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AHFO-based soil water content sensing technology considering soil-sensor thermal contact resistance
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作者 Mengya Sun Peng Wu +6 位作者 Bin Shi Jin Liu Jie Liu Juncheng Yao Yipin Lu Yunqiang Wang Xiaoyan Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第7期2715-2731,共17页
The actively heated fiber-optic(AHFO)technology has become emerged as a research focus due to its advantages of distributed,real-time measurement and good durability.These attributes have led to the gradual applicatio... The actively heated fiber-optic(AHFO)technology has become emerged as a research focus due to its advantages of distributed,real-time measurement and good durability.These attributes have led to the gradual application of AHFO technology to the water content measurement of in situ soil.However,all existing in situ applications of AHFO technology fail to consider the effect of soilesensor contact quality on water content measurements,limiting potential for the wider application of AHFO technology.To address this issue,the authors propose a method for determining the soilesensor thermal contact resistance based on the principle of an infinite cylindrical heat source.This is then used to establish an AHFO water content measurement technology that considers the thermal contact resistance.The reliability and validity of the new measurement technology are explored through a laboratory test and a field case study,and the spatial-temporal evolution of the soil water content in the case is revealed.The results demonstrate that method for determining the soilesensor thermal contact resistance is highly effective and applicable to all types of soils.This method requires only the moisture content,dry density,and thermal response of the in situ soil to be obtained.In the field case,the measurement error of soil water content between the AHFO method,which takes into account the thermal contact resistance,and the neutron scattering method is only 0.011.The water content of in situ soil exhibits a seasonal variation,with an increase in spring and autumn and a decrease in summer and winter.Furthermore,the response of shallow soils to precipitation and evaporation is significant.These findings contribute to the enhancement of the accuracy of the AHFO technology in the measurement of the water content of in situ soils,thereby facilitating the dissemination and utilization of this technology. 展开更多
关键词 Soil water content Actively heated fiber-optic(AHFO) technology Soilesensor thermal contact resistance RELIABILITY In situ application
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Gas pipeline explosion resistance technology 被引量:1
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作者 Zhao ZHU Zhen-Yuan JIA Kui-Jun WANG 《Journal of Coal Science & Engineering(China)》 2013年第3期353-357,共5页
