目的观察BlockBuster喉罩用于泌尿外科日间手术的临床效果。方法选择泌尿外科日间手术患者42例,男38例,女4例,年龄65~83岁,ASAⅠ~Ⅲ级,随机分为BlockBuster喉罩组（B组）和Proseal喉罩组（P组）,每组21例。麻醉诱导后根据患者体重选择...目的观察BlockBuster喉罩用于泌尿外科日间手术的临床效果。方法选择泌尿外科日间手术患者42例,男38例,女4例,年龄65~83岁,ASAⅠ~Ⅲ级,随机分为BlockBuster喉罩组（B组）和Proseal喉罩组（P组）,每组21例。麻醉诱导后根据患者体重选择适当型号的喉罩,B组置入BlockBuster喉罩,P组置入Proseal喉罩;记录两组喉罩一次置入成功率、喉罩置入后15 min PETCO2和Ppeak、经喉罩插管次数或喉罩换管次数、胃反流误吸和拔出喉罩后声嘶、咽痛等并发症的发生情况。结果 B组喉罩一次置入成功率明显高于P组,插管或换管率明显低于P组（P〈0.05）;B组喉罩置入后15min Ppeak明显低于P组（P〈0.05）;B组声嘶发生率明显低于P组（P〈0.05）。结论与Proseal喉罩比较,BlockBuster喉罩在泌尿外科日间手术中可提供良好的声门上气道管理,同时增加声门下应急气管插管通道,反流误吸发生风险小且术后声嘶、咽痛等并发症少,有效提高泌尿外科日间手术术后患者恢复质量。展开更多
THE Chinese film industry once again experienced a boom last year. According to a report released by the State Administration of Press, Publica- tion, Radio, Film and Television on January 5, China＇s box office reven...THE Chinese film industry once again experienced a boom last year. According to a report released by the State Administration of Press, Publica- tion, Radio, Film and Television on January 5, China＇s box office revenue in 2014 reached 29.6 billion yuan （S4.77 billion）, growing 36 percent. Although this sum fell short of the preset target of 30 billion yuan （S4,83 billion）, it more than sufficed to raise a few eyebrows in the inter- national film community, as global box office revenue registered only 4-percent year-on-year growth. In North America. box office numbers actually declined by 6 percent, according to the 2014-15 Chinese Film Industry Report published by EntGroup Consulting. a domestic film industry research firm.展开更多
More and more Chinese films are following the track of big investment. But can they attract more audiences to the cinema? The renowned Chinese director Zhang Yimou has been in the limelight in the entertainment news: ...More and more Chinese films are following the track of big investment. But can they attract more audiences to the cinema? The renowned Chinese director Zhang Yimou has been in the limelight in the entertainment news: he has joined forces again with Gong Li after an 11-year breakup. The former "golden couple" is now devoted to a new movie set in ancient China, which has展开更多
Nine new fluorine-containing drugs have been approved by the US Food and Drug Administration(FDA)in 2021,which are presented in this review article.These small molecular drugs feature aromatic fluorine,trifluoromethyl...Nine new fluorine-containing drugs have been approved by the US Food and Drug Administration(FDA)in 2021,which are presented in this review article.These small molecular drugs feature aromatic fluorine,trifluoromethyl and chlorodifluoro groups.The therapeutic areas of these fluorine-containing drugs include multiple myeloma,lymphoma,HIV,chronic heart failure,chronic myeloid leukemia,(ANCA)-associated vasculitis,migraines,von Hippel-Lindau disease,and non-small cell lung cancer.The brief biological activities and the synthetic methods have been discussed in this review for each of these nine drugs.展开更多
Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this review.Therapeutic areas of these new fluorinated pharmaceuticals include...Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this review.Therapeutic areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing's disease,neurofibromatosis,migraine,Alzheimer's disease,myelodysplastic syndromes,hereditary angioedema attacks,and various cancers.Molecules of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)groups.For each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.展开更多
Lu Jingshan (born 10June 1985),professionally known as Celina Jade,is an actress,singer-songwriter,model and martial artist. Internationally she is best known for her role as Shado (and Mei)in the 2010s CW series Arro...Lu Jingshan (born 10June 1985),professionally known as Celina Jade,is an actress,singer-songwriter,model and martial artist. Internationally she is best known for her role as Shado (and Mei)in the 2010s CW series Arrow.In China she's best known for starring in the 2017blockbuster Wolf Warrior 2,the highest-grossing Chinese film ever.展开更多
