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Cross-sectional and longitudinal studies on interaction between bladder compliance and outflow obstruction in men with benign prostatic hyperplasia 被引量:7
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作者 Li-Min Liao Werner Schaefer 《Asian Journal of Andrology》 SCIE CAS CSCD 2007年第1期51-56,共6页
Aim: To explore the interaction between bladder compliance (BC) and bladder outflow obstruction (BOO) in men with benign prostatic hyperplasia (BPH) using cross-sectional and longitudinal studies. Methods: A t... Aim: To explore the interaction between bladder compliance (BC) and bladder outflow obstruction (BOO) in men with benign prostatic hyperplasia (BPH) using cross-sectional and longitudinal studies. Methods: A total of 181 men with BPH were recruited, and 100 of them were followed for one year. Cystometry was performed in a standing or a sitting position with 30 mL/min infusion. BC was manually corrected and defined. Obstruction coefficient (OCO), linear passive urethral resistance relation and international continence society (ICS) nomogram were used to diagnose BOO. The obstructed parameters were compared between the reduced BC group and the non-reduced group. BC was compared between the first investigation at the beginning of study and the second investigation at the end of study during the one-year follow-up period. Results: The group with reduced BC had increased OCO and linear passive urethral resistance relation. BC was significantly lower in the obstructed group (55.7 mL/cm water) than that in unobstructed and equivocal one (74.9 mL/cm water, P 〈 0.01). BC gradually reduced with the increased obstructed grade. There was a significantly weak negative correlation between BC and OCO (r = - 0.132, P 〈 0.01). Over the one-year follow-up period in the longitudinal study, BC for all men changed from 54.4 to 48.8 mL/cm water (P 〉 0.05), and BC for the group with BOO fell from 58.4 ± 70.1 to 46.5 ± 38.7 mL/cm water (P 〉 0.05). Conclusion: In men with BPH, a significant systematic decrease occurred in BC in the obstructed group and a significant systematic increase with urethral resistance occurred in the low BC group. A longitudinal study of the tendency of BC reduction in a group with BOO is necessary in the future. 展开更多
关键词 benign prostatic hyperplasia bladder compliance bladder outflow obstruction
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Research Progress of Transurethral Prostatectomy for Benign Prostatic Hyperplasia with Bladder Stones
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作者 Navin Shrestha Huanchun Hu +1 位作者 Le Zhou Bo Wang 《Journal of Clinical and Nursing Research》 2020年第3期78-81,共4页
Benign prostatic hyperplasia,which can be abbreviated as prostatic hyperplasia,is a urinary system disease that has a high incidence in middle-aged and elderly male populations in China.The incidence of benign prostat... Benign prostatic hyperplasia,which can be abbreviated as prostatic hyperplasia,is a urinary system disease that has a high incidence in middle-aged and elderly male populations in China.The incidence of benign prostatic hyperplasia is increasing year by year.Patients with benign prostatic hyperplasia are prone to have bladder outlet obstruction,which in turn leads to an increase in residual urine volume in the bladder and impurities in the urine,such as upper urinary calculi that enter the bladder,urine crystals,various exfoliated cells,etc.If these substances stay in the bladder for a long time,stones in the bladder will be generated.Benign prostatic hyperplasia with bladder stones can severely obstruct the urinary tract,causing clinical symptoms such as urinary tract infections,urinary urgency,frequent urination,and dysuria.These symptoms seriously affects the physical and mental health of patients,leading to low levels of normal work and quality of life.With the development of medical technology,surgical treatment is commonly used in clinical practice.Among them,transurethral prostatectomy is widely used in clinical treatment,and has achieved good results. 展开更多
关键词 benign prostatic hyperplasia bladder stones Transurethral prostatectomy Application status Application advantages LIMITATIONS
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Clinical study of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia with overactive bladder
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作者 蒋晨 《外科研究与新技术》 2011年第4期256-257,共2页
Objective To evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH) with overactive bladder ( OAB) . Methods 82 patients with OAB and coexisting B... Objective To evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH) with overactive bladder ( OAB) . Methods 82 patients with OAB and coexisting BPH were randomly divided into tamsulosin group ( n 展开更多
关键词 IPSS OAB Clinical study of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia with overactive bladder
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Effect of warm bladder irrigation fluid for benign prostatic hyperplasia patients on perioperative hypothermia, blood loss and shiver: A meta-analysis 被引量:12
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作者 Jie Cao Xia Sheng +2 位作者 Yan Ding Lingjuan Zhang Xiaoying Lu 《Asian Journal of Urology》 CSCD 2019年第2期183-191,共9页