Based on the features and requirements of gas drainage system, an optimized explosion resistance technology is done after a comprehensive analysis and research about the triple IR (Infrared Ray) flame detection tech... Based on the features and requirements of gas drainage system, an optimized explosion resistance technology is done after a comprehensive analysis and research about the triple IR (Infrared Ray) flame detection technology, explosion resistance valve technology and explosion resistance control technology. An intelligent PLC (Programmable Logic Controller) resistance control system is designed which can cut offthe gas branch quickly and accurately, and the controller have automatic pressure maintaining function, valve rotation limit function, remote and local control interlock function. The reliability and rationality of explosion resistance technology is verified by gas pipeline explosion propagation and resistance simulation test. Overall response time of explosion resistance system is less than 100ms, and the spread of fire in gas pipeline can be prevented effectively. 展开更多
关键词 explosion resistance technology flame detection fast shut-off valve intelligent control
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National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology
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《China Foundry》 SCIE 2019年第1期82-83,共2页
Founded in 2012,the National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology at Jinan University,one of the'211'key national universities in China,specializes in... Founded in 2012,the National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology at Jinan University,one of the'211'key national universities in China,specializes in the research and development of iron based wear resistant materials and their casting technologies to provide support to the production process.The Research Center serves the'Guangdong Province Ceeusro Innovation Platform for Common Technology of High Performance Wear Resistant Materials”,“Guangdong Province Engineering Research Center for Wear Resistant and Special Functional Materials”. 展开更多
关键词 NATIONAL JOINT Engineering Research CENTER of High Performance METAL WEAR resistANT Materials technology
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Three-dimensional forward modeling and inversion of borehole-to-surface electrical imaging with different power sources 被引量:7
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作者 Bai Ze Tan Mao-Jin Zhang Fu-Lai 《Applied Geophysics》 SCIE CSCD 2016年第3期437-448,578,共13页
Borehole-to-surface electrical imaging (BSEI) uses a line source and a point source to generate a stable electric field in the ground. In order to study the surface potential of anomalies, three-dimensional forward ... Borehole-to-surface electrical imaging (BSEI) uses a line source and a point source to generate a stable electric field in the ground. In order to study the surface potential of anomalies, three-dimensional forward modeling of point and line sources was conducted by using the finite-difference method and the incomplete Cholesky conjugate gradient (ICCG) method. Then, the damping least square method was used in the 3D inversion of the formation resistivity data. Several geological models were considered in the forward modeling and inversion. The forward modeling results suggest that the potentials generated by the two sources have different surface signatures. The inversion data suggest that the low- resistivity anomaly is outlined better than the high-resistivity anomaly. Moreover, when the point source is under the anomaly, the resistivity anomaly boundaries are better outlined than when using a line source. 展开更多