This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular dis...This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular disorder,immunodeficiency,virology,and infectious diseases.Medicinal chemistry discovery,biological activity,and synthetic routes have been discussed for each drug.Also,new trends in structural positioning,functionality,and degree of fluorination are discussed.Besides fluorination,the importance of amino acid residues and chirality in the design of new pharmaceuticals is highlighted.展开更多
文摘目的观察BlockBuster喉罩用于泌尿外科日间手术的临床效果。方法选择泌尿外科日间手术患者42例,男38例,女4例,年龄65~83岁,ASAⅠ~Ⅲ级,随机分为BlockBuster喉罩组（B组）和Proseal喉罩组（P组）,每组21例。麻醉诱导后根据患者体重选择适当型号的喉罩,B组置入BlockBuster喉罩,P组置入Proseal喉罩;记录两组喉罩一次置入成功率、喉罩置入后15 min PETCO2和Ppeak、经喉罩插管次数或喉罩换管次数、胃反流误吸和拔出喉罩后声嘶、咽痛等并发症的发生情况。结果 B组喉罩一次置入成功率明显高于P组,插管或换管率明显低于P组（P〈0.05）;B组喉罩置入后15min Ppeak明显低于P组（P〈0.05）;B组声嘶发生率明显低于P组（P〈0.05）。结论与Proseal喉罩比较,BlockBuster喉罩在泌尿外科日间手术中可提供良好的声门上气道管理,同时增加声门下应急气管插管通道,反流误吸发生风险小且术后声嘶、咽痛等并发症少,有效提高泌尿外科日间手术术后患者恢复质量。
文摘THE Chinese film industry once again experienced a boom last year. According to a report released by the State Administration of Press, Publica- tion, Radio, Film and Television on January 5, China＇s box office revenue in 2014 reached 29.6 billion yuan （S4.77 billion）, growing 36 percent. Although this sum fell short of the preset target of 30 billion yuan （S4,83 billion）, it more than sufficed to raise a few eyebrows in the inter- national film community, as global box office revenue registered only 4-percent year-on-year growth. In North America. box office numbers actually declined by 6 percent, according to the 2014-15 Chinese Film Industry Report published by EntGroup Consulting. a domestic film industry research firm.
文摘More and more Chinese films are following the track of big investment. But can they attract more audiences to the cinema? The renowned Chinese director Zhang Yimou has been in the limelight in the entertainment news: he has joined forces again with Gong Li after an 11-year breakup. The former "golden couple" is now devoted to a new movie set in ancient China, which has
基金the financial support from the National Natural Science Foundation of China(No.21761132021)the Qing-Lan Project of Jiangsu Province(for Han)IKERBASQUE,Basque Foundation for Science(for Soloshonok)。
文摘Nine new fluorine-containing drugs have been approved by the US Food and Drug Administration(FDA)in 2021,which are presented in this review article.These small molecular drugs feature aromatic fluorine,trifluoromethyl and chlorodifluoro groups.The therapeutic areas of these fluorine-containing drugs include multiple myeloma,lymphoma,HIV,chronic heart failure,chronic myeloid leukemia,(ANCA)-associated vasculitis,migraines,von Hippel-Lindau disease,and non-small cell lung cancer.The brief biological activities and the synthetic methods have been discussed in this review for each of these nine drugs.
基金the financial support from the National Natural Science Foundation of China(No.21761132021)IKERBASQUE,Basque Foundation for Science.
文摘Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this review.Therapeutic areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing's disease,neurofibromatosis,migraine,Alzheimer's disease,myelodysplastic syndromes,hereditary angioedema attacks,and various cancers.Molecules of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)groups.For each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.
文摘Lu Jingshan (born 10June 1985),professionally known as Celina Jade,is an actress,singer-songwriter,model and martial artist. Internationally she is best known for her role as Shado (and Mei)in the 2010s CW series Arrow.In China she's best known for starring in the 2017blockbuster Wolf Warrior 2,the highest-grossing Chinese film ever.
基金support from the National Natural Science Foundation of China (No.21761132021)the Qing-Lan Project of Jiangsu Province (for Han) and IKERBASQUE,Basque Foundation for Science (for Soloshonok)。
文摘This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular disorder,immunodeficiency,virology,and infectious diseases.Medicinal chemistry discovery,biological activity,and synthetic routes have been discussed for each drug.Also,new trends in structural positioning,functionality,and degree of fluorination are discussed.Besides fluorination,the importance of amino acid residues and chirality in the design of new pharmaceuticals is highlighted.
