Numerical methods are used to evaluate variations of the electromagnetic fields generated by a head-sized birdcage coil as a function of load (“loading effect”). The loading effect was analyzed for the cases of a co...Numerical methods are used to evaluate variations of the electromagnetic fields generated by a head-sized birdcage coil as a function of load (“loading effect”). The loading effect was analyzed for the cases of a coil loaded with a conductive cylindrical sample, a dielectric cylindrical sample, and an anatomically precise head model. Maxwell equations were solved by means of finite difference time domain (FDTD) method conducted at 12.8, 64, and 128 MHz. Simulation results indicate that at 12.8 MHz the conservative electric field (Ec) caused by the scalar electric potentials between the coil and the load or within the load was significantly higher than the magnetically-induced electric field (Ei) and was the major component of the total electric field (Etotal). The amplitudes of Ec and Etotal are seen to be lower within a sample than at a corresponding location in an empty coil, but approximately 65% higher in the space between coil and sample than at a corresponding location in an empty coil. This is due to polarization effects generating an additional scalar potential parallel to the original field. The increased electric field between coil and sample may cause increased power deposition at the surface of the sample and may affect the RF-induced currents in external leads used for physiological recording, i.e. ECG, during MRI scanning.展开更多
In this study, we performed a numerical analysis of a novel EMF Birdcage wearable device for the treatment of Alzheimer’s disease (AD). We designed the new device to generate and radiate a frequency of 64 MHz and a s...In this study, we performed a numerical analysis of a novel EMF Birdcage wearable device for the treatment of Alzheimer’s disease (AD). We designed the new device to generate and radiate a frequency of 64 MHz and a specific absorption rate (SAR) of 0.6 W/kg to a simulated human brain tissue. We determined these parameters from our experimental studies on primary human brain cultures at the Indiana University School of Medicine (IUSM). We found that this frequency and SAR decreased the toxic Aβ levels in the cell cultures. The frequency of 64 MHZ has good skin depth penetration, which will easily pass through the various head layers, including hair, skin, fat, dura, the cerebrospinal (CSF), and grey matter, and reach deeply into the brain tissues. The SAR of 0.6 W/kg was achieved with lower power input and energy, decreasing the probability of thermal injury. Therefore, these parameters enhance the safety of these potential treatments. This Birdcage device emulates a small-scale MRI machine, producing the same 64 MHz frequency at much lower operating input power. In this work, we utilized a high-frequency simulation system (HFSS/EMPro) software to produce the birdcage structure for the required EMF parameters. The 64 MHz radiating frequency produced the scattering S11 parameter of −15 dbs. We obtained a SAR of 0.6 W/kg when an input power of 100 W was applied. The coil dimensions were found to be near 15 cm in height and 22 cm in diameter, which fits in wearable systems. We found that the distribution of the electric field and SAR radiate homogeneously over the simulated human head with good penetration into the brain, which proves to be an appropriate potential therapeutic strategy for Alzheimer’s disease.展开更多
The configuration, magnetic field calculation and field distribution of the birdcage RF coil is pre-sented. This type of coil can produce a circular Polarized magnetic field. It has been widely used in the MRIsystem f...The configuration, magnetic field calculation and field distribution of the birdcage RF coil is pre-sented. This type of coil can produce a circular Polarized magnetic field. It has been widely used in the MRIsystem for head and whole-body imaging which can achive nearly optimal RF field uniformity and signal-to-noise ratio(SNR). The rnagnetic field is evenly distributed over the coil. The features of the birdcage coil areanalyzed on the basis of numerical simulation and experimental studies.展开更多
文摘Numerical methods are used to evaluate variations of the electromagnetic fields generated by a head-sized birdcage coil as a function of load (“loading effect”). The loading effect was analyzed for the cases of a coil loaded with a conductive cylindrical sample, a dielectric cylindrical sample, and an anatomically precise head model. Maxwell equations were solved by means of finite difference time domain (FDTD) method conducted at 12.8, 64, and 128 MHz. Simulation results indicate that at 12.8 MHz the conservative electric field (Ec) caused by the scalar electric potentials between the coil and the load or within the load was significantly higher than the magnetically-induced electric field (Ei) and was the major component of the total electric field (Etotal). The amplitudes of Ec and Etotal are seen to be lower within a sample than at a corresponding location in an empty coil, but approximately 65% higher in the space between coil and sample than at a corresponding location in an empty coil. This is due to polarization effects generating an additional scalar potential parallel to the original field. The increased electric field between coil and sample may cause increased power deposition at the surface of the sample and may affect the RF-induced currents in external leads used for physiological recording, i.e. ECG, during MRI scanning.
文摘In this study, we performed a numerical analysis of a novel EMF Birdcage wearable device for the treatment of Alzheimer’s disease (AD). We designed the new device to generate and radiate a frequency of 64 MHz and a specific absorption rate (SAR) of 0.6 W/kg to a simulated human brain tissue. We determined these parameters from our experimental studies on primary human brain cultures at the Indiana University School of Medicine (IUSM). We found that this frequency and SAR decreased the toxic Aβ levels in the cell cultures. The frequency of 64 MHZ has good skin depth penetration, which will easily pass through the various head layers, including hair, skin, fat, dura, the cerebrospinal (CSF), and grey matter, and reach deeply into the brain tissues. The SAR of 0.6 W/kg was achieved with lower power input and energy, decreasing the probability of thermal injury. Therefore, these parameters enhance the safety of these potential treatments. This Birdcage device emulates a small-scale MRI machine, producing the same 64 MHz frequency at much lower operating input power. In this work, we utilized a high-frequency simulation system (HFSS/EMPro) software to produce the birdcage structure for the required EMF parameters. The 64 MHz radiating frequency produced the scattering S11 parameter of −15 dbs. We obtained a SAR of 0.6 W/kg when an input power of 100 W was applied. The coil dimensions were found to be near 15 cm in height and 22 cm in diameter, which fits in wearable systems. We found that the distribution of the electric field and SAR radiate homogeneously over the simulated human head with good penetration into the brain, which proves to be an appropriate potential therapeutic strategy for Alzheimer’s disease.
文摘The configuration, magnetic field calculation and field distribution of the birdcage RF coil is pre-sented. This type of coil can produce a circular Polarized magnetic field. It has been widely used in the MRIsystem for head and whole-body imaging which can achive nearly optimal RF field uniformity and signal-to-noise ratio(SNR). The rnagnetic field is evenly distributed over the coil. The features of the birdcage coil areanalyzed on the basis of numerical simulation and experimental studies.
