This paper is a sequel to a previous paper (Yang, Y. and Zhang, J. H. Existence of solutions for some fourth-order boundary value problems with parameters. Nonlinear Anal. 69(2), 1364-1375 (2008)) in which the n...This paper is a sequel to a previous paper (Yang, Y. and Zhang, J. H. Existence of solutions for some fourth-order boundary value problems with parameters. Nonlinear Anal. 69(2), 1364-1375 (2008)) in which the nontrivial solutions to the fourthorder boundary value problems were studied. In the current work with the same conditions near infinity but different near zero, the positive, negative, and sign-changing solutions are obtained by the critical point theory, retracting property, and invariant sets.展开更多
This paper presents a new explanatory model for schizophrenia based upon philosophical, molecular and neurobiological hypotheses as well as on years of experience in observing and treating these patients. To start wit...This paper presents a new explanatory model for schizophrenia based upon philosophical, molecular and neurobiological hypotheses as well as on years of experience in observing and treating these patients. To start with, a novel interpretation of the Hegelian concept of mediation is presented. Mediation is defined as the rejection of non-realizable programs, such as thoughts and ideas, at a certain point in time in the evolution of a living system. Whenever a system treats non-realizable programs as if they were realizable, its ability to “test the reality” is lost, and consequently a loss of ego-boundaries may occur. On the molecular level, I will try to show how “non-splicing” of introns during the mRNA splicing process is equivalent to a loss of the rejection function corresponding to mediation. At the cellular level in the brain, mediation can be explained in terms of glial-neuronal interactions. Glia exert a spatio-temporal boundary setting function determining the grouping of neurons into functional units. Mutations in genes that result in non-splicing of introns can produce truncated (“chimeric”) neurotransmitter receptors. I propose that such dysfunctional receptors are generated in glial cells and that they cannot interact properly with their cognate neurotransmitters. The glia will then lose their inhibitory-rejecting function with respect to the information processing within neuronal networks. This loss of glial boundary setting could be an explanation for the loss of ego or body boundaries in schizophrenia. Pertinent examples of case studies are given attempting to deduce the main symptoms of schizophrenia from the proposed hypothesis. Some implications for the design of delusional robots are also discussed. Finally, the evolutionary potency of non-coding introns is philosophically interpreted that schizophrenics may be “too soon on earth”.展开更多
An advanced geometric modeler GEMS4.0 has been developed, in whichfeature representation is used at the highest level abstraction of a productmodel. Boundary representation is used at the bottom level, while CSG model...An advanced geometric modeler GEMS4.0 has been developed, in whichfeature representation is used at the highest level abstraction of a productmodel. Boundary representation is used at the bottom level, while CSG modelis adopted at the median level. A BRep data structure capable of modelingnon-manifold is adopted. NURBS representation is used for all curved surfaces.Quadric surfaces have dual representations consisting of their geometric datasuch as radius, center point, and center tals. Boundary representation of freeform surfaces is easily built by sweeping and skinning method with NURBSgeometry Set operations on curved solids with boundary representation areperformed by an evaluation process consisting of four steps. A file exchangefacility is provided for the conversion between product data described by STEPand product information generated by GEMS4.0展开更多
In this paper, we study the integral solution operators for the -equations on pseudoconvex domains. As a generalization of [1] for the -dequations on pseudoconvex domains with boundary of class C∞, we obtain the ex...In this paper, we study the integral solution operators for the -equations on pseudoconvex domains. As a generalization of [1] for the -dequations on pseudoconvex domains with boundary of class C∞, we obtain the explicit integral operator solutions of C -form for the -equations on pseudoconvex open sets with boundary of Ck (k≥0) and the sup-norm estimates of which solutions have similar as that [1] in form.展开更多
基金Project supported by the National Natural Science Foundation of China (No. 10871096)the Foun-dation of Major Project of Science and Technology of Chinese Education Ministry (No. 205056)+2 种基金the Project of Graduate Education Innovation of Jiangsu Province (No. CX09B_284Z)the Foundation for Outstanding Doctoral Dissertation of Nanjing Normal Universitythe Foundation for Young Teachers of Jiangnan University (No. 2008LQN008)
文摘This paper is a sequel to a previous paper (Yang, Y. and Zhang, J. H. Existence of solutions for some fourth-order boundary value problems with parameters. Nonlinear Anal. 69(2), 1364-1375 (2008)) in which the nontrivial solutions to the fourthorder boundary value problems were studied. In the current work with the same conditions near infinity but different near zero, the positive, negative, and sign-changing solutions are obtained by the critical point theory, retracting property, and invariant sets.
文摘This paper presents a new explanatory model for schizophrenia based upon philosophical, molecular and neurobiological hypotheses as well as on years of experience in observing and treating these patients. To start with, a novel interpretation of the Hegelian concept of mediation is presented. Mediation is defined as the rejection of non-realizable programs, such as thoughts and ideas, at a certain point in time in the evolution of a living system. Whenever a system treats non-realizable programs as if they were realizable, its ability to “test the reality” is lost, and consequently a loss of ego-boundaries may occur. On the molecular level, I will try to show how “non-splicing” of introns during the mRNA splicing process is equivalent to a loss of the rejection function corresponding to mediation. At the cellular level in the brain, mediation can be explained in terms of glial-neuronal interactions. Glia exert a spatio-temporal boundary setting function determining the grouping of neurons into functional units. Mutations in genes that result in non-splicing of introns can produce truncated (“chimeric”) neurotransmitter receptors. I propose that such dysfunctional receptors are generated in glial cells and that they cannot interact properly with their cognate neurotransmitters. The glia will then lose their inhibitory-rejecting function with respect to the information processing within neuronal networks. This loss of glial boundary setting could be an explanation for the loss of ego or body boundaries in schizophrenia. Pertinent examples of case studies are given attempting to deduce the main symptoms of schizophrenia from the proposed hypothesis. Some implications for the design of delusional robots are also discussed. Finally, the evolutionary potency of non-coding introns is philosophically interpreted that schizophrenics may be “too soon on earth”.
文摘An advanced geometric modeler GEMS4.0 has been developed, in whichfeature representation is used at the highest level abstraction of a productmodel. Boundary representation is used at the bottom level, while CSG modelis adopted at the median level. A BRep data structure capable of modelingnon-manifold is adopted. NURBS representation is used for all curved surfaces.Quadric surfaces have dual representations consisting of their geometric datasuch as radius, center point, and center tals. Boundary representation of freeform surfaces is easily built by sweeping and skinning method with NURBSgeometry Set operations on curved solids with boundary representation areperformed by an evaluation process consisting of four steps. A file exchangefacility is provided for the conversion between product data described by STEPand product information generated by GEMS4.0
文摘In this paper, we study the integral solution operators for the -equations on pseudoconvex domains. As a generalization of [1] for the -dequations on pseudoconvex domains with boundary of class C∞, we obtain the explicit integral operator solutions of C -form for the -equations on pseudoconvex open sets with boundary of Ck (k≥0) and the sup-norm estimates of which solutions have similar as that [1] in form.