Objective:To find out whether warm bladder irrigation fluid can decrease the occurrence of perioperative hypothermia,blood loss and shiver in patients treated with benign prostatic hyperplasia(BPH).Method:A comprehens... Objective:To find out whether warm bladder irrigation fluid can decrease the occurrence of perioperative hypothermia,blood loss and shiver in patients treated with benign prostatic hyperplasia(BPH).Method:A comprehensive literature review and meta-analysis that included randomized controlled trials(RCTs)related to temperature of irrigation fluid in the perioperative treatment for BPH was taken by researchers.The relevant literature were searched in Chinese database,such as Retrieval Chinese Journal Full-text Database,VIP Journal Database,Wanfang database,as well as in English search engine and database,including Embase,Cochrane and Medline till January 2018.The study quality was assessed by recommended standards from Cochrane Handbook(version 5.1.0).Results:A total of 28 RCTs and 3858 patients were included.The results showed that the incidences of shiver(risk ratio[RR]Z 0.32,95%confidence interval[CI]:0.28e0.36,p<0.001,I^2 Z 0%)and hypothermia(RR Z 0.36,95%CI:0.21e0.59,p<0.001,I^2 Z 67%)in the group of warm irrigation fluid were lower than the group having room-temperature fluid.Room-temperature irrigation fluid group caused a greater drop in body temperature compared to warm irrigation fluid group(p<0.001,I^2 Z 96%).We performed a narrative descriptive statistics only because of substantial heterogeneity.Conclusions:Warm bladder irrigation fluid can decrease the drop of body temperature and the incidence of hypothermia and shiver during and after the operation for BPH.Warm irrigation fluid should be considered as a standard practice in BPH surgeries. 展开更多
关键词 Irrigation fluid Temperature bladder fluid benign prostatic hyperplasia HYPOTHERMIA Blood loss SHIVER
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Pressure-flow studies in patients with benign prostatic hyperplasia:a study comparing suprapubic and transurethral methods 被引量:2
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作者 Shan-Chao Zhao Shao-Bin Zheng Wan-Long Tan Peng Zhang Huan Qi 《Asian Journal of Andrology》 SCIE CAS CSCD 2006年第6期731-735,共5页
Aim: To compare the use of the suprapubic puncture method versus the transurethral method in pressure-flow studies in patients with benign prostatic hyperplasia. Methods: Twenty-three men with benign prostatic hyper... Aim: To compare the use of the suprapubic puncture method versus the transurethral method in pressure-flow studies in patients with benign prostatic hyperplasia. Methods: Twenty-three men with benign prostatic hyperplasia underwent both suprapubic and transurethral pressure-flow studies during a single session. Standard pressure-flow variables were recorded in all patients with both methods, enabling calculation of obstruction using commonly used grading systems, such as the urethral resistance algorithm, the Abrams-Griffith (AG) number and the Schaefer linear nomogram. Results: There were statistically significant differences between the methods in the mean values of maximum flow rate (P 〈 0.05), detrusor pressure at the maximum flow (P 〈 0.01), urethral resistance algorithm (P 〈 0.01), AG number (P 〈 0.01) and maximum cystic capacity (P 〈 0.01). Of the men in the study, 10 (43.5%) remained in the same Schaefer class with both methods and 18 (78.3%) in the same AG number area. Using the transurethral method, 12 (52.2%) men increased their Schaefer class by one and 1 (4.3%) by two. There were also differences between the suprapubic and transurethral methods using the AG number: 4 (17.4%) men moved from a classification of equivocal to obstructed and 1 (4.3%) from unobstructed to equivocal. Conclusion: The differences between the techniques for measuring intravesical pressure alter the grading of obstruction determined by several of the commonly used classifications. An 8 F transurethral catheter significantly increases the likelihood of a diagnosis of bladder outlet obstruction when compared with the suprapubic method. 展开更多
关键词 URODYNAMICS pressure-flow study SUPRAPUBIC TRANSURETHRAL benign prostatic hyperplasia bladder outlet obstruction
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Efficacy of Bladder Neck Incision (BNI) Versus Transurethral Resection of Prostate (TURP) in Management of Benign Prostatic Hyperplasia (BPH) Causing Obstruction: A Randomised Controlled Study 被引量:1
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作者 Hussein H. S. Saddam Jain Sudhir Kumar Singh Chandra Bhushan 《Open Journal of Urology》 2019年第8期119-129,共11页
Objective: To compare the efficacy of bladder neck incision (BNI) with transurethral resection of prostate (TURP) in the treatment of patients with urinary obstruction caused by benign prostatic hyperplasia (BPH) on t... Objective: To compare the efficacy of bladder neck incision (BNI) with transurethral resection of prostate (TURP) in the treatment of patients with urinary obstruction caused by benign prostatic hyperplasia (BPH) on the basis of short term follow up of 4 months. Patient and Methods: The study was conducted in Department of General Surgery in Maulana Azad Medical College, New Delhi. 60 men with proven clinical diagnosis of BPH of size 30 grams and less presenting with symptoms of bladder outlet obstruction (BOO) were randomised prospectively to undergo either of the two operative modalities. Preoperatively size of the prostate, symptom scoring (IPSS), peak flow rate (Qmax) were assessed. Postoperatively and during 4 months follow up the following data were collected—operative time, catheterisation period, hospital stay, blood loss, Qmax and IPSS. Results: Preoperative parameters in both the groups showed no statistically significant differences with respect to prostate size, Qmax and IPSS Scoring. At 4 months follow up Qmax increased from (6.35 ± 4.49) to (16.41 ± 2.28) in TURP group and (4.51 ± 3.57) to (15.95 ± 2.58) in BNI group. IPSS decreased from 18.70 to 5.7 in TURP group and 18.90 to 6.00 in BNI group. All differences were statistically significant. There was a statistically significant difference in operative time, blood loss, hospital stay, catheterisation timing favouring BNI. Conclusion: TURP and BNI are equally effective in providing symptomatic improvement. BNI has an upper hand in reference to operative time, hospital stay, duration of catheterisation and blood loss. 展开更多
