A Study on Hydroelastic Response of Box-Type Very Large Floating Structures

The application of very large floating structure (VLFS) to the utilization of ocean space and exploitation of ocean resources has become one of the issues of great interest in international ocean engineering field. Owing to the advantage of simplicity in structure and low cost of construction and maintenance, box-type VLFS can be used in the calm water area near the coast as the structure configuration of floating airport. In this paper, a 3D linear hydroelastic theory is used to study the dynamic response of box-type VLFS in sinusoidal regular waves. A beam model and a 3D FEM model are respectively employed to describe the dynamic characteristics of the box-type Structure in vacuum. A hydrodynamic model (3D potential theory of flexible body) is applied to investigate the effect of different dry models on the hydroelastic response of box-type structure. Based on the calculation of hydroelastic response in regular waves, the rigid body motion displacement, flexible deflection, and the short term and long term wave induced bending moments are also predicted.

Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammation

The transcription factor forkhead box protein A2(FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the early development to the organofaction, and subsequently in homeostasis and metabolism in the adult. In the embryonic development period, FOXA2 is require d for the formation of the primitive node and notochord, and its absence results in embryonic lethality. Moreover, FOXA2 plays an important role not only in lung development, but also in T helper type 2(Th2)-mediated pulmonary inflammation and goblet cell hyperplasia. In this article, the role of FOXA2 in lung development and Th2-mediated pulmonary inflammation, as well as in goblet cell hyperplasia, is reviewed. FOXA2 deletion in airway epithelium results into Th2-mediated pulmonary inflammation and goblet cell hyperplasia in developing lung. Leukotriene pathway and signal transducers and activators of transcription 6 pathway may mediate this inflammation through recruitment and activation of denditric cell during lung developments. FOXA2 is a potential treatment target for lung diseases with Th2 inflammation and goblet cell hyperplasia, such as asthma and chronic obstructive pulmonary disease.

Theoretical and Experimental Studies of a Box-Type Solar Cooker in Unfavorable Climatic Conditions

A box-type solar cooker with an inclined surface, equipped with a concentration reflector to allow maximum energy to be collected, enabled cooking tests to be carried out in the rainy season. Different thermocouples were implanted on various places of the cooker. The temperature measurements from these sensors were taken every 10 minutes. The tests presented in this article relate to the preparation of eggs and rice. The absorber temperatures during the tests exceeded 100°C. The cooking times were between 1 h 50 min and 2 h 20 min despite the numerous cloudy periods. The cooker made it possible to reach sufficient temperatures for healthy cooking of food. The results obtained for these first tests are satisfactory and very encouraging.

Analysis of MIKC^C-Type MADS-Box Gene Family in Gossypium hirsutum

MIKCC-type MADS-box genes encode transcription factors that are involved in plant developmental control and signal transduction. Few Gossypium hirsutum MADS-box genes have been reported thus far. Recently, the genome of Gossypium raimondii, considering the contributor of the D subgenome to G. hirsutum, was sequenced and provided a valuable resource to identify and analyze multiple MADS-box genes in G. hirsutum. Here we comprehensively analyzed 53 MIKCC-type MADS-box genes, including 34 newly cloned genes. Phylogenetic analysis of these genes with those from Arabidopsis and grapevine showed that the FLC and AGL12 subfamilies were absent in G. hirsutum. Proteins within a gene subfamily tended to share conserved motifs, and large differences occurred among subfamilies. Expression analysis in multiple tissues and lforal organs implied differing roles for the subfamilies in G. hirsutum. At nine loci, two or three genes co-occurred, indicating that they came from different subgenomes; these groups had similar expression patterns. The identiifcation of MIKCC-type MADS-box genes in G. hirsutum provides a valuable resource for further research into lfowering time, lfower development and ovule development in this important crop plant.

Analysis of Key Technologies in the Design of Small and Medium Span Basket Type Steel Box Tied Arch Bridge

In order to ensure the construction quality and safety of small and medium span basket type steel box tied arch bridge,this paper takes a practical project as an example to analyze the key technologies in its design process.It is hoped that this analysis can provide corresponding reference for the design and construction of this kind of arch bridge.

