Background: Blood pressure variability (BPV) in hypertensive patients is implicated as a remarkable feature leading to additional cardiovascular complications. The aim of the study was to identify the determinants inf...Background: Blood pressure variability (BPV) in hypertensive patients is implicated as a remarkable feature leading to additional cardiovascular complications. The aim of the study was to identify the determinants influencing BPV among patients with essential hypertension seen at the Cardiology department of the faculty of medicine, University of Alexandria, Egypt. Methods: This was a descriptive cross-sectional hospital-based study conducted from August 2019 to November 2019. All the eligible patients were made to fill out a standard questionnaire to obtain family and personal clinical history and undergo routine physical examination, laboratory tests and 24-hour ambulatory blood pressure monitoring. BPV was summarized as the standard deviation (SD) of all-day systolic and diastolic BP in both normal patients (with SD 11) and abnormal patients (with SD ≥ 11). Results: Out of a total of 114 patients, 18 (15.8%) non-hypertensive patients were included in the control group and the remaining 96 (84.3%) were classified based on the degree of hypertension. BPV in all these patients was found to be significantly related to the male gender, a mild or moderate degree of hypertension, high prevalence of non-dipping, diabetes, use of beta-blockers as antihypertensive medication, heart rate variability, BMI, and increased day-time variability. Conclusion: Variability in blood pressure influenced by different intrinsic and extrinsic factors plays an important role in the management of hypertension. In order to reduce the burden of disease and for a better quality of life for hypertensive patients, it is important that physicians start considering lowering BPV in addition to reducing physiological BP levels.展开更多
Objective: The aim of this work was to determine the prevalence, associated factors and quality of high blood pressure (HBP) management in three regions of Benin in 2015. Methodology: This was a cross-sectional study,...Objective: The aim of this work was to determine the prevalence, associated factors and quality of high blood pressure (HBP) management in three regions of Benin in 2015. Methodology: This was a cross-sectional study, with two components. The first component included adults aged from 18 to 69 years, selected using a three-stage random sampling within the households. Data were collected thanks to the French version of the WHO STEPS instrument. Anthropometric data, including blood pressure, capillary fasting glucose and total cholesterol were measured according to standard procedures. The second component included Public Health Centers (PHC) selected by a random stratified multi-stage sampling. Data were collected on the structures and the processes of HBP management using the standardized tool for assessing the capacities of management of non-communicable diseases in peripheral health centers provided by the World Health Organization. Results: A total of 4816 participants were included in the first component. The mean age was 35.8 ± 12.7 years. The weighted prevalence of HBP was 27.9% (95% Confidence Interval (CI) [25.6 - 30.2]). It was higher in the 60 - 69 years compared to the lower age groups (Adjusted Odd-ratio (ORa) = 5;95% CI [3.9 - 6.5)]). HBP was positively associated with urban residence (ORa = 1.26;95% CI [1.24 - 1.28]), obesity (ORa = 1.46;95% CI [1.43 - 1.50]), hyperglycemia (ORa = 1.13;95% CI [1.10 - 1.15)]) and hypercholesterolemia (ORa = 1.64;95% CI [1.59 - 1.70)]). A total of 27 PHC were included in the second component. Taking blood pressure and other anthropometric measurements was not routine in PHC. Several essential medicines were not available in the PHC. A low level of community involvement in the management of HBP was noted. Conclusion: This study confirms the high prevalence of HBP and shows inadequacies in its management in the targeted PHC. More appropriate prevention and control measures for HBP should be implemented.展开更多
Poor adherence to standard protocols of blood pressure(BP)measurement in routine clinical practice leads to higher readings than“research-quality”measurements.Whether this phenomenon exists in periodic health examin...Poor adherence to standard protocols of blood pressure(BP)measurement in routine clinical practice leads to higher readings than“research-quality”measurements.Whether this phenomenon exists in periodic health examinations was unknown.We aimed to explore the concordance between BP measurements in periodic health examinations and those measured following a standard measurement protocol.We used data from the Kailuan Study,an ongoing longitudinal cohort study in China,of which participants received biennial health examinations in health management centers.In addition,BPs were measured following standard protocols in a workplace-based hypertension management program nested in the Kailuan Study.We compared BP readings of the same person between the two settings using generalized linear mixed-effects