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Functional connectivity of paired default mode network subregions in patients with eye trauma
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作者 Zheng-Mao Xing Dan Song +12 位作者 Jin-Yu Hu Xian-Mei Zhou Xuan Liao Cheng Chen Hong Wei Min Kang Qian Ling Liang-Qi He Zhen-Zhe Liu Jie Zou Xu Chen Zhen-Kai Wu Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第12期2248-2255,共8页
AIM:To study functional brain abnormalities in patients with eye trauma(ET)and to discuss the pathophysiological mechanisms of ET.METHODS:Totally 31 ET patients and 31 healthy controls(HCs)were recruited.The age,gende... AIM:To study functional brain abnormalities in patients with eye trauma(ET)and to discuss the pathophysiological mechanisms of ET.METHODS:Totally 31 ET patients and 31 healthy controls(HCs)were recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the functional connectivity(FC)method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Pearson’s correlation analysis was used to explore the relationship between FC values in specific brain regions and clinical behaviors in patients with ET.RESULTS:Significantly increased FC between several regions was identified including the medial prefrontal cortex(MPFC)and left hippocampus formations(HF),the MPFC and left inferior parietal lobule(IPL),the left IPL and left medial temporal lobe(MTL),the left IPL and right MTL,and the right IPL and left MTL.No decreased region-to-region connectivity was detected in default mode network(DMN)sub-regions in patients with ET.Compared with HCs,ET patients exhibited significantly increased FC between several paired DMN regions,as follows:posterior cingulate cortex(PCC)and right HF(HF.R,t=2.196,P=0.032),right inferior parietal cortices(IPC.R)and left MTL(MTL.L,t=2.243,P=0.029),and right MTL(MTL.R)and HF.R(t=2.236,P=0.029).CONCLUSION:FC values in multiple brain regions of ET patients are abnormal,suggesting that these brain regions in ET patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of ET. 展开更多
关键词 eye trauma functional connectivity brain region
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Altered spontaneous brain activity in patients with diabetic optic neuropathy:A resting-state functional magnetic resonance imaging study using regional homogeneity 被引量:1
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作者 Gui-Ying Guo Li-Juan Zhang +7 位作者 Biao Li Rong-Bin Liang Qian-Min Ge Hui-Ye Shu Qiu-Yu Li Yi-Cong Pan Chong-Gang Pei Yi Shao 《World Journal of Diabetes》 SCIE 2021年第3期278-291,共14页
BACKGROUND Diabetes is a common chronic disease.Given the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased vision.Whether DON leads to abnorma... BACKGROUND Diabetes is a common chronic disease.Given the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased vision.Whether DON leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains unknown.AIM To investigate the local characteristics of spontaneous brain activity using regional homogeneity(ReHo)in patients with DON.METHODS We matched 22 patients with DON with 22 healthy controls(HCs).All