关键词 borehole-to-surface electrical imaging different types of exciting sources potential characteristic forward modeling resistivity inversion
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Technical Note and Brief Overview of the Materials Science and Technology along with Designing Aspects for Development of Spintronic Devices with Optimum Efficiency 被引量:1
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作者 Ritu Walia Kamal Nain Chopra 《Journal of Materials Science and Chemical Engineering》 2020年第4期98-105,共8页
One of the major challenges in designing and fabricating Spintronic devices is the choice of both, Materials and the Technology, along with understanding the intricacies of the Designing aspects. In this communication... One of the major challenges in designing and fabricating Spintronic devices is the choice of both, Materials and the Technology, along with understanding the intricacies of the Designing aspects. In this communication, we have attempted to briefly discuss these factors, with an aim to draw the attention of the Materials Scientists and Technologists to this serious challenge, in the direction of which, though a lot of research and development work has been done, still needs more concerted efforts to be made in order to make the Spintronic devices that can offer good efficiency for maximizing their usefulness. 展开更多
关键词 MATERIALS Science technology and DESIGNING ASPECTS of SPINTRONIC Devices Epitaxial growth Double Ion Beam Sputtering Technique Magnetic Tunnel JUNCTIONS Giant Magneto resistance
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A Study of Multi-Permeating TiN/Ti Alloying Layer Using Plasma Surface Alloying Technology
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作者 刘燕萍 徐晋勇 +6 位作者 隗小云 王建忠 高原 徐重 张广秋 葛袁静 张跃飞 《Plasma Science and Technology》 SCIE EI CAS CSCD 2006年第2期213-216,共4页
TiN/Ti multi-permeating alloying layer has been formed on the low carbon steel by means of the double glow-discharge plasma surface alloying technique and hollow-cathode effect. The alloying layer was detected by axio... TiN/Ti multi-permeating alloying layer has been formed on the low carbon steel by means of the double glow-discharge plasma surface alloying technique and hollow-cathode effect. The alloying layer was detected by axiovert 25 CA optical microscope with computer analyzing software (LEC), GDA-2 glow discharge spectroscopy (GDS), X-ray diffraction (XRD) and galvanochemical method. The results showed that the thickness of TiN/Ti multi-permeating alloying layer was about 10μm, the content of Ti on the surface was up to 63.48 wt% and the content of N was up to 12.46 wt%. The atom Ti and N concentrations changed gradually across the depth of the alloying layer and the preferred orientation of TiN/Ti alloying layer was crystal surface (200). The multi-permeating alloying layer and substrate were combined through metallurgy. The surface appearances of the multi-permeating alloying layer were uniform and of a compact cellular structure. The hardness of the surface was about 1600-3000 HV0.1. The corrosion resistance of the permeating TiN/Ti alloying layer in 0.5 mol/L H2SO4 solution was greatly increased and the corrosion rate was only 0.3082 g/m^2. h. 展开更多
关键词 plasma surface technology TiN multi-layer double glow discharge process diffusion structure corrosion resistance
