusion:Literature through the analysis of 10 years of research literature summary suggests that stem cell function in aging still needs further study;the United States is in the leading position in this regard,and the research results also show that research institutions dominate in the developed countries,North America and Europe in the increasing number of papers at the same time,and China should pay attention to the quality of the post,in order to make more progress.The literature of some high-quality scholars can be used as a reference to expand our thinking.The aging mechanism still needs to be many follow-upstudies to clarify the pathway and target in the treatment of more refined Alzheimer’s disease and other age-related diseases need to delve into.Subsequent scholars should study the specific role of stem cells in treating aging;in recent years,hot words,such as exosomes,oxidative stress,etc.,can be used as the thinking of the follow-up study and contribute to the development of the field.

Research status of peri-menopausal insomnia based on bibliometrics

Objective:To reflect the current situation and development level of the treatment of peri-menopausal insomnia,to provide ideas and basis for the treatment of peri-menopausal insomnia,and to lay a scientific foundation.Methods:The relevant literatures about peri-menopausal insomnia in the past 20 years from January 1,2000 to September 30,2020 were searched in full-text database,and the publication time distribution,periodical distribution and research types were statistically analyzed with the help of NoteExpress 4.2.0,Excel 2010 and UCINET 6.2 software.Bibliometrics and social network analysis were used to grasp the research status and research hotspots.Results:979 articles about insomnia in peri-menopausal period were included.The number of literatures showed an upward trend and decreased from 2018 to 2020.The top three journals are Inner Mongolia traditional Chinese Medicine,Guangming traditional Chinese Medicine and Sichuan traditional Chinese Medicine,with 30,25 and 22 articles respectively.A total of 1,846 authors participated in the publication.The top three authors were Hong Li(14,0.63%),Jun-Shan Huang(9,0.40%)and Ying Chen(9,0.40%).The social network map shows that“insomnia”,“peri-menopausal period”,“perimenopausal insomnia”,“peri-menopausal syndrome”,“traditional Chinese medicine therapy”and“acupuncture”are the research hotspots and have the strongest correlation.Conclusion:The number of articles about peri-menopausal insomnia shows a downward trend in recent years,and the“core author group”has not been formed.The clinical research in this field is relatively perfect,but a more complete theoretical system has not been formed yet.Most of the treatment of insomnia in peri-menopausal period is based on traditional Chinese medicine,which shows that traditional Chinese medicine is more effective in clinical use,and the curative effect of syndrome differentiation of traditional Chinese medicine has been affirmed.However,there are relative deficiencies,such as the lack of strict experimental research and evaluation standards,the lack of unilateral prescription research,and so on.Future researchers should pay more attention to the experimental research of traditional Chinese medicine in the treatment of peri-menopausal insomnia and unilateral empirical prescription research.