subjects underwent resting-state functional magnetic resonance imaging.The ReHo technique was used to record spontaneous changes in brain activity.Receiver operating characteristic(ROC)curves were applied to differentiate between ReHo values for patients with DON and HCs.We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis.RESULTS ReHo values of the right middle frontal gyrus(RMFG),left anterior cingulate(LAC),and superior frontal gyrus(SFG)/left frontal superior orbital gyrus(LFSO)were significantly lower in DON patients compared to HCs.Among these,the greatest difference was observed in the RMFG.The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON,and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO.We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values(r=-0.9336,P<0.0001 and r=-0.8453,P<0.0001,respectively).CONCLUSION Three different brain regions show ReHo changes in DON patients,and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients. 展开更多
关键词 DIABETES Diabetic optic neuropathy regional homogeneity Resting state functional magnetic resonance imaging brain activity
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Exploring the Abnormal Brain Regions and Abnormal Functional Connections in SZ by Multiple Hypothesis Testing Technique
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作者 Lan Yang Shun Qi +1 位作者 Chen Qiao Yanmei Kang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第10期215-237,共23页
Schizophrenia(SZ)is one of the most common mental diseases.Its main characteristics are abnormal social behavior and inability to correctly understand real things.In recent years,the magnetic resonance imaging(MRI)tec... Schizophrenia(SZ)is one of the most common mental diseases.Its main characteristics are abnormal social behavior and inability to correctly understand real things.In recent years,the magnetic resonance imaging(MRI)technique has been popularly utilized to study SZ.However,it is still a great challenge to reveal the essential information contained in the MRI data.In this paper,we proposed a biomarker selection approach based on the multiple hypothesis testing techniques to explore the difference between SZ and healthy controls by using both functional and structural MRI data,in which biomarkers represent both abnormal brain functional connectivity and abnormal brain regions.By implementing the biomarker selection approach,six abnormal brain regions and twenty-three abnormal functional connectivity in the brains of SZ are explored.It is discovered that compared with healthy controls,the significantly reduced gray matter volumes are mainly distributed in the limbic lobe and the basal ganglia,and the significantly increased gray matter volumes are distributed in the frontal gyrus.Meanwhile,it is revealed that the significantly strengthened connections are those between the middle frontal gyrus and the superior occipital gyrus,the superior occipital gyrus and the middle occipital gyrus as well as the middle occipital gyrus and the fusiform gyrus,and the rest connections are significantly weakened. 展开更多
