Analysis of herbs-combination of Professor Yang Su-qing in the treatment of psoriasis vulgaris with blood stasis syndrome

Objective:To explore Professor Yang Suqing’s experience in treating blood stasis syndrome of psoriasis vulgaris and analyze the characteristics of its prescription;Methods:Outpatient prescriptions for the treatment of psoriasis vulgaris with blood stasis syndrome were selected and extracted traditional Chinese medicine for standardized processing.Then analyze the data by using set visualization analysis and Apriori algorithm.Results:A total of 149 traditional Chinese herbs were extracted.Among them,and the top 12 commonly used herbs with frequency>30 were Licorice,Saposhnikovia,Schizonepeta tenuifolia,Angelica sinensis,Paeonia lactiflora,Ligusticum chuanxiong,Rehmannia glutinosa,Cicada slough,Oyster and Keel through the set visualization analysis,herbs association rules analysis,and herbs combination analysis.Saposhnikovia,Liquorice,Schizonepeta tenuifolia,Angelica sinensis and Paeonia Alba are the most commonly used combination of herbs by Professor Yang Suqing in the treatment of blood stasis syndrome of psoriasis vulgaris.Conclusion:In addition to invigorating blood circulation and removing blood stasis herbs,which are preferred for the treatment of blood stasis syndromes,Saposhnikovia and Schizonepeta tenuifolia,etc.,are used to synergistically exert the functions of invigorating blood circulation and removing blood stasis and eliminating wind expression,with remarkable efficacy.

Effect of Yinxieling decoction on PASI,TNF-α and IL-8 in patients with psoriasis vulgaris

Objective:To study the effect of Yinxieling decoction on PASI,TNF-α and IL-8 in patients with psoriasis vulgaris.Methods:A total of 120 cases of psoriasis vulgaris were divided into 4 groups according to syndrome differentiation of TCM and randomized controlled method:wind heat syndrome group(group A).blood stasis syndrome group(group B) blood dryness syndrome group(group C)nd control group(group D)(n=30 per group).Patients in observation groups were treated with Yinxieling decoction,while patients in control group were treated by placebo for 8 weeks.Levels of TNT-α and IL-8 were determined before treatment.4 and 8 weeks after treatment.psoriasis area and severity index score was also performed before and after treatment.Results:psoriasis area and severity index score and serum level of TNF-α,IL-8 were significantly decreased in all groups.The decrease in three observation groups was more significant(P<0.05 or P<0.01),and the decrease in wind heat syndrome group was the most significant(P<0.01).psoriasis area and severity index was positively correlated with TNF-α and IT.-8,respectively(P<0.05).Conclusions:Yinxieling decoction has therapeutical effect on psoriasis vulgaris via regulating TNF-α and IL-8.

Traditional Chinese Medicine nursing protocols for psoriasis vulgaris（英文）

Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes including psoriasis vulgaris, pustular psoriasis, guttate psoriasis and erythrodermic psoriasis, in which psoriasis vulgaris is most common. In recent years, Traditional Chinese Medicine(TCM) has attracted widespread attention in the treatment of psoriasis because of better efficacy and a lower incidence of adverse reactions. In TCM, psoriasis is considered to be caused by blood heat and the stagnation of Qi and blood. This article primarily investigated the key points of common syndromes, TCM nursing methods and healthy guidance of psoriasis vulgaris, aiming at maintaining and developing the strengths of TCM, improving its efficacy and standardizing its behavior.

Literature Research of Chinese Medicine Recipes for the Treatment of Psoriasis Vulgaris with Blood-heat Syndrome Type

Objective：To analyze and investigate the rules for drug utilization of Chinese medicine for the treatment of psoriasis vulgaris with blood-heat syndrome.Methods：The literatures that met the following inclusion criteria were screened out from China National Knowledge Infrastructure（CNKI） from January 1998 to December 2008,including the compositions and dosages of the recipes reported completely and accurately, the sample size being30 cases and the total effective rate being70%.Results：In total,289 papers meeting the inclusion criteria were retrieved,involving 301 recipes;in which 111 recipes consisting of 145 individual drugs were the function for clearing the heat,accounting for 52.84%.The three drugs with the highest utilized frequency were Radix Rehmanniae,Radix Arnebiae seu Lithospermi and Cortex Moutan.Meridian adscription of the drugs was mainly the Gan（肝）-meridian.Conclusion：There were rules for the treatment of psoriasis vulgaris of blood-heat syndrome with Chinese medicine prescriptions.