models.A total of 3988 men(the mean age was 44.9 years)had at least two BP measurements both in health examinations and management program with a time interval between the two settings that less than 90 days.The mean systolic blood pressures(SBP)and diastolic blood pressures(DBP)in health examinations were 4.2(95%CI 3.9–4.5)mm Hg and 3.3(95%CI 3.1–3.5)mm Hg higher than those in the management program,respectively.Bland–Altman analyses showed the wide agreement inter-vals ranging from-27.7-to 36.5-mm Hg for SBP and-18.3-to 24.7-mm Hg for DBP.In conclusion,BP measurements in periodic health examinations were generally higher than BPs measured following a standard protocol.Our findings highlight the importance of standard BP measurement to avoid overestimation of hypertension prevalence and treatment initiation.展开更多
目的分析北京市城乡老年人血压与应用抑郁量表(CES-D)检测出的抑郁症状的关系。方法于2000年对一个流行病学队列研究人群2 656例老年人进行血压测量及CES-D的检查,同时进行人口学因素及慢性病情况的调查。结果2 656例老人平均收缩压为(1...目的分析北京市城乡老年人血压与应用抑郁量表(CES-D)检测出的抑郁症状的关系。方法于2000年对一个流行病学队列研究人群2 656例老年人进行血压测量及CES-D的检查,同时进行人口学因素及慢性病情况的调查。结果2 656例老人平均收缩压为(141.16±23.88)mm Hg(1 mm Hg=0.133 kPa),平均舒张压为(80.28±12.15)mm Hg。CES-D平均得分(6.89±9.05)分。其中有抑郁症状者362例(13.6%)。收缩压≥160 mm Hg者抑郁发生率为16.9%,舒张压≥90 mm Hg者抑郁发生率为18.4%,分别显著高于收缩压<160 mm Hg者(12.8%)和舒张压<90 mm Hg者(12.2%),分层分析显示,女性、年龄<75岁、不吸烟的老人收缩压及舒张压增高者抑郁症状出现的比例增大;居住于城市、非文盲、已知有高血压史、高血压史10年以上的老人收缩压增高更易出现抑郁症状;而居住于农村、文盲、高血压史小于10年的老人舒张压增高更易出现抑郁症状。多元logistic回归分析显示,舒张压增高、慢性病史、女性、文盲、农村老人易患抑郁。结论老年人血压增高与抑郁相关。展开更多
文摘Background: Blood pressure variability (BPV) in hypertensive patients is implicated as a remarkable feature leading to additional cardiovascular complications. The aim of the study was to identify the determinants influencing BPV among patients with essential hypertension seen at the Cardiology department of the faculty of medicine, University of Alexandria, Egypt. Methods: This was a descriptive cross-sectional hospital-based study conducted from August 2019 to November 2019. All the eligible patients were made to fill out a standard questionnaire to obtain family and personal clinical history and undergo routine physical examination, laboratory tests and 24-hour ambulatory blood pressure monitoring. BPV was summarized as the standard deviation (SD) of all-day systolic and diastolic BP in both normal patients (with SD 11) and abnormal patients (with SD ≥ 11). Results: Out of a total of 114 patients, 18 (15.8%) non-hypertensive patients were included in the control group and the remaining 96 (84.3%) were classified based on the degree of hypertension. BPV in all these patients was found to be significantly related to the male gender, a mild or moderate degree of hypertension, high prevalence of non-dipping, diabetes, use of beta-blockers as antihypertensive medication, heart rate variability, BMI, and increased day-time variability. Conclusion: Variability in blood pressure influenced by different intrinsic and extrinsic factors plays an important role in the management of hypertension. In order to reduce the burden of disease and for a better quality of life for hypertensive patients, it is important that physicians start considering lowering BPV in addition to reducing physiological BP levels.
文摘Objective: The aim of this work was to determine the prevalence, associated factors and quality of high blood pressure (HBP) management in three regions of Benin in 2015. Methodology: This was a cross-sectional study, with two components. The first component included adults aged from 18 to 69 years, selected using a three-stage random sampling within the households. Data were collected thanks to the French version of the WHO STEPS instrument. Anthropometric data, including blood pressure, capillary fasting glucose and total cholesterol were measured according to standard procedures. The second component included Public Health Centers (PHC) selected by a random stratified multi-stage sampling. Data were collected on the structures and the processes of HBP management using the standardized tool for assessing the capacities of management of non-communicable diseases in peripheral health centers provided by the World Health Organization. Results: A total of 4816 participants were included in the first component. The mean age was 35.8 ± 12.7 years. The weighted prevalence of HBP was 27.9% (95% Confidence Interval (CI) [25.6 - 30.2]). It was higher in the 60 - 69 years compared to the lower age groups (Adjusted Odd-ratio (ORa) = 5;95% CI [3.9 - 6.5)]). HBP was positively associated with urban residence (ORa = 1.26;95% CI [1.24 - 1.28]), obesity (ORa = 1.46;95% CI [1.43 - 1.50]), hyperglycemia (ORa = 1.13;95% CI [1.10 - 1.15)]) and hypercholesterolemia (ORa = 1.64;95% CI [1.59 - 1.70)]). A total of 27 PHC were included in the second component. Taking blood pressure and other anthropometric measurements was not routine in PHC. Several essential medicines were not available in the PHC. A low level of community involvement in the management of HBP was noted. Conclusion: This study confirms the high prevalence of HBP and shows inadequacies in its management in the targeted PHC. More appropriate prevention and control measures for HBP should be implemented.
