Biodegradable magnesium(Mg) alloys are expected to be promising materials for cardiovascular stents(CVS), which can avoid the longterm clinical problems of current CVS, such as in-stent restenosis, late stent thrombos...Biodegradable magnesium(Mg) alloys are expected to be promising materials for cardiovascular stents(CVS), which can avoid the longterm clinical problems of current CVS, such as in-stent restenosis, late stent thrombosis, etc. Mg alloy stents exhibit superior biocompatibility and tunable biodegradability, compared with conventional permanent metallic stents. However, the poor formability and non-uniform corrosion of Mg alloy stents hinder their clinical application of CVS. This review focuses on the development of Mg alloys for CVS in recent years.According to the results of bibliometric analysis, we analyzed different biodegradable Mg alloy systems. Moreover, the structural design strategies for Mg alloy stents that can reduce the stress concentration, as well as the surface modification methods to control the corrosion behavior and biological performance of Mg alloy stents are also highlighted. At last, this review systematically discussed the potential directions and challenges of biodegradable magnesium stents(BMgS) in cardiovascular fields.展开更多
BACKGROUND： Poly （glycolide-co-L-lactide） （PGLA） braided regeneration conduits have been shown to be biocompatible for the repair of damaged nerve. Mechanical properties, such as radial compression and torsion, g...BACKGROUND： Poly （glycolide-co-L-lactide） （PGLA） braided regeneration conduits have been shown to be biocompatible for the repair of damaged nerve. Mechanical properties, such as radial compression and torsion, greatly influence nerve regeneration and functional recovery. OBJECTIVE： To observe the influence of conduit parameters and coating methods on torsion properties in an in vitro-degradation environment and at normal temperature. DESIGN, TIME AND SE＇I-FING： An in vitro, comparative study using repeated measures was performed at the College of Textiles, Donghua University, China from January 2005 to December 2007. MATERIALS： PGLA fiber and yarn （Shanghai Bio-TianQing, China）, as well as torsion property testing instrument （LaiZhou Electronic Instrument, China）, were used in the present study. METHODS： A total of 16 types of conduits were constructed according to braiding structures （regular/triaxial）, angles （50°/55°/60°/65°）nd coating methods （coated/uncoated）. At normal temperature, torsion properties of all conduits were tested at a predefined constant angle of 90°. Coated and uncoated conduits, which were triaxial and 65°, were incubated in a 5% CO2 incubator at 37 ℃ to simulate an in vitro degradation environment, and then torsion properties were tested at 4, 7, 11, 14, 17, 21,24, and 28 days in culture. MAIN OUTCOME MEASURES： Maximal torsion strength and torsion strength-torsion angle curve of conduits at normal temperature, as well as torsion strength-torsion angle curve, loss of torsion strength, and change in maximal torsion strength in an in vitro degradation environment. RESULTS： At normal temperature, the torsion properties of the triaxial structure were superior to the regular structure. Coated conduits performed better than uncoated ones, and the larger braiding angles exhibited superior torsion properties （P 〈 0.05）. In the in vitro degradation environment, with degradation time, torsion strength of uncoated conduits was deceased gradually and the loss of torsion strength was increased fast. Torsion strength of coated conduits was increased first and decreased afterwards; the loss of torsion strength was decreased slowly till 14 days; both became identical after 14 days （P 〉 0.05）. CONCLUSION： Torsion properties of coated conduits with a triaxial structure and large braiding angle were superior to uncoated conduits with regular structures and small braiding angles.展开更多
Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is...Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is needed in that multi-phased alloy to achieve a good combination of mechanical strength and corrosion resistance.However,the high complex RE addition accompanied with multiple second phases may bring the concern of biological hazards.Single-phased Mg-RE alloys with simpler compositions were proposed to improve the overall performance,i.e.,“Simpler alloy,better performance”.The single-phased microstructure can be successfully obtained with typical high-solubility REEs(Ho,Er or Lu)through traditional smelting,casting and extrusion in a wide compositional range.A good corrosion resistance with a macroscopically uniform corrosion mode was guaranteed by the homogeneously single-phased microstructure.The bimodal-grained structure with plenty of sub-grain microstructures allow us to minimize the RE addition to<1 wt%,without losing mechanical properties.The single-phased Mg-RE alloys show comparable mechanical properties to the clinically-proven Mg-based implants.They exhibited similar in-vitro and in-vivo performances(without local or systematic toxicity in SD-rats)compared to a high purity magnesium.In addition,metal elements in our single-phased alloys can be gradually excreted through the urinary system and digestive system,showing no consistent accumulation of RE in main organs,i.e.,less burden on organs.The novel concept in this study focuses on the simplification of Mg-RE based alloys for biomedical purpose,and other biodegradable metals with single-phased microstructures are expected to be explored.展开更多
基金funded by the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0993)the Chongqing Academician Special Fund (2022YSZXJCX0014CSTB)+1 种基金National Natural Science Foundation of China (52225101)the China Postdoctoral Science Foundation (2022M720551)。
文摘Biodegradable magnesium(Mg) alloys are expected to be promising materials for cardiovascular stents(CVS), which can avoid the longterm clinical problems of current CVS, such as in-stent restenosis, late stent thrombosis, etc. Mg alloy stents exhibit superior biocompatibility and tunable biodegradability, compared with conventional permanent metallic stents. However, the poor formability and non-uniform corrosion of Mg alloy stents hinder their clinical application of CVS. This review focuses on the development of Mg alloys for CVS in recent years.According to the results of bibliometric analysis, we analyzed different biodegradable Mg alloy systems. Moreover, the structural design strategies for Mg alloy stents that can reduce the stress concentration, as well as the surface modification methods to control the corrosion behavior and biological performance of Mg alloy stents are also highlighted. At last, this review systematically discussed the potential directions and challenges of biodegradable magnesium stents(BMgS) in cardiovascular fields.
