A new technique is proposed in this paper for real-time monitoring of brain neural activity based on the balloon model. A continuous-discrete extended Kalman filter is used to estimate the nonlinear model states. The ...A new technique is proposed in this paper for real-time monitoring of brain neural activity based on the balloon model. A continuous-discrete extended Kalman filter is used to estimate the nonlinear model states. The stability, controlla- bility and observability of the proposed model are described based on the simulation and measured clinical data analysis. By introducing the controllable and observable states of the hemodynamic signal we have developed a numerical tech- nique to validate and compare the impact of brain signal parameters affecting on BOLD signal variation. This model increases significantly the signal-to-noise-ratio (SNR) and the speed of brain signal processing. A linear-quadratic regulator (LQR) also has been introduced for optimal control of the model.展开更多
Objective To investigate the role of decompressive craniectomy (DC) to decrease intractable intracranial hypertension(ICH) due to diffuse brain swelling and / or cerebral edema after severe traumatic brain injury and ...Objective To investigate the role of decompressive craniectomy (DC) to decrease intractable intracranial hypertension(ICH) due to diffuse brain swelling and / or cerebral edema after severe traumatic brain injury and the time window of DC to affect on prognosis. Methods The clinical record of 132 patients who underwent DC for posttraumatic intractable ICH in our hospital from July 2003 to展开更多
This article reviews the constructs of stress, appraisal, coping, according to a transactional perspective, and executive function, and presents a stress control rating scale (ECOSTRESS), which design is founded in th...This article reviews the constructs of stress, appraisal, coping, according to a transactional perspective, and executive function, and presents a stress control rating scale (ECOSTRESS), which design is founded in these constructs. This psychometric tool is useful in the assessment of cognitive control of stress, correlated with the function of dorsolateral prefrontal cortex. It has been validated for its use in the assessment of Portuguese people in situations of stress related to unemployment and economic insufficiency. Also, within the context of the cognitive control of stress, it is highlighted the usefulness of low resolution brain electromagnetic tomography (LORETA).展开更多
目的分析脑氧饱和度(rSO_(2))监测控制性降压(CH)对麻醉患者脑保护和认知功能的影响。方法选取行rSO_(2)监测CH麻醉患者200例为研究对象。根据行rSO_(2)监测CH患者术后是否发生围术期神经认知障碍(PND)分为正常组(n=137)和PND组(n=63),...目的分析脑氧饱和度(rSO_(2))监测控制性降压(CH)对麻醉患者脑保护和认知功能的影响。方法选取行rSO_(2)监测CH麻醉患者200例为研究对象。根据行rSO_(2)监测CH患者术后是否发生围术期神经认知障碍(PND)分为正常组(n=137)和PND组(n=63),收集患者治疗前临床资料。采用单因素分析确定行rSO_(2)监测CH患者术后并发PND的影响因素。采用多因素二元Logistic回归分析法筛选行rSO_(2)监测CH患者术后并发PND的独立危险因素。基于筛选出的独立危险因素构建预测模型,并绘制受试者工作特征(ROC)曲线评估其预测价值。结果年龄、术中出血量、行血管外科手术、术中20 min rSO_(2)监测值、术中20 min中心静脉压(CVP)和合并高血压、脑卒中以及手术时间是行rSO_(2)监测CH患者术后并发PND的影响因素(P<0.05)。患者年龄>55岁、术中20 min CVP高、术中20 min rSO_(2)监测值低及行血管外科手术是行rSO_(2)监测CH患者术后并发PND的独立危险因素(P<0.05)。ROC曲线分析结果显示,预测模型曲线下面积(AUC)为0.855。结论临床可通过控制术中CVP以减少失血量,并依据rSO_(2)监测结果及时调整治疗方案,从而降低行rSO_(2)监测CH患者(年龄>55岁,行血管外科手术)术后并发PND的风险。展开更多
目的基于脑功能磁共振成像(Functional magnetic resonance imaging,fMRI),采用Meta分析系统评价针灸治疗抑郁症(Major depressive disorder,MDD)的有效性。方法检索CNKI、CBM、Wan fang、VIP、PubMed、Web of Science、Embase、Cochran...目的基于脑功能磁共振成像(Functional magnetic resonance imaging,fMRI),采用Meta分析系统评价针灸治疗抑郁症(Major depressive disorder,MDD)的有效性。方法检索CNKI、CBM、Wan fang、VIP、PubMed、Web of Science、Embase、Cochrane Library从建库以来至2023年10月31日针灸治疗MDD的随机对照研究(RCT),纳入研究质量评估采用Cochrane偏倚风险评估工具,利用RevMan 5.3软件行Meta分析,并采用Cochrane工具自带的GRADE系统进行证据质量评价。结果纳入文章9篇,包括7篇国内文章,2篇国外文章,总样本量636例(试验组325例,对照组311例)。9项研究均以fMRI为主要观察指标,结果显示针灸可调节差异脑区低频振幅(Amplitude of low frequency fluctuation,ALFF)、低频振幅比率(Fractional of amplitude low-frequency fluctuation,f ALFF)及局部一致性(Region homogeneity,ReHo)值,改变脑功能连接。次要结局指标分析结果显示针灸治疗可明显改善MDD患者的症状,提高临床疗效[OR=1.98,95%CI(1.30,2.99),P=0.001],减轻抗抑郁药物带来的副反应,并有效降低患者的汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分[MD=-3.08,95%CI(-4.46,-1.70),P<0.0001]、Zung抑郁自评量表(Self-rating depression scale,SDS)评分[MD=-4.67,95%CI(-6.93,-2.40),P<0.0001]、抗抑郁药副反应量表(Side-effect rating scale for antidepressant,SERS)总分,降低血浆促肾上腺皮质激素[MD=-3.22,95%CI(-5.00,-1.43),P=0.0004]水平及血清皮质醇激素水平。结论针灸治疗MDD效果显著,可激活边缘系统脑区,重组MDD发病的认知、情感加工及默认网络结构,并对额叶进行调节,从而改善抑郁。展开更多
文摘A new technique is proposed in this paper for real-time monitoring of brain neural activity based on the balloon model. A continuous-discrete extended Kalman filter is used to estimate the nonlinear model states. The stability, controlla- bility and observability of the proposed model are described based on the simulation and measured clinical data analysis. By introducing the controllable and observable states of the hemodynamic signal we have developed a numerical tech- nique to validate and compare the impact of brain signal parameters affecting on BOLD signal variation. This model increases significantly the signal-to-noise-ratio (SNR) and the speed of brain signal processing. A linear-quadratic regulator (LQR) also has been introduced for optimal control of the model.