关键词 Multiple hypothesis testing SCHIZOPHRENIA magnetic resonance imaging abnormal brain regions abnormal functional connectivity
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Activated and deactivated functional brain areas in the Deqi state: A functional MRI study 被引量:4
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作者 Yong Huang Tongjun Zeng +5 位作者 Guifeng Zhang Ganlong Li Na Lu Xinsheng Lai Yangjia Lu Jiarong Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第30期2362-2369,共8页
We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects cludng acupuncture, Twelve healthy volunteers received sham and true needling at ... We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects cludng acupuncture, Twelve healthy volunteers received sham and true needling at the Waiguan (TE5) acupoint. Real-time cerebral functional MRI showed that compared with non-sensation after sham needling, true needling activated Brodmann areas 3, 6, 8, 9, 10, 11, 13, 20, 21, 37, 39, 40, 43, and 47, the head of the caudate nucleus, the parahippocampal gyrus, thalamus and red nucleus. True needling also deactivated Brodmann areas 1,2, 3, 4, 5, 6, 7, 9. 10. 18.24.31.40 and 46. 展开更多
关键词 NEEDLING sham needling Waiguan (TE5) sham point DEQI functional MRI brain region activation DEACTIVATION neural regeneration
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Functional magnetic resonance imaging of regional homogeneity changes in parkinsonian resting tremor
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作者 Xian Liu Bo Liu Jun Chen Zhiguang Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第11期811-815,共5页
Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting... Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting-state functional magnetic resonance imaging scans were collected from nine Parkinson's disease patients with right resting tremor, and from eight age-matched normal controls. Regional homogeneity was compared between Parkinson's disease patients and controls. The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus. Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson's disease patients compared with healthy controls. 展开更多
关键词 Parkinson's disease resting tremor regional homogeneity functional magnetic resonance imaging resting state brain activity
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艾迪注射液联合常规化疗对肺癌脑转移患者的临床疗效 被引量:1
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作者 柳桂菊 李露 +2 位作者 赵青青 陈婧婧 潘炯伟 《中国药物与临床》 CAS 2024年第2期102-106,F0003,共6页
目的观察艾迪注射液联合化疗对肺癌脑转移患者认知障碍的缓解情况。方法回顾性分析2018年6月至2020年6月在浙江省丽水市人民医院就诊的80例肺癌脑转移患者的临床资料,按照不同治疗方法分为常规化疗组和艾迪组,常规化疗组患者采用顺铂联... 目的观察艾迪注射液联合化疗对肺癌脑转移患者认知障碍的缓解情况。方法回顾性分析2018年6月至2020年6月在浙江省丽水市人民医院就诊的80例肺癌脑转移患者的临床资料,按照不同治疗方法分为常规化疗组和艾迪组,常规化疗组患者采用顺铂联合多西他赛的化疗方案,艾迪组在常规化疗组基础上予以艾迪注射液。观察2组患者的近期疗效、认知功能以及毒副作用,评价联合艾迪注射液治疗的有效性和安全性。结果常规化疗组患者近期有效率50%,艾迪组患者近期有效率73%,2组差异有统计学意义(χ^(2)=4.266,P=0.039)。治疗开始前,常规化疗组和艾迪组患者的蒙特利尔认知评估量表(MoCA)评分和简易智能量表(MMSE)评分差异无统计学意义。治疗后2周,与常规化疗组比较,艾迪组患者的MoCA评分和MMSE评分均增加,差异具有统计学意义(t=-3.462、-2.507,P=0.001、0.047);治疗后2周艾迪组患者的Karnofsky评分和生活质量量表(QOL)评分升高,差异具有统计学意义(t=-4.634、-4.050,P<0.01)。与常规化疗组比较,艾迪组患者骨髓抑制和眩晕情况减轻,差异具有统计学意义(χ^(2)=4.126、4.050,P=0.042、0.044),恶心呕吐等胃肠道反应和脱发情况差异无统计学意义(P>0.05)。80例患者均因本病死亡。常规化疗组患者平均生存期为(15±3)个月,艾迪组患者的中位生存期为(18±4)个月,2组差异无统计学意义(χ^(2)=17.752,P<0.01)。结论艾迪注射液联合常规化疗方案治疗肺癌脑转移患者可提升近期疗效,缓解认知障碍,减轻化疗的毒副作用,但对于患者的生存期无明显影响。 展开更多
