Trabecular bone disconnection “hotspots” of real termini (ReTm) previously mapped as loci of weakness in the female aging spine and hip may be a source of free-floating cancellous segments found in the medullary spa...Trabecular bone disconnection “hotspots” of real termini (ReTm) previously mapped as loci of weakness in the female aging spine and hip may be a source of free-floating cancellous segments found in the medullary space using a bespoke, thick slice histological method for identifying ReTm. A factor in their origin is apparently microdamage proliferation (differentiated by en bloc silver staining) with occasional callus moderation. Validation of similar “floating segments” (FS) in the ex-breeder rat suggested a pilot model for a potentially common phenomenon. Following marrow elution and density fractionation of the isolated floating segments from the whole proximal rat femora, scanning electron microscopy (SEM) and elemental microanalysis (EDS) was performed. The eluent contained numbers of vertically truncated, laterally branched floating segments (acute severance of sequential tensile cross-struts, causing chronic compression overload of axial-struts, with ii) inadequate stabilising callus, facilitating ReTm stacking into predetermined, substructural “crumple zones” of force containment, spheroidal attrition and particulate dissociation. As a catabolic outcome of altered tensile and hormonal influence, FS number may add a novel variable to cancellous bone kinetics particularly in women of relevance to fracture predisposition.展开更多
AIM:To predict postoperative intraocular lens(IOL)position using the Sirius anterior segment analysis system and investigate the effect of lens position and IOL type on postoperative refraction.METHODS:A total of 97 p...AIM:To predict postoperative intraocular lens(IOL)position using the Sirius anterior segment analysis system and investigate the effect of lens position and IOL type on postoperative refraction.METHODS:A total of 97 patients(102 eyes)were enrolled in the final analysis.An anterior segment biometry measurement was performed preoperatively with Sirius and Lenstar.The results of predicted lens position(PLP)and IOL power were automatically calculated by the software used by the instruments.Effective lens position(ELP)was measured manually using Sirius 3 mo postoperatively.Pearson's correlation analysis and linear regression analysis were used to determine the correlation of lens position to other parameters.RESULTS:PLP and ELP were positively correlated to axial length(AL;r=0.42,P<0.0001 and r=0.49,P<0.0001,respectively).There was a weak correlation between the peLP(ELP-PLP)and the prediction error of spherical refraction(peSR;r=0.34,P<0.0001).The peLP of Softec HD IOL differed statistically from those of both the TECNIS ZCB00 and Sensor AR40E IOLs.Multiple linear regression was used to obtain the prediction formula:ELP=0.66+0.63×[aqueous depth(AQD)+0.6 LT](r=0.61,P<0.0001),and a new variable(AQD+0.6 LT)was found to have the strongest correlation with ELP.CONCLUSION:The Sirius anterior segment analysis system is helpful to predict ELP,which reduces postoperative refraction error.展开更多
On September 5,2022,the Luding M6.8 earthquake occurred in the Moxi-Shimian segment of the Xianshuihe fault,coinciding with the historical ruptured zone of the 1786 Moxi earthquake.Its seis-mogenic environment provide...On September 5,2022,the Luding M6.8 earthquake occurred in the Moxi-Shimian segment of the Xianshuihe fault,coinciding with the historical ruptured zone of the 1786 Moxi earthquake.Its seis-mogenic environment provides a foundation for comprehending the mechanism of the earthquake and its future hazard.In the Moxi-Shimian segment,we establish a series of near-field Global Navigation Satellite Systems(GNsS)stations to enhance the spatial resolution of observational data for the inversion of the interseismic kinematic parameters.In this study,with an elastic screw dislocation model con-strained by GNsS observations,the slip rate of the Moxi-Shimian segment is estimated to be 10.9±1.0 mm/yr,while the locking depth is 15.7±6.2 km.Additionally,we utilize a block-dislocation model to invert the interseismic fault coupling along the Kangding-Moxi-Shimian segment.The result indicates a gradual deepening of the locking depth along the section from Kangding to Shimian.The coseismic rupture of the 2022 event occurred within the high coupling regions in the Kangding-Moxi-Shimian segment,which indicates that the rupture kinematics in this event might be controlled by the interseismic deformation.The seismic moment accumulated within the ruptured zone of the Luding earthquake since 1786 ranges in[1.42-3.40]×10^(19) N-m,which is significantly greater than the seismic moment released during the 2022 event.As a result,we infer that the Luding earthquake released only a portion of the accumulated energy within the original rupture zone since 1786,indicating that the 2022 event has not caused a complete rupture in the Moxi-Shimian segment.Consequently,there remains a substantial seismic hazard in this area.展开更多
