Concern about the biological hazards involved in microbiological research, especially research involving laboratory animals, has increased in recent years. Working in an animal biosafety level 2 facility （ABSL-2）, c...Concern about the biological hazards involved in microbiological research, especially research involving laboratory animals, has increased in recent years. Working in an animal biosafety level 2 facility （ABSL-2）, commonly used for research on infectious diseases, poses various biological hazards. Here, the regulations and standards related to laboratory biosafety in China are introduced, the potential biological hazards present in ABSL-2 facilities are analyzed, and a series of strategies to control the hazards are presented.展开更多
With accelerating environmental change,technological development,and socio-economic globalisation,the potential for biosafety crises in many countries has intensified,and the sources of harm have become more extensive...With accelerating environmental change,technological development,and socio-economic globalisation,the potential for biosafety crises in many countries has intensified,and the sources of harm have become more extensive.Using a visual literature analysis tool,we analysed biosafety strategy knowledge maps of individual authors,institutions,and keywords in literature published between 2009 and 2019.Our results reflected the research hotspots,frontiers,and future trends in this field and demonstrated the necessity and urgency of strengthening biosafety strategy research.Our results showed,first,that biosafety strategy research groups are tightly concentrated and widely dispersed,and already possess a group of key research representatives;second,although cooperation among countries is relatively close,the nodal research institutions in this field are relatively scattered and cooperation among them is not strong;and third,“biosecurity”,“infection”,“biosafety”,and“strategy”,among others,are highfrequency keywords used by many recent academic publications,while“tuberculosis”,“biological invasion”,and“nanoparticle”are keywords denoting the frontiers of research activity.In view of these,China should focus on accelerating the introduction of biosafety laws and regulations at the national level in the following years;increasing biosafety supervision;improving biological hazard response systems;strengthening cooperation and innovation among research institutions;improving scientific research review mechanisms;and strengthening biotechnology risk assessment research.展开更多
Monkeypox is a zoonotic disease caused by the monkeypox virus(MPXV),which is a potential biological warfare agent of bioterrorism and poses the greatest threat to the world’s public biosafety and health after variola...Monkeypox is a zoonotic disease caused by the monkeypox virus(MPXV),which is a potential biological warfare agent of bioterrorism and poses the greatest threat to the world’s public biosafety and health after variola virus(VARV).While the coronavirus disease 2019(COVID-19)pandemic has not ended yet,monkeypox is spreading menacingly.The first case of monkeypox in a nonendemic country was confirmed on May 6^(th),2022,while the first imported case from Asia was found on June 21^(st).There were more than 16 thousand reported cases as of July 23^(rd),the day the World Health Organization(WHO)declared the global monkeypox outbreak a public health emergency of international concern(PHEIC)at the same level as smallpox and COVID-19;while there were more than 53 thousand cases as of September 1^(st).Therefore,we will propose relevant biosafety prevention and control strategies after analyzing the etiology of the 2022 multi-country monkeypox outbreak from the biological feature,transmissibility,epidemic,and variability of MPXV.展开更多
基金supported by the National Science and Technology Major Projects of Infectious Disease(2012ZX10004-404)
文摘Concern about the biological hazards involved in microbiological research, especially research involving laboratory animals, has increased in recent years. Working in an animal biosafety level 2 facility （ABSL-2）, commonly used for research on infectious diseases, poses various biological hazards. Here, the regulations and standards related to laboratory biosafety in China are introduced, the potential biological hazards present in ABSL-2 facilities are analyzed, and a series of strategies to control the hazards are presented.
文摘With accelerating environmental change,technological development,and socio-economic globalisation,the potential for biosafety crises in many countries has intensified,and the sources of harm have become more extensive.Using a visual literature analysis tool,we analysed biosafety strategy knowledge maps of individual authors,institutions,and keywords in literature published between 2009 and 2019.Our results reflected the research hotspots,frontiers,and future trends in this field and demonstrated the necessity and urgency of strengthening biosafety strategy research.Our results showed,first,that biosafety strategy research groups are tightly concentrated and widely dispersed,and already possess a group of key research representatives;second,although cooperation among countries is relatively close,the nodal research institutions in this field are relatively scattered and cooperation among them is not strong;and third,“biosecurity”,“infection”,“biosafety”,and“strategy”,among others,are highfrequency keywords used by many recent academic publications,while“tuberculosis”,“biological invasion”,and“nanoparticle”are keywords denoting the frontiers of research activity.In view of these,China should focus on accelerating the introduction of biosafety laws and regulations at the national level in the following years;increasing biosafety supervision;improving biological hazard response systems;strengthening cooperation and innovation among research institutions;improving scientific research review mechanisms;and strengthening biotechnology risk assessment research.
基金supported by the Science and Technology Planning Project of Guangdong Province(2021B1212040017)the Science and Technology Innovation Project of the Ministry of Education(2022ZL01)the Sun Yat-sen University Founded Program(2022_76220_B21127).
文摘Monkeypox is a zoonotic disease caused by the monkeypox virus(MPXV),which is a potential biological warfare agent of bioterrorism and poses the greatest threat to the world’s public biosafety and health after variola virus(VARV).While the coronavirus disease 2019(COVID-19)pandemic has not ended yet,monkeypox is spreading menacingly.The first case of monkeypox in a nonendemic country was confirmed on May 6^(th),2022,while the first imported case from Asia was found on June 21^(st).There were more than 16 thousand reported cases as of July 23^(rd),the day the World Health Organization(WHO)declared the global monkeypox outbreak a public health emergency of international concern(PHEIC)at the same level as smallpox and COVID-19;while there were more than 53 thousand cases as of September 1^(st).Therefore,we will propose relevant biosafety prevention and control strategies after analyzing the etiology of the 2022 multi-country monkeypox outbreak from the biological feature,transmissibility,epidemic,and variability of MPXV.
