The lead and barium contents in sixteen archaeological bone samples from 10 persons buried in Dalsby, Sweden, were determined by means of X- ray fluorescence analysis using two "Co sources for excitation and a pl...The lead and barium contents in sixteen archaeological bone samples from 10 persons buried in Dalsby, Sweden, were determined by means of X- ray fluorescence analysis using two "Co sources for excitation and a planar Ge detector for registration of the X- rays. The lead concentrations were found to be less than 168μ g/g, and the barium concentrations were in the range of 15- 97μg/g.展开更多
目的利用Meta分析的方法,研究铅暴露对人群骨代谢的影响。方法通过对中国期刊全文数据库、万方数据库、维普中文科技期刊数据库、PubMed、Web of science五个数据库,检索建库至2022年3月公开发表的铅暴露对人群骨代谢相关指标影响的文献...目的利用Meta分析的方法,研究铅暴露对人群骨代谢的影响。方法通过对中国期刊全文数据库、万方数据库、维普中文科技期刊数据库、PubMed、Web of science五个数据库,检索建库至2022年3月公开发表的铅暴露对人群骨代谢相关指标影响的文献,对文献进行筛选和资料提取。以AHRQ横断面研究评价标准对纳入文献进行质量评价。维生素D3、骨钙素、骨碱性磷酸酶作为骨代谢指标进行分析。采用Stata16、Review Manager 5.3软件进行森林图绘制、敏感性分析及发表偏倚检验,标准化均数差(SMD)及其95%可信区间(95%CI)作为效应指标。结果共纳入13篇文献(n=2029)。纳入的研究存在中高度异质性(I^(2)>50%),采取随机效应模型。相对于非铅接触人群,铅接触人群的钙磷代谢调节指标维生素D3的SMD为-1.11(95%CI:-2.20~-0.02),骨钙素的SMD为-0.50(95%CI:-0.91~-0.09),骨碱性磷酸酶的SMD为0.80(95%CI:0.42~1.19),差异均具有统计学意义(P<0.01)。结论Meta分析结果表明铅暴露影响人群的骨代谢,其中骨碱性磷酸酶水平升高,维生素D3、骨钙素水平下降。展开更多
Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated...Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants (i.e., 234, 249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women) were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 (P〈0.05) and 0.104 (P〈0.01) of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels (standardized β=0.091, P〈0.01) than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 (P〈0.01) and 0.179 (P〈0.01), respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 (P〈0.05) and 0.125 (P〈0.01), respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene A1298C polymorphism-related homocysteine is a possible risk factor for increased blood lead levels among Chinese women.展开更多
文摘The lead and barium contents in sixteen archaeological bone samples from 10 persons buried in Dalsby, Sweden, were determined by means of X- ray fluorescence analysis using two "Co sources for excitation and a planar Ge detector for registration of the X- rays. The lead concentrations were found to be less than 168μ g/g, and the barium concentrations were in the range of 15- 97μg/g.
文摘目的利用Meta分析的方法,研究铅暴露对人群骨代谢的影响。方法通过对中国期刊全文数据库、万方数据库、维普中文科技期刊数据库、PubMed、Web of science五个数据库,检索建库至2022年3月公开发表的铅暴露对人群骨代谢相关指标影响的文献,对文献进行筛选和资料提取。以AHRQ横断面研究评价标准对纳入文献进行质量评价。维生素D3、骨钙素、骨碱性磷酸酶作为骨代谢指标进行分析。采用Stata16、Review Manager 5.3软件进行森林图绘制、敏感性分析及发表偏倚检验,标准化均数差(SMD)及其95%可信区间(95%CI)作为效应指标。结果共纳入13篇文献(n=2029)。纳入的研究存在中高度异质性(I^(2)>50%),采取随机效应模型。相对于非铅接触人群,铅接触人群的钙磷代谢调节指标维生素D3的SMD为-1.11(95%CI:-2.20~-0.02),骨钙素的SMD为-0.50(95%CI:-0.91~-0.09),骨碱性磷酸酶的SMD为0.80(95%CI:0.42~1.19),差异均具有统计学意义(P<0.01)。结论Meta分析结果表明铅暴露影响人群的骨代谢,其中骨碱性磷酸酶水平升高,维生素D3、骨钙素水平下降。
基金This project was supported by grants-from the National Natural Science Foundation of China (No. 81573235), Health and Family Commission of Hubei Province (No. 2015CFB376), and Health and Family Commission of Wuhan Municipality (No. WG15D20).
文摘Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants (i.e., 234, 249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women) were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 (P〈0.05) and 0.104 (P〈0.01) of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels (standardized β=0.091, P〈0.01) than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 (P〈0.01) and 0.179 (P〈0.01), respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 (P〈0.05) and 0.125 (P〈0.01), respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene A1298C polymorphism-related homocysteine is a possible risk factor for increased blood lead levels among Chinese women.