China,America Have Coo[erated in Micro Biological Production Test

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The evaluation of biological productivity by triple isotope composition of oxygen trapped in ice-core bubbles and dissolved in ocean:a review

The ^(17)O anomaly of oxygen(Δ^(17)O,calculated from δ^(17)O and δ^(18)O)trapped in ice-core bubbles and dissolved in ocean has been respectively used to evaluate the past biosphere productivity at a global scale and gross oxygen production(GOP)in the mixed layer(ML)of ocean.Compared to traditional methods in GOP estimation,triple oxygen isotope(TOI)method provides estimates that ignore incubation bottle effects and calculates GOP on larger spatial and temporal scales.Calculated from TOI of O_(2) trapped in ice-core bubbles,the averaged global biological productivities in past glacial periods were about 0.83-0.94 of the present,and the longest time record reached 400 ka BP(thousand years before the present).TOI-derived GOP estimation has also been widely applied in open oceans and coastal oceans,with emphasis on the ML.Although the TOI method has been widely used in aquatic ecosystems,TOI-based GOP is assumed to be constant at a steady state,and the influence of physical transports below the ML is neglected.The TOI method applied to evaluate past total biospheric productivity is limited by rare samples as well as uncertainties related to O_(2) consumption mechanisms and terrestrial biosphere’s hydrological processes.Future studies should take into account the physical transports below the ML and apply the TOI method in deep ocean.In addition,study on the complex land biosphere mechanisms by triple isotope composition of O_(2) trapped in ice-core bubbles needs to be strengthened.

Analgesic-like activity of perillyl acetate:In vivo and in silico studies

Objective:To evaluate the antinociceptive activity of perillyl acetate in mice and in silico simulations.Methods:The vehicle,perillyl acetate(100,150 and/or 200 mg/kg,i.p.),diazepam(2 mg/kg,i.p.)or morphine(6 mg/kg,i.p.)was administered to mice,respectively.Rotarod test,acetic acidinduced abdominal writhing,formalin-induced nociception,hot plate test,and tail-flick test were performed.Opioid receptorsinvolvement in perillyl acetate antinociceptive effect was also investigated.Results:Perillyl acetate did not affect the motor coordination of mice.However,it reduced the number of acetic acid-induced abdominal twitches and licking times in the formalin test.There was an increase of latency time in the tail-flick test of 30 and 60minutes.Pretreatment with naloxone reversed the antinociceptive effect of perillyl acetate(200 mg/kg).In silico analysis demonstrated that perillyl acetate could bind toμ-opioid receptors.Conclusions:Perillyl acetate has antinociceptive effect at the spinal level in animal nociception models,without affecting the locomotor integrity and possibly throughμ-opioid receptors.In silico studies have suggested that perillyl acetate can act as aμ-opioid receptor agonist.

Assessment of nitrogen and sulphur cycle bacteria and shrimp production in ponds treated with biological products

Objective:To study the influence of biological products on the levels of nitrogen and sulphur cycle bacteria in shrimp culture systems of West Bengal,India.Methods:The pond water and sediment samples were analyzed for physico-chemical parameters as per standard methods.The bacteria involved in ammonification,nitrification,denitrification,sulphate reduction and sulphur oxidation were enumerated by most probable number technique.Results:The semi-intensive and modified extensive shrimp farms used a variety of biological products during various stages of production.No biological products were used in traditional farms.The water and sediment samples of modified extensive system recorded significantly higher mean heterotrophic bacterial counts.The counts of ammonia,nitrite and sulphur oxidizers,and nitrate and sulphate reducers varied among the systems.The cycling of nitrogen and sulphur appeared to be affected with the intensification of culture practices.Conclusions:The application of biological products in certain systems helped to maintain the bacteria involved in nitrogen and sulphur cycles and safe levels of ammonia,nitrite and nitrate.An assessment of these metabolically active bacteria in shrimp culture ponds and the application of right kind microbial products would help ameliorate the organic pollution in shrimp aquaculture.