关键词 benign prostatic hyperplasia (BPH) bladder Neck INCISION (BNI) bladder Outlet OBSTRUCTION (BOO) Peak Urinary Flow Rate (Qmax) International Prostate Scoring System (IPSS)
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Botulinum toxin and benign prostatic hyperplasia 被引量:2
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作者 Lay Guat Ng 《Asian Journal of Urology》 2018年第1期33-36,共4页
Benign prostatic hyperplasia(BPH)is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet.Treatment of t... Benign prostatic hyperplasia(BPH)is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet.Treatment of this condition with botulinum toxin has been used since 2003,but this interest has somewhat died down after two large randomized controlled trials(RCTs)showing equivalence of results between their treatment and placebo arms.However,with review of animal studies and unexplained exaggerated effect of the placebo arms of the two RCTs,together with recent data of sustained benefits after 18 months of treatment,the place of botulinum toxin in the BPH field is probably still present. 展开更多
关键词 benign prostatic hyperplasia Botulinum toxin bladder outlet obstruction
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Management of urethral strictures and stenosis caused by the endo-urological treatment of benign prostatic hyperplasiad-a single-center experience 被引量:1
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作者 Rajiv N.Kore 《Asian Journal of Urology》 CSCD 2023年第2期137-143,共7页
Objective:Urethral stricture disease after endo-urological treatment of benign prostatic hyperplasia(BPH)is a sparsely described complication.We describe management of five categories of these strictures in this retro... Objective:Urethral stricture disease after endo-urological treatment of benign prostatic hyperplasia(BPH)is a sparsely described complication.We describe management of five categories of these strictures in this retrospective observational case series.Methods:One hundred and twenty-one patients presenting with symptoms of bladder outflow obstruction after endo-urological intervention for BPH from February 2016 to March 2019 were evaluated.Among them,76 were eligible for this study and underwent reconstructive surgery.Preoperative and postoperative assessments were done with symptom scores,uroflowmetry,ultrasound for post-void residue,and urethrogram.Any intervention during follow-up was classed as a failure.The recurrence and 95%confidence interval for recurrence percentage were calculated.Results:The following five categories of patients were identified:Bulbo-membranous(33[43.4%]),navicular fossa(21[27.6%]),penile/peno-bulbar(8[10.5%]),bladder neck stenosis(6[7.9%]),and multiple locations(8[10.5%]).The average age was 69 years(range:60-84 years).Overall average symptom score,flow rate,and post-void residue changed from 21 to 7,6 mL/s to 19 mL/s,and 210 mL to 20 mL,respectively.The average follow-up was 34 months(range:12-58 months).Overall recurrence and complication rates were 10.5%and 9.2%,respectively.The recurrence in each category was seen in 3,1,2,1,and 1 patient,respectively.Overall 95% confidence interval for recurrence percentage was 4.66-19.69.Conclusion:Urethral stricture disease is a major long-term complication of endo-urological treatment of BPH.The bulbo-membranous strictures need continence preserving approach.Navicular fossa strictures require minimally invasive and cosmetic consideration.Peno-bulbar strictures require judicious use of grafts and flaps.Bladder neck stenosis in this cohort could be treated with endoscopic measures.Multiple locations need treatment based on their sites in single-stage as far as possible. 展开更多
关键词 Urethral stricture benign prostatic hyperplasia Transurethral resection of prostate URETHROPLASTY Holmium laser enucleation of prostate Trans-urethral bipolar electro-enucleation bladder neck stenosis
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A Review on Urinary Incontinence after Surgery for Benign Prostatic Hyperplasia 被引量:1
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作者 Constantin Martial Essissima Foé Yunfen Liao Guoxi Zhang 《Open Journal of Urology》 2022年第3期169-184,共16页
