Assessment of the relationship between body mass index (BMI) and dental age

The aim of the study was to determine the rela-tionship between Body Mass Index (BMI) and accelerated dental development. The dental developmental ages of 100 children aged between 8 and 12 years were determined using the Demirjian method and panoramic radiographs. BMI status was determined for each subject on the basis of the system developed by the International Obesity Task Force. There was a significant direct relationship between dental development and BMI (P < 0.01). Obese children have a higher rate of dental development compared to normal children. CLINICAL RELEVANCE: This is an important variable to be considered when planning for dental and orthodontic treatments in obese children. Brief objectives statement: Overweight or obesity can accelerate dental development. Accelerated dental development in overweight children is important to be considered in pediatric dentistry and orthodontics.

Eating Habits, Family Flexibility and the Body Mass Index (BMI) in Gifted Students

The aim of this research was to examine the effect of eating habits and family flexibility on the body mass index in gifted students of the eighth and ninth grade of high school. The research design of this study was descriptive-correlation. The statistical population of this research included all high school gifted students of the eighth and ninth grade. The sample consisted of 220 gifted students who were selected by random sampling method. The average age of these participants was 14.56 years old, SD 10.41. Average participants BMI was 31.25, SD 3.12. One hundred and fifteen (52.28%) of these students were females and one hundred and five (47.72%) were males. Family flexibility was measured by Shakeri flexibility scale, eating habits were measured through Coker and Roger Eating Habits Questionnaire and body mass index was tested by Omron digital device. Using SPSS software, the data were analyzed to calculate correlation and simultaneous regression. The results of correlation showed that in these students, concern with weight and dieting and total eating habits have significant relationship with BMI (P < 0.001). The result of simultaneous regression also showed that concern with weight and dieting and total eating habits could explain BMI in these students (P < 0.001) and family flexibility could not explain BMI in these students (P < 0.005). The results emphasize the more important role of eating habits than family flexibility on BMI in gifted students because of sensitive and higher level of intelligence and high peer competitions.

A comparison of elderly (20～65 yrs) life style with body mass index (BMI)25

Objective:compare the habits and features of obese (BMI>25) and normal (BMI<25) individuals and express a method to ameliorate the life styles using a cross-sectional experiment.Methods:A total of 220 randomly selected cases were divided into case group (n=110) and control group (n=100) according to the calculated BMI level.Samples with BMI>25 kg/m2 were assigned to the case (obsess) group and those with BMI ranging from 20 to 25 were assigned to control (normal) group.The Miller-Smith life style questionnaires consisting 20 questions each with 5 different answers were given to both groups.Data of the questionnaires were collected and analyzed using t-test and Chi-square with SPSS.Results:No significant differences were found among the two groups in terms of the mean age,gender,level of education,marital status,insurance,breakfast,lunch or dinner,fried meat,legumes,caffeinated beverages,the length of sleep during 24 h,cigarette smoking and losing job or spouse.However,in regards to use of vegetables,sausage,fried potatoes,enriched breads,low fat milk,low salt,candies and chocolates significant relations were found (P<0.05).Conclusion:The present study suggests one way to control obesity and prevent diseases is to ameliorate the life styles.There is a relation between health and stress and irregularity of meals,such as breakfast skipping,is associated with overweight and obesity in adolescence.

Effect of Body Mass Index on All-cause Mortality and Incidence of Cardiovascular Diseases─Report for Meta-Analysis of Prospective Studies on Optimal Cut-off Points of Body Mass Index in Chinese Adults

Objective To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index (BMI) to all-cause mortality, and incidence of cardiovascular diseases from pooled data of Chinese cohorts. Methods The prospective study data of existing cohort studies in China were collected, and the age-adjusted all-cause mortality stratified by BMI were estimated. The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers. The incidence of age-adjusted coronary heart disease (CHD) and stroke stratified by BMI were also analyzed. Multiple Cox regression coefficients of BMI for the incidence of CHD and stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke. Results The data of 4 cohorts including 76 227 persons, with 745 346 person-years of follow-up were collected and analyzed. The age-adjusted all-cause mortality stratified by BMI showed a U-shaped curve, even after excluding deaths within the first three years of follow-up and excluding smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. The incidence of CHD and stroke, especially ishemic stroke increased with increasing BMI, this was consistent with parallel increasing of risk factors. Cox regression analysis showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m2 increase in baseline BMI might cause 15.4%, 6.1% and 18.8 % increase in relative risk of CHD, total stroke and ischemic stroke. Reduction of BMI to under 24 might prevent the incidence of CHD by 11% and that of stroke by 15 % for men, and 22 % of both diseases for women. Conclusion BMI ≤18.5, 24-27.9 and ≥28 (kg/m2) is the appropriate cut-off points for underweight, overweight and obesity in Chinese adults.