10kV箱变改造为发电机转子护环感应加热电源的研究与应用

在某核电站汽轮发电机转子首次检修和绕组发生绝缘缺陷时,需要采用感应加热法拆除转子护环进行检查与处理。本文结合电站实际情况及护环拆装需求,经过分析与计算,按照最优的单绕组供电方案将工程建设期退役的10kV箱式变电站改造成拆装发电机转子护环所需的感应加热电源,并在两台百万千瓦级汽轮发电机的首次大修和转子绝缘缺陷处理中实现成功应用,有效保障了核电站发电机大修工期,节约了大修成本。

Effect of PWHT with Sheet-Type Ceramic Heater on Compressive Behaviors of Non-Stiffened Welded Steel Box Columns

A series of fundamental experimental investigation was conducted in order to examine the effect of PWHT by sheet-type ceramic heater on the residual stress, deformation and compressive behavior of non-stiffened welded box columns. The sheet-type ceramic heater was able to control the required temperature history for PWHT with high accuracy. The welding-induced tensile and compressive residual stresses of the specimens were reduced by 90% and 76% respectively with PWHT. Besides, PWHT could reduce the welding-induced out-of-plane deformation by 22%. It was revealed that the PWHT specimens had a slight higher stiffness than the As-welded specimens when applying monotonic static compressive load on both As-welded and PWHT specimens. They could also enhance the ultimate compressive load capacity about 32% of that of the As-welded specimens. The effectiveness of PWHT with the sheet-type ceramic heater could be confirmed.

超声造影联合血清Ficolin-3,FOXM1对2型糖尿病下肢动脉病变的诊断价值分析

目的超声造影联合血清纤维胶凝蛋白-3(Ficolin-3)、叉头框蛋白M1(FOXM1)对2型糖尿病(T2DM)下肢动脉病变的诊断价值分析。方法选取2022年2月至2023年2月我院收治的T2DM患者114例,以下肢动脉血管造影检查为金标准,将患者分为下肢动脉病变组23例(病变组)和无下肢动脉病变组91例(T2DM组),另选取同期于本院进行体检的健康志愿者91例为对照组。对患者及健康志愿者进行血清Ficolin-3、FOXM1及超声造影检查;ROC曲线分析血清Ficolin-3、FOXM1对T2DM下肢动脉病变的诊断价值;采用四格表法分析血清Ficolin-3、FOXM1、超声造影及3项联合对T2DM下肢动脉病变的诊断价值。结果病变组、T2DM组血清Ficolin-3水平显著高于对照组,且病变组血清Ficolin-3水平显著高于T2DM组(均P<0.05);病变组、T2DM组血清FOXM1水平显著低于对照组,且病变组血清FOXM1水平显著低于T2DM组(均P<0.05);血清Ficolin-3诊断T2DM下肢动脉病变的曲线下面积为0.868,敏感度为86.96%,特异度为75.82%,最佳截断值为35.12μg/ml;血清FOXM1诊断T2DM下肢动脉病变的曲线下面积为0.854,敏感度为82.61%,特异度为78.02%,最佳截断值为0.57;血清Ficolin-3、FOXM1检查结果与金标准均具有中度一致性(Kappa=0.480、0.481,均P<0.001);超声造影检查结果显示,T2DM下肢动脉病变的阳性检出率为73.91%,与金标准具有较高一致性(Kappa=0.631,P<0.001);3项联合检测的敏感度、漏诊率均显著优于超声造影单独诊断,准确度显著优于Ficolin-3、FOXM1单独诊断,差异均有统计学意义(均P<0.05)。结论血清Ficolin-3、FOXM1联合超声造影检查在T2DM下肢动脉病变诊断中的应用价值较高,进一步提升了诊断的敏感度、准确度,减少了误诊率。

