老年腹部手术患者BIS监测下异丙酚闭环与开环靶控输注模式的麻醉效果比较

目的探讨脑电双频指数(BIS)监测下异丙酚闭环与开环靶控输注在老年腹部手术患者中的麻醉效果。方法将76例老年腹部手术患者按照随机数字表法分为对照组38例[采用异丙酚开环靶控输注(OLTCI)]和研究组38例[采用异丙酚闭环靶控输注(CLTCI)]。比较两组患者的麻醉效果、麻醉药物使用情况、不同时间阶段血流动力学指标以及手术相关指标。结果在麻醉诱导阶段和麻醉维持阶段,研究组患者麻醉满意时间占比高于对照组,麻醉过深时间占比低于对照组,且麻醉维持阶段的麻醉过浅时间占比低于对照组(P<0.05或0.01)。研究组患者异丙酚诱导总量少于对照组,每小时泵调整次数多于对照组(P<0.01)。两组患者意识消失、插管即刻、插管后1 min时的心率(HR)均慢于麻醉诱导前,但研究组患者意识消失、插管即刻、插管后1 min时的HR均快于对照组(P<0.05或0.01)。研究组患者诱导阶段各时期的平均动脉压(MAP)水平无明显变化(P>0.05)。对照组患者意识消失、插管即刻、插管后1 min时的MAP水平均低于麻醉诱导前,且插管即刻、插管后1 min时的MAP水平低于研究组(P<0.05或0.01)。两组患者手术时间、麻醉时间、拔管时间、苏醒时间以及恶心、呕吐发生率等手术相关指标比较,差异无统计学意义(P>0.05)。结论对老年腹部手术患者行BIS监测下异丙酚CLTCI时,可按照BIS的数值及时调整异丙酚用量,避免了血流动力学指标的大幅度波动,可减少麻醉药物的用量,值得临床大力推广。

Engineering of oxygen vacancy and bismuth cluster assisted ultrathin Bi_(12)O_(17)Cl_(2)nanosheets with efficient and selective photoreduction of CO_(2)to CO

The photocatalytic conversion of CO_(2)into solar‐powered fuels is viewed as a forward‐looking strategy to address energy scarcity and global warming.This work demonstrated the selective photoreduction of CO_(2)to CO using ultrathin Bi_(12)O_(17)Cl_(2)nanosheets decorated with hydrothermally synthesized bismuth clusters and oxygen vacancies(OVs).The characterizations revealed that the coexistences of OVs and Bi clusters generated in situ contributed to the high efficiency of CO_(2)–CO conversion(64.3μmol g^(−1)h^(−1))and perfect selectivity.The OVs on the facet(001)of the ultrathin Bi_(12)O_(17)Cl_(2)nanosheets serve as sites for CO_(2)adsorption and activation sites,capturing photoexcited electrons and prolonging light absorption due to defect states.In addition,the Bi‐cluster generated in situ offers the ability to trap holes and the surface plasmonic resonance effect.This study offers great potential for the construction of semiconductor hybrids as multiphotocatalysts,capable of being used for the elimination and conversion of CO_(2)in terms of energy and environment.

Flexible Bis(benzimidazole)-based Ligands Directed the Structure Characteristics of Coordination Polymers Based on Diphenic Acid Co-ligands:Syntheses, Structures and Properties

Two new coordination polymers [Cu_2(bbim)(dpa)_2(C_2H_5OH)_2](1), [Co(dpa)_2(bbbm)](2)(H_2dpa = diphenic acid, bbim = 1,1?-(1,6-hexanediyl)bis-1H-benzimidazole, bbbm = 1,1?-(1,4-butanediyl)bis-1 H-benzimidazole) constructed from bis(benzimidazole)-based ligands with different lengths and diphenic acid co-ligand have been synthesized under solvothermal conditions.Complex 1 possesses Cu-dpa helical chains. The adjacent chains are connected by the bbim ligands into two-dimensional(2D) 3-connected(63) topology. Differently, the layer structure of 2 was consisted by one-dimensional chains containing alternated 8-and 18-membered rings. Furthermore,the thermal stability and fluorescence property for all crystalline materials have been investigated.