文摘Objective To investigate the role of decompressive craniectomy (DC) to decrease intractable intracranial hypertension(ICH) due to diffuse brain swelling and / or cerebral edema after severe traumatic brain injury and the time window of DC to affect on prognosis. Methods The clinical record of 132 patients who underwent DC for posttraumatic intractable ICH in our hospital from July 2003 to
文摘This article reviews the constructs of stress, appraisal, coping, according to a transactional perspective, and executive function, and presents a stress control rating scale (ECOSTRESS), which design is founded in these constructs. This psychometric tool is useful in the assessment of cognitive control of stress, correlated with the function of dorsolateral prefrontal cortex. It has been validated for its use in the assessment of Portuguese people in situations of stress related to unemployment and economic insufficiency. Also, within the context of the cognitive control of stress, it is highlighted the usefulness of low resolution brain electromagnetic tomography (LORETA).
文摘目的分析脑氧饱和度(rSO_(2))监测控制性降压(CH)对麻醉患者脑保护和认知功能的影响。方法选取行rSO_(2)监测CH麻醉患者200例为研究对象。根据行rSO_(2)监测CH患者术后是否发生围术期神经认知障碍(PND)分为正常组(n=137)和PND组(n=63),收集患者治疗前临床资料。采用单因素分析确定行rSO_(2)监测CH患者术后并发PND的影响因素。采用多因素二元Logistic回归分析法筛选行rSO_(2)监测CH患者术后并发PND的独立危险因素。基于筛选出的独立危险因素构建预测模型,并绘制受试者工作特征(ROC)曲线评估其预测价值。结果年龄、术中出血量、行血管外科手术、术中20 min rSO_(2)监测值、术中20 min中心静脉压(CVP)和合并高血压、脑卒中以及手术时间是行rSO_(2)监测CH患者术后并发PND的影响因素(P<0.05)。患者年龄>55岁、术中20 min CVP高、术中20 min rSO_(2)监测值低及行血管外科手术是行rSO_(2)监测CH患者术后并发PND的独立危险因素(P<0.05)。ROC曲线分析结果显示,预测模型曲线下面积(AUC)为0.855。结论临床可通过控制术中CVP以减少失血量,并依据rSO_(2)监测结果及时调整治疗方案,从而降低行rSO_(2)监测CH患者(年龄>55岁,行血管外科手术)术后并发PND的风险。
文摘目的基于脑功能磁共振成像(Functional magnetic resonance imaging,fMRI),采用Meta分析系统评价针灸治疗抑郁症(Major depressive disorder,MDD)的有效性。方法检索CNKI、CBM、Wan fang、VIP、PubMed、Web of Science、Embase、Cochrane Library从建库以来至2023年10月31日针灸治疗MDD的随机对照研究(RCT),纳入研究质量评估采用Cochrane偏倚风险评估工具,利用RevMan 5.3软件行Meta分析,并采用Cochrane工具自带的GRADE系统进行证据质量评价。结果纳入文章9篇,包括7篇国内文章,2篇国外文章,总样本量636例(试验组325例,对照组311例)。9项研究均以fMRI为主要观察指标,结果显示针灸可调节差异脑区低频振幅(Amplitude of low frequency fluctuation,ALFF)、低频振幅比率(Fractional of amplitude low-frequency fluctuation,f ALFF)及局部一致性(Region homogeneity,ReHo)值,改变脑功能连接。次要结局指标分析结果显示针灸治疗可明显改善MDD患者的症状,提高临床疗效[OR=1.98,95%CI(1.30,2.99),P=0.001],减轻抗抑郁药物带来的副反应,并有效降低患者的汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分[MD=-3.08,95%CI(-4.46,-1.70),P<0.0001]、Zung抑郁自评量表(Self-rating depression scale,SDS)评分[MD=-4.67,95%CI(-6.93,-2.40),P<0.0001]、抗抑郁药副反应量表(Side-effect rating scale for antidepressant,SERS)总分,降低血浆促肾上腺皮质激素[MD=-3.22,95%CI(-5.00,-1.43),P=0.0004]水平及血清皮质醇激素水平。结论针灸治疗MDD效果显著,可激活边缘系统脑区,重组MDD发病的认知、情感加工及默认网络结构,并对额叶进行调节,从而改善抑郁。
