Objective:To investigate the cardiovascular mechanism of black soybean,the biological characteristics of black soybean were studied by bioinformatics,and the mechanism of its treatment for atherosclerosis was further ...Objective:To investigate the cardiovascular mechanism of black soybean,the biological characteristics of black soybean were studied by bioinformatics,and the mechanism of its treatment for atherosclerosis was further determined.Methods:Firstly,the basic data sets of effective components and corresponding targets of black beans were constructed,and then mapped to the AS background network obtained from DisGeNET database and CTD database.Finally,the potential targets of black beans acting on AS were obtained.After constructing the protein-protein interaction(PPI)network,the topological characteristics of these targets were analyzed.KEGG and GO were enriched to obtain the potential mechanism of black soybean acting on AS.Results:There were 12 bioactive components reported in black soybean.Among them,beta-sitosterol,stigmasterol and N-(4-hydroxyphenylethyl)ACTINIDINE were the three most active components.There are 19 targets of black soybeans acting on PPI network of AS disease.Among them,ADRB2 and PTGS2 are important targets for black soybeans to alleviate AS.The therapeutic pathways include arachidonic acid metabolism and serotonin synapse.Conclusion:Black soybean can play a therapeutic role in AS through multi-target and multi-pathway.The application of network pharmacology can quickly clarify the characteristics of functional foods and identify their potential targets and mechanisms for disease treatment.展开更多
文摘Objective:To investigate the cardiovascular mechanism of black soybean,the biological characteristics of black soybean were studied by bioinformatics,and the mechanism of its treatment for atherosclerosis was further determined.Methods:Firstly,the basic data sets of effective components and corresponding targets of black beans were constructed,and then mapped to the AS background network obtained from DisGeNET database and CTD database.Finally,the potential targets of black beans acting on AS were obtained.After constructing the protein-protein interaction(PPI)network,the topological characteristics of these targets were analyzed.KEGG and GO were enriched to obtain the potential mechanism of black soybean acting on AS.Results:There were 12 bioactive components reported in black soybean.Among them,beta-sitosterol,stigmasterol and N-(4-hydroxyphenylethyl)ACTINIDINE were the three most active components.There are 19 targets of black soybeans acting on PPI network of AS disease.Among them,ADRB2 and PTGS2 are important targets for black soybeans to alleviate AS.The therapeutic pathways include arachidonic acid metabolism and serotonin synapse.Conclusion:Black soybean can play a therapeutic role in AS through multi-target and multi-pathway.The application of network pharmacology can quickly clarify the characteristics of functional foods and identify their potential targets and mechanisms for disease treatment.