Synthesis, Crystal Structure and Catalytic Properties of a New 2D Nickel(II) Coordination Polymer Based on Flexible Bis(benzimidazole)

A new Ni(II) coordination polymer [Ni(L)2(SCN)2]n(L = 1,4-bis(benzimidazol-1-yl)butane) was synthesized hydrothermally and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group C2/c with a = 9.4760(3), b = 24.0408(8), c = 16.5871(5) A, β = 99.832(3)°, V = 3723.2(2) A3, Z = 4, Dc = 1.348 g/cm3, F(000) = 1576, the final R = 0.0486 and w R = 0.0936 for 2938 observed reflections with I 】 2σ(I) for the complex. Structural analysis shows that the coordination polymer possesses a 2D(4,4) layer structure which is composed of Ni(II) centers bridged by L ligand with two kinds of conformations and further assembled into a 3D supramolecular network via π-π stacking interactions. In addition, the fluorescence and catalytic properties, for the degradation of Congo red, of the complex were investigated.

A 2D Wavy Parquet Architecture Based on the Biphenyl-3,3',4,4'-tetracarboxylic Acid and Bis(2-benzimidazole)alkanes Ligands

A double-T-shaped ligand （H4BPTC） and bis（2-benzimidazole）alkanes as the spacers have been firstly used to direct the assembly of a 2D coordination polymer with wavy parquet network topology, [Zn（BPTC）0.5（H2C2EIm）（H2O）]n （1, C24H18ZnN4O5, Mr = 507.79, H4BPTC = biphenyl-3,3＇,4,4＇-tetracarboxylic acid, H2C2EIm = 2,2＇-（1,2-ethanediyl）-bis（1H-benzi- midazole）, which was determined by single-crystal X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/n with a = 1.1844（5）, b = 1.4019（5）, c = 1.4026（5） nm, β = 108.359（5）°, V = 2.2104（15） nm3, Z = 4, Dc = 1.526 g/cm3, μ（MoKα） = 1.156 mm-1, F（000） = 1040, S = 1.038, the final R = 0.0427 and wR = 0.0793 for 3834 reflections with I 2σ（I）. The compound units are linked through BPTC ligands into a wavilness parquet 2D layer and further connected into a 3D framework via π-π packing interactions between the adjacent H2C2EIm ligands and weak N-H…O hydrogen bonding between uncoordinated carboxylate and the nitrogen atoms of H2C2EIm as well as the free water molecules.

Hydrothermal Syntheses,Crystal Structures,and Characterization of Two Zinc(Ⅱ)Complexes Containing Flexible Bis(benzimidazole)Ligands

Two zinc（II） complexes, namely, [Zn（L1）Cl2]2 （1） and {[Zn（L2）（tbta）]·3H2O}n （2） （L1 = 1,3-bis（2-methylbenzimidazol-1-ylmethyl）benzene, H2tbta = tetrabromoterephthalic acid, L2 = 1,3-bis（2-methylbenzimidazol-1-yl）-2-propanol） have been successfully obtained under hydrothermal conditions. Complex 1 displays binuclear structure which is further extended into a 1D supramolecular chain through π–π stacking. Complex 2 features 2D （4,4） network based on L2/tbta2– double linker. The thermal stability, fluorescence properties and catalytic activities of two complexes for degradation of Methyl orange in a Fenton-like process were discussed.

SYNTHESIS, CHARACTERIZATION, METAL-UPTAKE BEHAVIOR OF BIS(BENZIMIDAZOLE) RESIN SUPPORTED ON EPOXIDE POLYMER

The new chelate resins, abbreviated as PNBMZs and PBBMZs based on epoxide polymer, were synthesized by polycondensation of N,N-diglycidyl-4-glycidyloxyaniline or 1,4-bis（2,3-epoxypropyl）benzene with the primary amine group of 1,3-bis（benzimidazol-2yl）propylamine （BBPAH）. The ion exchangers contain 2.71-3.23 mmol of the ligand contents per gram of the resin. Batch extraction capacities were determined for the metal chloride salts in buffer solutions in the pH range from -1 to 6.0. The chelate resins were very selective for Cu^2＋, Zn^2＋, Cd^2＋ in the presence of other divalent transition metal ions. The maximum uptake capacities of PNBMZ （synthetic molar ratio = 1：1.5） under non-competitive condition were found to be 0.94 mmol/g for Cu^2＋ at pH = 2, 1.3 mmol/g for Cd^2＋ at pH = 1 and 1.75 mmol/g for Zn^2＋ at pH = -1 respectively. While in the case of PBBMZ, it was 1.39 mmol/g for Cd〉 at pH = 1. The metal-uptake behaviors for both of them showed strong pH dependence, and their extraction capacities increase with decreasing pH. The uptake of Cu^2＋ by the resin PNBMZs at pH = 1 was found to be rather fast with t1/2 = 18 min. Metal-uptake experiments under competitive conditions also confirm that the chelate resins have a high selectivity for Cu^2＋, Zn^2＋, Cd^2＋ and the contrary pH dependence.