Prediction of Abdominal Visceral Obesity From Body Mass Index,Waist Circumference and Waist-hip Ratio in Chinese Adults:Receiver Operating Characteristic Curves Analysis

Objective To evaluate the sensitivity and specificity of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) measurements in diagnosing abdominal visceral obesity. Methods BMI, WC, and WHR were assessed in 690 Chinese adults (305 men and 385 women) and compared with magnetic resonance imaging (MRI) measurements of abdominal visceral adipose tissue (VA). Receiver operating characteristic (ROC) curves were generated and used to determine the threshold point for each anthropometric parameter. Results 1) MRI showed that 61.7% of overweight/obese individuals (BMI≥25 kg/m2) and 14.2% of normal weight (BMI<25 kg/m2) individuals had abdominal visceral obesity (VA≥100 cm2). 2) VA was positively correlated with each anthropometric variable, of which WC showed the highest correlation (r=0.73-0.77, P<0.001). 3) The best cut-off points for assessing abdominal visceral obesity were as followed: BMI of 26 kg/m2, WC of 90 cm, and WHR of 0.93, with WC being the most sensitive and specific factor. 4) Among subjects with BMI≥28 kg/m2 or WC≥95 cm, 95% of men and 90% of women appeared to have abdominal visceral obesity. Conclusion Measurements of BMI, WC, and WHR can be used in the prediction of abdominal visceral obesity, of which WC was the one with better accuracy.

Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males

Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index （BMI） and sperm-zona pellucida binding ability assessed according to the zona binding （ZB） test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization （IVF） ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated.

代谢健康状态转变及其与BMI的交互作用对心血管疾病发生的影响

目的探讨代谢健康状态转变与体质指数(BMI)交互作用及与心血管疾病(CVD)的关联。方法基于“新疆多民族自然人群队列建设及健康随访研究”和田调查现场,进行前瞻性队列研究。经过3年随访,根据代谢状态转变将研究对象分为保持代谢健康(MH)、代谢健康转为代谢不健康(MH-MU)、保持代谢不健康(MU)、代谢不健康转为代谢健康(MU-MH)4组,多因素Logistic回归分析不同组代谢状态对CVD发生的影响。应用限制性立方样条探讨BMI为连续变量与CVD风险的关联,分析代谢状态转变和BMI交互作用与CVD的关联。结果共10232人纳入本研究,平均年龄为(52.43±10.29)岁。在随访3年期间新发心血管疾病349例(3.41%);其中MH、MH-MU、MU和MU-MH 4组心血管疾病发生率分别为2.48%、4.21%、5.13%、3.30%。与MH组相比,MH-MU、MU组心血管疾病发生风险分别为OR=1.42(95%CI:1.05~1.93)和OR=1.41(95%CI:1.03~1.92)。限制性立方样条分析表明,基线BMI与心血管疾病发生为非线性关联(P=0.023)。BMI分组与代谢状态转变存在交互作用(χ2=26.025,P=0.001),其归因于交互效应比例为3%[RERI=0.032(95%CI:0.005~0.06)、AP=0.031(95%CI:0.007~0.05)、S=2.157(95%CI:1.194~3.897)]。结论保持或转变为代谢不健康状态均可增加心血管疾病的风险。保持或转为代谢不健康状态与超重、肥胖交互作用能够增加心血管疾病的风险。