一种新型振弦式土压力盒的结构设计分析

在我国,岩土工程领域十分广阔,工程的应力检测、监测显得尤为重要。检测岩土基础的应力变化所用的土压力盒、土压力计种类繁多,有些土压力盒原理相同但结构多样,还有些土压力盒标定方法与实际应用完全不符。基于此,提出一种能够符合现场埋设应用的振弦式土压力盒。该设计是轮辐式工作膜在无盒状态下只接受压力传递片的压力和校准方法。

基于物联网的箱式变电站远程监控系统的设计

箱式变电站是电力系统中的关键环节,承担着用户侧降压和电力分配工作。为保证变电站可靠稳定运行的同时降低人工运营成本,以STM32单片机为核心控制单元,结合温湿度传感器、烟雾浓度传感器、人体红外感应传感器和电压电流功率计传感器等设计了一套远程监控系统。采集影响箱式变电站安全运行的环境信息数据如温度、湿度、输出电压电流值和烟雾浓度等,并通过WiFi模块将采集的数据实时与手机APP进行通信。同时在手机端可以设置可预知的危险阈值范围来判断预警信息,并且可以通过ESP32CAM摄像头模块视频监控变电站现场,方便后台运维人员进行安全管控。通过模拟实物的制作并进行测试,运行结果表明,该系统能够实时监测箱式变电站运行环境信息,拥有简单易操作、稳定可靠、成本低等优点,具有一定的实用性。

箱式双向调压塔在长距离重力流输水管道水锤防护中的新应用

本文提出箱式双向调压塔小塔径多塔代替大塔径单塔的水锤防护新思路,并通过数值模拟和理论计算得出,当1台塔在原位置、另1台塔在其上下游100m范围内时,不会对其水锤防护效果产生影响,管道仍可安全运行。

考虑风电出力不确定性的微电网两阶段鲁棒优化调度模型

为有效应对风电机组出力的不确定因素对微电网安全经济运行的影响,提出了考虑风电出力不确定性的微电网两阶段分布鲁棒优化调度模型。首先,利用改进DNN(深度神经网络)对风电场进行出力预测,计算预测误差;然后,采用非参数核密度估计方法对预测误差数据进行分析,依据误差累积概率密度曲线构建盒式不确定集;接着,建立min-max-min结构的微电网两阶段鲁棒优化调度模型;最后,运用强对偶理论将原问题分解为混合整数线性规划的主问题和子问题,通过迭代求解得到最优调度方案。算例结果表明,所提模型相较于传统两阶段鲁棒优化模型具备更强的鲁棒性。

油菜B-box型锌指蛋白基因BnSTO的克隆和表达

B-box型锌指蛋白参与植物多种生长发育和非生物逆境胁迫响应过程。笔者通过RT-PCR克隆得到甘蓝型油菜2个B-box型锌指蛋白基因Bn STO-1和Bn STO-2。Bn STO-1的ORF长度为723 bp,推测编码240个氨基酸,定位于A8染色体。Bn STO-2的ORF长度为726 bp,推测编码241个氨基酸,定位于C8染色体。2个基因均由3个外显子和2个内含子构成,在氨基酸水平上的相似性达到了96.68%。系统进化分析表明Bn STO与拟南芥At STO的亲缘关系较近,同源性较高。荧光实时定量PCR结果表明Bn STO在检测的各个组织中均有表达,其中叶和蕾中的表达量最高;高盐、干旱和高温能显著诱导Bn STO-1和Bn STO-2的表达,但出现峰值的时间不同,推测2个基因均可能参与了油菜的非生物逆境胁迫响应。

