Homogeneity of powder blend is essential to obtain uniform contents for the tablets and capsules.Near-infrared(NIR)spectroscopy with fiber-optic probe was used as an on-line technique for monitoring the homogeneity of...Homogeneity of powder blend is essential to obtain uniform contents for the tablets and capsules.Near-infrared(NIR)spectroscopy with fiber-optic probe was used as an on-line technique for monitoring the homogeneity of pharmaceutical blend during the blending process instead of the traditional techniques,such as high performance liquid chromatograph(HPLC)method.In this paper NIRS with a SabIR difuse reflectance fiber optic probe was used to monitor the blending process of coptis powder and lactose(excipient)with different contents,and further qualitative methods,like similarity,moving block of standard deviation and mean square were used for calculation purposes with the ollected spectra after the pretreatment of multiplicative signal correction(MSC)and second derivative.Correlation spectrum was used for the wavelength selection.Four different coptis were blended with lactose separately to validate the proposed method,and the blending process of "liu wei di huang"pill was also simulated in bottles to verify this method on multiple herbal blends.The overall results suggest that NIRS is a simple,efective and noninvasive technique can be sucssfuly applied to the determination of homogeneity in the herbal blend.展开更多
Morphology evolution of prior β grains of laser solid forming （LSF） Ti-xAl-yV （x 11,y 20） alloys from blended elemental powders is investigated. The formation mechanism of grain morphology is revealed by incorpor...Morphology evolution of prior β grains of laser solid forming （LSF） Ti-xAl-yV （x 11,y 20） alloys from blended elemental powders is investigated. The formation mechanism of grain morphology is revealed by incorporating columnar to equiaxed transition （CET） mechanism during solidification. The morphology of prior β grains of LSF Ti-6Al-yV changes from columnar to equiaxed grains with increasing element V content from 4 to 20 wt.-%. This agrees well with CET theoretical prediction. Likewise, the grain morphology of LSF Ti-xAl-2V from blended elemental powders changes from large columnar to small equiaxed with increasing Al content from 2 to 11 wt.-%. The macro-morphologies of LSF Ti-8Al-2V and Ti-11Al-2V from blended elemental powders do not agree with CET predictions. This is caused by the increased disturbance effects of mixing enthalpy with increasing Al content, generated in the alloying process of Ti, Al, and V in the molten pool.展开更多
基金support from China Postdoctoral Science Foundation Special Funded Project (2013T60604)Zhejiang Provincial Public Welfare Application Project of China (2012C21102)is gratefully acknowledged.
文摘Homogeneity of powder blend is essential to obtain uniform contents for the tablets and capsules.Near-infrared(NIR)spectroscopy with fiber-optic probe was used as an on-line technique for monitoring the homogeneity of pharmaceutical blend during the blending process instead of the traditional techniques,such as high performance liquid chromatograph(HPLC)method.In this paper NIRS with a SabIR difuse reflectance fiber optic probe was used to monitor the blending process of coptis powder and lactose(excipient)with different contents,and further qualitative methods,like similarity,moving block of standard deviation and mean square were used for calculation purposes with the ollected spectra after the pretreatment of multiplicative signal correction(MSC)and second derivative.Correlation spectrum was used for the wavelength selection.Four different coptis were blended with lactose separately to validate the proposed method,and the blending process of "liu wei di huang"pill was also simulated in bottles to verify this method on multiple herbal blends.The overall results suggest that NIRS is a simple,efective and noninvasive technique can be sucssfuly applied to the determination of homogeneity in the herbal blend.
基金supported by the State Key Laboratory of Solidification Processing in NWPU (Nos.SKLSP201102 and 06-BZ-2010)Lthe China Postdoc-toral Science Foundation (No.20100470040)the National Natural Science Foundation of China (No.50871089)
文摘Morphology evolution of prior β grains of laser solid forming （LSF） Ti-xAl-yV （x 11,y 20） alloys from blended elemental powders is investigated. The formation mechanism of grain morphology is revealed by incorporating columnar to equiaxed transition （CET） mechanism during solidification. The morphology of prior β grains of LSF Ti-6Al-yV changes from columnar to equiaxed grains with increasing element V content from 4 to 20 wt.-%. This agrees well with CET theoretical prediction. Likewise, the grain morphology of LSF Ti-xAl-2V from blended elemental powders changes from large columnar to small equiaxed with increasing Al content from 2 to 11 wt.-%. The macro-morphologies of LSF Ti-8Al-2V and Ti-11Al-2V from blended elemental powders do not agree with CET predictions. This is caused by the increased disturbance effects of mixing enthalpy with increasing Al content, generated in the alloying process of Ti, Al, and V in the molten pool.
