SbCl_3 Catalyzed Solventless Synthesis of Bis(indolyl)alkanes under Grinding

A clean and efficient method for the synthesis of bis（indolyl）alkanes with antimony trichloride（SbCl3） as the catalyst under solvent-free grinding conditions is described. This method provides several advantages, such as simple work-up procedure, neutral conditions and high yields.

Synthesis of bis(indolyl) methanes using aluminiumoxide(acidic) in dry media

Heterogeneous catalyst aluminium oxide(acidic) is found to be an effective catalyst for the solvent-free condensation reaction of indole with aldehydes in microwave irradiation with shorter reaction time and higher yields.

Efficient synthesis of bis(indolyl) methanes catalyzed by(PhCH_2PPh_3)^+Br_3^- under solvent-free conditions

Benzyltriphenylphosphonium tribromide（BTPTB） has been applied as an efficient catalyst for the preparation of bis（indolyl）-methanes （BIMs） via electrophilic substitution of indoles with aldehydes in the absence of solvent.

Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl-14H-dibenzo[a,j]xanthenes in water

A simple, efficient, and environment benign route was developed for the preparation of bis-（indolyl）methanes and 14-aryl-14H- dibenzo[aj]xanthenes from condensation of various aromatic aldehydes or ketones with indole, and 2-naphthol, respectively, using oxalic acid catalyst in aqueous medium. Use of cheap and easily available catalyst, better yields and simple reaction protocol are the advantages of the present method.

SOLVENT EFFECT ON CONFORMATIONS OF α,ω-BIS(4-NITROPHENOXY)-ALKANES

Solvent effect on the conformations of-bis(4-nitrophenoxy)-alkanes w th different chain Lengths(Nn)was studied by UV spectra.In poor solvents such as EG-H_2O and THF-H_2O,with the water content higher than 50%,the K-bands of N_4. N,N_6 and N_(10)in the UV absorption spectra shifted to longer wavelengths as compared wth 4-nitrophenoxyethane(N_0).It is suggested that in poor solvents the two aromatic gr(?)ps are close to each other in parallel,forming ground state complexes.The K- bead of N_4 showed a blue shift from that of N_0 when the water content was around 5%,probably attributable to a conformation with the nitro group of one benzene ring sit(?)ing on the plane of the other benzene ring.

n-Dodecylbenzene Sulfonic Acid (DBSA) as a Novel Brønsted Acid Catalyst for the Synthesis of Bis(indolyl)methanes and Bis(4-hydroxycoumarin-3-yl)methanes in Water

n-Dodecylbenzene sulfonic acid (DBSA) as a novel, biodegradable, and efficient Br?nsted acid catalyst used for the reaction of indoles/4-hydroxy coumarin with aldehydes to obtain a bis(indolyl)methanes/bis(4-hydroxycoumarin-3-yl)methanes, respectively. The catalyst exhibited remarkable activity, and tolerated a wide variety of functional groups providing the desired bis(indolyl)methanes and bis(4-hydroxycoumarin-3-yl)methanes in good to excellent yield (70%-96%) in water.

Spacer Length Effects on the Structure of Cd(Ⅱ)Coordination Polymers with Flexible Bis(thiabendazolyl)(1)Alkane and 1,2,4,5-Benzenetetracarboxylte Ligands

The hydrothermal reactions of Cd（OAc）2·2H2O with 1,2,4,5-benzenetetracarboxylic acid（H4bta） and 1,4-bis（thiabendazolyl）butane（L1） or 1,6-bis（thiabendazolyl）hexane（L2） afforded two coordination polymers [Cd2（L1）（bta）·2H2O]n（1） and [Cd2（L2）2（H2bta）2]n（2）. Complex 1 holds a rare 3D binodal（4,6）-connected framework with fsh topology. Complex 2 features an infinite meandering chain structure, which is further extended via O–H···O hydrogen bonding into a 3D supramolecular network. The thermal and fluorescence proprieties of the two complexes were investigated.

Efficient and Eco-friendly Process for the Synthesis of Bi(indolyl)methanes Catalyzed by Sodium Hydrogensulfate Monohydrate in Ionic Liquid n-Butylpyridinium Tetrafluoroborate

Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridinium tetrafluoroborate （[Bpy]BF4） to afford the corresponding bi（indolyl）methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.

Solvent-free Synthesis and Crystal Structure of 2,2＇-Dialkyl Bis(3-methyl-6,7- dihydrobenzofuran-4(5H)-one) Derivatives

A series of 2,2＇-dialkyl bis（3-methyl-6,7-dihydrobenzofuran-4（5H）-one） derivatives was prepared through H2SO4·SiO2 catalyzed condensation reaction under solvent-free conditions as potential anti-tumor agents. All of them were characterized by ESI-MS, IR and NMR spectra. Meanwhile, the single crystal of the target compound （4b）, C24H28O4, was also obtained and determined by X-ray crystallography. Crystal data： triclinic system, space group P , a = 8.463（10）, b = 9.612（11）, c = 13.828（15） , α = 74.29（5）, β = 80.93（5）, γ = 69.90（3）°, V = 1014（2） 3, Z = 2, F（000） = 408, Dc = 1.246 g/cm3, μ = 0.084 mm？1, R = 0.0883 and wR = 0.2440 for 4616 independent reflections （Rint = 0.1200） and 3490 observed ones （I 〉 2σ（I））.

