目的:评价基于呼吸信号检测原理的BC120全自动血培养系统在特定注射剂产品中作为替代方法开展无菌检查的可行性。方法:收集2种不同类型的无菌制剂,考察在专属性、检测限和方法适用性等方面与中国药典无菌检查法是否存在差异。结果:在严...目的:评价基于呼吸信号检测原理的BC120全自动血培养系统在特定注射剂产品中作为替代方法开展无菌检查的可行性。方法:收集2种不同类型的无菌制剂,考察在专属性、检测限和方法适用性等方面与中国药典无菌检查法是否存在差异。结果:在严格按照BC120全自动血培养系统使用说明操作的前提下,该系统在专属性和检测限参数上与药典方法无显著差异,多数情况下比药典方法更快地报告阳性结果。结论:BC120全自动血培养系统在风险管理的前提下,经过验证,可作为药典无菌检查的替代方法用于特定注射剂产品的生产过程控制和快速放行。Objective: To evaluate the feasibility of BC120 blood culture system as an alternative method for sterility test. Methods: Two aseptic preparations were collected, to examine the differences between them and pharmacopoeia method in specificity, detection limit and method applicability. Results: According to the instructions of BC120 blood culture system, there is no significant difference between the system and the pharmacopoeia method in specificity and detection limit parameters, and in most cases, the positive results are reported faster than the pharmacopoeia method. Conclusions: Under the premise of risk management, BC120 blood culture system can be used as an alternative method for sterile testing in the production process of specific injection products for sterile quality control and rapid release after validation.展开更多
A novel photo-catalytic system composed of N-doped biochars(NBCs),MnFe_(2)O_(4) and sulfite activation under ultraviolet(NBCs/MnFe_(2)O_(4)/sulfite/UV)was constructed to realize the efficient eliminate of tetracycline...A novel photo-catalytic system composed of N-doped biochars(NBCs),MnFe_(2)O_(4) and sulfite activation under ultraviolet(NBCs/MnFe_(2)O_(4)/sulfite/UV)was constructed to realize the efficient eliminate of tetracycline(TC).As the carrier of MnFe_(2)O_(4),NBCs were synthesized from alfalfa,which has large specific surface area,graphite like structure and hierarchical porous structure.The adsorption isotherm indicated that NBCs/MnFe_(2)O_(4)-2:1 had the best adsorption performance for TC(347.56 mg g^(-1)).Through synergistic adsorption and photocatalysis,the removal rate of TC reached 84%,which was significantly higher than that of MnFe_(2)O_(4).Electrochemical impedance spectroscopy(EIS)and Photoluminescence(PL)characterization results showed that the introduction of NBCs improved the separation efficiency of photogenerated electron and hole pairs and enhanced the photocatalytic performance.Moreover,the adsorption,degradation mechanism and degradation path of TC by the catalyst were systematically analyzed by coupling HPLC–MS measurement with the theoretical calculation.Considering the advantages of excellent degradation performance,low cost,easy separation and environmental friendliness of NBCs/MnFe_(2)O_(4),this work was expected to provide a new path for the practical application of biochar.展开更多
Field monitoring was conducted to investigate and quantify the long-term effects of peanut shell biochar on soil-grass interaction over three years.Three 10 m5 m grassed plots were constructed in completely decomposed...Field monitoring was conducted to investigate and quantify the long-term effects of peanut shell biochar on soil-grass interaction over three years.Three 10 m5 m grassed plots were constructed in completely decomposed granitic soil.Two of them were amended,respectively,with 5%and 10%biochar contents(m^(3)/m^(3))for grass growth,while the third was without biochar amendment.During the threeyear monitoring,plant characteristics,saturated water permeability(k_(s))of grassed soil and soil suction were measured.The monitored results show that the grass leaf area index(LAI)and root length density(RLD)with biochar amendment were improved by 38%and 200%,respectively.In the grassed plot without biochar,a threshold RLD existed with a value of 1.7 cm/cm^(3),beyond which k_(s) raised pronouncedly.The threshold RLD increased by 52%when biochar content increased from 0%to 10%.This implies that biochar may restrict the increase in k_(s) of grassed soil due to the rise in the threshold RLD.The presence of biochar and grass can retain over 100%higher suction after heavy rainfalls,while 54%lower peak suction under evapotranspiration(ET)compared with the non-amended plot.Biochar can alleviate the negative effects on hydraulic properties caused by plant growth and reduce ET-induced excessive water loss.A 5%peanut shell biochar content is recommended for the long-term management of vegetated earthen infrastructures.展开更多
