Predicted epitopes of H5N1 bird flu virus by bioinformatics method: a clue for further vaccine development

To the Editor： Bird flu or avian flu, caused by H5N1 virus, is a new emerging infectious disease. It is noted that this H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in many countries. The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality of humans infected with H5N1 are a source of great international concern.1 Providing sufficient antiviral drugs and development and approval of new vaccines are the keys for control of the possible emerging pandemic of this atypical influenza.1＇2 Based on the advance in bioinformatics, the immunomics becomes a new alternative in vaccine development.3 Advanced technologies for vaccine development, such as genome sequence analysis, microarray, proteomics approach, high-throughput cloning, bioinformatics database tools and computational vaccinology can be applied for vaccine development of several diseases including new emerging diseases.

安徽省疫源水鸟传播禽流感的风险分析

鸟类等重点疫源物种的迁徙增加了不同地区禽类病原体交叉感染的机会和概率,在禽流感病毒的传播中起着关键性作用。安徽省位于东亚-澳大利西亚候鸟重要迁徙通道,野生鸟类和湿地资源丰富。本文简要归纳了安徽省水鸟种类、分布及重点栖息地,通过研究禽流感在疫源水鸟中的传播途径和影响因素,分析了安徽省水鸟迁徙传播禽流感病毒的可能性,并从加强候鸟迁徙动态监测、开展疫源疫病病原体监测、加强法律法规体系建设、加强家禽养殖管理、增强监测防控能力等方面提出相应防控策略,以期为安徽省禽流感疫情的早期监测、预警与防控提供参考。

人感染H_7N_9禽流感病毒的流行特征分析

目的分析人感染H_7N_9禽流感病毒的流行特征,并对人感染H_7N_9禽流感与外界环境导致发病之间的关联进一步了解。方法分析自然因素、社会因素对人感染H_7N_9病毒流行特征的特点、影响因素。结果收集我科室68例人感染H_7N_9禽流感病毒病例,根据地区分布有3例死亡;根据年龄比较,≥60岁的有45例,≤60岁的有23例;根据性别:男性38例,女性30例;根据职业:离退休人员有22例,农民有26例,其他职业有20例;根据接触禽类史情况:确定与禽类接触史的有14例,剩余为不确定是否有接触史的有54例;根据按月份:3月21例,4月47例;比较发病至入院隔离时间:有33例入院时间明确,当天入院患者有11例,最长在12 d后入院;比较发病时间和检测时间:在进行H_7N_9检测中,有21例是在4 d内,47例在9 d内。结论人感染H_7N_9禽流感病毒的流行特征经过分析后,未能明确传染和流行特征。因此,需要对疫情加强监测,对自然、社会因素的作用进行深入研究。