期刊文献+
共找到2,806篇文章
< 1 2 141 >
每页显示 20 50 100
Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage
1
作者 Yue-Ying Wang Ke Li +5 位作者 Jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun Ji-Ping Qi Yue-Jia Song 《World Journal of Diabetes》 SCIE 2024年第9期1979-2001,共23页
BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patie... BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of diabetes.The role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are unknown.In this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.AIM To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.METHODS BMSC-exo were isolated from mouse BMSC media.This was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro analyses.The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of mice.RESULTS Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery.MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation.Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases.Furthermore,we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.CONCLUSION We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain. 展开更多
关键词 Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1
下载PDF
配筋率对钢箱-UHPC组合梁裂缝特征的影响
2
作者 莫时旭 房洋洋 +1 位作者 郑艳 农双秀 《山东科技大学学报(自然科学版)》 CAS 北大核心 2024年第3期85-93,共9页
为研究钢箱-超高性能混凝土(UHPC)组合梁负弯矩区裂缝特征,设计制作了3根配筋率分别为1%、2%和3%的UHPC翼板部分充填砼窄幅钢箱组合梁,通过对不同配筋率的试验梁进行反向加载试验研究组合梁的裂缝发展特征,并对最大裂缝宽度、裂缝间距... 为研究钢箱-超高性能混凝土(UHPC)组合梁负弯矩区裂缝特征,设计制作了3根配筋率分别为1%、2%和3%的UHPC翼板部分充填砼窄幅钢箱组合梁,通过对不同配筋率的试验梁进行反向加载试验研究组合梁的裂缝发展特征,并对最大裂缝宽度、裂缝间距及开裂荷载进行对比分析。研究结果表明:试验梁在不同配筋率条件下,UHPC面层裂缝发展明显不同,配筋率越高最大裂缝宽度越小,裂缝越密集,开裂荷载越大;与配筋率为1%的试验梁相比,配筋率为2%和3%的试验梁的开裂弯矩分别提高了30.3%和65.2%;可根据《公路钢筋混凝土及预应力混凝土桥涵设计规范》(JTG 3362—2018)中的裂缝宽度计算公式乘以0.78的修正系数,来计算窄幅钢箱-UHPC组合梁负弯矩区的裂缝宽度。 展开更多
关键词 窄幅钢箱组合梁 配筋率 裂缝发展特征 负弯矩区
下载PDF
部分充填式窄幅钢箱-UHPC组合梁抗剪试验研究
3
作者 莫时旭 熊豪 +1 位作者 郑艳 柴龙杰 《河南理工大学学报(自然科学版)》 CAS 北大核心 2024年第1期157-164,195,共9页
目的为研究部分充填式窄幅钢箱-UHPC组合梁的抗剪性能,方法对4根倒置组合梁试件通过三点加载方式进行了静载试验,通过研究其负弯矩作用下的破坏形态及变形特征,得到了组合梁的荷载-挠度曲线、应变分布、荷载-滑移曲线、最终破坏形态等... 目的为研究部分充填式窄幅钢箱-UHPC组合梁的抗剪性能,方法对4根倒置组合梁试件通过三点加载方式进行了静载试验,通过研究其负弯矩作用下的破坏形态及变形特征,得到了组合梁的荷载-挠度曲线、应变分布、荷载-滑移曲线、最终破坏形态等。结果试验研究结果表明:UHPC翼板显著提升了组合梁的变形能力和极限承载力;相较于试件SUCB-3(NC翼板),试件SUCB-1(1/2UHPC翼板和SUCB-4(全UHPC翼板))的承载力分别提高了18.2%和27.3%,变形能力则分别增强了38.02%和41.2%;钢纤维的添加能有效地抑制翼板裂缝的开展,钢纤维掺量从0提高到2%,试件的最大裂缝宽度从1.06 mm降低到0.92 mm,变形能力增强了23.61%,承载力则提高了4%。结论提出了考虑钢箱、UHPC翼板和充填混凝土贡献的组合梁抗剪承载力计算公式。 展开更多
关键词 窄幅钢箱-UHPC组合梁 静载试验 抗剪承载力 钢纤维掺量
下载PDF
窄幅钢箱-UHPC组合梁负弯矩下抗弯性能试验研究
4
作者 郑艳 刘晓贝 +2 位作者 羊海林 莫时旭 黄荆 《建筑科学与工程学报》 CAS 北大核心 2024年第4期42-50,共9页
为改善钢-混凝土组合梁负弯矩下的受力性能,提出一种新型窄幅钢箱-超高性能混凝土(UHPC)组合梁。通过6根试验梁的反向静力加载试验,得到试验梁受力全过程跨中荷载-挠度、荷载-应变、荷载-最大裂缝宽度关系曲线、裂缝发生发展及破坏形态... 为改善钢-混凝土组合梁负弯矩下的受力性能,提出一种新型窄幅钢箱-超高性能混凝土(UHPC)组合梁。通过6根试验梁的反向静力加载试验,得到试验梁受力全过程跨中荷载-挠度、荷载-应变、荷载-最大裂缝宽度关系曲线、裂缝发生发展及破坏形态等,基于简化塑性理论推导出了组合梁极限抗弯承载力计算公式。结果表明:窄幅钢箱-UHPC组合梁在负弯矩下具有良好的受力性能;提高配筋率、钢纤维掺量和UHPC相对板厚都可在一定程度上改善组合梁延性,提高其极限抗弯承载力;翼板配筋率对承载力影响较大,配筋率由1%增加至2%时,其极限抗弯承载力提高了15%;钢纤维掺量和UHPC相对板厚对初始开裂荷载影响较大,钢纤维掺量从1%增加到2%时,初始开裂荷载提高32%,UHPC相对板厚由0增加到0.5时,初始开裂荷载提高56%;增加钢纤维掺量和UHPC相对板厚可有效控制裂缝宽度,减少结构主裂缝数量,改善组合梁耐久性;组合梁极限抗弯承载力计算公式计算值与试验值吻合较好,表明塑性理论适用于窄幅钢箱-UHPC组合梁的承载力计算。 展开更多