Farnesoid X receptor regulators from natural products and their biological function

Metabolic syndrome(Met S)has been a growing public health concern worldwide without specific medicine.Through summarizing the chemical structure type and effect mechanisms of natural products targeted on farnesoid X receptor(FXR),to provide the research basis for exploring the treatment of Met S.The following databases were searched for natural products which targeting FXR:Pub Med,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,and Chinese Biomedical Literature Database.Totally 120 natural products were summarized,including terpenoids(51 compounds),steroidal saponins(27 compounds),phenylpropanolds(19 compounds),flavonoids(13 compounds),alkaloids(3 compounds)and others(7 compounds),most researches focus on terpenoids and part of synthetic FXR regulators were based on the structure of terpenoids.FXR regulators could improve cholestasis and liver injury,hyperlipidemia,diabetes and atherosclerosis.FXR is a potential target of treating Met S.Natural products are characteristics with unique novel structures and special biological activity,and they are important sources of bioactive precursor compounds and drug discovery.Exploring the effects and mechanism of natural products and its derivative on Met S by targeting FXR may be a new way to develop the new drugs of treating Met S.

What do oncologists need to know about biosimilar products?

Many biologic products have improved the outcomes of cancer patients,but the costs can substantially burden healthcare systems.Biosimilar products can potentially reduce drug costs and increase patient access to beneficial treatments.Approval of a biosimilar product relies on the demonstration of "comparability" or "no clinically meaningful differences" as compared to its reference biologic product.Biosimilar products for erythropoietin,granulocyte colonystimulating factor,trastuzumab,and rituximab are already available,and the regulatory processes in various countries are constantly evolving.It is important that oncologists be familiar with the potential issues surrounding the clinical use of biosimilar products.In this review article,we provide background information about biosimilar products and their regulatory approval processes,followed by a discussion of individual biosimilar drugs.

Optimization of fermentation medium for the new hydrogen bacterium E.Harbinense YUAN-3

This study is aiming at investigating the metabolic characteristics of Ethanoligenens Harbinense YUAN-3.The effects of yeast extract powder and supplemental vitamins on the growth medium were assessed.With yeast powder as the sole nitrogen source,the biomass yield and hydrogen-producing capacity of YUAN-3 from glucose fermentation significantly increased.Adding vitamin in yeast powder can enhance hydrogen yield compared with no adding.Therefore vitamin supplement can be considered as an effective growth factor in this study.Batch culture also produced larger yields of hydrogen.

Ya Du Biologic Product Company

In recent years, brain corroberant products have been very popular on the health products market in China. Such products as Duolingduo, Jinglingyu, Wangbuliao, Wang Zhong Wang, and Haidao are emerging on the market. Jinglingyu developed and produced by the Ya Du Biologic Product Company, has become one of the most popular products, although it appeared late.

Mangrove Ecosystem Services: Indus Delta (PQA), Sindh

Mangroves of the Indus Delta are the world’s fifth largest assemblage, and the largest in the arid zone. Mangroves of Indus delta (PQA) provide immense benefits, products and unrecognized regulatory services. Products of Direct Economic Value: Fish, Minerals and food. There are Products of Natural System (intangible) supplies of rich nutrients to support productivity. Coastal communities benefit in a multitude of ways from Mangrove ecosystems. Collectively, these benefits are known as ecosystem services. The ecological role of mangrove ecosystems in the Indus Deltaic area of Port Qasim Authority (PQA) is, economically and socially significant. The Mangroves are well known for their high biological productivity and their consequent importance provided to the coastal community in terms of services and products of direct and indirect value to the adjacent coastal waters. Mangrove Ecosystem services are regularly involved in the provisioning of food and services and the decomposition of organic wastes. They export organic matter, mainly in detritus form of leaf litter to the marine environment, thus providing a highly nutritious food source for themselves and for the Benthic and terrestrial animals found in the mangrove areas, as well as for those in neighboring estuarine and marine ecosystems. Apart from nutrient export, mangroves also contribute to offshore fisheries by acting as nurseries and shelters for many species of commercially important finfish and crustaceans. Degradation of Indus Deltaic mangrove in PQA would destabilize the economic potential and the livelihood of communities’ which include services and benefits offered by the mangrove ecosystem. Rehabilitation and conservation of mangroves ecosystem in PQA is essential for sustained biological productivity in the region.

