Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system w...Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.展开更多
There is considerable research interest and vigorous debate about the DNA binding of polypyridyl complexes including the electron transfer involving DNA. In this review, based on the fluorescence quenching experiments...There is considerable research interest and vigorous debate about the DNA binding of polypyridyl complexes including the electron transfer involving DNA. In this review, based on the fluorescence quenching experiments, it was proposed that DNA might serve as a conductor. From the time-interval CD spectra, the different binding rates of A- and A-enantiomer to calf thymus DNA were observed. The factors influencing the DNA-binding of polypyridyl complexes, and the potential bio-functions of the complexes are also discussed.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.31500777)the Research Start-up Funds of DGUT(Grant No.GC300501-082)the Characteristic Innovation Project of University in Guangdong(Grant No.2020KTSCX148)。
文摘Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.
基金Acknowledgements We are grateful to the State Key Laboratory of Coordination Chemistry in Nanjing University, the State Key Laboratory of Bio-organic and Natural Products Chemistry in Shanghai Institute of Organic Chemistry for their financial support. T
文摘There is considerable research interest and vigorous debate about the DNA binding of polypyridyl complexes including the electron transfer involving DNA. In this review, based on the fluorescence quenching experiments, it was proposed that DNA might serve as a conductor. From the time-interval CD spectra, the different binding rates of A- and A-enantiomer to calf thymus DNA were observed. The factors influencing the DNA-binding of polypyridyl complexes, and the potential bio-functions of the complexes are also discussed.