To determine the distribution of positional error of a line segment, Monte Carlo approach is applied to simulate the probability density function of a line segment with the assumption that the error of endpoints in a ...To determine the distribution of positional error of a line segment, Monte Carlo approach is applied to simulate the probability density function of a line segment with the assumption that the error of endpoints in a line segment follows a two-dimensional normal distribution. For such purpose, a stochastic generator used for uncertain endpoints with the two-dimensional normal distribution is presented. This forms the basis of the generation of random line segment for the simulation of the error model of a whole line segment. The error models cover the cases where two endpoints are either independent or dependent to each other, also including a special case that the distance between two random endpoints in a line segment is close enough.展开更多
Background: Laparoscopic hepatectomy for hepatocellular carcinoma(HCC) located in segment Ⅵ, Ⅶ, or Ⅷ of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In ...Background: Laparoscopic hepatectomy for hepatocellular carcinoma(HCC) located in segment Ⅵ, Ⅶ, or Ⅷ of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment Ⅵ, Ⅶ, or Ⅷ.Methods: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife position.Tumors located in segment Ⅵ, Ⅶ, or Ⅷ were assessed by preoperative dynamic computed tomography or magnetic resonance imaging. Operation time, intraoperative blood loss, postoperative fasting time, postoperative drainage time, major postoperative complications, and duration of postoperative hospital stay were recorded.Results: All surgeries were successfully completed. None of the patients required conversion to open surgery during the procedure, and no serious postoperative complications were observed.The median tumor size was 31 mm(range 23-41 mm) in diameter, the mean operation time was 166 ± 38 min, the mean intraoperative blood loss was220 ± 135 mL, and the median postoperative hospital stay was 4 days(range 2-7 days).Conclusions: For HCC located in segment Ⅵ, Ⅶ, or Ⅷ, laparoscopic hepatectomy with this novel position—the left jackknife position—is safe and effective during tumor resection by exposing a sufficient operating field.Trial registration ClinicalTrials.gov ID:展开更多
This research developed a hybrid position-channel network (named PCNet) through incorporating newly designed channel and position attention modules into U-Net to alleviate the crack discontinuity problem in channel an...This research developed a hybrid position-channel network (named PCNet) through incorporating newly designed channel and position attention modules into U-Net to alleviate the crack discontinuity problem in channel and spatial dimensions. In PCNet, the U-Net is used as a baseline to extract informative spatial and channel-wise features from shield tunnel lining crack images. A channel and a position attention module are designed and embedded after each convolution layer of U-Net to model the feature interdependencies in channel and spatial dimensions. These attention modules can make the U-Net adaptively integrate local crack features with their global dependencies. Experiments were conducted utilizing the dataset based on the images from Shanghai metro shield tunnels. The results validate the effectiveness of the designed channel and position attention modules, since they can individually increase balanced accuracy (BA) by 11.25% and 12.95%, intersection over union (IoU) by 10.79% and 11.83%, and F1 score by 9.96% and 10.63%, respectively. In comparison with the state-of-the-art models (i.e. LinkNet, PSPNet, U-Net, PANet, and Mask R–CNN) on the testing dataset, the proposed PCNet outperforms others with an improvement of BA, IoU, and F1 score owing to the implementation of the channel and position attention modules. These evaluation metrics indicate that the proposed PCNet presents refined crack segmentation with improved performance and is a practicable approach to segment shield tunnel lining cracks in field practice.展开更多
Objective To determine whether sleep-disordered breathing (SDB) may lead to nocturnal myocardial ischemia and whether the severity of this ischemia may be relieved by nasal continuous positive airway pressure (CPAP). ...Objective To determine whether sleep-disordered breathing (SDB) may lead to nocturnal myocardial ischemia and whether the severity of this ischemia may be relieved by nasal continuous positive airway pressure (CPAP). Methods Overnight polysomnogram examination and simultaneous 3-channel Holter monitoring were performed on 76 patients with moderate to severe SDB and no history of coronary heart disease. All the cases were treated with CPAP for one night. ST depression was defined as a ST segment decrease of more than 1 mm from baseline and lasting 1 min or more. The total duration (minutes) of ST depression was indexed to the total sleep time (minutes per hour of sleep). Results Twenty-eight patients (37%) showed ST segment depression during their sleep. Before CPAP treatment, the respiratory disturbance index (RDI) and arousal index were significantly higher during periods of ST depression than when ST segments were isoelectric, whereas no significant difference was found in blood oxygen saturation (SaO2). After the CPAP treatment of patients with ST depression, the duration of ST depression was significantly reduced from 36.8±18.9 to 11.4±13.2 min/h (P<0.05). ST depression-related indexes, including RDI, arousal index and the percentage of sleep time spent at SaO2 below 90% (TS90/ TST), were all significantly decreased, with RDI from 63.4±23.8 to 8.1±6.6 /h, arousal index from 51.2±18.9 to 9.6±5.4 /h, and TS90/ TST from 50.6±21.4 to 12.9±14.7% (P<0.05). Conclusion ST-segment depression is rather common in patients with moderate to severe SDB, and CPAP treatment can significantly reduce the duration of ST depression. ST depression in these patients may reflect the myocardial ischemia that really exists and the non-ischemic changes associated with recurrent SDB.展开更多