文摘BACKGROUND： Poly （glycolide-co-L-lactide） （PGLA） braided regeneration conduits have been shown to be biocompatible for the repair of damaged nerve. Mechanical properties, such as radial compression and torsion, greatly influence nerve regeneration and functional recovery. OBJECTIVE： To observe the influence of conduit parameters and coating methods on torsion properties in an in vitro-degradation environment and at normal temperature. DESIGN, TIME AND SE＇I-FING： An in vitro, comparative study using repeated measures was performed at the College of Textiles, Donghua University, China from January 2005 to December 2007. MATERIALS： PGLA fiber and yarn （Shanghai Bio-TianQing, China）, as well as torsion property testing instrument （LaiZhou Electronic Instrument, China）, were used in the present study. METHODS： A total of 16 types of conduits were constructed according to braiding structures （regular/triaxial）, angles （50°/55°/60°/65°）nd coating methods （coated/uncoated）. At normal temperature, torsion properties of all conduits were tested at a predefined constant angle of 90°. Coated and uncoated conduits, which were triaxial and 65°, were incubated in a 5% CO2 incubator at 37 ℃ to simulate an in vitro degradation environment, and then torsion properties were tested at 4, 7, 11, 14, 17, 21,24, and 28 days in culture. MAIN OUTCOME MEASURES： Maximal torsion strength and torsion strength-torsion angle curve of conduits at normal temperature, as well as torsion strength-torsion angle curve, loss of torsion strength, and change in maximal torsion strength in an in vitro degradation environment. RESULTS： At normal temperature, the torsion properties of the triaxial structure were superior to the regular structure. Coated conduits performed better than uncoated ones, and the larger braiding angles exhibited superior torsion properties （P 〈 0.05）. In the in vitro degradation environment, with degradation time, torsion strength of uncoated conduits was deceased gradually and the loss of torsion strength was increased fast. Torsion strength of coated conduits was increased first and decreased afterwards; the loss of torsion strength was decreased slowly till 14 days; both became identical after 14 days （P 〉 0.05）. CONCLUSION： Torsion properties of coated conduits with a triaxial structure and large braiding angle were superior to uncoated conduits with regular structures and small braiding angles.
基金This work was supported by the National Key R&D Program of China(Grant No.2021YFC2400700),the National Natural Science Foundation of China(Grant No.52101283)the Science and Technology Planning Project of Guangzhou(Grant No.202201011454)+1 种基金the NSFC Incubation Program of GDPH(Grant No.KY012021165)the High-level Hospital Construction Project(Grant No.KJ012019520).
文摘Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is needed in that multi-phased alloy to achieve a good combination of mechanical strength and corrosion resistance.However,the high complex RE addition accompanied with multiple second phases may bring the concern of biological hazards.Single-phased Mg-RE alloys with simpler compositions were proposed to improve the overall performance,i.e.,“Simpler alloy,better performance”.The single-phased microstructure can be successfully obtained with typical high-solubility REEs(Ho,Er or Lu)through traditional smelting,casting and extrusion in a wide compositional range.A good corrosion resistance with a macroscopically uniform corrosion mode was guaranteed by the homogeneously single-phased microstructure.The bimodal-grained structure with plenty of sub-grain microstructures allow us to minimize the RE addition to<1 wt%,without losing mechanical properties.The single-phased Mg-RE alloys show comparable mechanical properties to the clinically-proven Mg-based implants.They exhibited similar in-vitro and in-vivo performances(without local or systematic toxicity in SD-rats)compared to a high purity magnesium.In addition,metal elements in our single-phased alloys can be gradually excreted through the urinary system and digestive system,showing no consistent accumulation of RE in main organs,i.e.,less burden on organs.The novel concept in this study focuses on the simplification of Mg-RE based alloys for biomedical purpose,and other biodegradable metals with single-phased microstructures are expected to be explored.