Expression of T-Helper 17 Cells and Signal Transducers in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome and Blood-Stasis Syndrome

Objective： To investigate the levels of cytokines related to T-helper （Th） 17 cells in serum and signal transducers in the psoriatic lesions of patients with psoriasis vulgaris of blood-heat syndrome （BHS） and blood-stasis syndrome （BSS）. Methods： Sixty patients with psoriasis vulgaris were divided into the BHS and BSS groups according to the syndrome differentiation of Chinese medicine （CM）. Ten healthy subjects were considered as the control group. Cytokine levels of interleukin （IL）-17, IL-23 and IL-6 in serum were determined by enzyme-linked immunosorbent assay. Expression levels of signal transducer and activator of transcription 3 （STAT3）, p38-mitogen-activated protein kinase （MAPK） and STAT6 in the psoriatic lesions were determined using immunohistochemistry （IHC）, Western blot, and real-time quantitative reverse transcription polymerase chain reaction, respectively. Results： Production of IL-17, IL-23 and IL-6 in the BHS group and BSS group were significantly increased compared with those in the control group （P〈0.05）. Levels of IL-17 and IL-23 in the BHS group were higher than those in the BSS group （P〈0.05）. Compared with the control group, IHC positive expressions and protein expressions of STAT3 and p38-MAPK, and the STAT3 mRNA expressions in the BHS and BSS groups were significantly higher （P〈0.05 or P〈0.01）. The protein expression of STAT3 in the BHS group was significantly higher than that in the BSS group （P〈0.05）. Conclusions： Cytokines in serum and signal transducers in the psoriatic lesions alter with various CM syndromes of psoriasis. The results provide scientific basis for the treatment based on syndrome differentiation of CM in treating psoriasis vulgaris.

Circulating Levels of Inflammatory Cytokines in Patients with Psoriasis Vulgaris of Different Chinese Medicine Syndromes

Objective： To investigate whether the serum levels of inflammation-related cytokines might be different between the healthy individuals and the psoriatic patients diagnosed of three varied Chinese medicine （CM） syndromes [blood-stasis syndrome （BSS）, blood-dryness syndrome （BDS） and wind-heat syndrome （WHS）]. Methods： A total of 62 psoriatic patients were recruited and assigned to 3 groups according to their CM syndromes, including 27 patients of BSS, 21 of BDS and 14 of WHS. Another 20 sex- and age- matched healthy subjects were enrolled into the control group. Serum concentrations of multiple cytokines, including monocyte chemotactic protein-1 （MCP-1）, macrophage inflammatory protein-1α （MIP-1α）, soluble CD40 ligand （SCD40L）, tumor necrosis factor-α （TNF-α）, epidermal growth factor （EGF）, interleukin-8 （IL-8）, interleukin-17 （IL-17）, interferon γ inducible protein-10 （IP-10） and vascular endothelial growth factor （VEGF）, were measured by a multiplexed flow cytometric assay. Results： The circulating levels of MIP-1α, TNF-α, IL-8, and IP-10 were significantly increased in the psoriatic patients compared with the healthy controls （P〈0.01）. Male and female patients tended to have higher serum levels of MCP-1 and IP-10, respectively （P〈0.05）. Interestingly, compared with the control group, 6 out of the 9 cytokines （MCP-1, MIP-1α, TNF-α, EGF, IL-8 and IP-10） were substantially increased in the BSS group （P〈0.05 or P〈0.01）, whereas only MIP-1α and IL-8 levels were elevated in the BDS group （P〈0.05 or P〈0.01） concurrent with lowered concentrations of SCD40L and IL-17 （P〈0.05）. In the WHS group, MIP-1α was the only cytokine whose level was evidently increased （P〈0.01）, in contrast to IL-17 which was decreased as compared with the control （P〈0.05）. The psoriatic patients overall owned higher levels of MIP-1 a and IL-8 in the circulation which were comparable among the 3 groups of CM syndromes （P〈0.01）. In contrast, TNF-α level of the BSS group was the highest among the three （P〈0.01）, followed by the BDS and the WHS groups. Conclusions： The expression profiles of cytokines in the circulation might not be necessarily identical for psoriatic patients with different CM syndromes. Accordingly, the serum concentrations of certain cytokines could potentially be used as the ancillary indices for the clinical classification of psoriatic CM syndromes.

