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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection
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作者 Dongxiao Li Hong Zhou +2 位作者 Zhihao Ren Cheng Xu Chengkuo Lee 《Nano-Micro Letters》 SCIE EI CAS 2025年第1期262-280,共19页
Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from... Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance perturbations.Here,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning channel.We observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano lineshapes.These characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 detection.These findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions. 展开更多
关键词 Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled BIOSENSING
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An optimized, sensitive and stable reduced graphene oxide–gold nanoparticle-luminol-H_2O_2 chemiluminescence system and its potential analytical application
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作者 王闻硕 何大伟 +6 位作者 王继红 段嘉华 彭洪尚 吴洪鹏 富鸣 王永生 张希清 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第4期622-628,共7页
The chemiluminescence (CL) performance of luminol is improved using reduced graphene oxide/gold nanoparticle (rGO-AuNP) nano-composites as catalyst. To prepare this catalyst, we propose a linker free, one-step met... The chemiluminescence (CL) performance of luminol is improved using reduced graphene oxide/gold nanoparticle (rGO-AuNP) nano-composites as catalyst. To prepare this catalyst, we propose a linker free, one-step method to in- situ synthesize rGO-AuNP nano-composites. Various measurements are utilized to characterize the resulting rGO-AuNP samples, and it is revealed that rGO could improve the stability and conductivity. Furthermore, we investigate the CL signals of luminal catalyzed by rGO-AuNP. Afterwards, the size effect of particle and the assisted enhancement effect of rGO are studied and discussed in detail. Based on the discussion, an optimal, sensitive and stable rGO-AuNP-luminon- H202 CL system is proposed. Finally, we utilize the system as a sensor to detect hydrogen peroxide and organic compounds containing amino, hydroxyl, or thiol groups. The CL system might provide a more attractive platform for various analytical devices with CL detection in the field of biosensors, bioassays, and immunosensors. 展开更多
关键词 GRAPHENE NANOPARTICLES CHEMILUMINESCENCE biosensers
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Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications 被引量:14
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作者 Shuqi Wu Yang Li +3 位作者 Weihang Ding Letong Xu Yuan Ma Lianbing Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第6期1-26,共26页
Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation.In the past decade,persistent luminescence nanoparticles(PLNPs)with int... Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation.In the past decade,persistent luminescence nanoparticles(PLNPs)with intriguing optical properties have attracted a wide range of attention in various areas.Especially in recent years,the development and applications in biomedical fields have been widely explored.Owing to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission,many researches have focused on the manipulation of PLNPs in biosensing,cell tracking,bioimaging and cancer therapy.These achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple functions.In this review,we summarize the works on synthesis methods,bioapplications,biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing,imaging and imaging-guided therapy.We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications.Finally,the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications. 展开更多
关键词 PERSISTENT LUMINESCENCE NANOPARTICLES BIOSENSING BIOIMAGING Cell tracking Cancer THERAPY
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Black phosphorus:A novel nanoplatform with potential in the¯eld of bio-photonic nanomedicine 被引量:6
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作者 Taojian Fan Yansheng Zhou +1 位作者 Meng Qiu Han Zhang 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2018年第6期1-20,共20页
Single-or few-layer black phosphorus(FLBP)has attracted great attentions in scientic community with its excellent properties,including biodegradability,unique puckered lattice conguration,attractive electrical propert... Single-or few-layer black phosphorus(FLBP)has attracted great attentions in scientic community with its excellent properties,including biodegradability,unique puckered lattice conguration,attractive electrical properties and direct and tunable band gap.In recent years,FLBP has been widely studied in bio-photonicelds such as photothermal and photodynamic therapy,drug delivery,bioimaging and biosensor,showing attractive clinical potential.Because of the marked advantages of FLBP nanomaterials in bio-photonicelds,this review article reviews the latest advances of biomaterials based on FLBP in biomedical applications,ranging from biocompatibility,medical diagnosis to treatment. 展开更多
关键词 Black phosphorus BIOSENSING drug delivery biocompatibility photothermal and photodynamic therapies