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Study on Enzymatic Hydrolysis Technology and Antioxidant Activity of Glutinous Rice Glutinous Enzymatic Processes and Antioxidant Activity
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作者 Hongrui LI Jinshen MAI +1 位作者 Mingsheng XU Jun TAO 《Agricultural Biotechnology》 CAS 2013年第4期57-60,共4页
[ Objective] This study aimed to investigate enzymatic hydrolysis technology of glutinous rice and the oxidation resistance activity of the enzymatic hydrolysis solution. [ Method ] White glutinous rice was hydrolyzed... [ Objective] This study aimed to investigate enzymatic hydrolysis technology of glutinous rice and the oxidation resistance activity of the enzymatic hydrolysis solution. [ Method ] White glutinous rice was hydrolyzed using four kinds of proteases including neutral protease, alkaline protease, papain and trypsin. Using the scavenging rate of hydroxyl radical ( ·OH) as an indicator and appropriate protease as hydrolytic enzyme, the effects of protein substrate concentration, enzyme dosage, enzymatic hydrolysis temperature and initial pH on the abilities of proteases to scavenge hydroxyl radical from enzymatic hydrolysis solution of glutinous rice were investigated. Based on single-factor test, L9 (34) orthogonal experimental design was adopted, to determine the optimal enzymatic hydrolysis condi- tions leading to the highest oxidation resistance activity of enzymatic hydrolysis solution. [ Result] The optimized process parameters for enzymatic hydrolysis of glu- tinous rice protein with neutral protease were: protein substrate concentration of 2%, enzyme dosage of 24 000 U/g protein (protein meter), enzymatic hydrolysis temperature of 55 ℃, initial pH of 8.0, and enzymatic hydrolysis duration of 0.5 h; under these conditions, the hydroxyl radical scavenging rate could reach 56. 05% ; protein substrate concentration, enzyme dosage, enzymatic hydrolysis temperature and initial pH had extremely significant effects on the hydroxyl radical scavenging rate. In addition, the activities of antioxidant peptides in glutinous rice hydrolysates were well maintained within a temperature range of 60 - 100℃. [Condusion] The study produced theoretical feasibility reference for the production of functional base powder by spray drying. 展开更多
关键词 Glutinous rice Enzymatic hydrolysis technology Bioactive peptides Hydroxyl radical Oxidation resistance
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Tetracycline-Based Binary Ti Vectors pLSU with Efficient Cloning by the Gateway Technology for <i>Agrobacterium tumefaciens</i>-Mediated Transformation of Higher Plants
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作者 Seokhyun Lee Guiying Su +1 位作者 Eric Lasserre Norimoto Murai 《American Journal of Plant Sciences》 2013年第7期1418-1426,共9页