Body Mass Index and Hypertension Hemodynamic Subtypes in Yi Farmers and Migrants

Objective To examine the relationship between overweight or obesity and the risk of the various hypertension hemodynamic subtypes in Yi farmers and migrants. Methods A cross-sectional study of 2 358 Yi farmers and 2 392 Yi migrants was carried out in the Liangshan Yi autonomous prefecture, Sichuan, China in 2007. Results The standardized prevalence of overweight in female Yi farmers （6.22%） was higher than in males （3.25%）, whereas in Yi migrants 32.56% of males and 28.78% of females were overweight. The standardized prevalence of obesity was 0 and 0.62% in male and female Yi farmers, compared to 3.91% and 5.57% in male and female Yi migrants, respectively. For both genders the standardized prevalence of ISH, IDH, and SDH was higher in Yi migrants than Yi farmers. Overweight and obese Yi men and women had a higher risk for IDH and SDH （P〈O.002） than non-overweight/obese individuals. However, an association of overweight or obesity with ISH was observed only in men. Conclusion Yi migrants have substantially higher proportion of overweight and obese individuals, as well as individuals affected by ISH, IDH, and SDH, than do Yi farmers. Overweight and obesity are significant risk factors for the development of hypertension in Yi people.

Comparison of Various Foods Intakes and Their Relationships with Body Mass Index in Japanese Old Men and Women

Objective: Obesity is an important health problem, leading to many metabolic diseases such as type2 diabetes mellitus, cardiovascular diseases, cancer etc. There are many diet proposals to combat obesity. Since obesity is relatively rare in Japan, we wanted to know what kinds of foods influence body mass index (BMI) in old Japanese people. Methods: Healthy participants were given self-administered diet history questionnaires and described answers on each item by recollection of diets they took (7 days dietary recall). We used a brief-type self-administered diet history questionnaire (BDHQ) by using which the Japanese Ministry of Health, Labour and Welfare reports national Nutrition Surveys. From these questionnaires, we calculated the intakes of energy, carbohydrate, fat, protein or other foods. Results: Men take more alcohol, salt fruit, beans, and eggs than women. Intakes of major foods such as carbohydrate, lipid, and protein did not influence BMI in men and women. Conclusion: Within the range of foods intakes in Japan, no restriction of any food such as carbohydrate is not necessary for staying lean.

Decreased Gastric Body Mucosa Obestatin Expression in Abdominal Obesity Patients With Normal Body Mass Index

The aim of the study was to investigate whether the expression of obestatin in gastric body mucosa in abdominal obesity patients with normal body mass index （BMI） is different compared with healthy controls. Twenty abdominal obesity patients with normal BMI and twenty healthy controls were included in the study. The number of obestatin-positive cells in gastric body mucosa was significantly lower in abdominal obesity patients with normal BMI than that in healthy subjects.

Longitudinal changes in body weight of breastfeeding mothers in the first year after delivery and its relationship with human milk composition:a combined longitudinal and cross-sectional cohort study

Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term follow-up and preliminarily explore the relationship between maternal body weight and human milk composition,including macronutrients,leptin,and adiponectin.Methods:The study included a longitudinal cohort(122 mothers),and a cross-sectional cohort(37 mothers).The human milk,maternal weight,and dietary surveys were collected in the longitudinal cohort at different follow-up time points(1-14 days postpartum,2-4 months postpartum,5-7 months postpartum,and 12-17 months postpartum).The maternal body weight was analyzed using the responses in the survey questionnaires.A milk analyzer based on the mid-infrared spectroscopy(MIRS)was used to determine milk composition,and nutrition analysis software evaluated dietary intakes.In the cross-sectional cohort,participating mothers were asked to provide blood and human milk samples and pertinent information related to maternal body composition.Maternal body composition was measured by bioelectrical impedance analysis(BIA),while ELISA analyzed leptin and adiponectin in milk and serum.Results:At 5-7 months postpartum,the PPWR of breastfeeding mothers was(2.46±3.59)kg.At 12-17 months postpartum,the PPWR was(0.98±4.06)kg.PPWR was found to be negatively correlated with milk fat content within 14 days postpartum and positively correlated at 2-4 months postpartum.In addition,the maternal weight and body muscle mass were positively correlated with leptin and adiponectin in milk.Plasma leptin was positively correlated with the mother’s body weight,body mass index(BMI),FAT percentage,and body fat mass,while plasma adiponectin did not correlate with any parameter.The results also indicate that the PPWR did not correlate with leptin and adiponectin in plasma or milk.Conclusions:Breastfeeding mothers may retain considerable weight gain one year after delivery.Human milk composition may be related to changes in maternal body weight.Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition.This study supports the notion that maternal nutritional status may affect offspring health through lactation,and future research should focus on exploring weight management of postpartum mothers.