Image segmentation of sea-land remote sensing images is of great importance for downstream applications including shoreline extraction,the monitoring of near-shore marine environment,and near-shore target recognition....Image segmentation of sea-land remote sensing images is of great importance for downstream applications including shoreline extraction,the monitoring of near-shore marine environment,and near-shore target recognition.To mitigate large number of parameters and improve the segmentation accuracy,we propose a new Squeeze-Depth-Wise UNet(SDW-UNet)deep learning model for sea-land remote sensing image segmentation.The proposed SDW-UNet model leverages the squeeze-excitation and depth-wise separable convolution to construct new convolution modules,which enhance the model capacity in combining multiple channels and reduces the model parameters.We further explore the effect of position-encoded information in NLP(Natural Language Processing)domain on sea-land segmentation task.We have conducted extensive experiments to compare the proposed network with the mainstream segmentation network in terms of accuracy,the number of parameters and the time cost for prediction.The test results on remote sensing data sets of Guam,Okinawa,Taiwan China,San Diego,and Diego Garcia demonstrate the effectiveness of SDW-UNet in recognizing different types of sea-land areas with a smaller number of parameters,reduces prediction time cost and improves performance over other mainstream segmentation models.We also show that the position encoding can further improve the accuracy of model segmentation.展开更多
文摘Trabecular bone disconnection “hotspots” of real termini (ReTm) previously mapped as loci of weakness in the female aging spine and hip may be a source of free-floating cancellous segments found in the medullary space using a bespoke, thick slice histological method for identifying ReTm. A factor in their origin is apparently microdamage proliferation (differentiated by en bloc silver staining) with occasional callus moderation. Validation of similar “floating segments” (FS) in the ex-breeder rat suggested a pilot model for a potentially common phenomenon. Following marrow elution and density fractionation of the isolated floating segments from the whole proximal rat femora, scanning electron microscopy (SEM) and elemental microanalysis (EDS) was performed. The eluent contained numbers of vertically truncated, laterally branched floating segments (acute severance of sequential tensile cross-struts, causing chronic compression overload of axial-struts, with ii) inadequate stabilising callus, facilitating ReTm stacking into predetermined, substructural “crumple zones” of force containment, spheroidal attrition and particulate dissociation. As a catabolic outcome of altered tensile and hormonal influence, FS number may add a novel variable to cancellous bone kinetics particularly in women of relevance to fracture predisposition.
基金Supported by Jiangsu Provincial Medical Innovation Team(No.CXTDA2017039)the Soochow Scholar Project of Soochow University(No.R5122001)。
文摘AIM:To predict postoperative intraocular lens(IOL)position using the Sirius anterior segment analysis system and investigate the effect of lens position and IOL type on postoperative refraction.METHODS:A total of 97 patients(102 eyes)were enrolled in the final analysis.An anterior segment biometry measurement was performed preoperatively with Sirius and Lenstar.The results of predicted lens position(PLP)and IOL power were automatically calculated by the software used by the instruments.Effective lens position(ELP)was measured manually using Sirius 3 mo postoperatively.Pearson's correlation analysis and linear regression analysis were used to determine the correlation of lens position to other parameters.RESULTS:PLP and ELP were positively correlated to axial length(AL;r=0.42,P<0.0001 and r=0.49,P<0.0001,respectively).There was a weak correlation between the peLP(ELP-PLP)and the prediction error of spherical refraction(peSR;r=0.34,P<0.0001).The peLP of Softec HD IOL differed statistically from those of both the TECNIS ZCB00 and Sensor AR40E IOLs.Multiple linear regression was used to obtain the prediction formula:ELP=0.66+0.63×[aqueous depth(AQD)+0.6 LT](r=0.61,P<0.0001),and a new variable(AQD+0.6 LT)was found to have the strongest correlation with ELP.CONCLUSION:The Sirius anterior segment analysis system is helpful to predict ELP,which reduces postoperative refraction error.