基金supported by National Natural Science Foundation of China(81930124 and 82021005)Shanghai Municipal Science and Technology Major Project(Grant No.2017SHZDZX01).
文摘Poor adherence to standard protocols of blood pressure(BP)measurement in routine clinical practice leads to higher readings than“research-quality”measurements.Whether this phenomenon exists in periodic health examinations was unknown.We aimed to explore the concordance between BP measurements in periodic health examinations and those measured following a standard measurement protocol.We used data from the Kailuan Study,an ongoing longitudinal cohort study in China,of which participants received biennial health examinations in health management centers.In addition,BPs were measured following standard protocols in a workplace-based hypertension management program nested in the Kailuan Study.We compared BP readings of the same person between the two settings using generalized linear mixed-effects models.A total of 3988 men(the mean age was 44.9 years)had at least two BP measurements both in health examinations and management program with a time interval between the two settings that less than 90 days.The mean systolic blood pressures(SBP)and diastolic blood pressures(DBP)in health examinations were 4.2(95%CI 3.9–4.5)mm Hg and 3.3(95%CI 3.1–3.5)mm Hg higher than those in the management program,respectively.Bland–Altman analyses showed the wide agreement inter-vals ranging from-27.7-to 36.5-mm Hg for SBP and-18.3-to 24.7-mm Hg for DBP.In conclusion,BP measurements in periodic health examinations were generally higher than BPs measured following a standard protocol.Our findings highlight the importance of standard BP measurement to avoid overestimation of hypertension prevalence and treatment initiation.
文摘目的分析北京市城乡老年人血压与应用抑郁量表(CES-D)检测出的抑郁症状的关系。方法于2000年对一个流行病学队列研究人群2 656例老年人进行血压测量及CES-D的检查,同时进行人口学因素及慢性病情况的调查。结果2 656例老人平均收缩压为(141.16±23.88)mm Hg(1 mm Hg=0.133 kPa),平均舒张压为(80.28±12.15)mm Hg。CES-D平均得分(6.89±9.05)分。其中有抑郁症状者362例(13.6%)。收缩压≥160 mm Hg者抑郁发生率为16.9%,舒张压≥90 mm Hg者抑郁发生率为18.4%,分别显著高于收缩压<160 mm Hg者(12.8%)和舒张压<90 mm Hg者(12.2%),分层分析显示,女性、年龄<75岁、不吸烟的老人收缩压及舒张压增高者抑郁症状出现的比例增大;居住于城市、非文盲、已知有高血压史、高血压史10年以上的老人收缩压增高更易出现抑郁症状;而居住于农村、文盲、高血压史小于10年的老人舒张压增高更易出现抑郁症状。多元logistic回归分析显示,舒张压增高、慢性病史、女性、文盲、农村老人易患抑郁。结论老年人血压增高与抑郁相关。
文摘目的探讨血压变异性(BPV)与高血压小卒中患者急性期神经功能恶化的关系。方法选取高血压小卒中患者200例,根据患者是否发生急性期神经功能恶化分为稳定组(182例)和恶化组(18例),比较2组患者24 h动态血压监测的BPV,24 h收缩压血压变异系数(24 h CVSBP)、24 h舒张压血压变异系数(24 h CVDBP)、白昼收缩压血压变异系数(d CVSBP)、白昼舒张压血压变异系数(d CVDBP)、夜间收缩压血压变异系数(n CVSBP)、夜间舒张压血压变异系数(n CVDBP)。采用Binary Logistic回归分析高血压小卒中患者急性期神经功能恶化的BPV相关因素。结果与稳定组比较,恶化组24 h CVSBP为17.75%(17.54%,19.26%)vs 12.78%(10.67%,14.39%)、24 h CVDBP为25.48%(20.77%,27.87%)vs 17.95%(14.88%,21.46%)、d CVSBP为18.61%(17.65%,20.65%)vs 12.30%(10.10%,14.75%)、d CVDBP为25.65%(21.25%,29.78%)vs 17.76%(14.89%,22.19%)均升高,差异有统计学意义(均P<0.01)。Binary Logistic回归分析显示24 h CVSBP、d CVSBP是高血压小卒中患者急性期神经功能恶化的危险因素。结论 24 h BPV和白昼BPV增加可能与高血压小卒中患者急性期神经功能恶化有关,在卒中急性期和二级预防中应关注BPV。
