The mechanism of the mineralization process induced by natural mineralized collagen(MC)has been investigated for decades.The purpose of this study was to investigate the efficacy of selfassembled MC for peri-implant b...The mechanism of the mineralization process induced by natural mineralized collagen(MC)has been investigated for decades.The purpose of this study was to investigate the efficacy of selfassembled MC for peri-implant bone defect reconstruction in a mini pig.A standardized peri-implant bone defect model was created using 14 mini pig mandibles.Two materials were evaluated,i.e.a mixture of hydroxyapatite and collagen(Type A,TA),and self-assembled MC(Type B,TB).Bio-Oss(BO)and untreated(blank control,BC)groups were used as controls.After 3-and 6-month healing periods,the mini pigs were sacrificed for histomorphometric and microcomputed tomography analysis.After 3 months of healing,the average alveolar ridge height was 3.2761.57mm for group TA,3.28±2.02mm for group TB and 3.37±1.09mm for group BO,while group BC showed the lowest height of 2.68±0.47mm.After 6 months of healing,the average alveolar ridge height was 2.64±1.13mm for group TA,4.31±1.80mm for group TB and 3.8761.38mm for group BO,while group BC showed the lowest height of 2.48±1.80mm.The experimental groups and control group showed similar bone volume density,bone complexity and histological reaction.The self-assembled MC(Type B)stimulated new bone formation in the reconstruction of deficient alveolar ridges around the dental implant;it also displayed excellent clinical operability compared with bone grafts without collagen.展开更多
基金supported by Beijing Municipal Science&Technology Commission Projects(No.Z181100002018001).
文摘The mechanism of the mineralization process induced by natural mineralized collagen(MC)has been investigated for decades.The purpose of this study was to investigate the efficacy of selfassembled MC for peri-implant bone defect reconstruction in a mini pig.A standardized peri-implant bone defect model was created using 14 mini pig mandibles.Two materials were evaluated,i.e.a mixture of hydroxyapatite and collagen(Type A,TA),and self-assembled MC(Type B,TB).Bio-Oss(BO)and untreated(blank control,BC)groups were used as controls.After 3-and 6-month healing periods,the mini pigs were sacrificed for histomorphometric and microcomputed tomography analysis.After 3 months of healing,the average alveolar ridge height was 3.2761.57mm for group TA,3.28±2.02mm for group TB and 3.37±1.09mm for group BO,while group BC showed the lowest height of 2.68±0.47mm.After 6 months of healing,the average alveolar ridge height was 2.64±1.13mm for group TA,4.31±1.80mm for group TB and 3.8761.38mm for group BO,while group BC showed the lowest height of 2.48±1.80mm.The experimental groups and control group showed similar bone volume density,bone complexity and histological reaction.The self-assembled MC(Type B)stimulated new bone formation in the reconstruction of deficient alveolar ridges around the dental implant;it also displayed excellent clinical operability compared with bone grafts without collagen.