基金supported by Open Fund of Wuhan,Gravitation and Solid Earth Tides,National Observation and Research Station(WHYWZ202301)Scientific Research Fund from Institute of Seismology,CEA and National Institute of Natural Hazards,Ministry of Emergency Management of China grants IS202216316 and IS202226318+1 种基金State Key Laboratory of Geodesy and Earth's Dynamics,Innovation Academy for Precision Measurement Science and Technology,CAS SKLGED2023-2-5Science for Earthquake Resilience grant XH20038,and NSFC grant 42074015.
文摘On September 5,2022,the Luding M6.8 earthquake occurred in the Moxi-Shimian segment of the Xianshuihe fault,coinciding with the historical ruptured zone of the 1786 Moxi earthquake.Its seis-mogenic environment provides a foundation for comprehending the mechanism of the earthquake and its future hazard.In the Moxi-Shimian segment,we establish a series of near-field Global Navigation Satellite Systems(GNsS)stations to enhance the spatial resolution of observational data for the inversion of the interseismic kinematic parameters.In this study,with an elastic screw dislocation model con-strained by GNsS observations,the slip rate of the Moxi-Shimian segment is estimated to be 10.9±1.0 mm/yr,while the locking depth is 15.7±6.2 km.Additionally,we utilize a block-dislocation model to invert the interseismic fault coupling along the Kangding-Moxi-Shimian segment.The result indicates a gradual deepening of the locking depth along the section from Kangding to Shimian.The coseismic rupture of the 2022 event occurred within the high coupling regions in the Kangding-Moxi-Shimian segment,which indicates that the rupture kinematics in this event might be controlled by the interseismic deformation.The seismic moment accumulated within the ruptured zone of the Luding earthquake since 1786 ranges in[1.42-3.40]×10^(19) N-m,which is significantly greater than the seismic moment released during the 2022 event.As a result,we infer that the Luding earthquake released only a portion of the accumulated energy within the original rupture zone since 1786,indicating that the 2022 event has not caused a complete rupture in the Moxi-Shimian segment.Consequently,there remains a substantial seismic hazard in this area.
基金Funded by the National Natural Science Foundation of China (N0. 40501053), the Open Research Fund Program of LIESMARS (No. WKL040304) and theOpen Research Fund Program of Key Laboratory of Geomatics and Digital Technology, Shandong Province (No. SD040201)
文摘To determine the distribution of positional error of a line segment, Monte Carlo approach is applied to simulate the probability density function of a line segment with the assumption that the error of endpoints in a line segment follows a two-dimensional normal distribution. For such purpose, a stochastic generator used for uncertain endpoints with the two-dimensional normal distribution is presented. This forms the basis of the generation of random line segment for the simulation of the error model of a whole line segment. The error models cover the cases where two endpoints are either independent or dependent to each other, also including a special case that the distance between two random endpoints in a line segment is close enough.
基金supported by the National Natural Science Foundation of China(No:81602143)
文摘Background: Laparoscopic hepatectomy for hepatocellular carcinoma(HCC) located in segment Ⅵ, Ⅶ, or Ⅷ of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment Ⅵ, Ⅶ, or Ⅷ.Methods: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife position.Tumors located in segment Ⅵ, Ⅶ, or Ⅷ were assessed by preoperative dynamic computed tomography or magnetic resonance imaging. Operation time, intraoperative blood loss, postoperative fasting time, postoperative drainage time, major postoperative complications, and duration of postoperative hospital stay were recorded.Results: All surgeries were successfully completed. None of the patients required conversion to open surgery during the procedure, and no serious postoperative complications were observed.The median tumor size was 31 mm(range 23-41 mm) in diameter, the mean operation time was 166 ± 38 min, the mean intraoperative blood loss was220 ± 135 mL, and the median postoperative hospital stay was 4 days(range 2-7 days).Conclusions: For HCC located in segment Ⅵ, Ⅶ, or Ⅷ, laparoscopic hepatectomy with this novel position—the left jackknife position—is safe and effective during tumor resection by exposing a sufficient operating field.Trial registration ClinicalTrials.gov ID:
基金support from the Ministry of Science and Tech-nology of the:People's Republic of China(Grant No.2021 YFB2600804)the Open Research Project Programme of the State Key Labor atory of Interet of Things for Smart City(University of Macao)(Grant No.SKL-IoTSC(UM)-2021-2023/ORPF/A19/2022)the General Research Fund(GRF)project(Grant No.15214722)from Research Grants Council(RGC)of Hong Kong Special Administrative Re gion Government of China are gratefully acknowledged.
