Objectives: The overall aim is to propose a general framework to build any kind of interactive digital atlas. It can be used either as pedagogical support to study human anatomy or as a tool to aid health professional...Objectives: The overall aim is to propose a general framework to build any kind of interactive digital atlas. It can be used either as pedagogical support to study human anatomy or as a tool to aid health professionals improving the quality of the human resources formation. Methods: To illustrate the use of the proposed methodology was build an atlas of intracranial human anatomy. We used 3D surface rendering techniques to create a brain atlas that would allow us to correlate bi-dimensional MRI images with 3D brain structures. Results: The system was coded in Java and distributed under GNU/GLP license, making it available to use and/or to expand and serve as an educational tool allow medical students to use it to evaluate the special relationships among structures. Conclusions: The characteristics of the obtained Atlas are essential in the Brazilian public health context, where professionals in several different geographical locations (submitted to distinct informatics infrastructure) need to be trained.展开更多
Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influen...Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influenced by the complex interaction of brain networks which were under explored.We explored age-related brain network differences between ADHD patients and typically developing（TD） subjects using resting state f MRI（rs-f MRI） for three age groups of children,adolescents,and adults.We collected rs-f MRI data from 184 individuals（27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults）.The Brainnetome Atlas was used to define nodes in the network analysis.We compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal centrality.The left middle temporal gyrus showed significant interaction effects between disease status（i.e.,ADHD or TD） and age（i.e.,child,adolescent,or adult）（P 0.001）.Additional regions were identified at a relaxed threshold（P 0.05）.Many of the identified regions（the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus） were related to cognitive function.The results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD patients.These findings contribute to better understand how brain function influences the symptoms of ADHD.展开更多
Previous studies on brain functional connectivity networks in children have mainly focused on changes in function in specific brain regions, as opposed to whole brain connectivity in healthy children. By analyzing the...Previous studies on brain functional connectivity networks in children have mainly focused on changes in function in specific brain regions, as opposed to whole brain connectivity in healthy children. By analyzing the independent components of activation and network connectivity between brain regions, we examined brain activity status and development trends in children aged 3 and 5 years. These data could provide a reference for brain function rehabilitation in children with illness or abnormal function. We acquired functional magnetic resonance images from 15 3-year-old children and 15 5-year-old children under natural sleep cond让ions. The participants were recruited from five kindergartens in the Nanshan District of Shenzhen City, China. The parents of the participants signed an informed consent form with the premise that they had been fully informed regarding the experimental protocol. We used masked independent component analysis and BrainNet Viewer software to explore the independent components of the brain and correlation connections between brain regions. We identified seven independent components in the two groups of children, including the executive control network, the dorsal attention network, the default mode network, the left frontoparietal network, the right frontoparietal network, the salience network, and the motor network. In the default mode network, the posterior cingulate cortex, medial frontal gyrus, and inferior parietal lobule were activated in both 3- and 5-year-old children, supporting the "three-brain region theory” of the default mode network. In the frontoparietal network, the frontal and parietal gyri were activated in the two groups of children, and functional connectivity was strengthened in 5-year-olds compared with 3-year-olds, although the nodes and network connections were not yet mature. The high-correlation network connections in the default mode networks and dorsal attention networks had been significantly strengthened in 5-year-olds vs. 3-year-olds. Further, the salience network in the 3-year-old children included an activated insula/inferior frontal gyrus-anterior cingulate cortex network circu让 and an activated thalamus-parahippocampal-posterior cingulate cortex-subcortical regions network circuit. By the age of 5 years, no des and high-correlation network connections (edges) were reduced in the salience network. Overall, activation of the dorsal attention network, default mode network, left frontoparietal network, and right frontoparietal network increased (the volume of activation increased, the signals strengthened, and the high-correlation connections increased and strengthened) in 5-year-olds compared with 3-year-olds, but activation in some brain nodes weakened or disappeared in the salience network, and the network connections (edges) were reduced. Between the ages of 3 and 5 years, we observed a tendency for function in some brain regions to be strengthened and for the generalization of activation to be reduced, indicating that specialization begins to develop at this time. The study protocol was approved by the local ethics committee of the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences in China with approval No. SIAT-IRB- 131115-H0075 on November 15, 2013.展开更多
目的探讨是否有必要建立新疆维吾尔族活体大脑的立体定向标准化图谱。方法从2018年1月至2019年12月期间来新疆医科大学附属肿瘤医院行健康体检人群中随机抽取维吾尔族及汉族各50例健康成年人,采用统一规范扫描、标准测量获得维吾尔族、...目的探讨是否有必要建立新疆维吾尔族活体大脑的立体定向标准化图谱。方法从2018年1月至2019年12月期间来新疆医科大学附属肿瘤医院行健康体检人群中随机抽取维吾尔族及汉族各50例健康成年人,采用统一规范扫描、标准测量获得维吾尔族、汉族健康成年人颅脑3.0 T磁共振成像(MRI)数据,运用统计学方法进行基于大体结构和感兴趣区的两两对比分析,寻找差异性。结果新疆维吾尔族与汉族人大脑的长[(161.49±5.82) mm vs(159.93±5.22 mm)]、宽[(143.35±4.34) mm vs (142.82±3.36 mm)]、高[(110.68±2.50) mm vs (111.14±3.13) mm]及前联合-后联合[(25.96±1.05) mm vs (26.18±0.73) mm]比较差异均无统计学意义(P>0.05)。结论新疆维吾尔族活体大脑脑形态与汉族无显著差异,完全可以用汉族的脑图谱替代,在立体定向等方面利用汉族的脑图谱作为依据具有可行性及科学性。展开更多
文摘Objectives: The overall aim is to propose a general framework to build any kind of interactive digital atlas. It can be used either as pedagogical support to study human anatomy or as a tool to aid health professionals improving the quality of the human resources formation. Methods: To illustrate the use of the proposed methodology was build an atlas of intracranial human anatomy. We used 3D surface rendering techniques to create a brain atlas that would allow us to correlate bi-dimensional MRI images with 3D brain structures. Results: The system was coded in Java and distributed under GNU/GLP license, making it available to use and/or to expand and serve as an educational tool allow medical students to use it to evaluate the special relationships among structures. Conclusions: The characteristics of the obtained Atlas are essential in the Brazilian public health context, where professionals in several different geographical locations (submitted to distinct informatics infrastructure) need to be trained.