关键词 窄幅钢箱-UHPC组合梁 抗弯性能 负弯矩区 静载试验 极限抗弯承载力
下载PDF
CFRP-钢箱混凝土变截面新型跨座式轨道梁设计优化
5
作者 申彦利 韩建棒 杜鹏 《混凝土》 CAS 北大核心 2024年第7期195-198,203,共5页
为满足新型跨座式单轨系统需求,提出一种碳纤维复合材料(CFRP)-钢箱混凝土组合轨道梁形式。通过数值模拟试验,探究钢箱上室混凝土厚度对荷载作用下的钢箱混凝土轨道梁跨中顶面、底面、上室混凝土最大应力及竖向挠度的影响,得出钢箱上室... 为满足新型跨座式单轨系统需求,提出一种碳纤维复合材料(CFRP)-钢箱混凝土组合轨道梁形式。通过数值模拟试验,探究钢箱上室混凝土厚度对荷载作用下的钢箱混凝土轨道梁跨中顶面、底面、上室混凝土最大应力及竖向挠度的影响,得出钢箱上室混凝土的适宜厚度;在此基础上考虑运行维护阶段轨道梁抗弯性能需求,通过梁底粘贴预应力CFRP提高其抗弯性能,经分析得出钢箱混凝土变截面组合轨道梁跨中竖向挠度随梁底粘贴CFRP长度的变化趋势并给出CFRP-钢箱混凝土轨道梁的设计建议。研究结果表明:该CFRP-钢箱混凝土变截面新型跨座式单轨轨道梁抗弯性能良好,可满足实际工程需要。 展开更多
关键词 跨座式单轨轨道梁 钢箱混凝土 CFRP 体外预应力
下载PDF
公铁混合布置大跨度斜拉桥主梁断面形式研究--以赣江公铁大桥西支主桥设计为例
6
作者 郭安娜 王新国 +1 位作者 崔苗苗 周刚 《铁道标准设计》 北大核心 2024年第1期96-101,共6页
以赣江公铁两用大桥西支主桥设计为例,研究一种适应上层8车道公路、下层对称双线铁路+4车道公路混合布置的主梁断面形式。提出带挑臂双索面箱桁组合断面、带挑臂单索面箱桁组合断面、矩形箱桁组合断面、矩形钢桁梁断面4种主梁断面方案,... 以赣江公铁两用大桥西支主桥设计为例,研究一种适应上层8车道公路、下层对称双线铁路+4车道公路混合布置的主梁断面形式。提出带挑臂双索面箱桁组合断面、带挑臂单索面箱桁组合断面、矩形箱桁组合断面、矩形钢桁梁断面4种主梁断面方案,采用有限元软件分析各方案静动力性能及受力特点,综合考虑方案构造特点、技术指标、工程数量、公铁运营安全、景观效果等,确定该桥选用带挑臂双索面箱桁组合断面。该桥斜拉索最大索力16000 kN,锚固在下层钢箱梁两侧,通过有限元实体分析对锚拉板和钢锚箱式两种索梁锚固形式进行比选研究,钢锚箱形式受力合理、应力水平低、经济性好,设计采用钢锚箱形式。带挑臂双索面箱桁组合断面桥面空间布置合理、下层公铁行车干扰小、梁端竖向变形最小、经济性好,是一种适应公铁混合布置大跨度斜拉桥主梁断面形式。 展开更多
关键词 公铁两用桥 斜拉桥 公铁混合布置 主梁断面 带挑臂双索面箱桁组合断面 钢锚箱 设计
下载PDF
Closed-form solution for shear lag effects of steel-concrete composite box beams considering shear deformation and slip 被引量:10
7
作者 周旺保 蒋丽忠 +1 位作者 刘志杰 刘小洁 《Journal of Central South University》 SCIE EI CAS 2012年第10期2976-2982,共7页
Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs... Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs,the governing differential equations and boundary conditions of the steel-concrete composite box beams under lateral loading were derived using energy-variational method.The closed-form solutions for stress,deflection and slip of box beams under lateral loading were obtained,and the comparison of the analytical results and the experimental results for steel-concrete composite box beams under concentrated loading or uniform loading verifies the closed-form solution.The investigation of the parameters of load effects on composite box beams shows that:1) Slip stiffness has considerable impact on mid-span deflection and end slip when it is comparatively small;the mid-span deflection and end slip decrease significantly with the increase of slip stiffness,but when the slip stiffness reaches a certain value,its impact on mid-span deflection and end slip decreases to be negligible.2) The shear deformation has certain influence on mid-span deflection,and the larger the load is,the greater the influence is.3) The impact of shear deformation on end slip can be neglected.4) The strain of bottom plate of steel beam decreases with the increase of slip stiffness,while the shear lag effect becomes more significant. 展开更多