融合人脸图像深度和外观特征的BMI估计方法

身体质量指数(BMI)是人类健康重要指标。从2D正脸图像中估计3D人脸信息并提出一个端到端BMI估计框架,以进一步提高BMI估计性能。首先,计算人脸468个3D关键点,并根据关键点相对头部质心的深度绘制深度人脸图;其次,提取人脸图像的方向梯度直方图(HOG)并可视化以表示外观特征;最后,利用卷积神经网络(CNN)VGGNet、ResNet分别对深度人脸图和HOG进行特征提取,并使用Hadamard积融合2个骨干网络的特征以估计BMI。与目前已有方法的对比实验中,本文提出方法在2个公开数据集上的整体平均绝对误差(MAE)分别比最优结果低0.38和1。上述实验结果证明了本文提出的融合3D人脸图像深度和外观特征的BMI估计方法的有效性。

Perceptions of Body Mass Index as a Valid Indicator of Weight Status among Adults in the United States

Background: Being overweight or obese increases risk for heart disease, stroke, type 2 diabetes, joint disease, and certain cancers. The Body Mass Index (BMI) is commonly used to determine weight status. As rates of overweight and obesity have risen sharply in the United States over the past 30 years, perceptions of a “normal” or healthy weight are subject to change. The purpose of this study was to analyze perceptions of BMI as an indicator of weight status. Methods: An online survey was administered to 376 US adults. The survey collected demographic information including height, weight, and perceived weight status (underweight, healthy weight, overweight and obese). The survey software calculated and presented participants with their personal BMI values. Participants then answered questions about their perception of the BMI as a valid indicator of weight status. Results: More participants reported a healthy weight status (51.6%) than were classified as such according to their computed BMI (43.6%). The majority of the sample (85.1%) considered BMI to be a valid indicator of weight status, although perceptions of validity varied by weight status. Participants that perceived BMI to be invalid most commonly cited incongruence with one’s perception of their own body weight, no accounting for unique body shapes, and no accounting for additional muscle mass. Conclusion: BMI is generally perceived to be a valid indicator of weight status. These perceptions of validity can vary depending on the individuals’ actual weight status. In instances where perceptions are not favorable toward BMI, it is largely attributable to opinions of incongruence with BMI and body shape, type, or composition. Continued use of BMI as a preliminary tool for determining weight status appears to be accepted. Efforts to increase BMI-related awareness and education may be necessary for individuals that currently see it as invalid.

Prognostic value of body mass index before treatment for laryngeal squamous cell carcinoma

Objective: Patients with head and neck cancer often suffer from malnutrition. This study aims to investigate the influence of body mass index(BMI) on the prognosis of laryngeal squamous cell carcinoma(LSCC).Methods: A total of 473 patients with LSCC initially treated at Sun Yat-sen University Cancer Center between January 2005 and July 2009 were retrospectively reviewed. Survival analysis was performed by the Kaplan-Meier method and Cox regression model.Results: Low BMI before treatment was significantly associated with poor overall survival in patients with LSCC(P<0.001). BMI was an independent prognostic factor for patients with LSCC.Conclusion: Leanness before treatment was associated with poor prognosis in patients with LSCC. Good nutritional status is favorable to improve survival in patients with LSCC.

驾驶员BMI对肌肉疲劳度的影响研究

目的探究在相同驾驶条件下,个体BMI差异对驾驶员肌肉疲劳累积的影响。方法采用对照试验对驾驶员不同BMI与腰背肌肉疲劳之间的关系进行研究。12名被试以标准驾驶姿势进行时长60 min的模拟驾驶,采集被试驾驶期间腰背部竖脊肌及背阔肌表面肌电信号MPF。试验从主观测评、客观数据两个维度入手,分析各被试BMI与表面肌电信号之间的关系,从而判断长时间驾驶状态下,驾驶员不同BMI对腰背部肌肉疲劳度是否具有显著性影响。结果两组肌肉MPF值与驾驶时间均呈现显著性负相关。3组不同被试组间背阔肌、竖脊肌MPF值存在显著性差异。两组肌肉MPF趋势变化图均表明BMI值越大,MPF值越早出现下降趋势,且竖脊肌MPF值波动明显>背阔肌。结论驾驶员BMI值越大,肌肉越早出现疲劳,且腰部竖脊肌比背部背阔肌更容易出现疲劳现象。研究结果可为驾驶疲劳个体差异问题研究、驾驶座椅设计及驾驶疲劳检测因素研究提供一定参考。