箱体型正压式平板负离子抗菌陶瓷膜MBR在城市新鲜垃圾渗滤液处理应用实例

山东某垃圾焚烧厂中产生的新鲜垃圾渗滤液有机物和氨氮浓度高,同时含有多种重金属,属于难处理的废水。本工程采用气浮预处理+两级UASB+A/O+平板式MBR膜过滤+后续深度处理(纳滤+反渗透)工艺。厌氧处理阶段采用投加零价铁来提高处理效果。MBR工艺采用箱体型正压式优化结构,比传统的浸没式结构能提高膜通量和优化操作。MBR膜采用能抑菌杀菌的负离子抗菌平板陶瓷膜,具有膜通量大,缓解膜污染能力强的特点。工程运行表明,出水水质低于≤生活垃圾卫生填埋场污染控制标准≥(GB 16889-2008)表3中的标准要求,即COD≤60 mg/L,BOD_(5)≤20 mg/L,ρ(氨氮)≤8 mg/L,ρ(总氮)≤20 mg/L,ρ(SS)≤2.0 mg/L等。工程投资总成本500万左右。吨水成本将核算后为14.9元。

大豆MIKC型MADS-box基因家族分析

根据拟南芥的MIKC型MADS—box蛋白序列构建HMM（hidden markov model）模型，在大豆基因组中确定了57个MIKC型MADS-box同源基因。分子进化树分析表明，57个大豆MIKC型MADS-box基因分为14个亚类，而MIKC^＋型基因又分为两个进化支。控制花形态建成的ABCDE同源异型基因（如AP1，AG，AP3和PI等）和重要的控制开花时间的基因（如SVP和SOCl）在大豆基因组中表现出多拷贝的特征。MEME和SMART分析表明，大豆和拟南芥MIKC型MADS—box基因具有保守的MADS和K-box基序，还有一些亚类具有特异的基序。MIKC型MADS—box基因结构较为保守，多数基因具有7～8个外显子。本研究得到的MIKC型MADS—box基因为下一步研究大豆花形态建成和开花时间调控的分子机制提供了重要参考依据。

血清金属蛋白酶组织抑制剂3和性别决定区Y框蛋白2在2型糖尿病肾损伤早期诊断中的临床应用

目的探究血清金属蛋白酶组织抑制剂3(tissue inhibitors of metalloproteinases 3,TIMP3)和性别决定区Y框蛋白2(transcription factor determining region Y box protein 2,SOX2)对2型糖尿病(type 2 diabetes mellitus,T2DM)肾损伤的早期诊断。方法选取2022年4月至2023年4月在华北石油管理局总医院就诊的102例T2DM患者为研究对象,根据24 h尿蛋白排泄率(uri-nary albumin excretion rate,UAER)将T2DM患者分为肾损伤组(n=40)和无肾损伤组(n=62),另选取同期在华北石油管理局总医院行体检的健康者50名为对照组。酶联免疫吸附法测定所有受试者血清TIMP3、SOX2水平;比较3组受试者一般资料、糖化血红蛋白(hemoglobin A1c,HbA1c)、UAER、血肌酐(serum creatinine,Scr)、估算肾小球滤过率(estimated glomerular filtration rate,eGFR)、血清TIMP3、SOX2水平;Pearson相关性分析血清TIMP3与SOX2及两者与HbA1c、UAER、Scr、eGFR之间的关系;受试者工作特征曲线(receiver operating characteristic curve,ROC)分析血清TIMP3、SOX2对T2DM患者肾损伤的诊断价值。结果T2DM患者血清TIMP3[(0.68±0.17)μg/L比(1.35±0.35)μg/L]及eGFR[(105.99±20.56)mL·min^(-1)·(1.73 m^(2))比(133.15±26.18)mL·min^(-1)·(1.73 m^(2))^(-1)]显著低于对照组(P<0.05),且肾损伤患者血清TIMP3[(0.47±0.11)μg/L比(0.82±0.21)^(-1)μg/L]及eGFR[(74.69±10.22)mL·min^(-1)·(1.73 m^(2))比(126.18±27.23)mL·min^(-1)·(1.73 m^(2))^(-1)]显著低于无肾损伤患者(P<0.05);血清SOX2[(8.91±1.82)kU/L比(5.15±1.31)kU/L]及HbA1c[(8.80±1.55)%比(5.52±0.83)%]、UAER[(70.13±18.06)mg/24 h比(13.22±3.61)mg/24 h]、Scr[(82.14±15.23)µmol/L比(53.19±5.62)µmol/L]显著高于对照组(P<0.05),且肾损伤患者血清SOX2[(10.81±2.13)kU/L比(5.15±1.31)kU/L]及UAER[(156.83±40.29)mg/24 h比(13.22±3.61)mg/24 h]、Scr[(113.77±13.58)µmol/L比(53.19±5.62)µmol/L]显著高于无肾损伤患者(P<0.05)。Pearson相关性分析结果显示,TIMP3与UAER、Scr、HbA1c呈显著负相关(P<0.05),与eGFR呈显著正相关(P<0.05);SOX2与UAER、Scr、HbA1c呈显著正相关(P<0.05),与eGFR呈显著负相关(P<0.05);血清TIMP3与SOX2呈显著负相关(r=-0.590,P<0.05)。ROC结果显示,血清TIMP3联合SOX2诊断T2DM患者肾损伤的敏感度和特异度分别为95.0%、85.3%,显著高于TIMP3、SOX2单独测定。结论T2DM肾损伤患者血清TIMP3水平显著降低,SOX2水平显著升高,且两者与T2DM患者肾损伤密切相关,可用于T2DM患者肾损伤早期诊断。

