Objective: To observe the effect of theo polyphenols(TP)on function of trans membranous signal of acute ischemic myocardium in rats. Methods: Model of myocardial ischemia was established. Thirty five male rats wer...Objective: To observe the effect of theo polyphenols(TP)on function of trans membranous signal of acute ischemic myocardium in rats. Methods: Model of myocardial ischemia was established. Thirty five male rats were randomly divided into 5 groups, 7 rats in each group. Non ischemic group:the anterior descending branch of left coronary artery was not ligated;Ischemic group:the time of ischemia continued for 10 min;TP groups:the groups were divided into 3 subgroups, TP dose was respectively 1 mg/kg, 4 mg/kg, 16 mg/kg, TP was administered through celiac injection 20 min before the anterior descending branch of left coronary artery was ligated. Results: The levels of phosphatidylinositol 4, 5 biphosphate(PIP 2), inositol 1, 4, 5 triphosphate(IP 3)in the ischemic group were markedly higher than those in the non ischemic group. The raise of the levels of PIP 2, IP 3caused by acute myocardial ischemia were markedly inhibited by the TP. The relationship of dose effect was observed. Conclusion: TP has inhibitory effect of trans membranous signal system of acute ischemic myocardium. It has protective effect on myocardium.展开更多
文摘Objective: To observe the effect of theo polyphenols(TP)on function of trans membranous signal of acute ischemic myocardium in rats. Methods: Model of myocardial ischemia was established. Thirty five male rats were randomly divided into 5 groups, 7 rats in each group. Non ischemic group:the anterior descending branch of left coronary artery was not ligated;Ischemic group:the time of ischemia continued for 10 min;TP groups:the groups were divided into 3 subgroups, TP dose was respectively 1 mg/kg, 4 mg/kg, 16 mg/kg, TP was administered through celiac injection 20 min before the anterior descending branch of left coronary artery was ligated. Results: The levels of phosphatidylinositol 4, 5 biphosphate(PIP 2), inositol 1, 4, 5 triphosphate(IP 3)in the ischemic group were markedly higher than those in the non ischemic group. The raise of the levels of PIP 2, IP 3caused by acute myocardial ischemia were markedly inhibited by the TP. The relationship of dose effect was observed. Conclusion: TP has inhibitory effect of trans membranous signal system of acute ischemic myocardium. It has protective effect on myocardium.