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One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip 被引量:5
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作者 Chenchen Bao Lei Chen +4 位作者 Tao Wang Chong Lei Furong Tian Daxiang Cui Yong Zhou 《Nano-Micro Letters》 SCIE EI CAS 2013年第3期213-222,共10页
RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a speci... RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiF e-based magnetic biosensing cell chip combined with functionalized magnetic nanoparticles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cultured on the NiF e-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin.Cell lines such as Calu3, Hela, A549, CaF br, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost,easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition. 展开更多
关键词 Magnetic impedance Cancer cell Targeted detection Biosensing system Cell cultural chip
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Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine 被引量:4
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作者 Morteza Hasanzadeh Kafshgari Wolfgang HGoldmann 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第2期102-136,共35页
Titanium dioxide(TiO2)nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications.TiO2 nanostructures promise to improve current theranostic strategies by lever... Titanium dioxide(TiO2)nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications.TiO2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement,thermal conversion,specific surface area,and surface activity.This review highlights certain important aspects of fabrication strategies,which are employed to generate multifunctional TiO2 nanostructures,while outlining post-fabrication techniques with an emphasis on their suitability for nanomedicine.The biodistribution,toxicity,biocompatibility,cellular adhesion,and endocytosis of these nanostructures,when exposed to biological microenvironments,are examined in regard to their geometry,size,and surface chemistry.The final section focuses on recent biomedical applications of TiO2 nanostructures,specifically evaluating therapeutic delivery,photodynamic and sonodynamic therapy,bioimaging,biosensing,tissue regeneration,as well as chronic wound healing. 展开更多
关键词 TiO2 nanostructures Drug delivery systems BIOIMAGING BIOSENSING Tissue regeneration
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Nanozymes in Point-of-Care Diagnosis:An Emerging Futuristic Approach for Biosensing 被引量:2
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作者 Bhaskar Das Javier Lou Franco +3 位作者 Natasha Logan Paramasivan Balasubramanian Moon Il Kim Cuong Cao 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第12期44-94,共51页
Nanomaterial-based artificial enzymes(or nanozymes) have attracted great attention in the past few years owing to their capability not only to mimic functionality but also to overcome the inherent drawbacks of the nat... Nanomaterial-based artificial enzymes(or nanozymes) have attracted great attention in the past few years owing to their capability not only to mimic functionality but also to overcome the inherent drawbacks of the natural enzymes.Numerous advantages of nanozymes such as diverse enzyme-mimicking activities,low cost,high stability,robustness,unique surface chemistry,and ease of surface tunability and biocompatibility have allowed their integration in a wide range of biosensing applications. Several metal,metal oxide,metal–organic framework-based nanozymes have been exploited for the development of biosensing systems,which present the potential for point-of-care analysis. To highlight recent progress in the field,in this review,more than 260 research articles are discussed systematically with suitable recent examples,elucidating the role of nanozymes to reinforce,miniaturize,and improve the performance of point-of-care diagnostics addressing the ASSURED(a ordable,sensitive,specific,user-friendly,rapid and robust,equipment-free and deliverable to the end user) criteria formulated by World Health Organization. The review reveals that many biosensing strategies such as electrochemical,colorimetric,fluorescent,and immunological sensors required to achieve the ASSURED standards can be implemented by using enzyme-mimicking activities of nanomaterials as signal producing components. However,basic system functionality is still lacking. Since the enzyme-mimicking properties of the nanomaterials are dictated by their size,shape,composition,surface charge,surface chemistry as well as external parameters such as pH or temperature,these factors play a crucial role in the design and function of nanozyme-based point-of-care diagnostics. Therefore,it requires a deliberate exertion to integrate various parameters for truly ASSURED solutions to be realized. This review also discusses possible limitations and research gaps to provide readers a brief scenario of the emerging role of nanozymes in state-of-the-art POC diagnosis system development for futuristic biosensing applications. 展开更多
关键词 Nanozymes BIOSENSING Point-of-care diagnosis ASSURED diagnostics Catalytic nanomaterials
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Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells 被引量:2
