We evaluated the potential of orally fed new food formulations to inhibit biomarkers reported to be involved in the causes of allergic asthma in mice. Asthma, a serious non-communicable disease, affects both adults an...We evaluated the potential of orally fed new food formulations to inhibit biomarkers reported to be involved in the causes of allergic asthma in mice. Asthma, a serious non-communicable disease, affects both adults and children and can be undertreated. New functional foods could provide therapeutic approaches. Here, the anti-asthma mechanism of a new functional food and three isolated fractions produced by bioprocessing black rice bran with shiitake mushroom mycelia was evaluated in mast cells, B cells, and orally fed mice and compared with non-bioprocessed black rice bran. In vitro, the treatments inhibited RBL-2H3 cell degranulation and immunoglobulin E (IgE) production. The in vitro anti-asthma effects were confirmed in orally fed mice following asthma induction by alumina and chicken egg ovalbumin (OVA). The suppression of asthma resulted from the inhibition of inflammation- and immune-related substances, including OVA-specific IgE, thymic stromal lymphopoietin, eotaxin, leukotriene C4, prostaglandin D2, and vascular cell adhesion molecule-1 in bronchoalveolar lavage fluid and serum. The treatment also reversed the thickening of the lung airway wall. The inflammation and asthma inhibition seems to be regulated by the balance of the T-helper cells’ Th1/Th2 immune response and the inhibition of multiple biomarkers associated with the cause of asthma. Future human clinical studies with adults and children should determine the potential therapeutic value of the anti-asthma effects of the new functional foods.展开更多
Objective: To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black cumin.Methods: Purposely, rat modelling was carried out for 2 months by designing three stu...Objective: To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black cumin.Methods: Purposely, rat modelling was carried out for 2 months by designing three studies i.e. study Ⅰ(normal rats), study Ⅱ(hyperglycaemic rats) and study Ⅲ(hypercholesterolemic rats). Each study was further divided into three groups based on diet i.e.control, functional diet(contained extract of black cumin prepared by using conventional solvent) and nutraceutical diet(contained extract of black cumin prepared by supercritical fluid extraction system).Results: During whole trial, an abating trend was observed in the level of serum cholesterol with maximum reduction(12.8%) in nutraceutical group of study Ⅲ. Low density lipoprotein and triglyceride level was also lowered maximum in study Ⅲ as17.1% and 11.6%, respectively. Whereas, highest decline in glucose level was in nutraceutical group of study Ⅱ as 11.2%.Conclusions: Inclusion of black cumin extracts in diet significantly lowers the occurrence of hyperglycaemia and hypercholesterolaemia. Furthermore, hypoglycaemic and hypocholesterolemic potential of nutraceutical diet is more prominent as compared to functional diet.展开更多
The northeastern China is an important commodity grain region in China,as well as a notable corn belt and major soybean producing area.It thus plays a significant role in the national food security system.However,larg...The northeastern China is an important commodity grain region in China,as well as a notable corn belt and major soybean producing area.It thus plays a significant role in the national food security system.However,large-scale land reclamation and non-optimum farming practices give rise to soil degradation in the region.This study analyzed the food security issues coupled with global climate change in the northeastern China during 1980–2000,which is the period of modern agriculture.The results of statistical data show that the arable land area shrank markedly in 1992,and then increased slowly,while food production generally continually increased.The stable grain yield was due to the increase of applied fertilizer and irrigated areas.Soil degradation in the northeastern China includes severe soil erosion,reduced soil nutrients,a thinner black soil layer,and deterioration of soil physical properties.The sustainable development of the northeastern China is influenced by natural-artificial binary disturbance factors which consist of meteorological conditions,climate changes,and terrain factors as well as soil physical and chemical properties.Interactions between the increasing temperature and decreasing precipitation in the region led to reduced accumulation of soil organic matter,which results in poor soil fertility.Human-induced factors,such as large-scale land reclamation and non-optimum farming practices,unsuitable cultivation systems,dredging,road building,illegal land occupation,and extensive use of fertilizers and pesticides,have led to increasingly severe soil erosion and destruction.Solutions to several problems of soil degradation in this region requiring urgent settlement are proposed.A need for clear and systematic recognition and recording of land use changes,land degradation,food production and climate change conditions is suggested,which would provide a reference for food security studies in the northeastern China.展开更多
文摘We evaluated the potential of orally fed new food formulations to inhibit biomarkers reported to be involved in the causes of allergic asthma in mice. Asthma, a serious non-communicable disease, affects both adults and children and can be undertreated. New functional foods could provide therapeutic approaches. Here, the anti-asthma mechanism of a new functional food and three isolated fractions produced by bioprocessing black rice bran with shiitake mushroom mycelia was evaluated in mast cells, B cells, and orally fed mice and compared with non-bioprocessed black rice bran. In vitro, the treatments inhibited RBL-2H3 cell degranulation and immunoglobulin E (IgE) production. The in vitro anti-asthma effects were confirmed in orally fed mice following asthma induction by alumina and chicken egg ovalbumin (OVA). The suppression of asthma resulted from the inhibition of inflammation- and immune-related substances, including OVA-specific IgE, thymic stromal lymphopoietin, eotaxin, leukotriene C4, prostaglandin D2, and vascular cell adhesion molecule-1 in bronchoalveolar lavage fluid and serum. The treatment also reversed the thickening of the lung airway wall. The inflammation and asthma inhibition seems to be regulated by the balance of the T-helper cells’ Th1/Th2 immune response and the inhibition of multiple biomarkers associated with the cause of asthma. Future human clinical studies with adults and children should determine the potential therapeutic value of the anti-asthma effects of the new functional foods.