We constructed small high-yielding binary Ti vectors with a bacterial tetracycline resistance gene to facilitate efficient cloning afforded by the Gateway Technology (Invitrogen) for Agrobacterium tumefaciens-mediated... We constructed small high-yielding binary Ti vectors with a bacterial tetracycline resistance gene to facilitate efficient cloning afforded by the Gateway Technology (Invitrogen) for Agrobacterium tumefaciens-mediated transformation of higher plants. The Gateway Technology vectors are kanamycin-based, thus tetracycline-based destination and expression vectors are easily selected for the antibiotic resistance in the Escherichia coli media. We reduced the size of the tetracycline resistance gene TetC from pBR322 to 1468 bp containing 1191 bp of the coding region, 93 bp of 5’-upstream, and 184 bp 3’-downstream region. The final size of binary Ti vector skeleton pLSU11 is 5034 bp. pLSU12 and 13 have the kanamycin resistance NPTII gene as a plant-selectable marker. pLSU13?and 15 contain the hygromycin resistance HPH gene as a selection marker. pLSU13 and 15 also have the β-glucuronidase (GUS) reporter gene in addition to the plant selection marker. We also constructed a mobilizable version of tetracycline-based binary Ti vector pLSU16 in which the mob function of ColE1 replicon was maintained for mobilization of the binary vector from E. coli to A. tumefaciens by tri-parental mating. The final size of binary Ti vector skeleton pLSU16 is 5580 bp. New tetracycline- based binary Ti vectors pLSU12 were found as effective as kanamycin-based vector pLSU2 in promoting a 10-fold increase in fresh weight yield of kanamycin-resistant calli after A. tumefaciens-mediated transformation of tobacco leaf discs. Using the Gateway Technology we introduced the plant-expressible GUSgene to the T-DNA of binary Ti vector pLSU12. Expression of the β-glucuronidase enzyme activity was demonstrated by histochemical staining of the GUS activity in transformed tobacco leaf discs. 展开更多
关键词 Agrobacterium TUMEFACIENS BINARY TI VECTORS Gateway technology pLSU Tobacco Leaf Disk Transformation TETRACYCLINE resistance
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Performance of Double-Pole Four-Throw Double-Gate RF CMOS Switch in 45-nm Technology
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作者 Viranjay M. Srivastava 《Wireless Engineering and Technology》 2010年第2期47-54,共8页
In this paper, we have investigated the design parameters of RF CMOS switch, which will be used for the wireless tele-communication systems. A double-pole four-throw double-gate radio-frequency complementary-metal-oxi... In this paper, we have investigated the design parameters of RF CMOS switch, which will be used for the wireless tele-communication systems. A double-pole four-throw double-gate radio-frequency complementary-metal-oxide-semicon- ductor (DP4T DG RF CMOS) switch for operating at the 1 GHz is implemented with 45-nm CMOS process technology. This proposed RF switch is capable to select the data streams from the two antennas for both the transmitting and receiving processes. For the development of this DP4T DG RF CMOS switch we have explored the basic concept of the proposed switch circuit elements required for the radio frequency systems such as drain current, threshold voltage, resonant frequency, return loss, transmission loss, VSWR, resistances, capacitances, and switching speed. 展开更多
关键词 45-nm technology Capacitance of DOUBLE-GATE MOSFET DG MOSFET DP4T SWITCH Radio Frequency RF SWITCH resistance of DOUBLE-GATE MOSFET VLSI
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Establishment and Application of Identification Methods for Resistance to Sugarcane White Leaf Disease(SCWL)