Pyridinium tribromide catalyzed condensation of indoles and aldehydes to form bisindolylalkanes

An efficient synthetic method for bis（indol-3-yl）alkane derivatives has been developed.In the presence of 5 mol%of pyridinium tribromide（PTB）,the condensation of indoles and aldehydes proceeded smoothly under mild conditions,giving rise to the corresponding bis（indol-3-yl）alkanes in good to excellent yields.

α-Chymotrypsin-Catalyzed Synthesis of Bis(indolyl)alkanes in Water

A novel methodology for the synthesis of bis(indolyl)methanes by the reaction of aromatic aldehydes and indole in water has been developed,and a series of desired products were obtained in moderate to excellent yields(from 65%to 97%)using 1.2 mg/mLα-chymotrypsin as biocatalyst.

双吲哚基修饰杯[4]芳烃对Hg^2＋的比色传感行为

合成了上缘含双吲哚基团的杯[4]芳烃衍生物5,17-双吲哚甲基-25,27-二丙氧基-26,28-二羟基杯[4]芳烃(2),通过UV-Vis光谱研究了它对各种金属离子的化学传感行为.结果表明,主体2对Hg2+具有良好的选择性,向主体2的溶液中加入Hg2+离子,其吸收光谱在500nm左右出现了一个新的吸收峰,同时溶液颜色也由无色变为橙色.因此,化合物2有望作为一种新型的化学传感器用于检测Hg2+.

微波辅助法合成双吲哚甲烷衍生物

以吲哚、羰基化合物为原料,以路易斯酸固载蒙脱土为催化剂,微波辅助合成标题化合物。考察了溶剂、温度、反应时间、原料物质的量比及催化剂循环使用次数对产率的影响,最优条件下产率高达93.4%,催化剂循环3次产率仍可达71.0%,产物通过~1HNMR、IR、熔点进行表征。

双吲哚烯类受体对氨基酸的比色识别作用

设计合成了一系列3,3'-双吲哚烯类受体分子,应用紫外-可见吸收光谱研究了该类受体对20种天然氨基酸分子的识别作用.结果表明,在乙腈-水溶液中,双吲哚烯受体分子可以通过其氢键受体位点的质子化作用比色识别天冬氨酸及谷氨酸等酸性氨基酸;而硝基取代的双吲哚烯受体分子则通过其氢键供体位点的去质子化作用比色识别精氨酸和赖氨酸等碱性氨基酸.在乙腈-水的中性缓冲溶液体系中,硝基取代的双吲哚烯类受体分子通过与巯基发生亲核加成反应,高选择性地比色识别半胱氨酸和同型半胱氨酸.

微波辐射下双(2-苯并咪唑基)烷烃的合成

微波辐射条件下合成了 7种双 ( 2 -苯并咪唑基 )烷烃 ,为这类化合物的合成提供了一种新方法 ,相比于常规反应 ,反应时间大为缩短且产率相当。

磷钨酸催化合成双吲哚甲烷衍生物

在磷钨酸做催化剂条件下，各种醛、酮快速地与吲哚发生亲电取代反应，以较高（69％～95％）收率制得一系列双吲哚甲烷衍生物，产物结构经IR、^1H NMR、^13C NMR、MS和元素分析表征得以确证。

微波辐射下的相转移催化法合成二(苯并三唑基)烷烃

报道在常压的微波辐射下用相转移催化剂 PEG-4 0 0合成了 4个新化合物二 (苯并三唑基 )烷烃 ,该方法具有产率高、反应时间短和操作简便的优点。化合物的结构经元素分析、红外光谱和核磁共振氢谱确证。初步抗菌活性试验结果表明 , 和 具有强的抑制金黄色葡萄球菌活性 ,而 ～ 对枯草杆菌亦有一定活性。

超声辐射下双吲哚甲烷衍生物的合成

以吲哚、醛为原料,蒙脱土固载路易斯酸为催化剂,超声条件下合成双吲哚甲烷类衍生物。得到最优合成条件为n(吲哚)∶n(醛)=2.0∶1.1,蒙脱土负载氯化铜为催化剂,二氯甲烷作溶剂,反应温度为50℃,超声时间为15 min。产率最高达99.3%,催化剂循环3次产率仍可达81.3%。产物通过核磁、红外、熔点进行表征。

2-取代苯氧乙硫基-5-吡唑基-1,3,4-噁二唑和1,ω-二(5-吡唑基-1,3,4-口恶二唑-2-硫代)烷烃的合成及生物活性

以５－吡唑基－１，３，４－口恶二唑－２－硫酮为原料，利用相转移催化法，分别与２－溴乙基取代苯基醚和１，ω－二溴烷烃反应，合成了１１个标题化合物。用元素分析，１ＨＮＭＲ和ＭＳ确定了它们的结构。初步的生物活性测试结果表明：有２个化合物具有杀菌活性。

蒙脱土负载碘催化合成双吲哚甲烷衍生物

以蒙脱土负载碘(MMT/I2)作催化剂,醛(1a^1g)与吲哚(2)反应合成双吲哚甲烷衍生物(3a^3g),其结构经1H NMR和IR确证。以3a的合成为例,研究了催化剂、溶剂、反应时间、温度和物料比r[n(1)∶n(2)]对3产率的影响。结果表明:在最佳合成条件(2 1 mmol,r=1.1∶2.0,10 mol%MMT/I2,乙腈1 m L,于25℃反应5min)下,3a^3g产率67.9%~96.2%。MMT/I2循环使用3次,3a产率78.6%。