Applying latent tree analysis to classify Traditional Chinese Medicine syndromes(Zheng)in patients with psoriasis vulgaris

OBJECTIVE:To treat patients with psoriasis vulgaris using Traditional Chinese Medicine(TCM),one must stratify patients into subtypes(known as TCM syndromes or Zheng)and apply appropriate TCM treatments to different subtypes.However,no unified symptom-based classification scheme of subtypes(Zheng)exists for psoriasis vulgaris.The present paper aims to classify patients with psoriasis vulgaris into different subtypes via the analysis of clinical TCM symptom and sign data.METHODS:A cross-sectional survey was carried out in Beijing from 2005-2008,collecting clinical TCM symptom and sign data from 2764 patients with psoriasis vulgaris.Roughly 108 symptoms and signs were initially analyzed using latent tree analysis,with a selection of the resulting latent variables then used as features to cluster patients into subtypes.RESULTS:The initial latent tree analysis yielded a model with 43 latent variables.The second phase of the analysis divided patients into three subtype groups with clear TCM Zheng connotations:'blood deficiency and wind dryness';'blood heat';and'blood stasis'.CONCLUSIONS:Via two-phase analysis of clinic symptom and sign data,three different Zheng subtypes were identified for psoriasis vulgaris.Statistical characteristics of the three subtypes are presented.This constitutes an evidence-based solution to the syndromedifferentiation problem that exists with psoriasis vulgaris.

Correlation analysis of Treg/Th17 cells and related cytokines in patients with psoriasis vulgaris

OBJECTIVE: To investigate potential differences in circulating levels of T regulatory (Treg)/T helper 17 (Th17) cells, related inflammatory cytokines and specific transcription factors in healthy individuals and patients with psoriasis conforming to one of three Traditional Chinese Medicine (TCM) syndromes: blood-heat syndrome (BHS), blood-stasis syndrome (BSS) and blood-dryness syndrome (BDS). METHODS: Sixty-seven patients with psoriasis were recruited and assigned to one of three corresponding TCM syndrome groups: BHS (n = 40), BSS (n = 14) and BDS (n = 13 patients). The control group comprised 21 healthy individuals. The circulating levels of Treg/Th17 cells in peripheral blood were assessed using flow cytometry;the levels of inflammatory cytokines interleukin (IL)-10 and tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay;and the mRNA expression of T cell-specific transcription factors retinoic acid-related orphan receptor γt (RORγt) and forkhead box P3 (Foxp3) by quantitative real-time PCR. RESULTS: The ratio of Th17 cells and the levels of TNF-α and RORγt were all significantly higher in the BHS and BSS groups than the control group (P < 0.05), while the ratio of Treg cells and the levels of IL-10 and Foxp3 mRNA in the BHS group were significantly lower compared with the control group (P < 0.05). No significant differences were seen between the BSS group and the control group. The ratio of Th17 cells and the levels of TNF-α and RORγt in the BDS group were not significantly different from those of the control group;however, the ratio of Treg cells and the levels of IL-10 and Foxp3 were all lower than those in the healthy controls (P < 0.05). CONCLUSION: Compared with healthy individuals, the ratio of Th17 cells and the levels of related cytokines were higher, while the ratio of Treg cells and the levels of related cytokines were lower, in the peripheral blood of psoriasis/BHS patients;corresponding results for the BSS and BDS groups also showed differences. We propose that patterns of differentiation of immunological cells in psoriasis patients are reflected in corresponding TCM blood syndromes.