关键词 steel-concrete composite box beam shear lag effect shear deformation SLIP closed-form solution
下载PDF
箱形截面钢-混凝土组合连梁的抗震性能
8
作者 郑博文 张文元 《建筑结构》 北大核心 2024年第1期9-16,8,共9页
对一种箱形截面钢-混凝土组合连梁展开研究,通过有限元模拟和理论分析对其屈服模式、抗震性能进行了深入探索。对不同参数取值下组合连梁的屈服模式进行对比分析,基于组合连梁长度与屈服承载力的关系,给出屈服模式的判定准则,研究了不... 对一种箱形截面钢-混凝土组合连梁展开研究,通过有限元模拟和理论分析对其屈服模式、抗震性能进行了深入探索。对不同参数取值下组合连梁的屈服模式进行对比分析,基于组合连梁长度与屈服承载力的关系,给出屈服模式的判定准则,研究了不同参数对组合连梁屈服模式的影响规律。结果表明:减小截面高度、钢腹板高厚比、钢材屈服强度、混凝土强度,增大剪跨比、钢翼缘宽厚比、截面高宽比等措施均使耗能梁段更容易弯曲屈服。轴向受压时,弯曲屈服型构件的延性普遍优于剪切屈服型构件;轴向受拉时,剪切屈服型构件的延性优于弯曲屈服型构件。剪切屈服型构件的弹性段刚度、屈服荷载、极限荷载以及能量耗散系数普遍大于弯曲屈服型构件。 展开更多
关键词 箱形截面钢-混凝土组合连梁 屈服模式 抗震性能 参数分析
下载PDF
Lateral-torsional buckling of box beam with corrugated steel webs 被引量:9
9
作者 FENG Yu-lin JIANG Li-zhong +1 位作者 ZHOU Wang-bao HAN Jian-ping 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第7期1946-1957,共12页
Corrugated steel web is folded along the longitudinal direction and has the mechanical properties such as axial compression stiffness corrugation effect, shear modulus corrugation effect, similar to that of an accordi... Corrugated steel web is folded along the longitudinal direction and has the mechanical properties such as axial compression stiffness corrugation effect, shear modulus corrugation effect, similar to that of an accordion. In order to study the lateral-torsional buckling of box beams with corrugated steel webs (BBCSW) under the action of bending moment load, the neutral equilibrium equation of BBCSW under the action of bending moment load is derived through the stationary value theory of total potential energy and further, along with taking Kollbrunner-Hajdin correction method and the mechanical properties of the corrugated web into consideration. The analytical calculation formula of lateral-torsional buckling critical bending moment of BBCSW is then obtained. The lateral-torsional buckling critical bending moment of 96 BBCSW test specimens with different geometry dimensions are then calculated using both the analytical calculation method and ANSYS finite element method. The results show that the analytical calculation results agree well with the numerical calculation results using ANSYS, thus proving the accuracy of the analytical calculation method and model simplification hypothesis proposed in this paper. Also, compared with the box beams with flat steel webs (BBFSW) with the same geometry dimensions as BBCSW, within the common range of web space-depth ratio and web span-depth ratio, BBCSW’s lateral-torsional buckling critical bending moment is larger than that of BBFSW. Moreover, the advantages of BBCSW’s stability are even more significant with the increase of web space-depth ratio and web depth-thickness ratio. 展开更多
关键词 box beams with corrugated steel webs lateral-torsional buckling analytical solution accordion effect Kollbrunner-Hajdin method