基金supported by the Institute for Basic Science[grant No.IBS-R015-D1]the National Research Foundation of Korea(grant No.NRF-2016R1A2B4008545)
文摘Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and adults.These ADHD related symptoms are influenced by the complex interaction of brain networks which were under explored.We explored age-related brain network differences between ADHD patients and typically developing（TD） subjects using resting state f MRI（rs-f MRI） for three age groups of children,adolescents,and adults.We collected rs-f MRI data from 184 individuals（27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults）.The Brainnetome Atlas was used to define nodes in the network analysis.We compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal centrality.The left middle temporal gyrus showed significant interaction effects between disease status（i.e.,ADHD or TD） and age（i.e.,child,adolescent,or adult）（P 0.001）.Additional regions were identified at a relaxed threshold（P 0.05）.Many of the identified regions（the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus） were related to cognitive function.The results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD patients.These findings contribute to better understand how brain function influences the symptoms of ADHD.
基金supported by the Natural Science Foundation of Guangdong Province,No.2016A030313180(to FCJ)
文摘Previous studies on brain functional connectivity networks in children have mainly focused on changes in function in specific brain regions, as opposed to whole brain connectivity in healthy children. By analyzing the independent components of activation and network connectivity between brain regions, we examined brain activity status and development trends in children aged 3 and 5 years. These data could provide a reference for brain function rehabilitation in children with illness or abnormal function. We acquired functional magnetic resonance images from 15 3-year-old children and 15 5-year-old children under natural sleep cond让ions. The participants were recruited from five kindergartens in the Nanshan District of Shenzhen City, China. The parents of the participants signed an informed consent form with the premise that they had been fully informed regarding the experimental protocol. We used masked independent component analysis and BrainNet Viewer software to explore the independent components of the brain and correlation connections between brain regions. We identified seven independent components in the two groups of children, including the executive control network, the dorsal attention network, the default mode network, the left frontoparietal network, the right frontoparietal network, the salience network, and the motor network. In the default mode network, the posterior cingulate cortex, medial frontal gyrus, and inferior parietal lobule were activated in both 3- and 5-year-old children, supporting the "three-brain region theory” of the default mode network. In the frontoparietal network, the frontal and parietal gyri were activated in the two groups of children, and functional connectivity was strengthened in 5-year-olds compared with 3-year-olds, although the nodes and network connections were not yet mature. The high-correlation network connections in the default mode networks and dorsal attention networks had been significantly strengthened in 5-year-olds vs. 3-year-olds. Further, the salience network in the 3-year-old children included an activated insula/inferior frontal gyrus-anterior cingulate cortex network circu让 and an activated thalamus-parahippocampal-posterior cingulate cortex-subcortical regions network circuit. By the age of 5 years, no des and high-correlation network connections (edges) were reduced in the salience network. Overall, activation of the dorsal attention network, default mode network, left frontoparietal network, and right frontoparietal network increased (the volume of activation increased, the signals strengthened, and the high-correlation connections increased and strengthened) in 5-year-olds compared with 3-year-olds, but activation in some brain nodes weakened or disappeared in the salience network, and the network connections (edges) were reduced. Between the ages of 3 and 5 years, we observed a tendency for function in some brain regions to be strengthened and for the generalization of activation to be reduced, indicating that specialization begins to develop at this time. The study protocol was approved by the local ethics committee of the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences in China with approval No. SIAT-IRB- 131115-H0075 on November 15, 2013.
文摘目的探讨是否有必要建立新疆维吾尔族活体大脑的立体定向标准化图谱。方法从2018年1月至2019年12月期间来新疆医科大学附属肿瘤医院行健康体检人群中随机抽取维吾尔族及汉族各50例健康成年人,采用统一规范扫描、标准测量获得维吾尔族、汉族健康成年人颅脑3.0 T磁共振成像(MRI)数据,运用统计学方法进行基于大体结构和感兴趣区的两两对比分析,寻找差异性。结果新疆维吾尔族与汉族人大脑的长[(161.49±5.82) mm vs(159.93±5.22 mm)]、宽[(143.35±4.34) mm vs (142.82±3.36 mm)]、高[(110.68±2.50) mm vs (111.14±3.13) mm]及前联合-后联合[(25.96±1.05) mm vs (26.18±0.73) mm]比较差异均无统计学意义(P>0.05)。结论新疆维吾尔族活体大脑脑形态与汉族无显著差异,完全可以用汉族的脑图谱替代,在立体定向等方面利用汉族的脑图谱作为依据具有可行性及科学性。