吴淞治疗斑块型银屑病合并代谢综合征临证经验总结

银屑病是一种常见的难治性皮肤病。中医辨证斑块型银屑病时大多从血论治,往往收效欠佳。吴淞教授认为寻常型斑块型银屑病与代谢综合征双方的病理基础存在类似部分,然中医病机方面研究还存在不足。吴师提出,银屑病合并代谢综合征患者的发病过程中,大多阳气不足,玄府闭塞为基础,痰湿停滞以及瘀血壅塞起着关键性作用,病位主要在于肾、肺、脾、肝,主要病机为痰、湿、瘀三者互结,病性为本虚标实,治疗上,在温阳开通玄府的基础上灵活加以健脾除湿、活血化瘀、清热解毒等等其他疗法。同时配合中药外治、人文关怀、慢病管理等多种措施,疗效显著。

基于文献研究及德尔菲法构建寻常型银屑病脾虚湿蕴证的诊断标准

【目的】采用文献研究、专家主观经验评价及数理统计分析三者结合以构建寻常型银屑病脾虚湿蕴证的诊断标准。【方法】通过文献研究构建寻常型银屑病脾虚湿蕴证相关症状、体征备选条目池,运用德尔菲法对全国32位专家进行4轮问卷调查,分析专家对各备选条目意见的集中程度及协调程度。第三轮调查根据各条目的权重系数将诊断指标分为主症及次症,形成多个证候诊断判断条件选项,再通过第四轮专家调查,明确脾虚湿蕴证的诊断模式及诊断条件。【结果】根据专家意见集中程度、变异系数对各证候诊断备选条目进行筛选,经同类合并,形成诊断指标24个,形成主症3个(纳呆食少、便溏、舌淡胖边有齿印),次症21个(如腹胀、口淡不渴、形体肥胖、嗜睡、倦怠乏力、脉细滑、脉濡、大便完谷不化、皮损颜色淡红等)。第四轮专家调查确认了“病位脾”“病性气虚”“病性湿”为诊断的必要条件;银屑病脾虚湿蕴证的诊断条件确定为:(1)具有3个主要症状;(2)具备2个主要症状+任2个次要症状。【结论】所构建的寻常型银屑病脾虚湿蕴证的诊断标准包含主症及次症,条件要求明确,易于临床操作,具有较好的临床适用性。

寻常型银屑病中医证型与血清miR-155、TGF-β1及PASI评分相关性研究

目的:探讨寻常型银屑病中医证型与血清miR-155、转化生长因子β1(TGF-β1)、银屑病皮损面积及严重程度指数(PASI)评分相关性研究。方法:回顾性选取2021年9月~2023年9月北京中医药大学东直门医院收治120例的寻常型银屑病患者为研究对象。统计寻常型银屑病中医证型分布情况,比较不同中医证型患者血清miR-155、TGF-β1水平及PASI评分,分析寻常型银屑病中医证型与血清miR-155、TGF-β1水平与PASI评分的关系。结果:120例寻常型银屑病患者中血热证51例、血瘀证38例、血燥证31例;不同中医证型寻常型银屑病患者血清miR-155、TGF-β1水平及PASI评分为血热证>血瘀证>血燥证( P <0.05);寻常型银屑病患者血清miR-155、TGF-β1水平与PASI评分呈正相关(r=0.649、 P <0.05,r=0.676、 P <0.05)。结果:寻常型银屑病中医证型与血清miR-155、TGF-β1水平及PASI评分具有良好的相关性,可以为寻常型银屑病患者辨证施治提供指导。

李树君治疗寻常型银屑病经验介绍

介绍李树君主任医师治疗寻常型银屑病的临床经验。李树君认为寻常型银屑病的基本病机是血热内蕴,且贯穿病程始终,故将其基本病证分为血热和血燥两种证型,同时主张有侧重地运用从血辨证、从卫气营血辨证、从脏腑辨证、从经络辨证,治疗上重视调脾胃、护阴液、调冲任,辨证用药,并借鉴现代中药药理学研究成果针对性用药。

基于四川地域特色探讨寻常性银屑病的中医治疗

银屑病是常见的慢性炎症性皮肤病,中医又称白疕。历代中医医家非常重视地域因素对疾病造成的影响,强调气候、饮食、体质等因素在患病过程中所发挥的重要作用。结合四川地区独特的地理位置和气候环境,经过长期的临床实践与总结,本文提出寻常性银屑病以脾虚为本,湿热内蕴为因,皮肤红斑鳞屑为果,提倡以寒温并调、清热利湿、健脾疏肝为治法,以标本兼治、扶正祛邪为目的治疗银屑病,临床常取得较为满意的疗效。本文介绍了川派皮科对银屑病的中医认识及治疗经验,以期为中医治疗寻常性银屑病的提供思路。

