Biomimetic Modification of Super-wetting Electrospun Poly(vinylidene fluoride)Porous Fibers with Organic Dyes and Heavy Metal Ions Adsorption,Oil/Water Separation,and Sterilization Performances Toward Wastewater Treatment

Polymeric membranes with the integration of various functional performances toward wastewater treatment are urgently required.However,most of the polymeric membranes only exhibit a single function of highly efficiently removing one kind of pollutants.In this work,a biomimetic modification method was introduced to tailor the chemical and topological structure of the porous poly(vinylidene fluoride)(PVDF)fibers prepared by electrospinning.The polydopamine(PDA)nanoparticles were homogeneously introduced onto the surface of PVDF porous fibers via precisely tailoring the concentration of dopamine,which endowed the fibers with more polar groups and bigger roughness but did not destroy the crystalline structures.The fibrous membranes exhibited switchable superhydrophilicity and superlipophilicity characteristics,excellent adsorption abilities toward organic dyes,heavy metal ions and oils.The highest adsorption capacities achieved 917.4 mg/g toward methylene blue(MB),42.6 mg/g toward Cr(VI)and 74.6 g/g toward silicone oil,respectively.Specifically,the membrane could rapidly remove the trace MB when water flowed through the membrane.The membrane also exhibited excellent sterilization performances,and the bacterial eliminating rate achieved 99.9%for the E.coli and S.aureus.The excellent light-to-heat conversion ability endowed the membrane with the selfheating ability,furtherly intensifying the wastewater treatment efficiency.This work confirms that the PDA nanoparticles-decorated PVDF porous fibers might be the new generation adsorbents used in wastewater treatment.

Designing macrophage membrane-engineered ruthenium/selenium nanoparticles to block bone metastasis of breast cancer

Bone metastasis along with osteolysis is a common complication of advanced breast cancer,which directly destroys bone function and becomes one of the major causes of cancer-related mortality.It is crucial to develop a new strategy to achieve effective cancer therapy and inhibition of osteolytic bone metastasis.Metal ruthenium(Ru)complexes exhibit therapeutic potential in cancer chemotherapy.However,the clinical applications of Ru complexes were limited by poor bioavailability,lacking targeting,nonspecific distribution.Therefore,in this study,engineering of cell membrane biomimetic modification was used to construct a highly biocompatible nanoplatform with carrying Ru metal complex of RuPOP and Se nanoparticles(SeNPs).Strikingly,the obtained RPSR nanoparticles can efficiently inhibit the proliferation,invasion and migration of breast cancer cells(MDA-MB-231 cells)in vitro.More importantly,RPSR nanoparticles can induce cycle arrest,apoptosis by generating excessive intracellular(reactive oxygen species,ROS)to disrupt the normal redox balance and induce DNA damage in tumor cells.Furthermore,RPSR nanoparticles can also reshape bone microenvironment by regulating selenoproteins to inhibit osteoclasts and avoid osteolytic bone metastasis induced by tumor development.Taken together,this study not only provides an effective cell membrane biomimetic strategy to enhance the shortcomings of metal complexes,but also demonstrates potential clinical significance for the combined treatment of anti-cancer and bone metastasis inhibition.