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作者 Zhaoyuan Lyu Shichao Ding +6 位作者 Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第9期364-376,共13页
Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-at... Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. 展开更多
关键词 Single-atomic site catalysts NANOPROBE Peroxidase-like activities BIOSENSING Living cell
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A short review on cell-based biosensing:challenges and breakthroughs in biomedical analysis 被引量:1
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作者 Mihaela Gheorghiu 《The Journal of Biomedical Research》 CAS CSCD 2021年第4期255-263,共9页
Current cell-based biosensors have progressed substantially from mere alternatives to molecular bioreceptors into enabling tools for interfacing molecular machineries and gene circuits with microelectronics and for de... Current cell-based biosensors have progressed substantially from mere alternatives to molecular bioreceptors into enabling tools for interfacing molecular machineries and gene circuits with microelectronics and for developing groundbreaking sensing and theragnostic platforms.The recent literature concerning whole-cell biosensors is reviewed with an emphasis on mammalian cells,and the challenges and breakthroughs brought along in biomedical analyses through novel biosensing concepts and the synthetic biology toolbox.These recent innovations allow development of cell-based biosensing platforms having tailored performances and capable to reach the levels of sensitivity,dynamic range,and stability suitable for high analytic/medical relevance.They also pave the way for the construction of flexible biosensing platforms with utility across biological research and clinical applications.The work is intended to stimulate interest in generation of cell-based biosensors and improve their acceptance and exploitation. 展开更多
关键词 BIOSENSING electro-optical assays synthetic biology cell dynamics cell physiology THERANOSTICS
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Study on Technique of Surface Plasmon Resonance Imaging Sensing for Biomolecular Interaction
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作者 Ding Xiang Rong Xiaofeng Deng Yan Yu Xinglong 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2006年第A03期483-487,共5页
High resolution of surface plasmon resonance (SPR) detection is of vital importance.SPR biosensing system resolution is determined by intrinsic sensitivity of biochip and light signal acquisition system.In this articl... High resolution of surface plasmon resonance (SPR) detection is of vital importance.SPR biosensing system resolution is determined by intrinsic sensitivity of biochip and light signal acquisition system.In this article,different signal acquisition system resolutions on photodetector were analyzed based on light intensity and phase detection.Result shows that charge coupled device (CCD) with larger numbers of pixels is potential to achieve higher detection resolution.A 64 pixel line array CCD and a 12 bit ADC can achieve resolution of 10^(-7) refractive index unit (RIU).In array detection mode,increasing of detection throughput is at the cost of decreasing system resolution.Simulation analysis indicates that,if noise is taken into account,phase modulation methods are capable of providing better noise reduction performance than intensity methods. 展开更多
关键词 SPR biosensing intensity detection phase detection RESOLUTION
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Britton Chance's lab and thereafter:From NIR spectroscopy to molecular sensing via nanotechnology
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作者 Kyung.A.Kang 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2014年第2期1-11,共11页
I was fortunate to,work with/for Dr Britton Chance as his postdoctoral fellow,in the Bio-chemistry and Biophysics Department at the University of Pennsy lvania,bet ween August 1991and January 1994.As anyone who worked... I was fortunate to,work with/for Dr Britton Chance as his postdoctoral fellow,in the Bio-chemistry and Biophysics Department at the University of Pennsy lvania,bet ween August 1991and January 1994.As anyone who worked for him,I had a suficient dosage of"Brtton Chance"over the years.Initilly,to me,I felt that he was someone who was above regular people and faraway to reach,Then I became to know him as a person,who was simple and complicated at thesame time,with a persistent pursuit for his life interests,i.e,the advancement in science relatedto human health.As far as it goes to science(and perhaps with sailing),he had few boundary:Hecommunicated with any age group,any one from any country with any cultural background.Anyscientists were welcomed to his lab,his own house,and even his boat.He was happy with minimalmaterial things.He kept his friendship faithfully.From him,I came to lmow how much oneperson can actually do during a life time.am very gratefil that I got to lnow him during my lifepath In this paper,list some of my experiences with hin scientifically and also how and what ilearned from him impacted my research and personal life. 展开更多
关键词 BIOSENSING molecular sensing contrast agent Nanopartidles cancer detection.