Synthesis,Crystal Structure and in vitro Anticancer Studies of 1,2-Bis-benzimidazole-phenyl Copper(Ⅱ) Complex

One new benzimidazole derivative copper（II） complex 1（C10H6Cu N2, Mr = 217.71） has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbcn with a = 17.417（2）, b = 8.9963（8）, c = 11.3432（9） ？, V = 1777.3（3） ？3, Z = 8, μ（Mo Kα） = 2.403, F（000） = 872, Dc = 1.627 g/cm3. The final R = 0.0598 for 1153 observed reflections with I 〉 2σ（I） and w R = 0.17 for all data. The in vitro anti-cancer activities of 1, Cu Cl2 and the benzimidazole ligand L were investigated using human cervical（Hela） and hepatocellular carcinoma（Hep-G2） cancer cell lines. The copper（II） complex can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both the ligand and copper（II） salt.

Cadmium(Ⅱ) Nitrite Complex Based on the Bis(2-benzimidazole) and Aromatic Carboxylate Ligands

A new cadmium（Ⅱ） nitrite complex Cd2（H2C3PIm）2（BDC）（NO2）2（1,H2C3PIm = 2,2＇-（1,3-propanediyl）bis（1H-benzimidazole）,H2BDC = 1,4-benzenedicarboxylic acid） has been synthesized by solvothermal reaction in formamide,and its structure（C42H36Cd2N10O8,Mr = 1033.61） was determined by single-crystal X-ray diffraction analysis.The crystal belongs to the monoclinic system,space group P21/n with a = 0.9859（5）,b = 0.8936（5）,c = 2.3188（5） nm,β = 97.576（5）°,V = 2.025（16） nm3,Z = 2,Dc = 1.695 g/cm3,μ（MoKα） = 1.118 mm-1,F（000） = 1036,S = 1.017,the final R = 0.0304 and wR = 0.0752 for 3761 reflections with I 〉 2σ（I）.The centrosymmetric complex 1 contains a dimer in which two distorted octahedral Cd（II） centers are bridged by BDC ligand and chelated by H2C3PIm.The units of the complex are linked via weak N-H···O hydrogen bonds between the nitrito and the BDC ligands,leading to the formation of a 1D zigzag chain along the b axis.The π-π packing interactions contribute to the formation of a three-dimensional supramolecular architecture.The complex exhibits strong photoluminescence at room temperature.

Synthesis and Crystal Structure of catena-Poly[bis-(benzimidazole)cobalt(II) μ-Phthalato]

The title polymeric complex [Co（C8H4O4）（C7H6N2）2]n has been prepared and its crystal structure was determined by X-ray diffraction method. The crystal belongs to monoclinic, space group C2/c with a=7.7865（12）, b=20.4215（18）, c=13.4880（14）A°,β=103.298（2）°, V=2087.3（4）A°^3, Mr=459.32, Z=4, Dc=1.462 g/cm^3,μ=0.859 mm^-1, F（000）=940, R=0.0636 and wR=0.1639 for 1278 observed reflections （I〉2σ（I））. The complex assumes a distorted tetrahedral coordination geometry, formed by two phthalate anions and two benzimidazoles （bzim）. The phthalate anions bridge the neighboring Co（Ⅱ） atoms to form the polymeric chains. The centroid distance of 3.471（3）A° between the parallel bzim rings of adjacent polymeric chains suggests the existence of π-π stacking.

BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis

BACKGROUND The development of new vasculatures(angiogenesis)is indispensable in supplying oxygen and nutrients to fuel tumor growth.Epigenetic dysregulation in the tumor vasculature is critical to colorectal cancer(CRC)progression.Sirtuin(SIRT)enzymes are highly expressed in blood vessels.BZD9L1 benzimidazole analogue is a SIRT 1 and 2 inhibitor with reported anticancer activities in CRC.However,its role has yet to be explored in CRC tumor angiogenesis.AIM To investigate the anti-angiogenic potential of BZD9L1 on endothelial cells(EC)in vitro,ex vivo and in HCT116 CRC xenograft in vivo models.METHODS EA.hy926 EC were treated with half inhibitory concentration(IC50)(2.5μM),IC50(5.0μM),and double IC50(10.0μM)of BZD9L1 and assessed for cell proliferation,adhesion and SIRT 1 and 2 protein expression.Next,2.5μM and 5.0μM of BZD9L1 were employed in downstream in vitro assays,including cell cycle,cell death and sprouting in EC.The effect of BZD9L1 on cell adhesion molecules and SIRT 1 and 2 were assessed via real-time quantitative polymerase chain reaction(qPCR).The growth factors secreted by EC post-treatment were evaluated using the Quantibody Human Angiogenesis Array.Indirect co-culture with HCT116 CRC cells was performed to investigate the impact of growth factors modulated by BZD9L1-treated EC on CRC.The effect of BZD9L1 on sprouting impediment and vessel regression was determined using mouse choroids.HCT116 cells were also injected subcutaneously into nude mice and analyzed for the outcome of BZD9L1 on tumor necrosis,Ki67 protein expression indicative of proliferation,cluster of differentiation 31(CD31)and CD34 EC markers,and SIRT 1 and 2 genes via hematoxylin and eosin,immunohistochemistry and qPCR,respectively.RESULTS BZD9L1 impeded EC proliferation,adhesion,and spheroid sprouting through the downregulation of intercellular adhesion molecule 1,vascular endothelial cadherin,integrin-alpha V,SIRT1 and SIRT2 genes.The compound also arrested the cells at G1 phase and induced apoptosis in the EC.In mouse choroids,BZD9L1 inhibited sprouting and regressed sprouting vessels compared to the negative control.Compared to the negative control,the compound also reduced the protein levels of angiogenin,basic fibroblast growth factor,platelet-derived growth factor and placental growth factor,which then inhibited HCT116 CRC spheroid invasion in co-culture.In addition,a significant reduction in CRC tumor growth was noted alongside the downregulation of human SIRT1(hSIRT1),hSIRT2,CD31,and CD34 EC markers and murine SIRT2 gene,while the murine SIRT1 gene remained unaffected,compared to vehicle control.Histology analyses revealed that BZD9L1 at low(50 mg/kg)and high(250 mg/kg)doses reduced Ki-67 protein expression,while BZD9L1 at the high dose diminished tumor necrosis compared to vehicle control.CONCLUSION These results highlighted the anti-angiogenic potential of BZD9L1 to reduce CRC tumor progression.Furthermore,together with previous anticancer findings,this study provides valuable insights into the potential of BZD9L1 to co-target CRC tumor vasculatures and cancer cells via SIRT1 and/or SIRT2 down-regulation to improve the therapeutic outcome.

利多卡因复合右美托咪定静脉输注对术前BIS值及镇静的影响

目的:观察利多卡因复合右美托咪定静脉输注对下肢骨折患者术前BIS值的影响。方法:选择硬膜外阻滞麻醉行下肢骨折手术患者80例,随机分为4组:利多卡因组(L组)、右美托咪定组(D组)、利多卡因+右美托咪定组(LD组)和对照组(C组),每组20例。手术开始前20 min L组、D组、LD组分别泵注利多卡因1.5 mg/kg、右美托咪定0.5μg/kg和利多卡因1.5 mg/kg复合右美托咪定0.5μg/kg,10 min输完;C组泵注等容量的生理盐水。记录患者给药前(T_0)、给药后5 min(T_1)、给药后10 min(T_(2))、给药后15 min(T_(3))和给药后20 min(T_(4))的BIS值、MAP、HR、SpO_(2),并记录各时点的镇静评分及镇静满意度。结果:T_(2)-T_(4)时D组和LD组BIS明显低于C组和L组(P<0.05),T_(2)-T_(4)时D组和LD组Ramsay评分明显高于C组和L组(P<0.05)。T_(2)-T_(4)时LD组BIS明显低于D组,Ramsay评分明显高于D组(P<0.05);T_(2)-T_(4)时D组和LD组HR明显低于C组和L组(P<0.05)。结论:利多卡因复合右美托咪定静脉输注较单独输注右美托咪定或利多卡因能进一步降低术前BIS值,镇静满意度高,且不抑制呼吸,对血流动力学影响小。