下载PDF
UHPC-部分充填窄幅钢箱组合梁抗弯性能
10
作者 郑艳 刘帅 +3 位作者 羊海林 柴龙杰 农双秀 黄荆 《混凝土》 CAS 北大核心 2024年第7期28-32,38,共6页
为研究UHPC-部分充填窄幅钢箱组合梁负弯矩下的抗弯性能,制作了6根试验梁探究翼板配筋率、UHPC钢纤维掺量及板厚对组合梁截面应变分布、破坏形式及极限承载力的影响。试验结果表明:3%钢纤维掺量的UHPC翼板开裂荷载比0、1%、2%钢纤维掺量... 为研究UHPC-部分充填窄幅钢箱组合梁负弯矩下的抗弯性能,制作了6根试验梁探究翼板配筋率、UHPC钢纤维掺量及板厚对组合梁截面应变分布、破坏形式及极限承载力的影响。试验结果表明:3%钢纤维掺量的UHPC翼板开裂荷载比0、1%、2%钢纤维掺量的UHPC翼板分别大63.1%、29.8%、7.7%,说明钢纤维的加入,能够控制裂缝的发展,提高翼板的塑性,可有效改善破坏时的脆性现象。翼板配筋率提高1%时,抗弯承载力提高5.3%。用UHPC替代翼板1/2厚度的普通混凝土,开裂能力提高了56.2%,极限荷载提高了7%。基于简化塑性理论提出了组合梁抗弯承载力计算式,计算值与试验值吻合较好。 展开更多
关键词 钢箱组合梁 UHPC 抗弯性能 负弯矩 承载能力
下载PDF
A new 3-D element formulation on displacement of steel-concrete composite box beam 被引量:2
11
作者 周凌宇 余志武 贺桂超 《Journal of Central South University》 SCIE EI CAS 2013年第5期1354-1360,共7页
Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were establi... Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were established. Analytic solutions of combined differential equations were also established. Partial degree of freedom was adopted to establish a new FEA element of three-dimensional beam, taking into account the slip effect. Slip and its first-order derivative were introduced into the nodes of composite box beams as generalized degree of freedom. Stiffness matrix and load array of beam elements were established. A three-dimensional nonlinear calculation program was worked out. The results show that the element is reliable and easy to divide and is suitable for special nonlinear analysis of large-span composite box beams. 展开更多
关键词 steel-concrete composite box beam shear deformation slip effect variational method finite beam element method
下载PDF
部分充填式窄幅钢箱-UHPC组合梁负弯矩下抗剪强度
12
作者 杨彬 郑艳 +1 位作者 莫时旭 檀新宁 《科学技术与工程》 北大核心 2024年第19期8186-8192,共7页
为研究部分充填式窄幅钢箱-超高性能混凝土(ultra-high performance concrete,UHPC)组合梁在负弯矩下的裂缝开展、局部屈曲和竖向抗剪强度,对5根不同UHPC翼板层厚和钢箱不同充填高强混凝土(high strength concrete,HSC)高度的组合梁试... 为研究部分充填式窄幅钢箱-超高性能混凝土(ultra-high performance concrete,UHPC)组合梁在负弯矩下的裂缝开展、局部屈曲和竖向抗剪强度,对5根不同UHPC翼板层厚和钢箱不同充填高强混凝土(high strength concrete,HSC)高度的组合梁试件进行反置正向加载,得到了试件在加载过程中的破坏过程、荷载-裂缝宽度曲线、荷载-跨中挠度曲线、跨中应变分布和腹板应力应变等并进行分析。结果表明:相比于普通混凝土(normal concrete,NC)翼板试件,半UHPC和全UHPC翼板试件其抗剪承载力提升不大,仅8.3%和11.6%;相比于未充填试件,半充填和全充填试件其抗剪承载力分别提升了61.7%和87.2%。用UHPC替换部分NC翼板后试件能有效地控制裂缝发展,钢箱内充填HSC能有效地减小腹板局部屈曲。考虑翼板、钢梁和充填HSC对抗剪承载力的贡献,通过分项叠加法确定试件的抗剪承载力计算方法,能较准确地计算试件的抗剪承载力。 展开更多
关键词 -混凝土组合梁 充填式窄幅钢箱 UHPC 负弯矩 抗剪强度
下载PDF
基于改进NSGA-Ⅱ和IGA-BP神经网络的索梁锚固区结构优化研究
13
作者 胡翌刚 何博文 +3 位作者 袁庆 尹俊宇 刘国坤 郭伟奇 《公路工程》 2024年第2期31-38,115,共9页
为实现大跨度斜拉桥索梁锚固区钢锚箱的结构优化,依托某大跨度斜拉桥索梁锚固区结构实际工程,提出了一种基于NSGA-Ⅱ算法与IGA-BP神经网络模型的结构参数优化方法。首先基于BP神经网络确定了钢锚箱响应数据预测的拓扑结构,采用自适应交... 为实现大跨度斜拉桥索梁锚固区钢锚箱的结构优化,依托某大跨度斜拉桥索梁锚固区结构实际工程,提出了一种基于NSGA-Ⅱ算法与IGA-BP神经网络模型的结构参数优化方法。首先基于BP神经网络确定了钢锚箱响应数据预测的拓扑结构,采用自适应交叉变异改进的遗传算法对钢锚箱结构响应神经网络预测模型的权值阈值调参,得到满足拟合精度要求的IGA-BP神经网络预测模型。然后建立考虑结构平均应力和主要板件上峰值应力的数学优化模型,采用改进交叉、变异算子的NSGA-Ⅱ算法设计了钢锚箱结构参数优化流程。最后联合改进NSGA-Ⅱ算法和IGA-BP模型实现了钢锚箱结构参数的优化求解。结果表明:自适应遗传算法对BP神经网络权值与阈值调参的效果良好,相较于标准BP神经网络,IGA-BP神经网络的拟合精度和训练效率均更高;改进NSGA-Ⅱ算法可以实现对钢锚箱结构参数的寻优求解,根据Pareto协调最优解的结果,钢锚箱支撑板与承压板厚度有一定增加,加劲板和锚垫板厚度略微降低;优化后的结构上平均应力降幅约为2.7%,其中承压板应力峰值由200.9 MPa降低至178.1 MPa,降幅约为11.3%,支撑板应力峰值由199.6 MPa下降至179.5 MPa,降幅约为10.07%。优化后结构高应力区域峰值应力明显降低,中等应力区域分布较优化前更大,一定程度上改善了结构应力集中现象,验证了该方法的可行性。 展开更多