Background: Benign prostatic hyperplasia (BPH) is characterized by the abnormal proliferation of cells, leading to structural changes. It is one of the most common diseases in ageing men. Its clinical presentations ar... Background: Benign prostatic hyperplasia (BPH) is characterized by the abnormal proliferation of cells, leading to structural changes. It is one of the most common diseases in ageing men. Its clinical presentations are dominated by lower urinary tract symptoms (LUTS). The therapeutic methods can be grouped into two options: the medical option and the surgical option in which prostate enucleation is found. In recent years many studies have reported the onset of urinary incontinence (UI) after prostate enucleation. The management of UI occurring after prostate enucleation is embarrassing for both the practitioner and the patient, and generates additional costs. Purpose: Cite the causes of UI after prostate enucleation for BPH, as well as ways to prevent the onset of UI after this surgery, specifically by the study of the vesicosphincteric system aimed at improving the technique of enucleation;our review will also deal with the therapeutic means of UI. Method: We retrieved studies from Science Direct, Wiley and Pubmed. Results: There are multiple etiologies of UI after prostate enucleation including urethral sphincter insufficiency (USI) and bladder dysfunction (BD). The management of UI after surgery could be conservative, surgical, or use new technologies. Urodynamic assessment before prostate enucleation for BPH is relevant. Conclusion: UI is a common post-operative complication of prostate enucleation. The study of the vesicosphincteric system leads us to believe that prostate enucleation for BPH, partially sparing the mucosa and the external urethral sphincter could decrease the incidence of UI after surgery. 展开更多
关键词 benign prostatic hyperplasia (BPH) Urinary Incontinence (UI) Urethral Sphincter Insufficiency (USI) bladder Dysfunction (BD) Detrusor Overactivity (DO) Prostate Enucleation
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Predictive Factors for a Successful Day Case Benign Prostatic Hyperplasia Surgery: A Review
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作者 Henry Kimbi Yisa Yunfen Liao Guoxi Zhang 《Open Journal of Urology》 2021年第12期496-508,共13页
<strong>Introduction:</strong> Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is one among the foremost common diseases affecting the aging man with, almost 80% of the ... <strong>Introduction:</strong> Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is one among the foremost common diseases affecting the aging man with, almost 80% of the lads greater than 70 affected. BPH is caused by unregulated proliferation within the prostate, which may cause physical obstruction of the prostatic urethra and result in anatomic bladder outlet obstruction (BOO). Transurethral resection of the prostate (TURP) has been the historical gold standard up till now to which all endoscopic procedures for benign prostatic hyperplasia (BPH) are compared with a mean hospital stay of three days. This surgery although efficacious has been related with increased morbidity and increased day case failure rates as compared to newer techniques. These shortcomings have prompted the utilization of newer methods like Transurethral enucleation and resection of the prostate (TUERP), Holmium laser enucleation of the prostate (HoLEP) and Thulium laser enucleation of the prostate (ThuLEP). This review will discuss the enucleation techniques, advantages and therefore the predictive factors for a successful day case prostate surgery. <strong>Materials and Methods:</strong> During this review, we discuss the newer techniques utilized in day case BPH surgery as well as the predictive factors for a successful BPH surgery, both enucleation, benefits and morcellation are covered also. <strong>Results:</strong> TUERP, ThuLEP and HoLEP have literature supporting the advantages of these techniques, which demonstrates its ability in day case BPH surgeries in specially selected cases with favorable factors and a 61% overall success rate. <strong>Conclusion:</strong> TUERP, ThuLEP and HoLEP Have proven to show favorable outcomes in day case BPH surgery with urologist’s experience, prostate size, duration of operation, age, use of anticoagulants, morning theatre list and ASA score being the key factors for a successful day case surgery. 展开更多
关键词 benign prostatic hyperplasia (BPH) Transurethral Resection of the Prostate (TURP) Transurethral Enucleation and Resection of the Prostate (TUERP) Holmium Laser Enucleation (HoLEP) Thulium Laser Enucleation (THuLEP) Lower Urinary Tract Symptoms (LUTS) Catheterisation Time (CT) Operation Time (OT) bladder Outlet Obstruction (BOO) American Society of Anesthesiologists (ASA)
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Stable state of serum inflammatory cytokines during induction of benign prostate hyperplasia in dogs
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作者 Kamran Golchin-Rad Asghar Mogheiseh +3 位作者 Fahimeh Heidari Saeed Nazifi Nooshin Derakhshandeh Mohammad Abbaszadeh Hasiri 《Asian pacific Journal of Reproduction》 2019年第6期283-288,共6页
Objective:To monitor serum inflammatory cytokines during induction of benign prostate hyperplasia in dogs.Methods:This research was designed as a case-control study.There were 20 adult mixed-breed intact male dogs,whi... Objective:To monitor serum inflammatory cytokines during induction of benign prostate hyperplasia in dogs.Methods:This research was designed as a case-control study.There were 20 adult mixed-breed intact male dogs,which were divided into the normal group(n=10)and the benign prostate hyperplasia group(n=10).In the benign prostate hyperplasia group,benign prostate hyperplasia was induced by injection of testosterone(75.00 mg/dog,i.m.)and estrogen(0.75 mg/dog,i.m.)on day 0(day of the first injection),day 21,day 42,and day 63.The doses of testosterone were doubled on days 21,42,and 63.The normal group did not receive any injection.Blood sampling was performed from the jugular vein at days 0,21,42,and 63.The concentrations of interleukin-8,interleukin-10,and tumor necrosis factor-α(TNF-α)were assayed by enzyme-linked immunosorbent assay.Results:The levels of interleukin-8,interleukin-10 and TNF-αwere not significantly different between the normal group and the benign prostate hyperplasia group.Also,concentrations of the pro-inflammatory cutokines were not significantly different between the normal group and the BPH group in each day of sampling.Conclusions:In spite of the induction of benign prostate hyperplasia,changes in the concentration of blood serum inflammatory cytokines were not significantly different with that of the normal group and between the days of induction of benign prostate hyperplasia during two months.It reveals that there is a stable state of serum inflammatory cytokines during induction of benign prostate hyperplasia in dogs. 展开更多