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Component spectroscopic properties of light-harvesting complexes with DFT calculations
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作者 SHYAM BADU SANJAY PRABHAKAR RODERICK MELNIK 《BIOCELL》 SCIE 2020年第3期279-291,共13页
Photosynthesis is a fundamental process in biosciences and biotechnology that influences profoundly the research in other disciplines.In this paper,we focus on the characterization of fundamental components,present in... Photosynthesis is a fundamental process in biosciences and biotechnology that influences profoundly the research in other disciplines.In this paper,we focus on the characterization of fundamental components,present in pigment-protein complexes,in terms of their spectroscopic properties such as infrared spectra,nuclear magnetic resonance,as well as nuclear quadrupole resonance,which are of critical importance for many applications.Such components include chlorophylls and bacteriochlorophylls.Based on the density functional theory method,we calculate the main spectroscopic characteristics of these components for the Fenna-Matthews-Olson light-harvesting complex,analyze them and compare them with available experimental results.Future outlook is discussed in the context of current and potential applications of the presented results. 展开更多
关键词 PHOTOSYNTHESIS BACTERIOCHLOROPHYLLS Light HARVESTING Pigment-protein complexes Density functional theory Complex networks Photocatalysis BIOSENSING and bioplasmonics
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Super-Resolution Displacement Spectroscopic Sensing over a Surface“Rainbow”
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作者 Lyu Zhou Nan Zhang +7 位作者 Chang Chieh Hsu Matthew Singer Xie Zeng Yizheng Li Haomin Song Josep Jornet Yun Wu Qiaoqiang Gan 《Engineering》 SCIE EI CAS 2022年第10期75-81,共7页
Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical imaging.For these applications,miniaturized spectrometers are desirable to ena... Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical imaging.For these applications,miniaturized spectrometers are desirable to enable the on-chip analysis of spectral information.In particular,for imaging-based spectroscopic sensing mechanisms,the key challenge is to determine the spatial-shift information accurately(i.e.,the spatial displacement introduced by wavelength shift or biological or chemical surface binding),which is similar to the challenge presented by super-resolution imaging.Here,we report a unique"rainbow"trapping metasurface for on-chip spectrometers and sensors.Combined with super-resolution image processing,the low-setting 4×optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as0.002 mm2.This unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength shift.Using this low-setting 4×microscope imaging system,we demonstrate a biosensing resolution of 1.92×109exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor(EGFR)expression values,thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications. 展开更多
关键词 Rainbow trapping Metasurface Surface plasmon polaritons Super-resolution displacement On-chip biosensing
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Advances in Application of Biosensing Technology in Detection of Animal Epidemic Diseases
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作者 Han TAO Laping HE +1 位作者 Li CHEN Yiming ZHANG 《Agricultural Biotechnology》 CAS 2013年第6期59-62,67,共5页
The development of rapid and sensitive detection technologies for animal epidemic diseases is very important to early diagnosis and disease control. Biosensing technology is a novel biological detection technology dev... The development of rapid and sensitive detection technologies for animal epidemic diseases is very important to early diagnosis and disease control. Biosensing technology is a novel biological detection technology developed in recent years and has been listed as one of the five medical inspection technologies in the 21" century, which is considered as a rapid and effective technology for detection and diagnosis of animal epidemic diseases. In this paper, the latest research progresses on the application of biosensing technology in detection of bacterial infectious diseases, viral infectious diseases and parasitic diseases were summarized. 展开更多
关键词 BIOSENSING Animal epidemic diseases DETECTION
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Biomimetic microstructural scaffolds and their applications in tissue engineering
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作者 Ru-Rong Lin Cheng Chen +6 位作者 Hai-Bin Zheng Chun-Yi Pu Jian-Xing Huang Qi-Xiang Duan Shuai Liu Xiao-Zhong Qiu Hong-Hao Hou 《Biomedical Engineering Communications》 2022年第1期36-48,共13页