In order to reduce the waste of resources and environmental pollution caused by excessive application of chemical fertilizers, improve the utilization rate of fertilizers, and promote the large-scale and high-quality ...In order to reduce the waste of resources and environmental pollution caused by excessive application of chemical fertilizers, improve the utilization rate of fertilizers, and promote the large-scale and high-quality development of the Chinese rose industry. In this experiment, corn stover biochar, phosphoric acid modified biochar and organic fertilizer were used as test materials, and the effects of mixed application of modified biochar and organic fertilizer on the growth and development of Chinese rose as well as soil physicochemical properties were investigated by using the method of pot planting test. The results showed that modified biochar with organic fertilizer had the most significant effect on the enhancement of soil pH, organic matter content and soil carbon-to-nitrogen ratio. After 120 d of planting, modified biochar with organic fertilizer had the most significant effect on the enhancement of plant height and crown width of Chinese rose;both organic fertilizer and modified biochar with organic fertilizer significantly increased the chlorophyll content of Chinese rose. The number of flowers and the number of branches were the highest in the modified biochar with organic fertilizer treatment. In conclusion, the application of modified biochar with organic fertilizer can better improve the soil pH, and increase the soil organic matter content and carbon-to-nitrogen ratio to change the biological traits of Chinese rose. The results of this study provide a theoretical basis for the reduction of chemical fertilizers and the resource utilization of agricultural wastes and guarantee the sustainable development of the cut flower industry.展开更多
Lithium-sulfur batteries are emerging as sustainable replacements for current lithium-ion batteries.The commercial viability of this novel type of battery is still under debate due to the extensive use of highly react...Lithium-sulfur batteries are emerging as sustainable replacements for current lithium-ion batteries.The commercial viability of this novel type of battery is still under debate due to the extensive use of highly reactive lithium-metal anodes and the complex electrochemistry of the sulfur cathode.In this research,a novel sulfur-based battery has been proposed that eliminates the need for metallic lithium anodes and other critical raw materials like cobalt and graphite,replacing them with biomass-derived materials.This approach presents numerous benefits,encompassing ample availability,cost-effectiveness,safety,and environmental friendliness.In particular,two types of biochar-based anode electrodes(non-activated and activated biochar)derived from spent common ivy have been investigated as alternatives to metallic lithium.We compared their structural and electrochemical properties,both of which exhibited good compatibility with the typical electrolytes used in sulfur batteries.Surprisingly,while steam activation results in an increased specific surface area,the non-activated ivy biochar demonstrates better performance than the activated biochar,achieving a stable capacity of 400 mA h g^(−1)at 0.1 A g^(−1)and a long lifespan(>400 cycles at 0.5 A g^(−1)).Our results demonstrate that the presence of heteroatoms,such as oxygen and nitrogen positively affects the capacity and cycling performance of the electrodes.This led to increased d-spacing in the graphitic layer,a strong interaction with the solid electrolyte interphase layer,and improved ion transportation.Finally,the non-activated biochar was successfully coupled with a sulfur cathode to fabricate lithium-metal-free sulfur batteries,delivering a specific energy density of~600 Wh kg^(−1).展开更多
Biochar amendment offers a chance for sustainable agriculture.However,the effectiveness of biochar relies on its physical and chemical properties,which are heavily affected by biochar production conditions and managem...Biochar amendment offers a chance for sustainable agriculture.However,the effectiveness of biochar relies on its physical and chemical properties,which are heavily affected by biochar production conditions and management practices.Therefore,substantial uncertainties regarding the use of biochar exist in agricultural systems globally.This study provides the first quantitative evaluation of the impacts of biochar characteristics and management practices on key ecosystem services by performing a second-order meta-analysis based on 34,628 paired observations in biochar-amended and unamended systems.Overall,biochar enhances phytotoxicity alleviation,physiology regulation,soil remediation and carbon sequestration,and microbial functional gene abundance.However,some prominent trade-offs exist between crop productivity and ecosystem service deliveries including for nutrient cycling,microbial function,climate change mitigation,and the soil microbial community.The adoption of low C:N biochar produced at high pyrolysis temperatures from sewage sludge-derived feedstock,in combination with a moderate application rate and inorganic fertilizer input,shows potential for achieving synergistic promotion of crop productivity and ecosystem services.These outcomes highlight the need for judicious implementation of biochar-based solutions to site-specific soil constraints.The quantified synergy and tradeoff relationships will aid the establishment of a sustainable biochar development framework that strengthens necessary ecosystem services commensurate with food security assurance.展开更多