关键词 benign prostate hyperplasia CYTOKINES Dog INTERLEUKIN tumor NECROSIS factor
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Bethanechol Remains the Preferred Drug in Suspected Underactive Bladder: Findings from Nation-Wide Prescription Analysis
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作者 Sanjay Vasant Kamble Anjana Kalpesh Yadav +1 位作者 Maneesha Tarkeshwar Sharma Radha Ratnadeep Bhosle 《Open Journal of Urology》 2024年第5期301-311,共11页
Background: Bethanechol chloride, a cholinergic agonist, is often prescribed in suspected underactive bladders to improve detrusor contractility, despite its limited clinical efficacy. We investigated the usage patter... Background: Bethanechol chloride, a cholinergic agonist, is often prescribed in suspected underactive bladders to improve detrusor contractility, despite its limited clinical efficacy. We investigated the usage pattern of bethanechol in actual practice with the understanding that it would enable the physicians to make an informed decision on the coherent use of bethanechol. Methods: A nation-wide survey was carried out to obtain the responses of the urologists. Out of the 755 urologists approached, 630 survey responses were considered for analysis. Results: Usage of bethanechol was advocated as very common [318 (50.48%)], common [200 (31.75%)], not so common [107 (16.98%)], and rare [5 (0.79%)] in postoperative urinary retention, where it was preferred either exclusively [255 (40.48%)] or along with alpha blockers [247 (39.21%)]. Predilection to use alpha-blocker [247 (39.21%)], alpha-blocker plus naloxone [4 (0.64%)], naloxone [1 (0.16%)], alpha-blocker plus bethanechol plus naloxone [1 (0.16%)] was also observed. It was also preferred individually in pathologies causing urinary retention such as benign prostatic hyperplasia [125 (19.84%)], diabetic neuropathy [82 (13.02%)], neurological diseases [69 (10.95%)], senile bladder [14 (2.22%)], drugs [13 (2.06%)], and infective/inflammatory conditions [6 (0.95%)]. Other [321 (50.95%)] physicians opted to prescribe bethanechol in two or more of the enumerated indications. Bethanechol was prescribed orally as 25 mg thrice daily [441 (70.00%)], 50 mg thrice daily [86 (13.65%)], 25 mg four times daily [59 (9.37%)], and many “strongly agree” and “agree” that its sustained release formulation may offer better treatment compliance [565 (89.68%)], safety [548 (86.99%)], and efficacy [544 (86.35%)]. Conclusion: Bethanechol was the most prescribed drug for the management of postoperative urinary retention and other pathologies suspected to cause underactive bladder. 展开更多
关键词 BETHANECHOL benign prostatic hyperplasia Detrusor Underactivity Urinary Retention Underactive bladder
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Urine Flow Acceleration Is Superior to Qmax in Diagnosing BOO in Patients with BPH 被引量:3
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作者 文建国 崔林刚 +5 位作者 李一冬 尚小平 朱文 张瑞莉 孟庆军 张胜军 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2013年第4期563-566,共4页
Summary: We performed a retrospective, case-control study to evaluate whether the urine flow acceleration (UFA, mL/s2) is superior to maximum uroflow (Qmax, mL/s) in diagnosing bladder outlet obstruction (BOO) ... Summary: We performed a retrospective, case-control study to evaluate whether the urine flow acceleration (UFA, mL/s2) is superior to maximum uroflow (Qmax, mL/s) in diagnosing bladder outlet obstruction (BOO) in patients with benign prostatic hyperplasia (BPH). In this study, a total of 50 men with BPH (age: 58±12.5 years) and 50 controls (age: 59±13.0 years) were included. A pressure-flow study was used to determine the presence of BOO according to the recommendations of Incontinence Control Society (ICS). The results showed that the UFA and Qmax in BPH group were much lower than those in the control group [(2.05±0.85) vs. (4.60±1.25) mL/s2 and (8.50±1.05) vs. (13.00±3.35) mL/s] (P〈0.001). Accol;ding to the criteria (UFA〈2.05 mL/s2, Qmax〈10 mL/s), the sensitivity and specificity of UFA vs. Qmax in diagnosing BOO were 88%, 75% vs. 81%, 63%. UFA vs. Omax, when compared with the results of P-Q chart (the kappa values in corresponding analysis), was 0.55 vs. 0.35. The pros- tate volume, post void residual and detrusor pressure at Qmax between the two groups were 28.6±9.8 vs. 24.2±7.6 mL, 60.4±1.4 vs. 21.3±2.5 mL and 56.6±8.3 vs. 21.7±6.1 cmHzO, respectively (P〈0.05). It was concluded that the UFA is a useful urodynamic parameter, and is superior to Qmax in diagnosing BOO in patients with BPH. 展开更多
关键词 benign prostate hyperplasia (BPH) bladder outlet obstruction (BOO) urine flow accelera-tion (UFA) Qmax P-Q chart
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Bladder calculi concomitant with benign prostatic enlargement:is prostate surgery mandatory in patients who have never received medical therapy?