文摘This research developed a hybrid position-channel network (named PCNet) through incorporating newly designed channel and position attention modules into U-Net to alleviate the crack discontinuity problem in channel and spatial dimensions. In PCNet, the U-Net is used as a baseline to extract informative spatial and channel-wise features from shield tunnel lining crack images. A channel and a position attention module are designed and embedded after each convolution layer of U-Net to model the feature interdependencies in channel and spatial dimensions. These attention modules can make the U-Net adaptively integrate local crack features with their global dependencies. Experiments were conducted utilizing the dataset based on the images from Shanghai metro shield tunnels. The results validate the effectiveness of the designed channel and position attention modules, since they can individually increase balanced accuracy (BA) by 11.25% and 12.95%, intersection over union (IoU) by 10.79% and 11.83%, and F1 score by 9.96% and 10.63%, respectively. In comparison with the state-of-the-art models (i.e. LinkNet, PSPNet, U-Net, PANet, and Mask R–CNN) on the testing dataset, the proposed PCNet outperforms others with an improvement of BA, IoU, and F1 score owing to the implementation of the channel and position attention modules. These evaluation metrics indicate that the proposed PCNet presents refined crack segmentation with improved performance and is a practicable approach to segment shield tunnel lining cracks in field practice.
文摘Objective To determine whether sleep-disordered breathing (SDB) may lead to nocturnal myocardial ischemia and whether the severity of this ischemia may be relieved by nasal continuous positive airway pressure (CPAP). Methods Overnight polysomnogram examination and simultaneous 3-channel Holter monitoring were performed on 76 patients with moderate to severe SDB and no history of coronary heart disease. All the cases were treated with CPAP for one night. ST depression was defined as a ST segment decrease of more than 1 mm from baseline and lasting 1 min or more. The total duration (minutes) of ST depression was indexed to the total sleep time (minutes per hour of sleep). Results Twenty-eight patients (37%) showed ST segment depression during their sleep. Before CPAP treatment, the respiratory disturbance index (RDI) and arousal index were significantly higher during periods of ST depression than when ST segments were isoelectric, whereas no significant difference was found in blood oxygen saturation (SaO2). After the CPAP treatment of patients with ST depression, the duration of ST depression was significantly reduced from 36.8±18.9 to 11.4±13.2 min/h (P<0.05). ST depression-related indexes, including RDI, arousal index and the percentage of sleep time spent at SaO2 below 90% (TS90/ TST), were all significantly decreased, with RDI from 63.4±23.8 to 8.1±6.6 /h, arousal index from 51.2±18.9 to 9.6±5.4 /h, and TS90/ TST from 50.6±21.4 to 12.9±14.7% (P<0.05). Conclusion ST-segment depression is rather common in patients with moderate to severe SDB, and CPAP treatment can significantly reduce the duration of ST depression. ST depression in these patients may reflect the myocardial ischemia that really exists and the non-ischemic changes associated with recurrent SDB.
基金This paper is supported by the following funds:The National Key Research and Development Program of China(2018YFF01010100)The Beijing Natural Science Foundation(4212001)+1 种基金Basic Research Program of Qinghai Province under Grants No.2021-ZJ-704Advanced information network Beijing laboratory(PXM2019_014204_500029).
文摘Image segmentation of sea-land remote sensing images is of great importance for downstream applications including shoreline extraction,the monitoring of near-shore marine environment,and near-shore target recognition.To mitigate large number of parameters and improve the segmentation accuracy,we propose a new Squeeze-Depth-Wise UNet(SDW-UNet)deep learning model for sea-land remote sensing image segmentation.The proposed SDW-UNet model leverages the squeeze-excitation and depth-wise separable convolution to construct new convolution modules,which enhance the model capacity in combining multiple channels and reduces the model parameters.We further explore the effect of position-encoded information in NLP(Natural Language Processing)domain on sea-land segmentation task.We have conducted extensive experiments to compare the proposed network with the mainstream segmentation network in terms of accuracy,the number of parameters and the time cost for prediction.The test results on remote sensing data sets of Guam,Okinawa,Taiwan China,San Diego,and Diego Garcia demonstrate the effectiveness of SDW-UNet in recognizing different types of sea-land areas with a smaller number of parameters,reduces prediction time cost and improves performance over other mainstream segmentation models.We also show that the position encoding can further improve the accuracy of model segmentation.