Bis(2-butoxyethyl) Phthalate Delays Puberty Onset by Increasing Oxidative Stress and Apoptosis in Leydig Cells in Rats

Objective This study investigated the effects of bis(2-butoxyethyl) phthalate(BBOP) on the onset of male puberty by affecting Leydig cell development in rats.Methods Thirty 35-day-old male Sprague-Dawley rats were randomly allocated to five groups mg/kg bw per day that were gavaged for 21 days with BBOP at 0, 10, 100, 250, or 500 mg/kg bw per day. The hormone profiles;Leydig cell morphological metrics;mRNA and protein levels;oxidative stress;and AKT,mTOR, ERK1/2, and GSK3β pathways were assessed.Results BBOP at 250 and/or 500 mg/kg bw per day decreased serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels mg/kg bw per day(P < 0.05). BBOP at 500 mg/kg bw per day decreased Leydig cell number mg/kg bw per day and downregulated Cyp11a1, Insl3, Hsd11b1,and Dhh in the testes, and Lhb and Fshb mRNAs in the pituitary gland(P < 0.05). The malondialdehyde content in the testis significantly increased, while Sod1 and Sod2 mRNAs were markedly downregulated, by BBOP treatment at 250–500 mg/kg bw per day(P < 0.05). Furthermore, BBOP at 500mg/kg bw per day decreased AKT1/AKT2, mTOR, and ERK1/2 phosphorylation, and GSK3β and SIRT1levels mg/kg bw per day(P < 0.05). Finally, BBOP at 100 or 500 μmol/L induced ROS and apoptosis in Leydig cells after 24 h of treatment in vitro(P < 0.05).Conclusion BBOP delays puberty onset by increasing oxidative stress and apoptosis in Leydig cells in rats.The graphical abstract is available on the website www.besjournal.com.

A New Efficient Synthesis of Bisphenol A Diether Bis-imidazoles and Bis-benzimidazoles

A new efficient synthesis of bisphenol A diether bis-imidazoles and bis-benzimidazoles by bromoalkylation and imidazolylation or benzimidazolylation two-step reactions from commercial bisphenol A, imidazole, 2-methylimidazole and benzimidazole is reported.

Third-Order Nonlinear Optical Responses of Bis(15-crown-5)-stilbenes Binding to One-or Two-Alkali Metal Cation(Li^(+),Na^(+)and K^(+))

Bis(15-crown-5)-stilbenes containing crown ether parts have been widely used in a variety of chemical applications,such as cation detectors,because of their ability to selectively bind to alkali metal cations,Bis(15-crown-5)-stilbenes and its derivatives with complexation of one-or two-alkali metal cation(Li^(+),Na^(+)and K^(+))have been theoretically investigat-ed by quantum chemistry methods.The coordination of alkali cations results in partial shrinkage of crown ethers,which directly affected natural distribution analysis charges and molecular orbital energy levels.The number of alkali metal ions has significant effects on absorption spectra and mean second hyperpolarizability.When one alkali metal ion was added to the anticonformer of bis(15-crown-5)-stilbene,the absorption spectra were obvious-ly redshifted and the mean second hyperpolarizability values were slightly increased;while two alkali metal ions were added to bis(15-crown-5)-stilbene,the absorption spectra were ob-viously blue shifted and the mean second hyperpolarizability values decreased.On the other hand,as the radius of the alkali ions increased,the mean second hyperpolarizability values of the compounds increased gradually.It is indicated that the mean second hyperpolarizability value is sensitive to the number and radius of the alkali metal cations,thus the third order nonlinear optical response can be used as a signal to detect the number and type of alkali met-al ions.

麻醉气体浓度监测结合BIS监测在全麻术中的应用效果分析

分析实验组的联合监测手段对全麻术的应用价值与临床效果。方法 收治50例全麻术患者进行研究,开展差异化监测。结果 实验组清醒时间、拔管时间、复苏室内停留时间等指标与对照组对比,差别较大,(p<0.05)。结论 对全麻术患者实施麻醉气体浓度监测结合BIS监测,其对麻醉药物药品用量有一定控制作用,并使得患者可以在短时间内苏醒,控制拔管时间以及全麻术患者在复苏室内的停留时间,提升其麻醉满意度、监测效果。