某钢箱梁人行天桥承载能力与舒适度评估

为了研究钢箱梁人行天桥的承载能力、动力特性及振动舒适度情况,评定桥梁的性能状态和使用功能,为桥梁竣工验收提供技术依据,同时为桥梁科学管理和提高养护水平积累技术资料,建立和健全完备的桥梁技术档案。采用现场加载试验和人行激励试验的方法及有限元数值模拟,基于静载试验测试桥梁的应力和挠度,结合动载试验,通过对桥梁进行模态分析,得到桥梁自振频率、阻尼比等参数测定桥梁的自振特性,并且进行现场人行激励试验,分别采用规避敏感频率法和限制动力响应值法,评价结构舒适度。将现场试验实测值与有限元计算理论值对比得出结论,荷载试验测试数据表明,结构承载能力和整体刚度均满足设计和使用要求,可以按照设计人群荷载正常使用。天桥上部结构竖向基频及竖向加速度峰值满足相关规范对结构舒适度的要求。

箱体类零件加工支撑装置研究

随着焊接技术的不断发展,越来越多的箱体类零件采用焊接方式初加工,再由机床精加工,精加工时,通过增加内部支撑装置防止零件加工时产生变形。对于高度较小且深度较大的箱体类零件,如高度小于300 mm、且深度大于1 500 mm的箱体类零件,由于手臂可触及的范围有限,无法将支撑装置放置到指定位置,箱体类零件得不到很好支撑,导致零件加工后变形量较大。针对以上问题,研究了一种支撑装置,利用UG三维建模技术及虚拟样机技术对产品进行设计和虚拟装配,验证了支撑装置的合理性和可行性。支撑装置的使用使高度较小且深度较大的箱体类零件的制造周期缩短25%以上;同时,装置设置有压力传感器和显示系统,能够实时检测和显示支撑装置的支撑力,将支撑装置的调整时间减少30%以上,很好地解决了高度较小且深度较大的箱体类零件在机加工过程中支撑较难的问题,提高箱体类零件的加工精度和制造质量,为企业带来经济效益。

补偿收缩混凝土在某箱体式污水处理厂中的应用

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基于新材料应用的轻量化U型自卸车厢的优化仿真

自卸车是重型商用车最基础的一款专用车产品。在我国近几年的自卸车行业发展中,随着国家对环境的重视,在生产制作和使用中矩形箱结构重量大的问题日益突出,车厢结构开始由原来的矩形箱逐渐开始向U型车厢转变。文章模型采用三维软件SolidWorks造型建模,采用高效的有限元软件进行分析。模拟不同路况及装载情况下的车厢受力情况,根据分析结果从钢板材质和车厢结构方面对车厢进行优化。