With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named ＂The Fourth Paradigm,＂ has become a new paradigm of scien...With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named ＂The Fourth Paradigm,＂ has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the ＂causality inference＂ to ＂correlativity analysis.＂ This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine （TCM）, and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.展开更多
Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chine...Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.展开更多
Horticultural therapy has a long history,and its application in China has been delayed for more than 20 years than that in the United States and the United Kingdom.The psychological mechanism of horticultural therapy ...Horticultural therapy has a long history,and its application in China has been delayed for more than 20 years than that in the United States and the United Kingdom.The psychological mechanism of horticultural therapy is mainly to improve emotional cognition and emotional state,and promote physical and mental health.Based on the character of traditional Chinese medicine,combined with the modern probiotics and the environmental protection measures of sewage treatment,the research of preventing and treating insomnia and depression was carried out by using the living Chinese herbal medicine ecosystem,and good results were obtained.Based on the concepts of traditional Chinese medicine,big health and environment protection,the mechanism of horticultural therapy should be further studied.Horticultural therapy should be integrated extensively in the construction of landscaping,to construct horticultural therapy system with Chinese characteristics.展开更多
文摘With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named ＂The Fourth Paradigm,＂ has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the ＂causality inference＂ to ＂correlativity analysis.＂ This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine （TCM）, and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.
基金supported by grants from the National Natural Science Foundation of China (Grant Nos. 81830111 and 81774201)National Key Research and Development Program of China (2017YFC1702104 and 2017YFC1702303)+2 种基金the Youth Innovation Team of Shaanxi Universities and Shaanxi Provincial Science and Technology Department Project (No. 2016SF-378, China)the Fundamental Research Funds for the Central public Welfare Research Institutes (ZXKT17058, China)the National Science and Technology Major Project of China (2019ZX09201005-001-003)。
文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very.
基金Supported by General Projects of Changsha Social Science Planning(2021csskkt43).
文摘Horticultural therapy has a long history,and its application in China has been delayed for more than 20 years than that in the United States and the United Kingdom.The psychological mechanism of horticultural therapy is mainly to improve emotional cognition and emotional state,and promote physical and mental health.Based on the character of traditional Chinese medicine,combined with the modern probiotics and the environmental protection measures of sewage treatment,the research of preventing and treating insomnia and depression was carried out by using the living Chinese herbal medicine ecosystem,and good results were obtained.Based on the concepts of traditional Chinese medicine,big health and environment protection,the mechanism of horticultural therapy should be further studied.Horticultural therapy should be integrated extensively in the construction of landscaping,to construct horticultural therapy system with Chinese characteristics.
