西双版纳粗榧内生真菌菌株CM112中分离到的两个新bisabolane型倍半萜（英文）

目的从西双版纳粗榧内生真菌菌株也Aspergillus sp.CM112中分离和鉴定抗菌活性产物。方法.采用反相硅胶色谱、凝胶色谱和HPLC等分离技术,对菌株CM112的发酵产物进行分离纯化;通过ID、2DNMR、HR-ESI-MS以及旋光数据进行结构测定。结果鉴定了5个bisabolane型倍半萜的结构,包括两个新化合物(7S,11S)-(+)-ll-hydroxyl-sydonol(l)和(7S,11S)-(+)-11-hydroxylaspergiterpenoidA(2)以及3个己知化合物(7S,11S)-(+)-l1-hydroxysydonicacid(3),(7S,1lS)-(+)-ll,12-dihydroxysydonicacid(4)和(7S;11S)-(+)-12-hydroxysydonicacid(5);并通过纸片扩散法测试了它们对3株病原细菌的抗菌活性。结论化合物1和2是新的bisabolane型倍半蔽,2和3为抗菌活性成分。

Two New Bisabolane Sesquiterpenes from Leontopodium longifolium

Two new bisabolane sesquiterpenes were isolated from the roots of Leontoptdium longifolium. Their structures were elucidated as 4α, 5α-diacetoxy-lα-angeloyloxybisabol-2, 9, ll-triene and 4α, 5α-diacetoxy-lα-angeloyloxy-ll-hydroxybisabol-2, 9-diene by spectroscopic methods including the 2D NMR techniques.

Two New Bisabolane Sesquiterpenes from Ligularia Thyrsoidea

ＩｎＣｈｉｎａ，ｍｏｒｅｔｈａｎ２０Ｌｉｇｕｌａｒｉａｓｐｅｃｉｅｓ（Ｃｏｍｐｏｓｉｔａｅ）ｈａｖｅｂｅｅｎｕｓｅｄｆｏｒｆｏｌｋｍｅｄｉｃｉｎｅｓｗｉｔｈａｎｔｉｂｉｏｔｉｃ，ａｎｔｉｐｈｌｏｇｉｓｔｉｃａｎｄａｎｔｉｔｕｍｏｒａｃｔｉｖｉｔｉｅｓ...

Synthesis of bisabolane sesquiterpenes:A Johnson-Claisen rearrangement approach

Several bisabolane sesquiterpenes,（±）-curcumene,（±）-curcuphenol,（±）-curcudiol and（±）-curcuhydroquinone,have been synthesized in racemic form and fully characterized.The salient characteristic of our approach is that a Johnson-Claisen arrangement was involved as a key step.

A New Sesquiterpene from Ligularia Songarica

A new bisabolane sesquiterpene, 5 beta-acetoxy-4 beta, 8-diangeloyloxy-2 beta,3 beta, :10,11-diepoxy-bisabola-7 (14)-ene, was isolated from the roots of Ligularia songarica and its structure was elucidated on the basis of spectroscopic methods, especially 2D-NMR techniques.

款冬花中倍半萜类成分的研究进展

款冬花为菊科植物款冬Tussilago farfara的干燥花蕾,是中医临床和中药工业常用中药之一,主要含有倍半萜、三萜、黄酮、酚酸、生物碱等化学成分。其中,倍半萜是款冬花的特征成分,《中国药典》2015年版收载的质量评价指标即为倍半萜类成分款冬酮。款冬花中的倍半萜以bisabolane和oplopane骨架为主,已报道的倍半萜具有广泛的药理活性,包括抗炎、抗过敏、抗癌、神经保护、抑制血小板活化因子等。对款冬花中的倍半萜类成分的结构和生物活性进行综述,为款冬花的深入研究及开发利用提供参考。