关键词 艾迪注射液 化疗 肺肿瘤 脑转移 认知功能 临床疗效
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首发重度抑郁症脑功能变化:基于静息态fMRI的低频振幅和局部一致性分析 被引量:2
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作者 叶郭锡 徐凡 +3 位作者 熊玉超 陈松 叶泳松 曾旭文 《放射学实践》 CSCD 北大核心 2024年第2期164-168,共5页
目的:基于静息态fMRI探讨首发重度抑郁症患者(MDD)发作期间各脑区低频振幅(ALFF)和局部一致性(ReHo)的特点,进一步明确抑郁发病的脑神经机制。方法:纳入2022年1月-2022年10月在本院根据《精神障碍诊断和统计手册》第四版(DSM-IV)确诊的... 目的:基于静息态fMRI探讨首发重度抑郁症患者(MDD)发作期间各脑区低频振幅(ALFF)和局部一致性(ReHo)的特点,进一步明确抑郁发病的脑神经机制。方法:纳入2022年1月-2022年10月在本院根据《精神障碍诊断和统计手册》第四版(DSM-IV)确诊的首发MDD患者40例和健康志愿者(对照组)50例,使用3.0T磁共振仪对每例受试者行静息态fMRI及高分辨率T 1WI检查,采用双样本t检验比较两组间临床资料及各脑区ALFF及ReHo测量值的差异。结果:两组间年龄和受教育程度的差异无统计学意义(P>0.05)。与对照组相比,首发MDD组左侧颞下回、双侧丘脑、双侧额中回及左侧辅助运动区的ALFF值增高,而双侧中央后回、左侧颞中回、左枕中回、左侧后扣带回及左侧楔前叶的ALFF值降低(AlphaSim校正,体素水平P<0.05,簇水平P<0.05);双侧颞下回、左脑岛和双侧额中回的ReHo值增高,左颞中回、双侧中央后回、左枕中回和右侧楔前叶的ReHo值降低(AlphaSim校正,体素水平P<0.05,簇水平P<0.05)。ALFF及ReHo值均升高的脑区主要位于左颞下回、双额中回,均降低的脑区位于左颞中回、双侧中央后回和左枕中回。结论:首发MDD患者的感觉运动网络、视听觉网络、默认网络和执行控制网络的脑活动存在广泛异常改变,从而为更好地了解MDD的发生发展提供初步线索。 展开更多
关键词 首发抑郁症 脑功能 功能磁共振成像 低频振幅 局部一致性
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静息态功能磁共振分析轻微型肝性脑病不同脑区的功能变化
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作者 梁斌 温志波 《中国CT和MRI杂志》 2024年第2期32-35,共4页
目的探讨静息态功能磁共振(rs-fMRI)分析轻微型肝性脑病(MHE)不同脑区的功能变化。方法选取2017年2月~2022年5月于本院就诊的88例肝硬化患者作为研究对象,根据是否发生MHE分为MHE组(n=45)和非MHE组(n=43),并选取同期在本院进行体检的健... 目的探讨静息态功能磁共振(rs-fMRI)分析轻微型肝性脑病(MHE)不同脑区的功能变化。方法选取2017年2月~2022年5月于本院就诊的88例肝硬化患者作为研究对象,根据是否发生MHE分为MHE组(n=45)和非MHE组(n=43),并选取同期在本院进行体检的健康人员(n=50)作为对照组。通过倾向性评分匹配(PSM)法按照1:1:1匹配后三组各为40例,比较三组受试者的一般资料。受试者均行头颅rs-fMRI扫描,采用统计学方法分析比较三组受试者全脑不同脑区的功能连接(FC)。分析三组受试者认知功能评分情况。Spearman相关性检验分析肝硬化患者认知功能评分与FC改变的相关性。结果与对照组相比,MHE组双侧中央后回、双侧楔叶/枕上小叶、左侧枕中回、左侧盖部额下回以及右侧舌回FC明显降低,差异具有统计学意义(P<0.05)。与对照组相比,MHE组数字连接试验(NCT-A)测试结果更高(P<0.05),数字符号试验(DST)评分更低(P<0.05)。NCT-A与DST量表评分与双侧楔叶/枕上小叶、左侧盖部额下回以及左侧颞上回的FC改变均呈显著负相关(P<0.05)。结论若肝硬化患者伴有MHE,双侧中央后回、双侧楔叶/枕上小叶、左侧枕中回、左侧盖部额下回以及右侧舌回FC存在异常,会出现认知功能障碍,其认知功能障碍可能与不同脑区FC改变有关。 展开更多
关键词 静息态功能磁共振 轻微型肝性脑病 脑区 功能连接
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rSO_(2)-BIS目标导向麻醉管理对非急性期脆弱脑功能患者术后认知功能的影响研究
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作者 梁光宇 杜燕燕 +1 位作者 夏莹 彭学强 《中国现代药物应用》 2024年第1期84-87,共4页
目的 观察局部脑氧饱和度(rSO_(2))-脑电双频谱指数(BIS)目标导向麻醉管理对非急性期脆弱脑功能患者术后认知功能的影响。方法 70例非急性期脆弱脑功能患者,按照麻醉管理方式不同分为对照组与实验组,各35例。对照组实施BIS目标导向麻醉... 目的 观察局部脑氧饱和度(rSO_(2))-脑电双频谱指数(BIS)目标导向麻醉管理对非急性期脆弱脑功能患者术后认知功能的影响。方法 70例非急性期脆弱脑功能患者,按照麻醉管理方式不同分为对照组与实验组,各35例。对照组实施BIS目标导向麻醉管理,实验组实施rSO_(2)-BIS目标导向麻醉管理。比较两组不同时刻血流动力学参数、认知功能、进手术室时(T0)及术后2 d(T5)时的视觉模拟评分法(VAS)评分、并发症发生情况。结果 T0时,两组心率、平均动脉压比较,差异无统计学意义(P>0.05);与T0时比较,麻醉诱导后(T1)、插管后即刻(T2)、切皮时(T3)、手术结束时(T4)两组的心率、平均动脉压均降低,但实验组高于同期对照组,差异有统计学意义(P<0.05)。实验组术后谵妄(POD)发生率5.71%低于对照组的22.86%, POD持续时间(16.5±0.7)h短于对照组的(20.5±1.4)h,差异均有统计学意义(P<0.05)。两组术后认知功能障碍(POCD)发生率比较,差异无统计学意义(P>0.05)。T5时,两组VAS评分均高于T0时,但实验组VAS评分(3.43±0.08)分低于对照组的(5.13±0.11)分,差异有统计学意义(P<0.05)。实验组并发症发生率5.71%低于对照组的22.86%,差异有统计学意义(P<0.05)。结论 非急性期脆弱脑功能患者采用rSO_(2)-BIS目标导向麻醉管理效果显著优于BIS目标导向麻醉管理。 展开更多