文摘目的:评价基于呼吸信号检测原理的BC120全自动血培养系统在特定注射剂产品中作为替代方法开展无菌检查的可行性。方法:收集2种不同类型的无菌制剂,考察在专属性、检测限和方法适用性等方面与中国药典无菌检查法是否存在差异。结果:在严格按照BC120全自动血培养系统使用说明操作的前提下,该系统在专属性和检测限参数上与药典方法无显著差异,多数情况下比药典方法更快地报告阳性结果。结论:BC120全自动血培养系统在风险管理的前提下,经过验证,可作为药典无菌检查的替代方法用于特定注射剂产品的生产过程控制和快速放行。Objective: To evaluate the feasibility of BC120 blood culture system as an alternative method for sterility test. Methods: Two aseptic preparations were collected, to examine the differences between them and pharmacopoeia method in specificity, detection limit and method applicability. Results: According to the instructions of BC120 blood culture system, there is no significant difference between the system and the pharmacopoeia method in specificity and detection limit parameters, and in most cases, the positive results are reported faster than the pharmacopoeia method. Conclusions: Under the premise of risk management, BC120 blood culture system can be used as an alternative method for sterile testing in the production process of specific injection products for sterile quality control and rapid release after validation.
基金gratefully acknowledge the financial support for this research from the National Natural Science Foundation of China(Grant No.:21978047,21776046)the Six Talent Climax Foundation of Jiangsu(Grant No.:XCL-079).
文摘A novel photo-catalytic system composed of N-doped biochars(NBCs),MnFe_(2)O_(4) and sulfite activation under ultraviolet(NBCs/MnFe_(2)O_(4)/sulfite/UV)was constructed to realize the efficient eliminate of tetracycline(TC).As the carrier of MnFe_(2)O_(4),NBCs were synthesized from alfalfa,which has large specific surface area,graphite like structure and hierarchical porous structure.The adsorption isotherm indicated that NBCs/MnFe_(2)O_(4)-2:1 had the best adsorption performance for TC(347.56 mg g^(-1)).Through synergistic adsorption and photocatalysis,the removal rate of TC reached 84%,which was significantly higher than that of MnFe_(2)O_(4).Electrochemical impedance spectroscopy(EIS)and Photoluminescence(PL)characterization results showed that the introduction of NBCs improved the separation efficiency of photogenerated electron and hole pairs and enhanced the photocatalytic performance.Moreover,the adsorption,degradation mechanism and degradation path of TC by the catalyst were systematically analyzed by coupling HPLC–MS measurement with the theoretical calculation.Considering the advantages of excellent degradation performance,low cost,easy separation and environmental friendliness of NBCs/MnFe_(2)O_(4),this work was expected to provide a new path for the practical application of biochar.
基金the financial sponsorship from the National Natural Science Foundation of China(Grant Nos.U20A20320,52308342)the Fundamental Research Funds for the Central Universities(Grant No.RF1028623071).
文摘Field monitoring was conducted to investigate and quantify the long-term effects of peanut shell biochar on soil-grass interaction over three years.Three 10 m5 m grassed plots were constructed in completely decomposed granitic soil.Two of them were amended,respectively,with 5%and 10%biochar contents(m^(3)/m^(3))for grass growth,while the third was without biochar amendment.During the threeyear monitoring,plant characteristics,saturated water permeability(k_(s))of grassed soil and soil suction were measured.The monitored results show that the grass leaf area index(LAI)and root length density(RLD)with biochar amendment were improved by 38%and 200%,respectively.In the grassed plot without biochar,a threshold RLD existed with a value of 1.7 cm/cm^(3),beyond which k_(s) raised pronouncedly.The threshold RLD increased by 52%when biochar content increased from 0%to 10%.This implies that biochar may restrict the increase in k_(s) of grassed soil due to the rise in the threshold RLD.The presence of biochar and grass can retain over 100%higher suction after heavy rainfalls,while 54%lower peak suction under evapotranspiration(ET)compared with the non-amended plot.Biochar can alleviate the negative effects on hydraulic properties caused by plant growth and reduce ET-induced excessive water loss.A 5%peanut shell biochar content is recommended for the long-term management of vegetated earthen infrastructures.