关键词 索梁锚固区 钢锚箱 结构优化 BP神经网络 非支配排序遗传算法
下载PDF
MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss 被引量:1
14
作者 Xiang-li PANG Jie LI +2 位作者 Jing WANG Si-si YAN Jing YANG 《Current Medical Science》 SCIE CAS 2024年第1期195-211,共17页
Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target... Objective Innate lymphoid cells(ILCs)are a class of newly discovered immunocytes.Group 1 ILCs(ILC1s)are identified in the decidua of humans and mice.High mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related diseases.Furthermore,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling pathway.This study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling pathway.Methods Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different groups.The targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were investigated.In addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,respectively.Furthermore,changes of the NF-κB signaling pathway in ILC1s were examined in the different groups.For the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling pathway.Results The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion miR-142-3p can regulate ILC1s by targeting HMGB1 via the NF-κB signaling pathway,and attenuate the inflammation at the maternal-fetal interface in abortive mice. 展开更多
关键词 maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p ABORTION
下载PDF
Restrained Bending of Thin-Walled Box Beam with Honeycomb Core
15
作者 臧庆来 张行 吴国勋 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2005年第3期223-229,共7页
Restrained bending of thin-walled box beam with honeycomb core is analyzed on the basis of rigid profile assumption. The method of variable separation is applied and two ordinary differential governing equations are e... Restrained bending of thin-walled box beam with honeycomb core is analyzed on the basis of rigid profile assumption. The method of variable separation is applied and two ordinary differential governing equations are established and solved. The boundary conditions are satisfied rigorously and the solutions are expressed by means of eigen function expansions. The diagram of shearing force is formulated by trigonometric series and used to determine the coefficients in above expansions. The computational resuits give the chord and span wise distributions of nomal and shear stress in the cover plate and the honeycomb core. At the same time, the attenuation of additional stress from fixed end to free end along the length of beam is shown clearly. 展开更多