关键词 局部脑氧饱和度 脑电双频谱指数 目标导向麻醉管理 非急性期脆弱脑功能
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基于ReHo的7~15岁不同程度肥胖儿童静息态fMRI研究
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作者 李倩 王心 杨明 《南京医科大学学报(自然科学版)》 CAS 北大核心 2024年第9期1257-1261,共5页
目的:利用静息态功能磁共振(resting state functional MRI,rs-fMRI)探讨7~15岁不同程度肥胖儿童大脑局部一致性(regional homogeneity,ReHo)的特征。方法:选取单纯性肥胖(obesity,OB)儿童35例、肥胖伴代谢综合征(metobolicsyndrom,MS)... 目的:利用静息态功能磁共振(resting state functional MRI,rs-fMRI)探讨7~15岁不同程度肥胖儿童大脑局部一致性(regional homogeneity,ReHo)的特征。方法:选取单纯性肥胖(obesity,OB)儿童35例、肥胖伴代谢综合征(metobolicsyndrom,MS)儿童20例及健康对照(healthy control,HC)儿童24例,均进行rs-fMRI扫描,计算ReHo值并对比3组之间的差异,而后将差异脑区与临床资料进行相关性分析。结果:与HC组相比,OB组及MS组右侧梭状回、左侧颞下回的ReHo值升高,右内侧额上回、左背外侧额上回的ReHo值降低;与OB组相比,MS组左背外侧额上回ReHo值降低,且左背外侧额上回的ReHo值与丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转氨酶(aspartate aminotransferase,AST)呈显著负相关(r=-0.350,P=0.009;r=-0.294,P=0.029)。结论:肥胖儿童在参与摄食调节、抑制控制等脑区功能活动异常,左背外侧额上回的活动异常与肥胖程度相关,可为早期干预和治疗提供影像学依据。 展开更多
关键词 肥胖儿童 代谢综合征 脑功能 局部一致性
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基于fNIRS的主动、被动与想象屈肘运动脑激活的特点及比较
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作者 喻多多 魏聪惠 罗军 《南昌大学学报(医学版)》 2024年第3期46-51,共6页
目的 利用功能性近红外光谱成像(functional near-infrared spectroscopy, fNIRS)技术探究健康成年人主动屈肘、被动屈肘和想象屈肘运动脑激活的特点。方法 选取30名健康大学生为被试者,男女各15例,年龄(21.22±1.42)岁,选择右手主... 目的 利用功能性近红外光谱成像(functional near-infrared spectroscopy, fNIRS)技术探究健康成年人主动屈肘、被动屈肘和想象屈肘运动脑激活的特点。方法 选取30名健康大学生为被试者,男女各15例,年龄(21.22±1.42)岁,选择右手主动、被动和想象屈肘任务作为刺激模式,采用近红外光谱脑功能成像系统实时采集被试者3种不同运动模式下脑功能区氧合血红蛋白(Oxyhemoglobin, HbO2)水平作为脑激活的特征值,并以静息态(resting state, RS)的HbO2水平为基线值,比较3种运动模式下脑激活的特点。结果 非参数检验结果表明,不同运动模式下,右侧初级运动皮层(H=13.309,P=0.004),右侧前额叶前部皮层(H=20.30,P<0.001),右侧背外侧前额叶皮层(H=12.194,P=0.007),左侧初级体感皮层(H=12.642,P=0.005),左侧初级运动皮层(H=20.03,P<0.001),左侧前额叶前部皮层(H=18.187,P<0.001),左侧背外侧前额叶皮层(H=13.379,P=0.004)的HbO2水平比较差异有统计学意义;而其右侧初级体感皮层(H=4.284,P=0.232),右侧前运动区和辅助运动皮层(H=4.201,P=0.241),左侧前运动区和辅助运动皮层(H=8.793,P=0.052)HbO2水平比较差异无统计学意义。结论 不同运动模式下存在特定的脑功能区激活,其激活程度既有相似性又有差异性,主动运动和被动运动任务下的脑激活区最类似。 展开更多
关键词 功能性近红外光谱成像技术 主动运动 被动运动 想象运动 氧合血红蛋白 脑功能区 脑激活
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近红外光谱监测在先天性心脏病患儿围术期应用的研究进展
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作者 史晓莉 陈佳祥 +1 位作者 梁昌盛 陈芳 《临床麻醉学杂志》 CAS CSCD 北大核心 2024年第3期310-314,共5页
先天性心脏病是儿童最常见的心脏病,大部分先天性心脏病患儿需及时进行手术治疗矫正畸形。然而,术后脑损伤和神经发育不良一直是心肺转流下先天性心脏病手术后常见的神经系统并发症,严重影响患儿的预后。有效的监测手段对于积极预防、... 先天性心脏病是儿童最常见的心脏病,大部分先天性心脏病患儿需及时进行手术治疗矫正畸形。然而,术后脑损伤和神经发育不良一直是心肺转流下先天性心脏病手术后常见的神经系统并发症,严重影响患儿的预后。有效的监测手段对于积极预防、尽早发现和及时处理神经系统并发症至关重要。应用近红外光谱(NIRS)监测局部脑组织氧饱和度(rScO 2),或联合其他脑神经功能监测手段进行多模式监测,有助于及时发现脑缺血缺氧不良事件,进而循序调整影响因素进行干预,有利于降低术后神经损伤的发生率,改善患儿预后。本文就NIRS的原理、影响因素及其在先天性心脏病患儿围术期单独应用和与其他监测方法联合应用进行综述,旨在为先天性心脏病患儿围术期脑神经功能监测提供参考。 展开更多
关键词 心肺转流 近红外光谱 脑氧饱和度 脑神经功能监测
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不同侧小脑梗死患者脑区比率低频振幅的改变及其与认知功能改变的关联
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作者 黄钦彬 冯兵 +1 位作者 陈晓琪 张夏伟 《河北医学》 CAS 2024年第6期992-997,共6页