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作者 Hakan Anil Umut Unal +2 位作者 Kaan Karamik Ferhat Ortoglu Hakan Ercil 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第5期604-607,共4页
The historical dogma that bladder calculi comprise the main indication for prostatic surgery has recently been questioned.In this study,we aimed to predict which patients should undergo simultaneous prostate and bladd... The historical dogma that bladder calculi comprise the main indication for prostatic surgery has recently been questioned.In this study,we aimed to predict which patients should undergo simultaneous prostate and bladder calculi surgery or only bladder calculi removal by evaluating preoperative risk factors.One hundred and seventeen men with bladder stones and concomitant benign prostate enlargement(BPE)who had not received medical treatment before were included in the study.In the first step,only the bladder calculi of patients were removed and medical treatment was given for BPE.The patients who benefited from medical treatment during the follow-up were defined as Group 1 and the patients who required prostate surgery for any indication comprised Group 2.Risk factors for prostate surgery requirements were determined by comparing preoperative characteristics between the two groups with a cox regression model.In the follow-up of 117 patients with bladder stones removed and medical treatment initiated,49(41.9%)patients had prostate surgery indications.The indication for 33(67.3%)of 49 patients was medical treatment failure.The presence of intravesical prostatic protrusion(IPP;hazard ratio:2.071,95%confidence interval[Cl]:1.05-4.05,P=0.034),and high postvoiding residual urine volume(hazard ratio:1.013,95%Cl:1.007-1.019,P<0.001)were found to be preoperative risk factors for needing future prostate surgery.In patients who have not received medical treatment for BPE before,bladder calculi developing secondary to BPE do not always constitute an indication for prostate surgery. 展开更多
关键词 benign prostate hyperplasia bladder calculi intravesical prostatic protrusion medical therapy prostate surgery
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同期与分期TURBT/PKRP手术对膀胱癌合并前列腺增生患者疗效对比
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作者 张建斌 韩晖 郝晓杰 《中国肿瘤外科杂志》 CAS 2024年第4期393-396,共4页
目的分析同期与分期经尿道膀胱肿瘤切除术(TURBT)/经尿道前列腺等离子电切术(PKRP)对膀胱癌合并前列腺增生患者术后恢复的影响。方法选取2020年12月至2023年12月山西省肿瘤医院膀胱癌合并前列腺增生患者98例,其中同期行TURBT术与PKRP术... 目的分析同期与分期经尿道膀胱肿瘤切除术(TURBT)/经尿道前列腺等离子电切术(PKRP)对膀胱癌合并前列腺增生患者术后恢复的影响。方法选取2020年12月至2023年12月山西省肿瘤医院膀胱癌合并前列腺增生患者98例,其中同期行TURBT术与PKRP术治疗者52例纳入同期组,分期行TURBT术与PKRP术治疗者46例纳入分期组。比较两组疗效;前列腺功能指标[最大尿流率(Qmax)、残余尿量(RU)、国际前列腺症状(IPSS)评分、最大尿道闭合压、最大尿道压]、预后(膀胱癌复发、前列腺窝种植转移情况)。结果同期组疗效优于分期组;相较于术前,术后6个月两组Qmax均升高,RU、IPSS评分、最大尿道闭合压、最大尿道压均降低,且同期组相较于分期组Qmax更高,RU、IPSS评分、最大尿道闭合压、最大尿道压更低,差异有统计学意义(P<0.05);同期组膀胱癌复发率及前列腺窝种植转移率均低于分期组(P<0.05)。结论针对膀胱癌合并前列腺增生患者采取同期TURBT术与PKRP术同期治疗疗效较好,肿瘤复发及转移风险较低。 展开更多
关键词 经尿道膀胱肿瘤切除术 经尿道前列腺等离子电切术 膀胱癌 前列腺增生
