Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several revie...Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed.展开更多
Land use and land cover change(LULCC) strongly influence regional and global climate by combining both biochemical and biophysical processes. However, the biophysical process was often ignored, which may offset the bi...Land use and land cover change(LULCC) strongly influence regional and global climate by combining both biochemical and biophysical processes. However, the biophysical process was often ignored, which may offset the biogeochemical effects, so measures to address climate change could not reach the target. Thus, the biophysical influence of LULCC is critical for understanding observed climate changes in the past and potential scenarios in the future. Therefore, it is necessary to identify the mechanisms and effects of large-scale LULCC on climate change through changing the underlying surface, and thus the energy balance. The key scientific issues on understanding the impacts of human activities on global climate that must be addressed including:(1) what are the basic scientific facts of spatial and temporal variations of LULCC in China and comparative countries?(2) How to understand the coupling driving mechanisms of human activities and climate change on the LULCC and then to forecasting the future scenarios?(3) What are the scientific mechanisms of LULCC impacts on biophysical processes of land surface, and then the climate?(4) How to estimate the contributions of LULCC to climate change by affecting biophysical processes of land surface? By international comparison, the impacts of LULCC on climate change at the local, regional and global scales were revealed and evaluated. It can provide theoretical basis for the global change, and have great significance to mitigate and adapt to global climate changes.展开更多
基金supported by the National Natural Science Foundation of China(31971169,81822022,81771846,81571810)the Beijing Natural Science Foundation(7182180)+2 种基金National Key Research and Development Program of China(2018YFC0116003,2016YFA0201400)Beijing Talents Foundation(2018000021223ZK48)Peking University Third Hospital(BYSYZD2019018,jyzc2018-02,BYSY2015023)。
文摘Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed.
基金National Natural Science Foundation of China,No.41371409,No.41371019Global Change Scientific Research Program of China,No.2010CB950900
文摘Land use and land cover change(LULCC) strongly influence regional and global climate by combining both biochemical and biophysical processes. However, the biophysical process was often ignored, which may offset the biogeochemical effects, so measures to address climate change could not reach the target. Thus, the biophysical influence of LULCC is critical for understanding observed climate changes in the past and potential scenarios in the future. Therefore, it is necessary to identify the mechanisms and effects of large-scale LULCC on climate change through changing the underlying surface, and thus the energy balance. The key scientific issues on understanding the impacts of human activities on global climate that must be addressed including:(1) what are the basic scientific facts of spatial and temporal variations of LULCC in China and comparative countries?(2) How to understand the coupling driving mechanisms of human activities and climate change on the LULCC and then to forecasting the future scenarios?(3) What are the scientific mechanisms of LULCC impacts on biophysical processes of land surface, and then the climate?(4) How to estimate the contributions of LULCC to climate change by affecting biophysical processes of land surface? By international comparison, the impacts of LULCC on climate change at the local, regional and global scales were revealed and evaluated. It can provide theoretical basis for the global change, and have great significance to mitigate and adapt to global climate changes.