TyG-BMI对非酒精性脂肪性肝病的预测价值分析

目的观察甘油三酯葡萄糖指数(triglyceride-glucose index,TyG)、体质量指数(body mass index,BMI)和复合指标TyG-BMI与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病的相关性,比较3个指标对NAFLD的预测价值。方法选取2021年1月~2022年2月于长沙市第四医院诊断为NAFLD患者131例(NAFLD组)及同期来院接受健康体检且身体健康,B超等未检测出脂肪肝的250名成年人作为研究对象(健康对照组)。比较NAFLD组与健康对照组的肝功能、血脂、空腹血糖、TyG指数、TyG-BMI等指标。TyG指数、BMI、TyG-BMI按照四分位数分为4组(Q1~Q4),观察各组NAFLD患病率。使用受试者工作特征曲线评价3个指标对NAFLD的诊断价值。结果NAFLD组TC、TG、LDL-C、ALT、FPG、BMI、TyG指数、TyG-BMI高于健康对照组,HDL-C低于健康对照组,差异有统计学意义(P<0.05)。随着TyG指数、BMI、TyG-BMI的升高,NAFLD患病率亦升高。3个指标Q4、Q3四分位组的NAFLD患病率均高于Q1四分位组,Q4四分位组患病率均高于Q2四分位组;TyG指数和TyG-BMI的Q4四分位组患病率高于Q3四分位组;BMI和TyG-BMI的Q2四分位组患病率高于Q1四分位组;TyG-BMI Q3四分位组的NAFLD患病率高于Q2四分位组,差异均有统计学意义(P<0.05)。TyG指数、BMI、TyG-BMI的ROC曲线下面积分别为0.732、0.698、0.796,TyG-BMI对NAFLD的预测价值高于TyG指数和BMI。结论TyG指数、BMI、TyG-BMI升高均与NAFLD发生风险升高相关,与TyG指数、BMI相比,TyG-BMI对NAFLD的预测价值更高。

不同年龄儿童BMI指数及贫血与龋齿的相互作用研究

目的探讨不同年龄儿童BMI指数及贫血与龋齿的相互作用。方法前瞻性选取2019年8月至2022年8月进行口腔检查的150例学龄前儿童作为调查对象,收集其临床资料,测量所有研究对象的体重、身高,并对其血红蛋白水平进行检测,采用speraman相关性分析法分析龋齿数与儿童各生育指标的相关性。根据儿童是否患有龋齿分为龋齿组(n=63)和无龋齿组(n=87),通过单因素和多因素分析方法分析儿童BMI及贫血与龋齿的相互作用。结果共150例学龄前儿童总龋齿率为42.00%,其中4~5岁儿童的龋齿率为56.45%、3~4岁为35.00%、2~3岁为25.00%,组间对比,4~5岁儿童的龋齿率较其他年龄组明显偏高(P<0.05)。各年龄段患儿的BMI、血红蛋白水平比较,差异均无统计学意义(P>0.05)。不同BMI组儿童的dmft指数、dmft+DMFT指数比较差异有统计学意义(P<0.05),其中肥胖组儿童的dmft指数、dmft+DMFT指数最低。Spearman相关性分析结果显示,BMI与dmft指数、dmft+DMFT指数呈负相关(R=-0.063、-0.520,P<0.05)。根据儿童的血红蛋白水平差异对其进行分组,其中正常76例,贫血64例。血红蛋白水平正常组儿童的dmft指数、dmft+DMFT指数均明显低于贫血组儿童(P<0.05)。Spearman相关性分析结果显示,血红蛋白与dmft指数、dmft+DMFT指数呈正相关(R=0.454、0.865,P<0.001)。Logstic回归分析结果显示,儿童偏瘦、贫血及家庭年收入≤3万元是影响其罹患龋齿的独立危险因素(P<0.05)。结论BMI偏低和发生贫血会明显增加学龄前儿童发生龋齿的风险,而龋齿的发生则会进一步阻碍幼儿的正常发育,提示应注意定期进行口腔检查。