光伏组件产品印度BIS认证简析

自2018年4月起,印度政府对光伏组件产品开始实施强制认证——BIS认证。众所周知,BIS认证周期长,一般需要6~8个月,且整个流程非常繁琐,与一般光伏组件产品的常规认证差异较大。本文主要对BIS政策进行解读,并总结BIS认证项目开展的经验。

BIS监测调控精准麻醉对老年全麻手术患者围术期并发症及术后认知的影响

探究BIS监测(bispect ral index monitor, BISM)调控精准麻醉对老年全麻手术(General anesthesia operation, GAO)患者(pts)围术期并发症及术后认知的影响效果。方法 选取我院2020年7月至2022年6月收治的需要经气管内插管GAO的老年pts80例,将其随机分为两组,每组40例。CON组pts使用常规监测,BIS组根据 BIS 值调整麻醉深度,对比两组pts围术期指标、血流动力学、围术期并发症以及术后认知功能(cognitive function, CF)评分。结果 经对比分析,BIS组pts麻醉诱导量以及麻醉药物总量均相较于CON组pts更低,且苏醒时间、离室时间<CON组pts,组间差异有统计学意义(P<0.05),但两组pts住院时间近似,组间差异不具备统计学意义(P>0.05);BIS组pts各时期的HR、MAP指标均相较于CON组pts更低,组间差异较为明显,统计学意义显现(P<0.05);BIS组pts围术期并发症发生率显著低于CON组pts,组间差异明显,具备统计学意义(P<0.05),术前以及术后1d BIS组CF评分高于CON组,无统计学差异(P>0.05),术后3d BIS组ptsCF评分高于CON组,组间差异统计学意义显著(P<0.05)。结论 为老年GAO pts实施BISM调控精准麻醉,能够更好地保障pts围术期状态得到改善,在麻醉用药量更小的前提下,也能够保障麻醉效果。经BISM调控精准麻醉,pts术后并发症发生率明显下降,且CF得到良好提升,可以将其进行临床推广应用。

基于改进YOLOv8的无人机航拍图像目标检测算法

针对现存无人机航拍图像目标检测算法检测精度较低、模型较为复杂的问题,提出一种改进YOLOv8的目标检测算法。在骨干网络引入多尺度注意力EMA,捕捉细节信息,以提高模型的特征提取能力;改进C2f模块,减小模型的计算量。提出了轻量级的Bi-YOLOv8特征金字塔网络结构改进YOLOv8的颈部,增强了模型多尺度特征融合能力,改善网络对小目标的检测精度。使用WIoU Loss优化原网络损失函数,引入一种动态非单调聚焦机制,提高模型的泛化能力。在无人机航拍数据集VisDrone2019上的实验表明,提出算法的mAP50为40.7%,较YOLOv8s提升了1.5%,参数量降低了42%,同时相比于其他先进的目标检测算法在精度和速度上均有提升,证明了改进算法的有效性和先进性。

围麻醉期脑氧饱和度联合BIS监测对老年肠梗阻患者术后谵妄发生的影响

目的:观察围麻醉期脑氧饱和度联合脑电双频指数(BIS)监测对老年肠梗阻患者术后谵妄发生的影响。方法:收集浙江大学医学院附属第二医院2020年6月—2022年6月收治的老年肠梗阻患者100例,按随机数字表法分为对照组和试验组,每组50例,分别给予常规脑氧饱和度监测、脑氧饱和度联合BIS监测。比较两组患者手术前后血清中多巴胺(DA)和5-羟色胺(5-HT)水平、术后谵妄发生率和蒙特利尔认知评估量表(MoCA)评分,并统计不良反应发生率。结果:术前,两组患者的DA、5-HT水平比较,差异无统计学意义(P>0.05);术后24h,两组DA和5-HT水平均上升,试验组DA和5-HT水平均低于对照组,差异有统计学意义(P<0.05)。试验组术后谵妄总发生率低于对照组,差异有统计学意义(P<0.05)。术前,两组MoCA评分比较,差异无统计学意义(P>0.05);术后1d,两组MoCA评分均低于术前,差异有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05);术后7d,两组患者MoCA评分均回升至与术前相当水平,但试验组MoCA评分高于对照组,差异有统计学意义(P<0.05)。试验组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论:老年肠梗阻手术患者围麻醉期进行脑氧饱和度联合BIS监测有助于降低术后谵妄发生率,保护患者的神经功能,减少对患者认知功能的不良影响,并降低术后不良反应的发生率。