National Ecological Deficit Accounting of China with Detailed Ecological Footprint

Ecological footprint is a new method to assess sustainable development quantitatively. It translates production into biologically productive areas offering material flows to measure the utilized degree of nature by humankind. At present, China runs ecological deficits because footprints required for consumption are larger than available ones. In the paper, the ecological footprint model is applied to calculate the deficits by resource, environment and import-export accounting. It is clear that the deficits have caused enormous pressure to resource and environment, which would become bigger with more factors of resource and environment being accounted. In the primary production and energy trade, import footprint turned from deficit to surplus after 1996, which benefited the conservation of national resource. But compared with the huge depletion caused by resource and environment, they had small effects on deficits.

Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China

Traditional Chinese herbal medicines not only cure human diseases,but also play an important role as insecticides.Compared with conventional chemical agents,traditional Chinese herbal medicines are characterized by low toxicity,low residues,and being eco-friendly,and they have become a research hotspot.Traditional Chinese herbal medicines have tremendous flexibility and indefinite potential.Therefore,this paper reviewed the types of insecticides belonging to traditional Chinese herbal medicines in Inner Mongolia,China,including their traditional uses,secondary metabolites,biological activities,action mechanisms,application methods,and development status.In addition,the most relevant issues involved in the development of traditional Chinese herbal medicines was discussed.We believe that traditional Chinese herbal medicines can be better implemented and developed;such that its other advantages,such as an insect repellent,can be promoted.Moreover,this study lays a solid foundation for further research on traditional Chinese herbal medicines in Inner Mongolia,China.

Biological Hydrogen Production:A Comprehensive Review for Converting Wastes into Wealth

Energy shortages have hindered global economic development.By utilizing waste as a substrate for microbial fermentation,hydrogen production can transform waste into a valuable resource,significantly reducing the cost of hydrogen production and addressing a significant hurdle in achieving large-scale production of microbial hydrogen.This approach has significant potential for future hydrogen-production applications.Two-stage indirect photohydrolysis has recently emerged as a promising and efficient method for hydrogen production using cyanobacteria and green algae.However,this method cannot be directly applied to organic wastewater for hydrogen production.In contrast,dark fermentation by bacteria,particularly ethanol-type fermentation,is highly efficient for producing hydrogen.Therefore,the combination of the indirect photohydrolysis of algae and dark fermentation by bacteria is expected to significantly enhance the hydrogen-production capacity of organic wastewater,laying the groundwork for future large-scale microbial hydrogen production.This study reviews the main types and technical principles of microbial hydrogen production from waste,available waste types,research progress in the microbial hydrogen-production process,strategies to improve the hydrogen-production rate,and challenges faced during industrialization.Future research directions for microbial-waste hydrogen production are also proposed.The aim of this study is to provide a valuable reference for large-scale biological hydrogen-production research.

RESEARCH AND DEVELOPMENT OF BIOLOGICAL PRODUCTS IN CHINA

There are six large production institutes of bio-logicals in China. The Kunming Institute of Medical Biology is the largest primate center, specializing in the production of live poliomyelitis vaccine and recently, of live hepatitis vaccine as well. All these institutes have research laboratories of their own which are engaged in the improvement of existing products and development of new ones. The National Institute for Control of Phamaceutical and Biological Products, created in 1951, is responsible for the direction of laboratories located in each production institute, for the testing of natively produced as well as imported biological products and for the preparation and issuing of national standards. Three additional bodies managed directly by the Ministry of Public Health are: Office for the Review of Drugs (including biologicals), Committee for Standardization of Biological Products and Office for Supervision of Drugs. These together consistiute the regulatory system in China.

Potential of natural medicines for treatment of osteoporosis:a narrative review

OBJECTIVE:To organize the fragmented information available in the literature to describe and summarize the extracts used by natural medicines in the treatment of bone loss,and to provide evidence and support for the potential use of natural medicines in the treatment of osteoporosis.METHODS:A literature survey for relevant information regarding the osteogenesis of Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,was conducted using PubM ed,ScienceDirect,MEDLINE,Springer LINK and Google Scholar electronic databases from the years 2000-2020.RESULTS:Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,both inhibit the activity of osteoclasts and reduce bone resorption by regulation of signaling pathways through interacting with signaling molecules.CONCLUSIONS:In this review,the current knowledge of the novel medicines with osteogenesis properties were summarized and their potential in the treatment of bone loss were demonstrated,but the lack of research on the regulation of the signaling pathway’s mechanism of action,and the corresponding theoretical basis for the application of natural medicines in clinical osteoporosis,made it difficult to be widely applied and promoted in clinical practice.Further experiments with some of the medicines and the mechanisms is needed to realize their potential as osteoporosis treatments.

