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Zingiber cassumunar blended patches for skin application:Formulation,physicochemical properties,and in vitro studies 被引量:1
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作者 Jirapornchai Suksaeree Laksana Charoenchai +4 位作者 Fameera Madaka Chaowalit Monton Apirak Sakunpak Tossaton Charoonratana Wiwat Pichayakorn 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2015年第4期341-349,共9页
Our work was to study the preparation,physicochemical characterization,and in vitro characteristic of Zingiber cassumunar blended patches.The Z.cassumunar blended patches incorporating Z.cassumunar Roxb.also known as ... Our work was to study the preparation,physicochemical characterization,and in vitro characteristic of Zingiber cassumunar blended patches.The Z.cassumunar blended patches incorporating Z.cassumunar Roxb.also known as Plai were prepared from chitosan and polyvinyl alcohol with glycerin as plasticizer.They were prepared by adding all ingredients in a beaker and homogeneously mixing them.Then,they were transferred into Petri-dish and dried in hot air oven.The hydrophilic nature of the Z.cassumunar blended patches was confirmed by the moisture uptake,swelling ratio,erosion,and porosity values.The FTIR,DSC,XRD,and SEM studies showed revealed blended patches with amorphous region that was homogeneously smooth and compact in both surface and cross section dimensions.They exhibited controlled the release behavior of(E)-4-(30,40-dimethoxyphenyl)but-3-en-lol(compound D)that is the main active compound in Z.cassumunar for anti-inflammation activity.However,in in vitro skin permeation study,the compound D was accumulated in newborn pig skin more than in the receptor medium.Thus,the blended patches showed the suitable entrapment and controlled release of compound D.Accordingly,we have demonstrated that such chitosan and polyvinyl alcohol formulated patches might be developed for medical use. 展开更多
关键词 CHITOSAN Polyvinyl alcohol Z.cassumunar patches Blended patches Skin application
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