基金partially supported by Higher Education Commission,Pakistan under Pak-US Science and Technology Cooperation Program Phase IV(Project Grant No.10/01/10-09/30/12)“Establishment of Functional and Nutraceutical Food Research Section at the National Institute of Food Science and Technology,University of Agriculture,Faisalabad,Pakistan”
文摘Objective: To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black cumin.Methods: Purposely, rat modelling was carried out for 2 months by designing three studies i.e. study Ⅰ(normal rats), study Ⅱ(hyperglycaemic rats) and study Ⅲ(hypercholesterolemic rats). Each study was further divided into three groups based on diet i.e.control, functional diet(contained extract of black cumin prepared by using conventional solvent) and nutraceutical diet(contained extract of black cumin prepared by supercritical fluid extraction system).Results: During whole trial, an abating trend was observed in the level of serum cholesterol with maximum reduction(12.8%) in nutraceutical group of study Ⅲ. Low density lipoprotein and triglyceride level was also lowered maximum in study Ⅲ as17.1% and 11.6%, respectively. Whereas, highest decline in glucose level was in nutraceutical group of study Ⅱ as 11.2%.Conclusions: Inclusion of black cumin extracts in diet significantly lowers the occurrence of hyperglycaemia and hypercholesterolaemia. Furthermore, hypoglycaemic and hypocholesterolemic potential of nutraceutical diet is more prominent as compared to functional diet.
基金Under the auspices of National Natural Science Foundation of China(No.41171335)Hydroinformatics for Ecohydrology Program of United Nations Educational+2 种基金Scientific and Cultural Organization(UNESCO)China Postdoctoral Science Foundation(No.20110490447)Beijing Postdoctoral Science Foundation(No.2012-49)
文摘The northeastern China is an important commodity grain region in China,as well as a notable corn belt and major soybean producing area.It thus plays a significant role in the national food security system.However,large-scale land reclamation and non-optimum farming practices give rise to soil degradation in the region.This study analyzed the food security issues coupled with global climate change in the northeastern China during 1980–2000,which is the period of modern agriculture.The results of statistical data show that the arable land area shrank markedly in 1992,and then increased slowly,while food production generally continually increased.The stable grain yield was due to the increase of applied fertilizer and irrigated areas.Soil degradation in the northeastern China includes severe soil erosion,reduced soil nutrients,a thinner black soil layer,and deterioration of soil physical properties.The sustainable development of the northeastern China is influenced by natural-artificial binary disturbance factors which consist of meteorological conditions,climate changes,and terrain factors as well as soil physical and chemical properties.Interactions between the increasing temperature and decreasing precipitation in the region led to reduced accumulation of soil organic matter,which results in poor soil fertility.Human-induced factors,such as large-scale land reclamation and non-optimum farming practices,unsuitable cultivation systems,dredging,road building,illegal land occupation,and extensive use of fertilizers and pesticides,have led to increasingly severe soil erosion and destruction.Solutions to several problems of soil degradation in this region requiring urgent settlement are proposed.A need for clear and systematic recognition and recording of land use changes,land degradation,food production and climate change conditions is suggested,which would provide a reference for food security studies in the northeastern China.