The dynamic structures of extracellular matrix regulate cell behaviors by providing three-dimension ecological niche and mechanical cues.Under the progress of both surface patterning and biomaterials,the cues of micro... The dynamic structures of extracellular matrix regulate cell behaviors by providing three-dimension ecological niche and mechanical cues.Under the progress of both surface patterning and biomaterials,the cues of micro-and nanoscale topography on microstructural scaffold biomaterials are increasingly recognized as decisive factors of biomimetic materials.In this review,we provide an overview of the recent progress of biomimetic microstructured scaffolds,including advances in their biomimetic manufacturing technology,functionality,potential applications and future challenges.We highlight recent progress in the fabrication of microstructured scaffold materials with various biological and physicochemical characteristics of native extracellular matrix.The recent key advances of microstructured scaffold for tissue engineering,bio-adhesive,antibacterial and biosensing applications were offered.Eventually,we summarize by offering our perspective on this fast-growing field. 展开更多
关键词 tissue engineering biomimetic scaffold microstructure bio-adhesive ANTIBACTERIAL BIOSENSING
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Recent progress in MOFs-based nanozymes for biosensing 被引量:4
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作者 Imamdin Chandio Yongjian Ai +1 位作者 Lei Wu Qionglin Liang 《Nano Research》 SCIE EI CSCD 2024年第1期39-64,共26页
Nanozymes are nanomaterials with enzyme-mimicking catalytic activity.Compared to natural enzymes,nanozymes show various properties such as easy to manufacture,stable,adjustable,and inexpensive.Nanozymes play key roles... Nanozymes are nanomaterials with enzyme-mimicking catalytic activity.Compared to natural enzymes,nanozymes show various properties such as easy to manufacture,stable,adjustable,and inexpensive.Nanozymes play key roles in biosensing,biocatalysis,and disease treatment.As an important kind of nanozymes,metal-organic framework(MOF)-based nanozymes are receiving a lot of attention due to their structural properties and composition.Rationally developing MOF with enzymes-like catalytic properties has opened new perspectives in biosensing.This review summarizes the up-to-date developments in synthesizing two-dimensional and three-dimensional MOF-based nanozymes and their applications in biosensing.Firstly,classification of nanozymes obtained by MOFs is categorized,and different properties of MOF-based nanozymes are described.Then,the distinctive applications of MOF-based nanozymes in identifying various analytes are thoroughly summarized.Finally,the recent challenges and progressive directions in this area are highlighted. 展开更多
关键词 METAL-ORGANIC frameworks nanozymes METAL-ORGANIC FRAMEWORK (MOF)-based nanozymes BIOSENSING ANALYTES
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Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics 被引量:2
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作者 Zhaoyue Lv Mengxue Huang +3 位作者 Peiran Li Mengdi Xu Chi Yao Dayong Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第2期223-231,共9页
DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and biocompatibility.Hybridization chain reaction(HCR)is a simple and efficient iso... DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and biocompatibility.Hybridization chain reaction(HCR)is a simple and efficient isothermal enzyme-free amplification strategy of DNA,generating nicked double helices with repeated units.Through the design of HCR hairpins,multiple nanomaterials with desired functions are assembled by DNA,exhibiting great potential in biomedical applications.Herein,the recent progress of HCR-based DNA nanomaterials for biosensing,bioimaging and therapeutics are summarized.Representative works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and constructed.The challenges and prospects of the development of HCR-based DNA nanomaterials are discussed.We envision that rationally designing HCR-based DNA nanomaterials will facilitate the development of biomedical applications. 展开更多
关键词 DNA nanotechnology Hybridization chain reaction DNA nanomaterials BIOSENSING BIOIMAGING Therapeutics
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Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications 被引量:2
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作者 Jia Min Loh Yun Jie Larissa Lim +3 位作者 Jin Ting Tay Hui Mei Cheng Hong Liang Tey Kun Liang 《Bioactive Materials》 SCIE CSCD 2024年第2期222-241,共20页