目的:研究不同侧小脑梗死患者不同脑区域的比率低频振幅(fALFF)值的改变及其与认知功能改变的关联性。方法:回顾性研究2022年4月至2024年3月我院神经内科明确诊断的急性单侧小脑梗死的患者92例,以梗死位置分为左侧组45例与右侧组47例,... 目的:研究不同侧小脑梗死患者不同脑区域的比率低频振幅(fALFF)值的改变及其与认知功能改变的关联性。方法:回顾性研究2022年4月至2024年3月我院神经内科明确诊断的急性单侧小脑梗死的患者92例,以梗死位置分为左侧组45例与右侧组47例,另选取健康体检的受检者50例作为健康对照组,对比不同分组之间的认知功能评分,以及左侧与右侧组患者的fALFF值差异,以及不同脑区域fALFF值与认知功能的相关性。结果:小脑梗死组患者的MMSE评分、RAVLT评分、BNT评分均明显低于健康对照组(P<0.05),TMT耗时相比对照组明显延长(P<0.05)。小脑梗死组患者右侧扣带回、右侧额下回、左侧额上回、小脑后叶的fALFF值差异均相比健康对照组明显升高(P<0.05)。左侧组患者右侧扣带回、额下回、左侧额上回的fALFF值均显著高于右侧组(P<0.05),小脑后叶的fALFF值相比右侧组明显降低(P<0.05)。右侧组右侧额叶的fALFF值与MMSE评分正相关(P<0.05),右侧顶下小叶与MMSE评分负相关(P<0.05),左侧前扣带回与RAVLT评分正相关(P<0.05),左侧顶叶与TMT耗时负相关(P<0.05)。左侧组右侧前额叶、顶下小叶、扣带回与MMSE评分负相关(P<0.05),右侧顶下小叶与RAVLT评分负相关(P<0.05),右侧枕叶与RAVLT评分正相关(P<0.05),右侧顶叶与TMT耗时正相关(P<0.05)。结论:小脑梗死患者相比健康人群的认知功能明显降低,同时梗死对侧关键脑区的fALFF值表现出明显的代偿性升高,与认知功能水平相关性较强。 展开更多
关键词 小脑梗死 脑区 比率低频振幅 认知功能
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左束支区域起搏对心室起搏患者心脏功能、血浆BNP水平及心律失常发生率的影响
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作者 胡钦 韩卫卫 +3 位作者 梁洁 周峰 计承 刘金波 《中国心血管病研究》 CAS 2024年第6期549-553,共5页
目的 探讨左束支区域起搏(LBBP)对心室起搏患者心脏功能、血浆B型脑钠肽(BNP)水平及心律失常发生率的影响。方法 回顾性分析2021年5月至2023年5月就诊于石家庄市人民医院的62例需心室起搏的患者,按心脏起搏电极植入部位不同分为LBBP组(3... 目的 探讨左束支区域起搏(LBBP)对心室起搏患者心脏功能、血浆B型脑钠肽(BNP)水平及心律失常发生率的影响。方法 回顾性分析2021年5月至2023年5月就诊于石家庄市人民医院的62例需心室起搏的患者,按心脏起搏电极植入部位不同分为LBBP组(32例)和右心室间隔部起搏(RVSP)组(30例),比较两组心脏功能[左心室射血分数(LVEF)、左心房容积指数(LAVI)、三尖瓣环收缩期位移(TAPSE)、二尖瓣环处舒张早期峰值流速(Ea)、二尖瓣口舒张早期的血流峰值速度(E)与二尖瓣环舒张早期峰值速度(Ea)的比值(E/Ea)]、起搏参数及QRS波时限、血浆BNP和6 min步行试验(6-MWT)和心律失常发生率。结果 术后6个月,RVSP组LVEF、TAPSE相比术前RVSP组和术后6个月LBBP组均降低(P<0.05),术后6个月RVSP组LAVI、E/Ea相比术前RVSP组和术后6个月LBBP组均升高(P<0.05)。术后1周、术后1个月、术后6个月LBBP组和RVSP组起搏参数(阈值、感知、阻抗)比较均无明显差异(P>0.05)。术后1周、术后1个月、术后6个月LBBP组QRS波时限均低于RVSP组(P<0.05)。两组术后心律失常发生率比较差异不明显(P>0.05)。结论 与RVSP相比,LBBP应用于心室起搏患者可有效降低术后血浆BNP水平和QRS波时限,有助于心脏功能的改善。 展开更多
关键词 心室起搏 左束支区域起搏 心脏功能 血浆B型脑钠肽 心律失常
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Modulatory effect of International standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI 被引量:11
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作者 Wai-Yeung Chung Song-Yan Liu +7 位作者 Jing-Chun Gao Yi-Jing Jiang Jing Zhang Shan-Shan Qu Ji-Ping Zhang Xiao-Long Tan Jun-Qi Chen Sheng-Xu Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第12期2126-2131,共6页
The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, an... The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women;50–70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043). 展开更多
关键词 nerve REGENERATION RESTING-STATE functional magnetic resonance imaging International Standard SCALP Acupuncture acupoint specificity brain functional CONNECTIVITY healthy elderly volunteers low frequency fluctuation regional homogeneity functional CONNECTIVITY neural REGENERATION
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Mechanism of Kinect-based virtual reality training for motor functional recovery of upper limbs after subacute stroke 被引量:15
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作者 Xiao Bao Yurong Mao +6 位作者 Qiang Lin Yunhai Qiu Shaozhen Chen Le Li Ryan S.Cates Shufeng Zhou Dongfeng Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第31期2904-2913,共10页
