Objective To determine the effects of prostaglandin El (PGEl ) on the pulmonary bind flow by using retrograde flush (RF) in lung preservation. Methods Twelve canine donor lungs were treated with RF with UW solution. ...Objective To determine the effects of prostaglandin El (PGEl ) on the pulmonary bind flow by using retrograde flush (RF) in lung preservation. Methods Twelve canine donor lungs were treated with RF with UW solution. In group A (n = 6 ), 250μg of PGE1 wes infused into the pulmonary artery (PA ) before RF and another 250μg wes mixed with UW solution. No PGE1 wes used in group B (n = 6 ). After storage in the mine solution at 4℃ for 22 ~ 25h, the left lung wus transplanted to a recipient followed by 120min reperfusion. Pulmonary bind flow was determined by a microsphere technique. Colored microspheres were infused into the right atrium at the following time: before RF and donor lungs procurement (red ), prior to resecting the recipient left lung (red, served as vaseline), and 120min after donor lung implantation (yellow). Micro- sphere distribution was expressed by optical density per gram lung tissue (OD/g). Results The red microsphere distribution after transplantation in group A wus reduced as compered with baseline (P < 0. 05 ). And more bind flew to the right lung (P < 0. 05 ). The yellow microsphere distribution was also significantly reduced in group A when compered with that of group B (P < 0. 01 ). The hemodynamic bata and bind gases for the two groups were not significantly different. Conclusion After single left lung transplantation, more bind flows to the right side. Pretreatment with PGEl further reduces the flow distribution in the left side.展开更多
文摘Objective To determine the effects of prostaglandin El (PGEl ) on the pulmonary bind flow by using retrograde flush (RF) in lung preservation. Methods Twelve canine donor lungs were treated with RF with UW solution. In group A (n = 6 ), 250μg of PGE1 wes infused into the pulmonary artery (PA ) before RF and another 250μg wes mixed with UW solution. No PGE1 wes used in group B (n = 6 ). After storage in the mine solution at 4℃ for 22 ~ 25h, the left lung wus transplanted to a recipient followed by 120min reperfusion. Pulmonary bind flow was determined by a microsphere technique. Colored microspheres were infused into the right atrium at the following time: before RF and donor lungs procurement (red ), prior to resecting the recipient left lung (red, served as vaseline), and 120min after donor lung implantation (yellow). Micro- sphere distribution was expressed by optical density per gram lung tissue (OD/g). Results The red microsphere distribution after transplantation in group A wus reduced as compered with baseline (P < 0. 05 ). And more bind flew to the right lung (P < 0. 05 ). The yellow microsphere distribution was also significantly reduced in group A when compered with that of group B (P < 0. 01 ). The hemodynamic bata and bind gases for the two groups were not significantly different. Conclusion After single left lung transplantation, more bind flows to the right side. Pretreatment with PGEl further reduces the flow distribution in the left side.