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作者 Wenfeng LI Rongyue ZHANG +4 位作者 Xiaoyan WANG Hongli SHAN Jie LI Yinhu LI Yingkun HUANG 《Agricultural Biotechnology》 CAS 2023年第1期12-15,共4页
[Objectives]This study was conducted to establish simple, efficient, stable, standardized and practical identification methods for sugarcane resistance to white leaf disease(SCWL), and promote the breeding for sugarca... [Objectives]This study was conducted to establish simple, efficient, stable, standardized and practical identification methods for sugarcane resistance to white leaf disease(SCWL), and promote the breeding for sugarcane resistance to SCWL. [Methods]The identification technology of sugarcane resistance to SCWL was systematically studied and explored from the aspects of sugarcane material treatment and planting, inoculation liquid preparation, inoculation method, disease investigation, grading standard formulation, etc., and two sets of simple, efficient, stable, standardized and practical accurate identification methods for sugarcane resistance to SCWL were created for the first time, namely, the seed cane coating inoculation method and the stem-cutting inoculation method at the growth stage. The seed cane coating inoculation method includes the steps of directly screening SCWL phytoplasma, extracting juice from cane and adding 10 times of sterile water to prepare an inoculation liquid, spraying seed cane on plastic film to keep moisture, planting the inoculated materials in barrels in an insect-proof greenhouse for cultivation, investigating the incidence rate 30 d after inoculation, and evaluating the disease resistance according to the 1-5 level standard. The method of stem-cutting inoculation includes the steps of directly screening sugarcane stems carrying SCWL phytoplasma and adding 10 times of sterile water to prepare an inoculation liquid, cultivating the identification materials in an insect-proof greenhouse, dropping 100 μl of the inoculation liquid into each root incision with a pipette gun at the age of 6 months, investigating the incidence rate 20 d after planting, and evaluating the disease resistance according to the 1-5 level standard. [Results] The two methods are similar to the natural transmission method. After inoculation, SCML occurred significantly, with high sensitivity and good reproducibility. The results of resistance identification were consistent with those of natural disease in the field. Through the two inoculation methods and field natural disease investigation, the resistance of 10 main cultivars to SCML was identified, which was true and reliable. [Conclusions] This study can provide standard varieties for identification of SCML resistance in the future. 展开更多
关键词 Sugarcane white leaf disease Inoculation technology Seed cane-spraying inoculation Stem-cutting inoculation method Identification of disease resistance
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不同纤维增韧环氧沥青混合料性能 被引量:3
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作者 肖鹏 陈家骏 +3 位作者 康爱红 孔贺誉 邓续康 张垚 《实验技术与管理》 CAS 北大核心 2024年第1期52-56,共5页
为探究不同种类纤维(玄武岩纤维、玻璃纤维和聚酯纤维)对环氧沥青混合料抗开裂和耐疲劳性能的提升效果,在混合料配比设计的基础上,采用车辙试验、低温小梁试验、浸水马歇尔试验以及冻融劈裂试验等对其进行路用性能测试。通过冲击试验,... 为探究不同种类纤维(玄武岩纤维、玻璃纤维和聚酯纤维)对环氧沥青混合料抗开裂和耐疲劳性能的提升效果,在混合料配比设计的基础上,采用车辙试验、低温小梁试验、浸水马歇尔试验以及冻融劈裂试验等对其进行路用性能测试。通过冲击试验,探究纤维对环氧沥青混合料的三种增韧效果:在环氧沥青混合料中添加纤维可以不同程度提高其路用性能;低温性能再加入纤维后,提升效果较为明显;添加玄武岩纤维路用性能优于玻璃纤维和聚酯纤维。 展开更多