Natural products for treatment of premature ovarian failure:a narrative review

Premature ovarian failure(POF) is a female reproductive system disease caused by many factors and systems,which has seriously affected the quality of life of women of childbearing age.Clinically,the disease is difficult to treat while its incidence rate shows an increasing trend.In recent years,natural products used as multi-pathway,multi-target and efficient drugs,have become the focus of many research and clinical studies in China and abroad,and the effect of phytochemicals derived from edible plants and Chinese medicine herbs on POF were investigated in several papers.Using "premature ovarian failure" or "ovary" and related natural products as keywords,we retrieved and reviewed research articles from China National Knowledge Infrastructure Database,Wanfang,Pub Med,Web of Science and other literature databases.Up to October,2021,natural compounds with prophylactic or interference inhibition effects on POF mainly included flavonoids,polysaccharides,saponins,and polyphenols.Their effect on POF and ovarian function was closely related to their antioxidant,antiapoptotic,antiaging,immunoregulatory and estrogenlike activities.

The Population Carrying Capacity of Waters Ecosystem in China

The study of waters ecosystem and their population carrying capacity demonstrates the role of these ecosystems in economic and social development and provides a theoretical basis for the management and allocation of aquatic ecosystems. In this study, the concept of waters ecosystem population carrying capacity was defined and developmental trends in the population carrying capacity of waters ecosystem in China were evaluated. Results show that waters ecosystem population carrying capacity in China increased from 0.176×109 person year-1 in 2000 to 0.255 × 109 person year-1 in 2010; the population carrying capacity of the standard sea remained at 0.2-0.3 person ha 1; and the standard inland waters population carrying capacity increased from 1.8 to 3.2 person ha-1. This analysis indicates notable regional difference in waters population carrying capacity. In southeastern coastal China and Yangtze River drainage areas where inland waters are widely distributed and aquaculture is developed, the population carrying capacity is higher; however, in northwest China where water resource are deficient and the distribution is relatively small, the waters population carrying capacity is low. The waters ecosystem population carrying capacity of China in 2030 was predicted and results indicate strong potential for increasing waters population carrying capacity.

Methanogenesis and Methanotrophy in Soil: A Review

Global warming, as a result of an increase in the mean temperature of the planet, might lead to catastrophic events for humanity. This temperature increase is mainly the result of an increase in the atmospheric greenhouse gases （GHG） concentration. Water vapor, carbon dioxide （CO2）, methane （CH4） and nitrous oxide （N20） are the most important GHG, and human activities, such as industry, livestock and agriculture, contribute to the production of these gases. Methane, at an atmospheric concentration of 1.7 gmol tool-1 currently, is responsible for 16% of the global warming due to its relatively high global warming potential. Soils play an important role in the CH4 cycle as methanotrophy （oxidation of CH4） and methanogenesis （production of CH4） take place in them. Understanding methanogenesis and methanotrophy is essential to establish new agriculture techniques and industrial processes that contribute to a better balance of GHG. The current knowledge of methanogenesis and methanotrophy in soils, anaerobic CH4 oxidation and methanotrophy in extreme environments is also discussed.

Herbal anthelmintic agents: a narrative review

Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases,considered as neglected tropical diseases(NTDs)that infect around two billion people worldwide.Plants have been used as anthelmintics from ancient times.This review is a compilation of plants as source of anthelmintic drug.All information presented in this review article regarding the anthelmintic activities of plants from 2005 and has been acquired by approaching various electronic databases,including Scopus,Google scholar,Web of science and PubMed.Literature was surveyed for anthelmintic activity of plants which showed that secondary metabolites of plants like terpenes,glycosides,saponins,flavonoids,tannins and alkaloids were having anthelmintic activity.Since this review is a compilation of anthelmintic activity of plants from the year 2005,it will definitely be a fruitful study for researchers working in this field.