Numerous diseases and pathologies impair the delivery of oxygen to brain, with rapid and deleterious consequences. For example, diseases related to systemic hypoxemia （e.g., chronic pulmonary disorders, cystic fibro...Numerous diseases and pathologies impair the delivery of oxygen to brain, with rapid and deleterious consequences. For example, diseases related to systemic hypoxemia （e.g., chronic pulmonary disorders, cystic fibrosis）, decreased oxygen carrying capacity of blood （e.g., anemia）, or decreased transport （e.g., heart attack, stroke） can all reduce or entirely prevent the delivery of oxygen to brain cells, resulting in the initiation of programmed cell death pathways, necrosis, or excitotoxic cell death in brain （Pamenter, 2014）. However, oxygen-limited environments are common on earth and many organisms naturally experience periods of intermit- tent or prolonged hypoxia or anoxia in their daily and/or annual life cycles （Bickler and Buck, 2007）.展开更多
基金supported by Natural Sciences and Engineering Research Council of Canada Discovery grant and a Parker B Francis Fellowship to MEP
文摘Numerous diseases and pathologies impair the delivery of oxygen to brain, with rapid and deleterious consequences. For example, diseases related to systemic hypoxemia （e.g., chronic pulmonary disorders, cystic fibrosis）, decreased oxygen carrying capacity of blood （e.g., anemia）, or decreased transport （e.g., heart attack, stroke） can all reduce or entirely prevent the delivery of oxygen to brain cells, resulting in the initiation of programmed cell death pathways, necrosis, or excitotoxic cell death in brain （Pamenter, 2014）. However, oxygen-limited environments are common on earth and many organisms naturally experience periods of intermit- tent or prolonged hypoxia or anoxia in their daily and/or annual life cycles （Bickler and Buck, 2007）.