关键词 环氧沥青 纤维环氧沥青混合料 增韧技术 抗裂性能 路用性能
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超疏水表面加工技术及耐磨性能研究进展 被引量:1
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作者 黄云 黄建超 +3 位作者 肖贵坚 刘帅 林瓯川 刘振扬 《中国机械工程》 EI CAS CSCD 北大核心 2024年第1期2-26,共25页
当前制备的超疏水表面耐磨性能普遍较差,因而其在各领域的应用受到限制。研究表明微纳结构和低表面能是实现功能表面超疏水性能的关键因素,因此,首先基于超疏水表面作用机制,对超疏水表面织构进行了归纳,旨在通过优化表面织构来解决微... 当前制备的超疏水表面耐磨性能普遍较差,因而其在各领域的应用受到限制。研究表明微纳结构和低表面能是实现功能表面超疏水性能的关键因素,因此,首先基于超疏水表面作用机制,对超疏水表面织构进行了归纳,旨在通过优化表面织构来解决微纳结构易磨损难题;然后对超疏水表面加工技术进行了梳理总结,从成本和效率两个方面分析了降低表面能的措施,为拓展超疏水表面加工体系提供思路;进而详细总结了超疏水表面耐磨性的分析手段,并阐述了提高超疏水表面耐磨性的方法;最后,展望了耐磨性超疏水表面的未来发展前景,以期推动超疏水表面在工程中的大规模应用。 展开更多
关键词 超疏水表面 加工技术 耐磨性 微纳结构 低表面能
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成像测井解释评价方法及其地质应用 被引量:2
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作者 赖锦 肖露 +5 位作者 白天宇 范旗轩 黄玉越 李红斌 赵飞 王贵文 《地质科技通报》 CAS CSCD 北大核心 2024年第3期323-340,共18页
为了系统梳理成像测井解释评价存在的问题并拓展其在地质与工程领域中的应用范围,首先回顾了成像测井采集系列的发展历程及资料处理步骤与解释流程,然后提出了“四个层次”为约束(图像直接解释、常规测井约束、岩心约束以及地质理论约束... 为了系统梳理成像测井解释评价存在的问题并拓展其在地质与工程领域中的应用范围,首先回顾了成像测井采集系列的发展历程及资料处理步骤与解释流程,然后提出了“四个层次”为约束(图像直接解释、常规测井约束、岩心约束以及地质理论约束)的成像测井精细解释方法。成像测井相模式可划分出具有地质意义的块状、条带状、线状、斑状、杂乱、递变模式和对称沟槽状模式七大类。成像测井可用于岩心定向、地层产状获取、裂缝评价、断层性质分析、地应力方向判别、沉积特征拾取以及古水流方向判别等领域中。通过阿尔奇公式反算,成像测井数据矩阵可以生成孔隙度频谱以及视地层水电阻率谱,并可分别运用于储层质量评价以及流体性质识别。成像测井切片处理可凸显沉积纹层等信息,可实现细粒沉积岩纹层结构拾取及非常规油气储层高分辨率测井评价。Poro Tex图像结构分析技术可用于拾取孔洞缝等储集空间特征,并定量计算孔隙度和裂缝孔隙度等参数,因此被广泛运用至非均质性较强的碳酸盐岩储层测井综合评价工作中。研究成果可规避成像测井解释中的误区同时可扩展成像测井应用领域。 展开更多
关键词 成像测井 孔隙度谱 视地层水电阻率谱 切片图像 Poro Tex技术 地质应用
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藜麦—蓝靛果复合汁发酵工艺及其上清液抗氧化与抗疲劳作用研究
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作者 白海军 庞惟俏 +1 位作者 张智慧 王颖 《食品与机械》 CSCD 北大核心 2024年第7期148-154,共7页
[目的]优化藜麦—蓝靛果复合汁发酵工艺,开发营养价值高的抗运动疲劳食品。[方法]以黑藜麦和蓝靛果为原料,酵母菌复配乳酸菌协同发酵,通过单因素及正交试验优化复合发酵汁发酵工艺条件,并基于动物试验深入探究其对小鼠抗运动疲劳的作用... [目的]优化藜麦—蓝靛果复合汁发酵工艺,开发营养价值高的抗运动疲劳食品。[方法]以黑藜麦和蓝靛果为原料,酵母菌复配乳酸菌协同发酵,通过单因素及正交试验优化复合发酵汁发酵工艺条件,并基于动物试验深入探究其对小鼠抗运动疲劳的作用。[结果]藜麦—蓝靛果复合汁最佳发酵工艺条件为:初始pH 4.0,发酵时间32 h,发酵温度37℃,白砂糖添加量8%,发酵产物中超氧化物歧化酶的活力为253.49 U/mL。体外抗氧化试验表明,藜麦—蓝靛果复合汁发酵上清液具有较强的抗氧化作用且抗氧化性与其浓度成正比。动物试验结果表明,不同剂量的藜麦—蓝靛果复合汁发酵上清液均延长了小鼠负重力竭游泳时间,显著降低了血清中尿素氮等指标,并使肝糖原和肌糖原储备显著增加(P<0.05)。[结论]最优发酵条件下的藜麦—蓝靛果复合汁发酵上清液抗氧化性强,并且可以提高小鼠机体运动耐力。 展开更多
关键词 藜麦 蓝靛果 抗氧化 抗运动疲劳 发酵工艺
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飞灰含碳在线测量在660 MW机组锅炉燃烧中应用 被引量:2
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作者 张超 柳宁 +1 位作者 绳鹏鹏 崔小军 《冶金能源》 北大核心 2024年第1期54-56,共3页
针对失重法飞灰测碳装置在取样及测量方面的不足,利用防堵耐磨等技术提高飞灰测碳装置的测量精度和取样稳定性,并将装置应用于660 MW机组锅炉智慧燃烧系统中,通过精准飞灰含碳测量反映炉内燃烧状态,确保燃烧优化控制模型预测的正确性。... 针对失重法飞灰测碳装置在取样及测量方面的不足,利用防堵耐磨等技术提高飞灰测碳装置的测量精度和取样稳定性,并将装置应用于660 MW机组锅炉智慧燃烧系统中,通过精准飞灰含碳测量反映炉内燃烧状态,确保燃烧优化控制模型预测的正确性。研究结果表明,飞灰含碳实际值与预测值误差保持在较小范围内,最大误差不超过0.015%。优化燃烧系统后的现场运行结果表明,飞灰含碳量均值由2.1%降到1.5%,锅炉效率平均提高0.21%。 展开更多
关键词 飞灰含碳 在线测量技术 防堵耐磨 智慧燃烧
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异时性多复发灶耐药基因分子异质性的胃肠道间质瘤1例报告及文献复习
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作者 王玥 吴迪 +1 位作者 于丹丹 段秀梅 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2024年第2期545-550,共6页