老年人群体质量指数与慢性代谢性疾病的关系

目的·评估老年人群体质量指数(body mass index,BMI)与慢性代谢性疾病发生风险的关系。方法·以2014—2021年在上海交通大学医学院附属仁济医院体检中心进行体检的老年人(≥60岁)为研究对象。收集其各项生化指标。由经过培训的护士测量其身高、体质量和血压。采用问卷法收集研究对象既往慢性代谢性疾病史。收缩压≥140 mmHg(1 mmHg=0.133 kPa)、舒张压≥90 mmHg或既往有高血压病史,定义为高血压。空腹血糖≥7.0 mmol/L或既往有糖尿病病史,定义为糖尿病。总胆固醇≥6.2 mmol/L、三酰甘油≥2.3 mmol/L或既往有脂代谢异常病史,定义为脂质代谢紊乱。BMI与高血压、糖尿病和脂质代谢紊乱之间的关系采用受试者操作特征(receiver operator characteristic,ROC)曲线和二元Logistic回归进行分析评估。结果·共收集59083例研究对象的资料,其中男性30807例,女性28276例,平均年龄(67.9±6.3)岁。高血压、糖尿病和脂质代谢紊乱的发生率分别为76.5%(45219/59083)、24.1%(14225/59083)和50.0%(29544/59083)。与60~74岁的老年人群相比,75岁及以上的老年人患高血压和糖尿病的比例更高,患脂质代谢紊乱和无代谢异常的比例更低。通过ROC曲线分析,BMI对于高血压、糖尿病和脂质代谢紊乱的切点值分别为24.3、23.9和23.9 kg/m^(2)。老年男性高血压和糖尿病的BMI切点值和老年女性十分接近(高血压BMI切点值:老年男性24.3 kg/m^(2)vs老年女性24.2 kg/m^(2);糖尿病BMI切点值:老年男性24.0 kg/m^(2)vs老年女性23.7 kg/m^(2)),但老年男性脂质代谢紊乱的BMI切点值明显高于老年女性(老年男性24.0 kg/m^(2)vs老年女性22.5 kg/m^(2))。60~74岁老年人的BMI对慢性代谢性疾病的切点值(24.2~24.7 kg/m^(2))高于75岁及以上的老年人(22.9~23.8 kg/m^(2))。结论·60~74岁老年人群应将BMI控制在24.0 kg/m^(2)以下,而75岁及以上老年人群应将BMI控制在23.0 kg/m^(2)以下,则有利于降低其慢性代谢性疾病的风险。

司美格鲁肽治疗多囊卵巢综合征伴胰岛素抵抗60例临床分析

目的探讨GLP-1受体激动剂(司美格鲁肽)治疗具有胰岛素抵抗的多囊卵巢综合征(PCOS-IR)不孕患者临床疗效。方法选取60例胰岛素抵抗的PCOS-IR不孕症患者,随机分为观察组(应用司美格鲁肽治疗)和对照组(应用二甲双胍治疗),每组30例。比较治疗前后两组患者血清中性激素、胰岛素、血糖、糖化血红蛋白指标变化情况,包括促卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、催乳素(PRL)、胰岛素(INS)、C-肽、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)水平,评估用药的有效性。结果治疗前,两组患者性激素、胰岛素、血糖、糖化血红蛋白指标比较差异均无统计学意义(P>0.05);治疗后,两组患者相关指标FPG、FINS、HDMA-IR及HbAlc显著降低(P<0.05)。结论司美格鲁肽能够显著改善PCOS合并IR患者胰岛素抵抗及糖代谢水平,并对改善患者排卵和调整受孕周期有显著疗效。

偏冷环境下不同身体质量指数人群热舒适对比研究

传统的热舒适标准未考虑我国持续增长的超重或肥胖人群对热舒适的需求,这可能对人体舒适度和建筑节能产生重要影响。本文探讨了不同身体质量指数(BMI)人群在偏冷环境下的主观反应和生理反应的差异。结果显示:高BMI人群的平均皮肤温度显著低于低BMI人群,且随着温度的下降而下降;在偏冷环境下,高BMI人群的代谢率比低BMI人群低,尽管没有显著性差异,但会导致比低BMI人群具有更高的热不满意百分比;在预测热感觉时需要对不同BMI人群分别进行预测。