The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patient... The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains un- clear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects. The FugI-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up. Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects. Contralateral primary sensorimotor cortex, the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects. Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sen- sorimotor cortex. 展开更多
关键词 neural regeneration neurological rehabilitation rehabilitation training neural plasticity virtual reality functional MRI stroke Kinect-based virtual reality training upper limb cerebral cortex brain activation region of interest grants-supported paper NEUROREGENERATION
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Acupuncture inhibits cue-induced heroin craving and brain activation 被引量:5
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作者 Xinghui Cai Xiaoge Song +3 位作者 Chuanfu Li Chunsheng Xu Xiliang Li Qi Lu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第33期2607-2616,共10页
Previous research using functional MRI has shown that specific brain regions associated with drug dependence and cue-elicited heroin craving are activated by environmental cues. Craving is an important trigger of hero... Previous research using functional MRI has shown that specific brain regions associated with drug dependence and cue-elicited heroin craving are activated by environmental cues. Craving is an important trigger of heroin relapse, and acupuncture may inhibit craving. In this study, we performed functional MRI in heroin addicts and control subjects. We compared differences in brain activation between the two groups during heroin cue exposure, heroin cue exposure plus acupuncture at the Zusanli point (ST36) without twirling of the needle, and heroin cue exposure plus acupuncture at the Zusanli point with twirling of the needle. Heroin cue exposure elicited significant activation in craving-related brain regions mainly in the frontal lobes and callosal gyri. Acupuncture without twirling did not significantly affect the range of brain activation induced by heroin cue exposure, but significantly changed the extent of the activation in the heroin addicts group. Acupuncture at the Zusanli point with twirling of the needle significantly decreased both the range and extent of activation induced by heroin cue exposure compared with heroin cue exposure plus acupuncture without twirling of the needle. These experimental findings indicate that presentation of heroin cues can induce activation in craving-related brain regions, which are involved in reward, learning and memory, cognition and emotion. Acupuncture at the Zusanli point can rapidly suppress the activation of specific brain regions related to craving, supporting its potential as an intervention for drug craving. 展开更多
关键词 ACUPUNCTURE Zusanli (ST36) heroin addiction cues induction functional MRI CRAVING twirling activation of brain regions traditional Chinese medicine neural regeneration
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Evidence of cortical reorganization of language networks after stroke with subacute Broca's aphasia:a blood oxygenation level dependent-functional magnetic resonance imaging study 被引量:8