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基于流固耦合的膀胱颈角对排尿影响程度的应用研究
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作者 贾旭东 郭小皖 +6 位作者 张婉泽 路丽娟 王亚轩 刘凯隆 王东彬 柳跃鹏 齐进春 《中华男科学杂志》 CAS CSCD 2024年第9期789-797,共9页
目的:本研究利用膀胱颈角(BNA)评估膀胱颈开口变形程度,并通过流固耦合分析,评估膀胱颈角对排尿的影响。方法:建立理想化的膀胱、前列腺及尿道的几何模型:BNA正常模型、BNA增大模型。通过流固耦合模拟尿液在膀胱、膀胱颈、尿道内的流速... 目的:本研究利用膀胱颈角(BNA)评估膀胱颈开口变形程度,并通过流固耦合分析,评估膀胱颈角对排尿的影响。方法:建立理想化的膀胱、前列腺及尿道的几何模型:BNA正常模型、BNA增大模型。通过流固耦合模拟尿液在膀胱、膀胱颈、尿道内的流速和压力变化及前列腺的位移,评估BNA变化对尿流的影响。回顾性分析2020年6月至2023年6月期间145例就诊于河北医科大学第二医院泌尿外科的下尿路症状患者,根据患者是否合并急性尿潴留(AUR),将其分为AUR组(39例)和无AUR组(106例),并根据前列腺体积及尿流率大小分组,评估BNA对排尿的影响。结果:通过对BNA正常模型与BNA增大模型对比仿真分析发现两组模型流体域总压及流速分布有明显差异(P<0.05),前列腺位移最大的部位为膀胱颈部,BNA正常模型膀胱颈部位移较小且尿道内径未发生变化,BNA增大模型膀胱颈部位移更大且尿道开口内径缩小。通过流固耦合结果分析证明BNA增大对排尿有显著影响。AUR组与无AUR组间PSA、TPV、TZV、IPSS、Qmax、IPP、PUA、BNA存在明显差异(P<0.05)。按照尿流率大小分为3组,各组平均BNA:Qmax<10 ml/s组为83.7°±2.5°、Qmax 10~15ml/s组为67.5°±1.8°,Qmax>15ml/s组为65.1°±4.8°,差异有统计学意义(P<0.05)。使用非参数秩和检验组间对比,Qmax<10ml/s组BNA与另外两组差异有统计学意义(P<0.05)。良性前列腺增生分组各组平均BNA:Ⅳ度组为105.8°±6.0°,Ⅲ度组为82.8°±3.5°,Ⅱ度组为71.5°±2.0°,Ⅰ度组为67.2°±3.1°,正常组为65.0°±3.7°(P<0.05),正常组、Ⅰ度组、Ⅱ度组的组间BNA差异均无统计学意义(P>0.05),Ⅲ度组、Ⅳ度组的组间BNA差异有统计学意义(P<0.05),Ⅲ度组、Ⅳ度组分别与正常组、Ⅰ度组、Ⅱ度组之间BNA差异有统计学意义(P<0.05)。Spearman相关因素分析结果显示BNA与TPV、TZV、IPP、PUA、IPSS、Qmax之间存在很强的相关性(P<0.05)。结论:BNA的改变会对排尿造成影响,且与良性前列腺增生严重程度关系密切。BNA可能是评估良性前列腺增生患者下尿路症状严重程度的重要的解剖学因素。 展开更多
关键词 膀胱颈角 流固耦合 计算流体力学 良性前列腺增生
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前癃通胶囊介导miR-216a-5p/TPT1/mTORC1通路调控良性前列腺增生的实验研究
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作者 黄鸿宇 郭子莘 +7 位作者 朱文雄 袁轶峰 贺菊乔 刘涛 谭梅鑫 杨金玉 曹雨昙 张熙 《湖南中医药大学学报》 CAS 2024年第3期374-382,共9页
目的通过细胞实验探讨前癃通胶囊(qian long tong capsule,QLTC)能否通过调控miR-216a-5p/肿瘤蛋白翻译控制1/哺乳动物雷帕霉素靶蛋白复合物1(miR-216a-5p/tumor protein translationally controlled 1/mammalian target of rapamycin c... 目的通过细胞实验探讨前癃通胶囊(qian long tong capsule,QLTC)能否通过调控miR-216a-5p/肿瘤蛋白翻译控制1/哺乳动物雷帕霉素靶蛋白复合物1(miR-216a-5p/tumor protein translationally controlled 1/mammalian target of rapamycin complex 1,miR-216a-5p/TPT1/mTORC1)信号通路抑制良性前列腺增生(benign prostatic hyperplasia,BPH)。方法将25只大鼠随机分为对照组(等体积生理盐水),QLTC低(56.25 mg/mL)、中(112.50 mg/mL)、高(225.00 mg/mL)剂量组,LBSC组(168.75 mg/mL),每组5只。每组灌胃1 mL/次,2次/d,连续5 d。各组大鼠麻醉后制备含药血清。根据实验目的不同,将CP-H022细胞分5步做实验处理,每部分实验进行独立分组。将miR-216a-5p过表达和沉默表达,及TPT1过表达进行对照研究;RT-qPCR法检测正常和BPH模型CP-H022细胞内miR-216a-5p表达量,并观察不同浓度QLTC处理的BPH细胞中miR-216a-5p表达量的差异;细胞集落形成实验检测细胞增殖能力;CCK-8法检测BPH模型细胞增殖;RT-qPCR法检测miR-216a-5p、TPT1 mRNA表达水平;流式细胞术检测细胞凋亡;生信分析、双荧光素酶实验验证miR-216a-5p与TPT1的靶向关系;过表达TPT1后,Western blot法检测BPH细胞中TPT1/mTORC1信号通路相关分子表达情况。结果与对照组1比较,模型组1的CP-H022细胞内miR-216a-5p表达量下调(P<0.05);不同浓度的QLTC均能上调miR-216a-5p表达量(P<0.05);根据本实验结果,本研究将选用QLTC(高剂量)组CP-H022细胞进行后续实验。与模型组2比较,QLTC组2细胞增殖减少、凋亡增加(P<0.05),B细胞淋巴瘤-2(B-cell lymphoma-2,Bcl-2)表达降低(P<0.05),Bcl-2关联X蛋白单克隆抗体(monoclonal antibody to Bcl-2 associated X protein,Bax)、cleaved Caspase-3表达升高(P<0.05)。敲低miR-216a-5p后,与模型组4比较,QLTC组4细胞增殖增强、凋亡减少(P<0.05),Bcl-2表达升高(P<0.05),Bax、cleaved Caspase-3表达降低(P<0.05)。与mimic-NC组比较,miR-216a-5p mimic组TPT1表达量降低(P<0.05);QLTC处理后,细胞TPT1、p-mTORC1表达均降低(P<0.05);过表达TPT1后BPH细胞增殖功能增强(P<0.05),凋亡减少(P<0.05),Bcl-2表达升高(P<0.05),Bax、cleaved Caspase-3表达下降(P<0.05)。结论QLTC可通过介导miR-216a-5p下调TPT1/mTORC1通路,进而抑制BPH。 展开更多
