Background： Although many previous studies have confirmed that perioperative blood transfusion is associated with poor outcomes after liver transplantation （LT）, few studies described the influence of single-donor ...Background： Although many previous studies have confirmed that perioperative blood transfusion is associated with poor outcomes after liver transplantation （LT）, few studies described the influence of single-donor platelet apheresis transfusion in living donor LT （LDLT）. This study aimed to assess the effect of blood products on outcomes for LDLT recipients, focusing on apheresis platelets. Methods： This retrospective study included 126 recipients who underwent their first adult-to-adult LDLT. Twenty-four variables including consumption of blood products of 126 LDLT recipients were assessed for their link to short-term outcomes and overall survival. Kaplan-Meier survival curve and the log-rank test were used for recipient survival analysis. A multivariate Cox proportional-hazard model and a propensity score analysis were applied to adjust confounders after potential risk factors were identified by a univariate Cox analysis. Results： Patients who received apheresis platelet transfusion had a lower 90-day cumulative survival （78.9% vs. 94.2%, P = 0.009）, but had no significant difference in overall survival in the Cox model, compared with those without apheresis platelet transfusion. Units of apheresis platelet transfusion（hazard ratio[HR]=3.103,95% confidence interval[CI]：1.720–5.600,P〈0.001）and preoperative platelet count（HR=0.170,95% CI：0.040–0.730,P=0.017）impacted 90-day survival independently.Multivariate Cox regression analysis also found that units of red blood cell（RBC）transfusion（HR=1.036,95% CI：1.006–1.067,P=0.018）,recipient＇s age（HR=1.045,95% CI：1.005–1.086,P=0.025）,and ABO blood group comparison（HR=2.990,95% CI：1.341–6.669,P=0.007）were independent risk factors for overall survival after LDLT. Conclusions： This study suggested that apheresis platelets were only associated with early mortality but had no impact on overall survival in LDLT. Units of RBC, recipient＇s age, and ABO group comparison were independent predictors of long-term outcomes.展开更多
目的调查研究机采血小板献血者血液初筛不合格的原因。方法将驻马店市中心血站2022年6月至2022年12月480例机采血小板献血者作为研究对象。在单采血小板献血前,所有献血者均采集肘静脉血4 m L并进行血样初筛,依据《血站技术规程2019版...目的调查研究机采血小板献血者血液初筛不合格的原因。方法将驻马店市中心血站2022年6月至2022年12月480例机采血小板献血者作为研究对象。在单采血小板献血前,所有献血者均采集肘静脉血4 m L并进行血样初筛,依据《血站技术规程2019版》确定血液筛查结果,统计480例机采血小板献血者血液初筛结果与初筛不合格项目;另外对比男性、女性初筛不合格项目。结果共计筛查480例,其中共40例出现血液初筛不合格,初筛不合格率为8.33%;机采血小板献血者血液初筛不合格项目中,丙氨酸转氨酶(ALT)检测值>50 U/L占比为17.50%、血小板计数检测值<150×10^(9)/L占比为25.00%、血细胞比容(HCT)检测值<0.36占比为25.00%、血红蛋白(Hb)检测值不合格占比为2.50%、白细胞计数(WBC)检测值不合格占比为15.00%、乳糜血不合格占比为12.50%、乙型肝炎病毒表面抗原(HBs Ag)阳性占比为2.50%;男性、女性机采血小板献血者血液初筛不合格项目中ALT检测值>50 U/L、Hb检测值不合格率对比差异有统计学意义(P<0.05),其余对比差异无统计学意义(P>0.05)。结论机采血小板献血者血液初筛不合格的项目主要包括ALT检测值>50 U/L、血小板计数检测值<150×10^(9)/L、HCT检测值<0.36占比最高,男性初筛不合格项目主要以ALT检测值>50 U/L为主,女性则主要以Hb检测值不合格为主。展开更多
文摘Background： Although many previous studies have confirmed that perioperative blood transfusion is associated with poor outcomes after liver transplantation （LT）, few studies described the influence of single-donor platelet apheresis transfusion in living donor LT （LDLT）. This study aimed to assess the effect of blood products on outcomes for LDLT recipients, focusing on apheresis platelets. Methods： This retrospective study included 126 recipients who underwent their first adult-to-adult LDLT. Twenty-four variables including consumption of blood products of 126 LDLT recipients were assessed for their link to short-term outcomes and overall survival. Kaplan-Meier survival curve and the log-rank test were used for recipient survival analysis. A multivariate Cox proportional-hazard model and a propensity score analysis were applied to adjust confounders after potential risk factors were identified by a univariate Cox analysis. Results： Patients who received apheresis platelet transfusion had a lower 90-day cumulative survival （78.9% vs. 94.2%, P = 0.009）, but had no significant difference in overall survival in the Cox model, compared with those without apheresis platelet transfusion. Units of apheresis platelet transfusion（hazard ratio[HR]=3.103,95% confidence interval[CI]：1.720–5.600,P〈0.001）and preoperative platelet count（HR=0.170,95% CI：0.040–0.730,P=0.017）impacted 90-day survival independently.Multivariate Cox regression analysis also found that units of red blood cell（RBC）transfusion（HR=1.036,95% CI：1.006–1.067,P=0.018）,recipient＇s age（HR=1.045,95% CI：1.005–1.086,P=0.025）,and ABO blood group comparison（HR=2.990,95% CI：1.341–6.669,P=0.007）were independent risk factors for overall survival after LDLT. Conclusions： This study suggested that apheresis platelets were only associated with early mortality but had no impact on overall survival in LDLT. Units of RBC, recipient＇s age, and ABO group comparison were independent predictors of long-term outcomes.