文摘In order to reduce the waste of resources and environmental pollution caused by excessive application of chemical fertilizers, improve the utilization rate of fertilizers, and promote the large-scale and high-quality development of the Chinese rose industry. In this experiment, corn stover biochar, phosphoric acid modified biochar and organic fertilizer were used as test materials, and the effects of mixed application of modified biochar and organic fertilizer on the growth and development of Chinese rose as well as soil physicochemical properties were investigated by using the method of pot planting test. The results showed that modified biochar with organic fertilizer had the most significant effect on the enhancement of soil pH, organic matter content and soil carbon-to-nitrogen ratio. After 120 d of planting, modified biochar with organic fertilizer had the most significant effect on the enhancement of plant height and crown width of Chinese rose;both organic fertilizer and modified biochar with organic fertilizer significantly increased the chlorophyll content of Chinese rose. The number of flowers and the number of branches were the highest in the modified biochar with organic fertilizer treatment. In conclusion, the application of modified biochar with organic fertilizer can better improve the soil pH, and increase the soil organic matter content and carbon-to-nitrogen ratio to change the biological traits of Chinese rose. The results of this study provide a theoretical basis for the reduction of chemical fertilizers and the resource utilization of agricultural wastes and guarantee the sustainable development of the cut flower industry.
基金supported by the Special Research Fund(BOF23PD03,P.Salimi)the Research Foundation Flanders(FWO SB-1S92022N,W.Vercruysse).
文摘Lithium-sulfur batteries are emerging as sustainable replacements for current lithium-ion batteries.The commercial viability of this novel type of battery is still under debate due to the extensive use of highly reactive lithium-metal anodes and the complex electrochemistry of the sulfur cathode.In this research,a novel sulfur-based battery has been proposed that eliminates the need for metallic lithium anodes and other critical raw materials like cobalt and graphite,replacing them with biomass-derived materials.This approach presents numerous benefits,encompassing ample availability,cost-effectiveness,safety,and environmental friendliness.In particular,two types of biochar-based anode electrodes(non-activated and activated biochar)derived from spent common ivy have been investigated as alternatives to metallic lithium.We compared their structural and electrochemical properties,both of which exhibited good compatibility with the typical electrolytes used in sulfur batteries.Surprisingly,while steam activation results in an increased specific surface area,the non-activated ivy biochar demonstrates better performance than the activated biochar,achieving a stable capacity of 400 mA h g^(−1)at 0.1 A g^(−1)and a long lifespan(>400 cycles at 0.5 A g^(−1)).Our results demonstrate that the presence of heteroatoms,such as oxygen and nitrogen positively affects the capacity and cycling performance of the electrodes.This led to increased d-spacing in the graphitic layer,a strong interaction with the solid electrolyte interphase layer,and improved ion transportation.Finally,the non-activated biochar was successfully coupled with a sulfur cathode to fabricate lithium-metal-free sulfur batteries,delivering a specific energy density of~600 Wh kg^(−1).
基金funded by the National Natural Science Foundation of China(32272233)the National Key Research and Development Program of China(2023YFD2302300)+1 种基金the Shaanxi Innovative Talents Promotion Plan,China(2023KJXX-012)the Science and Technology Plan Project of Inner Mongolia,China(2022YFDZ0018)。
文摘Biochar amendment offers a chance for sustainable agriculture.However,the effectiveness of biochar relies on its physical and chemical properties,which are heavily affected by biochar production conditions and management practices.Therefore,substantial uncertainties regarding the use of biochar exist in agricultural systems globally.This study provides the first quantitative evaluation of the impacts of biochar characteristics and management practices on key ecosystem services by performing a second-order meta-analysis based on 34,628 paired observations in biochar-amended and unamended systems.Overall,biochar enhances phytotoxicity alleviation,physiology regulation,soil remediation and carbon sequestration,and microbial functional gene abundance.However,some prominent trade-offs exist between crop productivity and ecosystem service deliveries including for nutrient cycling,microbial function,climate change mitigation,and the soil microbial community.The adoption of low C:N biochar produced at high pyrolysis temperatures from sewage sludge-derived feedstock,in combination with a moderate application rate and inorganic fertilizer input,shows potential for achieving synergistic promotion of crop productivity and ecosystem services.These outcomes highlight the need for judicious implementation of biochar-based solutions to site-specific soil constraints.The quantified synergy and tradeoff relationships will aid the establishment of a sustainable biochar development framework that strengthens necessary ecosystem services commensurate with food security assurance.