走罐联合火针治疗血瘀型白疕临床观察

目的 观察走罐联合火针治疗血瘀型白疕的临床效果。方法 将2020年1月—2021年3月于江西省中西医结合医院皮肤科住院的80例血瘀型白疕患者随机分为试验组和对照组。试验组在常规护理的基础上使用走罐联合火针治疗,对照组在常规护理的基础上外擦卡泊三醇软膏和黄连膏治疗,治疗时间均为30 d。对比2组皮损面积和严重程度指数(PASI)评分、瘙痒情况及临床疗效。结果 试验组PASI评分低于对照组(P<0.05);试验组瘙痒情况优于对照组(P<0.05);试验治疗总有效率95.00%(38/40)高于对照组的75.00%(30/40)(P<0.05)。结论 走罐联合火针治疗对血瘀型白疕患者的恢复具有促进作用。

儿童寻常型银屑病辨证论治临床经验总结

银屑病是一种慢性、复发性、免疫性、系统性皮肤病,临床以红斑、丘疹,其上覆白色鳞屑为主要临床表现,分为寻常型、脓疱型、红皮病型、关节型四种类型,中医俗称“白疕”“松皮癣”等,中医病因病机与多血分热毒炽盛,营血亏耗,瘀血阻滞,化燥生风,肌肤失养关系密切,西医病因病机与遗传、环境、免疫功能等因素密切相关。儿童银屑病则以儿童为发病群体,儿童寻常型银屑病是儿童银屑病中最常见的类型,以点滴状皮损表现最为多见。文章指出中医病因病机还应考虑肺卫受邪致病,西医病因病机常与溶血性链球菌感染相关。在儿童寻常型银屑病的诊疗过程中还需注意儿童“心肝有余,脾肾易虚,肺为娇脏,易实易虚”的特殊体质,结合体质辨证处方用药。王建青主任认为儿童寻常型银屑病以肺卫热毒为主要病机,病变主要在卫分,治疗以轻宣肺卫、透表解毒为主要治则,以牛蒡解肌汤加减组方,擅长运用轻宣透邪之品,其独特的治疗经验在临床应用中取得了满意疗效。

自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)的临床疗效及对生活质量的影响

目的:观察自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)的临床疗效及对患者生活质量的影响。方法:将80例寻常型银屑病(血热证)患者随机分为观察组和对照组,每组40例。对照组予以阿维A胶囊20~30 mg/d,卡泊三醇轻柔均匀涂抹于皮损处,2次/d,治疗4周。观察组加用自拟解毒凉血汤,药用生槐花15 g,紫草20 g,生地黄30 g,牡丹皮20 g,白茅根15 g,土茯苓15 g,金银花15 g,白鲜皮15 g,水牛角30 g,板蓝根15 g,龙骨(先煎)30 g,牡蛎(先煎)30 g,远志15 g,由医院统一制成装袋,200 mL/袋,1袋/次,2次/d,治疗4周。比较两组治疗后临床疗效、皮损面积和严重程度、炎性因子水平、瘙痒程度、生活质量评分。结果:治疗后,观察组总有效率高于对照组(P<0.05),炎性因子水平、银屑病皮损面积和严重程度评分、瘙痒评分、生活质量评分均低于对照组(P<0.05)。结论:自拟解毒凉血汤联合西药治疗寻常型银屑病(血热证)能提高临床疗效,改善临床症状,降低炎性反应,提高患者生活质量。

基于文献研究及德尔菲法的寻常型银屑病肝气郁结证诊断标准的建立

目的调查专家对寻常型银屑病肝气郁结证的证候诊断经验,筛选该证候的诊断指标,评价其重要性,形成本病证候诊断标准。方法在文献研究的基础上,通过德尔菲法对全国32位专家进行4轮问卷调查,分析专家意见集中程度及协调程度,第4轮根据权重将各诊断指标分为主症及次症,形成肝气郁结证诊断标准。结果基于文献研究,共有27个证候诊断备选条目进入备选条目池。根据专家意见集中程度、协调程度对各证候诊断指标进行筛选,形成诊断指标19个,经同类合并,形成主症3个、次症7个。专家认可度较高的诊断标准判断条件选项为2个。结论专家的积极程度和专业程度较高,意见可信度较高,且协调程度较高。经过4轮调查,形成寻常型银屑病肝气郁结证的诊断标准。

