Biomimetics is the development of novel theories and technologies by emulating the models and systems of nature.The transfer of function from biological science into engineering promotes emerging research areas across...Biomimetics is the development of novel theories and technologies by emulating the models and systems of nature.The transfer of function from biological science into engineering promotes emerging research areas across many disparate disciplines.Recently,advances in biomimetic intelligence and robotics have gained great popularity.Biomimetic robotics are designed with biological characteristics and functions to be applied in different scenarios,such as humanoid robot in the home environment,quadruped robot in the field,and bird-like flying robot in the sky.Biomimetic intelligence aims to solve many complex problems by studying the principles of biological systems,resulting in a series of efficient algorithms,such as the genetic algorithm and neural network.Biomimetic intelligence further facilitates the performance of biomimetic robotics,making it possible to be deployed in more and more practical applications.This survey introduces the development of biomimetic intelligence and biomimetic robotics.We survey different biomimetic robots,biomimetic sensors and sensing technologies,and popular biomimetic intelligence algorithms.The conclusion is drawn by discussing current challenges and future research directions.展开更多
Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(E.coli),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies.This wo...Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(E.coli),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies.This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages(MΦs),consisting of an intelligent controlling center(a living MΦ)and a Fenton reaction catalyst(Fe_(3)O_(4)@poly(lactic-co-glycolic acid)(PLGA)nanoparticles)for killing MDR E.coli without harming normal cells.The MΦ-Fe_(3)O_(4)@PLGA particles(i.e.,the intelligent catalysis particles)exhibit selective biocatalysis activity toward MDR E.coli by producing H_(2)O_(2) and lipid droplets(LDs).This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis.The H_(2)O_(2) further reacts with Fe_(3)O_(4)@PLGA to form highly toxic hydroxyl radicals(·OH),while the LDs contain antimicrobial peptides and can target MDR E.coli.The highly toxicOH and antimicrobial peptides are shown to combat with MDR E.coli,such that the antibacterial efficiency of the MΦ-Fe_(3)O_(4)@PLGA particles against MDR E.coli is 99.29%±0.31%in vitro.More importantly,after several passages,the intelligent catalysis function of the MΦ-Fe_(3)O_(4)@PLGA particles is well maintained.Hence,the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.展开更多
基金supported by Shenzhen Key Laboratory of Robotics Perception and Intelligence(ZDSYS20200810171800001)Southern University of Science and Technology,Shenzhen 518055,China,Hong Kong RGC CRF grant C4063-18GHong Kong RGC GRF grant#14200618。
文摘Biomimetics is the development of novel theories and technologies by emulating the models and systems of nature.The transfer of function from biological science into engineering promotes emerging research areas across many disparate disciplines.Recently,advances in biomimetic intelligence and robotics have gained great popularity.Biomimetic robotics are designed with biological characteristics and functions to be applied in different scenarios,such as humanoid robot in the home environment,quadruped robot in the field,and bird-like flying robot in the sky.Biomimetic intelligence aims to solve many complex problems by studying the principles of biological systems,resulting in a series of efficient algorithms,such as the genetic algorithm and neural network.Biomimetic intelligence further facilitates the performance of biomimetic robotics,making it possible to be deployed in more and more practical applications.This survey introduces the development of biomimetic intelligence and biomimetic robotics.We survey different biomimetic robots,biomimetic sensors and sensing technologies,and popular biomimetic intelligence algorithms.The conclusion is drawn by discussing current challenges and future research directions.
基金supported by the China National Funds for Distinguished Young Scientists (51925104)the National Natural Science Foundation of China (NSFC) (51871162 and 52173251)+1 种基金NSFC-Guangdong Province Joint Program (U21A2084)the Central Guidance on Local Science and Technology Development Fund of Hebei Province (226Z1303G).
文摘Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(E.coli),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies.This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages(MΦs),consisting of an intelligent controlling center(a living MΦ)and a Fenton reaction catalyst(Fe_(3)O_(4)@poly(lactic-co-glycolic acid)(PLGA)nanoparticles)for killing MDR E.coli without harming normal cells.The MΦ-Fe_(3)O_(4)@PLGA particles(i.e.,the intelligent catalysis particles)exhibit selective biocatalysis activity toward MDR E.coli by producing H_(2)O_(2) and lipid droplets(LDs).This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis.The H_(2)O_(2) further reacts with Fe_(3)O_(4)@PLGA to form highly toxic hydroxyl radicals(·OH),while the LDs contain antimicrobial peptides and can target MDR E.coli.The highly toxicOH and antimicrobial peptides are shown to combat with MDR E.coli,such that the antibacterial efficiency of the MΦ-Fe_(3)O_(4)@PLGA particles against MDR E.coli is 99.29%±0.31%in vitro.More importantly,after several passages,the intelligent catalysis function of the MΦ-Fe_(3)O_(4)@PLGA particles is well maintained.Hence,the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.