关键词 前癃通胶囊 良性前列腺增生 细胞实验 miR-216a-5p 肿瘤蛋白翻译控制1 哺乳动物雷帕霉素靶蛋白复合物1 信号通路
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不同功率HoLEP联合钬激光碎石术在治疗良性前列腺增生合并膀胱结石的疗效及安全性分析
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作者 夏东东 曾明辉 +1 位作者 秦锁炳 蒋东方 《河北医学》 CAS 2024年第10期1680-1685,共6页
目的:研究不同功率钬激光前列腺剜除术(HoLEP)联合钬激光碎石术(HLC)在治疗良性前列腺增生(BPH)合并膀胱结石的疗效及安全性分析。方法:收集2019年1月至2024年1月丹阳市人民医院收治的110例BPH合并膀胱结石患者的临床资料,根据手术方式... 目的:研究不同功率钬激光前列腺剜除术(HoLEP)联合钬激光碎石术(HLC)在治疗良性前列腺增生(BPH)合并膀胱结石的疗效及安全性分析。方法:收集2019年1月至2024年1月丹阳市人民医院收治的110例BPH合并膀胱结石患者的临床资料,根据手术方式,将接受高功率HoLEP联合HLC的患者纳入HP组(n=62),接受低功率HoLEP联合HLC的患者纳入LP组(n=48)。比较两组围术期指标、排尿功能、应激指标、术后并发症。结果:HP组手术时间(68.49±15.36)min、剜除组织质量(41.42±10.59)g、膀胱冲洗时间(1.86±0.66)d、术后尿管留置时间(2.34±0.85)d与LP组[(70.15±15.71)min、(42.81±9.93)g、(1.81±0.72)d、(2.58±0.92)d]比较差异无统计学意义(P>0.05);HP组腺体剜除时间(35.80±7.21)min、住院时间(3.62±0.64)d短于LP组[(41.64±7.83)min、(3.86±0.50)d],剜除效率(1.15±0.25)g/min、血红蛋白下降幅度(8.05±1.58)g/L高于LP组[(1.02±0.18)g/min、(7.36±1.72)g/L],差异有统计学意义(P<0.05);术后3个月,HP组Qmax、PVR、PSA治疗前后差值与LP组比较差异无统计学意义(P>0.05);术后24h,HP组SP、PGE2、NE治疗前后差值与LP组比较差异无统计学意义(P>0.05);HP组术后并发症(12.88%)与LP组(10.40%)比较,差异无统计学意义(P>0.05)。结论:高功率、低功率HoLEP联合HLC对BPH合并膀胱结石的疗效相当,高功率HoLEP剜除效率更高,腺体剜除时间、住院时间更短,低功率HoLEP的止血效果更好。 展开更多
关键词 低功率钬激光前列腺剜除术 高功率钬激光前列腺剜除术 钬激光碎石术 良性前列腺增生 膀胱结石
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新术式治疗前列腺增生术后膀胱颈挛缩防治的研究进展
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作者 杨朴深 王浩 +4 位作者 谢大炜 王思琦 何威峰 卫宜锐 王建文 《中国医药导报》 CAS 2024年第10期199-200,F0003,共3页
膀胱颈挛缩(BNC)为前列腺增生术后远期并发症之一,主要症状为排尿困难等,可能由炎症因子刺激及微血管病变等原因所致。BNC可通过术前治疗前列腺炎症及改善微循环,术中行预防性膀胱颈切开及调整器械用法,术后治疗尿路感染及监测瘢痕形成... 膀胱颈挛缩(BNC)为前列腺增生术后远期并发症之一,主要症状为排尿困难等,可能由炎症因子刺激及微血管病变等原因所致。BNC可通过术前治疗前列腺炎症及改善微循环,术中行预防性膀胱颈切开及调整器械用法,术后治疗尿路感染及监测瘢痕形成指标进行预防。BNC的手术方式一般为经尿道膀胱颈手术,难治性BNC可采用膀胱颈成形术。本文将从新术式治疗前列腺增生术后BNC的发生机制、预防手段及治疗方式展开综述,以帮助临床工作的开展。 展开更多
关键词 良性前列腺增生 膀胱颈挛缩 并发症 激光
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普乐安联合琥珀酸索利那新治疗良性前列腺增生术后膀胱过度活动症的效果观察
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作者 叶俊杰 吴琦 《浙江医学》 CAS 2024年第11期1183-1186,1196,共5页
目的探讨普乐安联合琥珀酸索利那新治疗良性前列腺增生(BPH)术后膀胱过度活动症(OAB)的临床效果。方法回顾性选取2022年5月至2023年6月在丽水市人民医院行经尿道前列腺钬激光剜除术后发生OAB的60例BPH患者为研究对象,其中普乐安联合琥... 目的探讨普乐安联合琥珀酸索利那新治疗良性前列腺增生(BPH)术后膀胱过度活动症(OAB)的临床效果。方法回顾性选取2022年5月至2023年6月在丽水市人民医院行经尿道前列腺钬激光剜除术后发生OAB的60例BPH患者为研究对象,其中普乐安联合琥珀酸索利那新治疗(联合组)31例,仅琥珀酸索利那新治疗(单药组)29例;比较两组患者术后膀胱过度活动症状评分(OABSS)、OAB缓解率(OABSS降低至3分以下且1 d内未明显升高)、残余尿量、生活质量评分(QOL)、国际前列腺症状评分(IPSS)等疗效指标,采用单因素及多因素Cox回归分析OAB缓解的影响因素。结果联合组术后半个月及1个月OABSS均低于单药组(均P<0.05),术后半个月及1个月OAB缓解率均高于单药组(均P<0.05);两组患者术后3个月OABSS、OAB缓解率、残余尿量、QOL、IPSS比较,差异均无统计学意义(均P>0.05)。联合治疗方案(HR=0.562)是OAB缓解的独立保护因素,术后用药前OABSS尿急评分4~5分(HR=2.082)、术后用药前QOL 4~6分(HR=2.180)、吸烟(HR=3.466)是OAB缓解的独立危险因素,差异均有统计学意义(均P<0.05)。结论普乐安联合琥珀酸索利那新治疗能加快缓解BPH患者术后OAB症状,是OAB缓解的独立保护因素。 展开更多
关键词 普乐安 索利那新 良性前列腺增生 膀胱过度活动症
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