雷公藤多苷片辅助治疗寻常型银屑病血热证临床研究

目的:观察雷公藤多苷片辅助治疗寻常型银屑病血热证的临床疗效。方法:按随机数字表法将82例血热证银屑病患者分为联合组和对照组各41例。对照组给予窄谱中波紫外线(NB-UVB)全身照射治疗,联合组在对照组基础上加用雷公藤多苷片治疗。比较2组治疗前后中医证候积分、皮损面积与严重程度指数量表(PASI)评分、生活质量指数量表(DLQI)评分、皮肤屏障功能、炎性因子,统计临床疗效及不良反应发生率。结果:联合组总有效率为90.24%,高于对照组73.17%(P<0.05)。治疗后,2组各项中医证候评分均较治疗前降低(P<0.05),且联合组各项中医证候评分低于对照组(P<0.05)。治疗后,2组PASI、DLQI评分较治疗前降低(P<0.05),且联合组PASI、DLQI评分低于对照组(P<0.05)。治疗后,2组角质层含水量、皮脂含量较治疗前增高,经表皮水分丢失率(TEWL)较治疗前降低(P<0.05);且联合组角质层含水量、皮脂含量高于对照组,TEWL低于对照组(P<0.05)。治疗后,2组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)水平较治疗前降低(P<0.05),且联合组血清TNF-α、IL-17水平低于对照组(P<0.05)。结论:雷公藤多苷片辅助治疗寻常型银屑病血热证患者疗效更佳,能降低皮损严重程度与炎症反应、调节皮肤屏障功能,提高生活质量,且安全性较高。

加味芩珠凉血方及辨证加减治疗寻常型银屑病(血热证)的临床疗效观察

目的观察加味芩珠凉血方及辨证加减治疗寻常型银屑病(血热证)的临床疗效。方法选取105例寻常型银屑病血热证患者,随机分为加味芩珠凉血方辨证加减治疗组39例、加味芩珠凉血方固定方治疗组36例和复方青黛胶囊治疗组30例,用药前后观察三组银屑病面积和严重程度评分法(PASI)的变化。结果临床研究显示,辨证加减治疗组总有效率为77.8%,愈显率为41.7%。固定方组总有效率为61.29%,愈显率为32.3%。复方青黛组总有效率为46.37%,愈显率为3.3%。辨证加减组总有效率明显优于固定方组和复方青黛组,愈显率与固定方组相当,优于复方青黛组,固定方组总有效率及愈显率均优于复方青黛组,经统计学分析差异有显著性(P<0.05)。结论该研究证实加味芩珠凉血方治疗寻常型银屑病血热证的疗效稳定、安全、有效,在此原则上,辨证加减更能提高疗效,减少副反应。

应用集对分析法构建寻常型银屑病血热证辨证模型

目的通过对寻常型银屑病血热证临床症状进行同、异、反的定量刻画,建立相应的集对分析数学模型,从而指导临床,提高临床辨证的准确性。方法选择采用凉血潜阳法治疗后具有完整资料的202例寻常型银屑病血热证患者,系统收集其临床症状、体征等。通过集对分析的方法 ,将治疗结局为痊愈及显效的归为同部,有效归为异部,无效归为反部,根据公式计算各项辨证因子的U值,筛选寻常型银屑病血热证中医辨证相关的联系因子,根据各辨证因子联系数的大小,构建寻常型银屑病血热证辨证模型。结果鳞屑积分>2.04,红斑积分>2.34,年龄>50岁,面积积分>2.07,口干,脉滑,苔黄,脉濡,大便干结为银屑病血热证的主要辨证因子;汗出减少,失眠,脉数,任何程度的病变浸润,皮损发于任何部位,舌红,精神抑郁,病程1～360个月,年龄16～50岁,脉弦,苔薄,面积积分0+～2.07,苔白,舌紫,鳞屑积分0+～2.04,脉细弱为次要辨证因子;红斑积分0+～2.34,舌淡为再次辨证因子。寻常型银屑病血热证集对分析模型建立为:U血热证=∑An/N+∑Bmi/M+∑Cpj/P。结论 U血热证≥0.75可判定为血热证,采用中医凉血治疗即可取得不错的疗效;U血热证<0.75,则患者在血热证基础上伴有其他证型,单纯凉血治疗效果不好。