关键词 box beam HONEYCOMB restrained bending method of variable separation eigen function expansion
下载PDF
Restrained Torsion of Thin-walled Box Beam with Honeycomb Core
16
作者 臧庆来 张行 吴国勋 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2005年第4期336-345,共10页
Restrained torsion of thin-walled box beam with honeycomb core is analyzed on the basis of rigid profile assumption. The method of variable separation is applied and two ordinary differential governing equations are e... Restrained torsion of thin-walled box beam with honeycomb core is analyzed on the basis of rigid profile assumption. The method of variable separation is applied and two ordinary differential governing equations are established and solved. The boundary conditions are satisfied rigorously and the solutions are expressed by means of eigen function expansions. The diagram of torque is formulated by trigonometric series and used to determine the coefficients in above expansions. The results of computation provide the chord-wise and span-wise distributions of normal and shear stress in the face plate along with shear stress in the honeycomb core. 展开更多
关键词 box beam HONEYCOMB restrained torsion method of variable separation eigen function expansion
下载PDF
Optimal Design for Thin-Walled Box Beam Based on Material Strength Reliability
17
作者 刘刚 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2003年第1期69-71,共3页
According to the reliability of material strength,the optimal design for the cross sectional size of thin walled box beam was studied.Firstly the cross sectional size as design random variable was determined,then its... According to the reliability of material strength,the optimal design for the cross sectional size of thin walled box beam was studied.Firstly the cross sectional size as design random variable was determined,then its stochastic nature was researched,with which the objective function is to seek the maximum reliability of the beam under given constraint conditions.This way is not the same as the conventional optimal design for the minimum weight of the material.With establishing the optimal objective,the reliability of the material under conditions of static and fatigue was considered.The corresponding calculated expressions are given.Normally the cross section sizes are fitted to the normal distribution,for the simplification of the design variable,the variation of the section size is assumed as a dependent variable proportional to the mean of the size.The way is different not only with the conventional optimal design but also with the common reliability design.The maximum reliability of material is obtained,meanwhile the area of the cross section is reduced,i.e.,the weight of the material is decreased. 展开更多
关键词 material strength RELIABILITY thin walled box beam optimal design
下载PDF
电动机械提梁机在钢-混组合箱梁预制桥面板安装中的应用
18
作者 杨宏 《科技资讯》 2024年第2期165-168,共4页