目的:分析1例长期伊马替尼治疗后多部位、异时性复发病灶敏感/耐药共存的少见胃肠道间质瘤(GISTs)患者的临床资料,揭示GISTs继发突变的异质性是复发耐药过程中的重要属性。方法:收集1例复发GISTs患者的临床资料,采用HE染色法进行组织学... 目的:分析1例长期伊马替尼治疗后多部位、异时性复发病灶敏感/耐药共存的少见胃肠道间质瘤(GISTs)患者的临床资料,揭示GISTs继发突变的异质性是复发耐药过程中的重要属性。方法:收集1例复发GISTs患者的临床资料,采用HE染色法进行组织学观察,免疫组织化学染色检测相关蛋白表达,一代和二代测序技术分析肿瘤基因变异情况。结果:患者,男性,66岁,因胃间质瘤行胃部分切除术。一代测序技术检测结果显示为原癌基因,受体酪氨酸激酶(KIT)基因11号外显子缺失突变(p.551-554del)。伊马替尼治疗1年左右,停药4个月后复发,患者出现脾区病灶,继续采用伊马替尼一线治疗,脾区病灶得到控制。59个月后盆腔发现新病灶,采用伊马替尼加量(600 mg·d^(-1))并舒尼替尼二线治疗,治疗2个月后CT检查结果显示患者脾区病灶大小趋于稳定,而盆腔新病灶体积持续增大。二代测序技术检测结果显示两复发灶在原有KIT基因11号外显子缺失突变的基础上,分别继发KIT基因13号外显子(p.V654A)和17号外显子(p.Y823D)突变。结论:GISTs在靶向药物选择作用的压力下,肿瘤生物学行为表现出复杂性,即时间异质性、空间异型性和分子异质性,不同复发灶可以出现不同的耐药机制。 展开更多
关键词 胃肠道间质瘤 复发耐药 异质性 二代测序技术 伊马替尼
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间变性淋巴瘤激酶在治疗非小细胞肺癌中的作用及潜在医学应用
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作者 陈波 阚连娣 +2 位作者 叶发青 孙艳亭 陈立颖 《中国药理学通报》 CAS CSCD 北大核心 2024年第3期415-420,共6页
在非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗过程中,随着靶向表皮生长因子受体剂(epidermal growth factor receptor,EGFR)抑制剂的使用,不少患者出现了耐药,耐药的主要原因有EGFR位点的突变,旁路激活等原因。在旁路激活... 在非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗过程中,随着靶向表皮生长因子受体剂(epidermal growth factor receptor,EGFR)抑制剂的使用,不少患者出现了耐药,耐药的主要原因有EGFR位点的突变,旁路激活等原因。在旁路激活中主要有间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)等通路的激活。最近有权威研究发现ALK与免疫治疗有密切的关系。该文从ALK的结构和生理功能,ALK的小分子抑制剂,ALK的生物学功能及其与NSCLC相关的应用现状进行综述,并展望了未来的发展方向,从而使ALK更好地应用于NSCLC的治疗。 展开更多
关键词 非小细胞肺癌 间变性淋巴瘤激酶 免疫治疗 靶向蛋白降解技术(PROTAC) 嵌合抗原受体T细胞 耐药
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堤坝蚁巢综合物探技术研究进展
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作者 谭磊 彭渊 +3 位作者 张平松 徐虎 江晓益 胡雄武 《水利水电科技进展》 CSCD 北大核心 2024年第5期7-15,47,共10页
通过梳理不同时期土石坝蚁巢的类型与规模,阐述了蚁巢的结构特点及成灾模式,总结了蚁巢物探的物性基础;着重介绍了直流电阻率法、探地雷达技术、地震勘探法等在蚁巢探测中的应用现状,从成果维度、探测效率、工作强度、探查精度等视角论... 通过梳理不同时期土石坝蚁巢的类型与规模,阐述了蚁巢的结构特点及成灾模式,总结了蚁巢物探的物性基础;着重介绍了直流电阻率法、探地雷达技术、地震勘探法等在蚁巢探测中的应用现状,从成果维度、探测效率、工作强度、探查精度等视角论述了探测方法的适用条件,指出现有物探技术还不能有效支撑蚁巢的高精度、高效率、立体化探测,并提出了普查-详查-治理-监控的蚁患综合物探服务架构。立足于蚁巢探查技术的客观需要,提出未来蚁巢物探技术应聚焦研制蚁巢发育阶段的1∶1病害物理模拟装置及隐患图谱,研发适应堤坝地形的蚁巢探测装备及正反演算法,构建堤坝蚁害常态化巡查体系及时移电阻率监控系统。 展开更多
关键词 堤坝 蚁巢 物探技术 渗漏探测 探地雷达 电阻率法
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PCB中耐高温有机可焊保护剂成膜机理及性能研究
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作者 王跃峰 姜其畅 +3 位作者 马紫微 贾明理 苏振 孙慧霞 《电子科技大学学报》 EI CAS CSCD 北大核心 2024年第4期487-494,共8页
印制电路板铜焊盘表面生成耐高温有机可焊保护剂(HT-OSP)膜是克服无铅高温回流焊工艺并获得良好焊点的关键。选用2-[(2,4-二氯苯基)甲基]-1H-苯并咪唑(C_(14)H_(10)Cl_(2)N_(2))作为成膜剂,在铜层表面生成了HT-OSP膜。理论计算结合对比... 印制电路板铜焊盘表面生成耐高温有机可焊保护剂(HT-OSP)膜是克服无铅高温回流焊工艺并获得良好焊点的关键。选用2-[(2,4-二氯苯基)甲基]-1H-苯并咪唑(C_(14)H_(10)Cl_(2)N_(2))作为成膜剂,在铜层表面生成了HT-OSP膜。理论计算结合对比实验,研究C_(14)H_(10)Cl_(2)N_(2)分子与Cu原子反应生成HT-OSP膜机理。基于量子化学密度泛函理论,模拟C_(14)H_(10)Cl_(2)N_(2)分子与Cu^(+)之间的络合反应;利用红外光谱对HT-OSP膜中的特征官能团进行表征;借助X射线光电子能谱测试HT-OSP膜中Cu元素的化合价;设计对比实验分析Cu^(2+)对生成HT-OSP膜的影响。结果表明:HT-OSP膜生成机理是C_(14)H_(10)Cl_(2)N_(2)分子与Cu原子发生反应生成HT-OSP膜并沉积在铜层表面,Cu^(2+)通过络合反应促进HT-OSP膜生长。另外,HT-OSP膜的分解温度高达531℃,HT-OSP膜保护的铜层放置在自然环境中180天没有被氧化,证明HT-OSP膜具有优异的耐热性和抗氧化性。 展开更多
关键词 表面处理技术 耐高温有机可焊保护剂 成膜机理 密度泛函理论 印制电路板
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高产、优质、多抗酿造用糯高粱杂交种辽糯22选育及栽培技术
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作者 王艳秋 张飞 +2 位作者 朱凯 王佳旭 邹剑秋 《辽宁农业科学》 2024年第5期87-89,共3页
糯高粱杂交种辽糯22(LA34×LNR8)是辽宁省农业科学院高粱研究所于2018年以自选不育系LA34为母本,自选恢复系LNR8为父本,于2018年春季在海南组配而成LA34×LNR8杂交组合。2018~2019年连续2年在所内进行了产量和抗性鉴定,表现优异... 糯高粱杂交种辽糯22(LA34×LNR8)是辽宁省农业科学院高粱研究所于2018年以自选不育系LA34为母本,自选恢复系LNR8为父本,于2018年春季在海南组配而成LA34×LNR8杂交组合。2018~2019年连续2年在所内进行了产量和抗性鉴定,表现优异,2020~2021年参加全国高粱品种区域试验,平均产量587.8 kg/667m^(2)。2023年12月通过农业农村部非主要农作物品种登记。该品种熟期适中、农艺性状好、糯性遗传稳定,是一个高产、优质、多抗的酿造用糯高粱杂交种。 展开更多
关键词 高产 优质 多抗 糯高粱 选育 栽培技术
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