Microneedles(MNs)is an emerging technology that employs needles ranging from 10 to 1000μm in height,as a minimally invasive technique for various procedures such as therapeutics,disease monitoring and diagnostics.The... Microneedles(MNs)is an emerging technology that employs needles ranging from 10 to 1000μm in height,as a minimally invasive technique for various procedures such as therapeutics,disease monitoring and diagnostics.The commonly used method of fabrication,micromolding,has the advantage of scalability,however,micromolding is unable to achieve rapid customizability in dimensions,geometries and architectures,which are the pivotal factors determining the functionality and efficacy of the MNs.3D printing offers a promising alternative by enabling MN fabrication with high dimensional accuracy required for precise applications,leading to improved performance.Furthermore,enabled by its customizability and one-step process,there is propitious potential for growth for 3D-printed MNs especially in the field of personalized and on-demand medical devices.This review provides an overview of considerations for the key parameters in designing MNs,an introduction on the various 3D-printing techniques for fabricating this new generation of MNs,as well as highlighting the advancements in biomedical applications facilitated by 3D-printed MNs.Lastly,we offer some insights into the future prospects of 3D-printed MNs,specifically its progress towards translation and entry into market. 展开更多
关键词 MICRONEEDLES 3D printing Drug delivery Extraction of biological specimen BIOSENSING
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Activity regulation and applications of metal-organic framework-based nanozymes 被引量:1
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作者 Ge Fang Shou-Xin Bao +1 位作者 Gen-Xiu Zhou Cui-Cui Ge 《Rare Metals》 SCIE EI CAS CSCD 2024年第3期900-914,共15页
As a new generation of artificial enzymes,nanozymes show outstanding advantages such as high stability,low cost,and facile synthesis,which endow them with promising applications in biomedical and environmental fields.... As a new generation of artificial enzymes,nanozymes show outstanding advantages such as high stability,low cost,and facile synthesis,which endow them with promising applications in biomedical and environmental fields.Among the various reported nanozymes,metal-organic frameworks(MOFs)could mimic the active center of natural enzymes and provide a hydrophobic environment,which makes MOFs attractive alternatives to natural enzymes.Owing to the highly structural diversity and tailorability of MOFs,rational design will contribute to improve the activity of MOF-based nanozymes and promote their potential applications in both biomedical and environmental fields.Therefore,a comprehensiye suminary of activity regulatory strategies of MOF-based nanozymes is urgently needed.Firstly,we summarized the activity regulatory strategies of MOFs with intrinsic enzyme-like activities via modulation of metal nodes,ligands,structures and morphologies.Then the applications of MOF-based nanozymes in biosensing,hazardous degradation,antibacterial,and cancer therapy were also introduced.Finally,the current challenges and future perspectives were discussed in depth.It is highly expected that this review will provide a better understanding on the rational design of novel high-performance MOF-based nanozymes. 展开更多
关键词 Metal-organic frameworks(MOF)-based nanozymes Activity regulation BIOSENSING Cancer therapy Hazardous degradation ANTIBACTERIAL
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Near-infrared Emissive 1,2-Dioxetane-based Chemiluminescent Probes
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作者 CHEN Yingqi BUDIANTA Richard NING Yingying 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2024年第5期806-823,共18页
Chemiluminescence,a phenomenon emitting light from chemical reactions rather than photon absorption,has gained significant interest for applications in bioimaging and biosensing due to its high sensitivity and low bac... Chemiluminescence,a phenomenon emitting light from chemical reactions rather than photon absorption,has gained significant interest for applications in bioimaging and biosensing due to its high sensitivity and low background interference.Now there is a growing interest in near-infrared(NIR)chemiluminescent probes for improved tissue penetration and reduced autofluorescence.This review summarizes NIR emissive chemiluminescent probes based on 1,2-dioxetane and discusses their chemical structures and applications.Structure modification strategies for red-shifting wavelength and enhancing brightness include incorporating electron-withdrawing groups,designing chemiluminophore-fluorophore cassettes,and exploring alternative chemiluminescent scaffolds.This review aims to inspire the exploration of NIR chemiluminescent probes in disease detection and treatment. 展开更多
关键词 CHEMILUMINESCENCE NEAR-INFRARED DIOXETANE BIOIMAGING BIOSENSING
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