以甘肃省兰州市某公路工程建设项目桥梁工程上部结构施工为例,对双向六车道一级公路桥梁上部为宽幅钢波纹腹板-混凝土组合箱梁双钢梁的箱间预制桥面板安装施工工况进行分析,主要包括工艺原理、施工准备、测量放样、预制桥面板运输、电... 以甘肃省兰州市某公路工程建设项目桥梁工程上部结构施工为例,对双向六车道一级公路桥梁上部为宽幅钢波纹腹板-混凝土组合箱梁双钢梁的箱间预制桥面板安装施工工况进行分析,主要包括工艺原理、施工准备、测量放样、预制桥面板运输、电动机械提梁机起吊、预制桥面板安装架设等内容。针对该种施工条件,通过专门设计制作的轮胎式电动机械提梁机,将预制桥面板快速安装至钢波纹腹板-混凝土组合箱梁双钢箱梁箱之间预定位置上。这提高了施工安全性和稳定性,加快了施工进度和生产效率,减少了燃油消耗和车辆尾气的排放,对减少施工成本、提升安全环保文明施工水平具有良好的效用。 展开更多
关键词 电动机械 提梁机组合 箱梁预制桥面板 架设安装
下载PDF
Distortional buckling analysis of steel-concrete composite box beams considering effect of stud rotational restraint under hogging moment
19
作者 JIANG Li-zhong NIE Lei-xin +2 位作者 ZHOU Wang-bao WU Xia LIU Li-li 《Journal of Central South University》 SCIE EI CAS CSCD 2022年第9期3158-3170,共13页
Restrained distortional buckling is an important buckling mode of steel-concrete composite box beams(SCCBB)under the hogging moment.Rotational and lateral deformation restraints of the bottom plate by the webs are ess... Restrained distortional buckling is an important buckling mode of steel-concrete composite box beams(SCCBB)under the hogging moment.Rotational and lateral deformation restraints of the bottom plate by the webs are essential factors affecting SCCBB distortional buckling.Based on the stationary potential energy principle,the analytical expressions for the rotational restraint stiffness(RRS)of the web upper edge as well as the RRS and the lateral restraint stiffness(LRS)of the bottom plate were derived.Also,the SCCBB critical moment formula under the hogging moment was derived.Using twenty specimens,the theoretical calculation method is compared with the finite-element method.Results indicate that the theoretical calculation method can effectively and accurately reflect the restraint effect of the studs,top steel flange,and other factors on the bottom plate.Both the RRS and the LRS have a nonlinear coupling relationship with the external loads and the RRS of the web’s upper edge.Under the hogging moment,the RRS of the web upper edge has a certain influence on the SCCBB distortional buckling critical moment.With increasing RRS of the web upper edge,the SCCBB critical moment increases at first and then tends to be stable. 展开更多
关键词 steel-concrete composite box beams distortional buckling elastic rotational restraint boundary lateral restraint stiffness buckling moment
下载PDF
某高速公路钢-混组合梁桥设计分析与研究
20
作者 段宇 陆久飞 +1 位作者 李春生 李杰 《价值工程》 2024年第10期70-73,共4页
钢混组合梁结构是充分利用钢梁与混凝土的组合性能的优势,提升了桥梁结构安全、经济、美观等综合性能。以具体的钢混组合梁结构设计项目为例,桥面板为混凝土桥面,桥面板底设置2根槽型钢箱梁,通过剪力钉连接桥面板与槽型钢箱梁,横向是通... 钢混组合梁结构是充分利用钢梁与混凝土的组合性能的优势,提升了桥梁结构安全、经济、美观等综合性能。以具体的钢混组合梁结构设计项目为例,桥面板为混凝土桥面,桥面板底设置2根槽型钢箱梁,通过剪力钉连接桥面板与槽型钢箱梁,横向是通过内横撑和箱间横梁连接,主要是从结构总体设计、结构的验算和施工工艺方法三个方面对钢-混凝土组合梁结构进行设计分析研究,结果表明该组合梁结构合理、安全可靠;进一步利用大型桥梁专用软件Midas/Civil建立钢-混凝土组合梁结构的有限元空间梁格模型并进行分析,理论计算结果表明,钢混组合梁桥力学性能满足规范设计要求;钢箱梁在制造加工、运输、吊装等过程中整体稳定性和刚度均满足要求。 展开更多
关键词 钢混组合梁 有限元分析 梁格模型 结构设计 结构计算
下载PDF
上一页 1 2 141 下一页 到第
使用帮助 返回顶部