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作者 Wei-hong Qiu Hui-xiang Wu +7 位作者 Qing-lu Yang Zhuang Kang Zhao-cong Chen Kui Li Guo-rong Qiu Chun-qing Xie Gui-fang Wan Shao-qiong Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第1期109-117,共9页
Aphasia is an acquired language disorder that is a common consequence of stroke.The pathogenesis of the disease is not fully understood,and as a result,current treatment options are not satisfactory.Here,we used blood... Aphasia is an acquired language disorder that is a common consequence of stroke.The pathogenesis of the disease is not fully understood,and as a result,current treatment options are not satisfactory.Here,we used blood oxygenation level-dependent functional magnetic resonance imaging to evaluate the activation of bilateral cortices in patients with Broca's aphasia 1 to 3 months after stroke.Our results showed that language expression was associated with multiple brain regions in which the right hemisphere participated in the generation of language.The activation areas in the left hemisphere of aphasia patients were significantly smaller compared with those in healthy adults.The activation frequency,volumes,and intensity in the regions related to language,such as the left inferior frontal gyrus(Broca's area),the left superior temporal gyrus,and the right inferior frontal gyrus(the mirror region of Broca's area),were lower in patients compared with healthy adults.In contrast,activation in the right superior temporal gyrus,the bilateral superior parietal lobule,and the left inferior temporal gyrus was stronger in patients compared with healthy controls.These results suggest that the right inferior frontal gyrus plays a role in the recovery of language function in the subacute stage of stroke-related aphasia by increasing the engagement of related brain areas. 展开更多
关键词 nerve regeneration functional magnetic resonance imaging cortical functional connectivity language regions neuroplasticity Perisylvian language regions brain activation right hemisphere picture-naming task neural regeneration
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复杂脑动静脉畸形的显微外科手术治疗效果分析 被引量:1
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作者 刘建刚 陆晓诚 +1 位作者 王中 虞正权 《临床神经外科杂志》 2023年第1期104-107,113,共5页
目的 探讨显微外科手术治疗复杂脑动静脉畸形的诊治要点。方法 回顾性分析苏州大学附属第一医院神经外科2011年1月—2021年1月通过单纯显微手术切除及复合手术治疗的38例复杂脑动静脉畸形患者的临床资料,根据Spetzler-Martin分级,Ⅲ级24... 目的 探讨显微外科手术治疗复杂脑动静脉畸形的诊治要点。方法 回顾性分析苏州大学附属第一医院神经外科2011年1月—2021年1月通过单纯显微手术切除及复合手术治疗的38例复杂脑动静脉畸形患者的临床资料,根据Spetzler-Martin分级,Ⅲ级24例,Ⅳ级9例,Ⅴ级5例。畸形血管团平均大小为5.9 cm(3.5~12.3 cm),位于功能区27例,非功能区11例,术前行CTA、DSA及MRI检查,术后行CT、CTA或DSA检查,定期随访,格拉斯哥预后评分(GOS)评价神经功能障碍。结果 所有患者中,28例接受介入加手术综合治疗,10例接受单纯显微手术切除。术后影像学示,35例(92.1%)全切,3例(7.9%)较术前明显缩小。术后随访6~79个月,其中恢复良好34例(GOS=4~5分),中度残障2例(GOS=3分),重度残障1例(GOS=2分),死亡1例(GOS=1分)。结论 显微外科手术切除是治疗复杂脑动静脉畸形的有效方法之一,通过和血管内介入栓塞紧密结合,加之术前精准影像学评估,术中导航、荧光血流监测技术的应用及术中科学的显微操作,均是手术成功的关键。 展开更多
关键词 脑动静脉畸形 功能区 术前评估 显微外科手术 介入栓塞
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基于功能性磁共振成像技术探讨针刺太冲穴脑激活区的性别差异 被引量:1
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作者 蔡美意 崔海玲 +4 位作者 李燎原 李小贾 朱一芳 徐春生 吴子建 《安徽中医药大学学报》 CAS 2023年第5期55-59,共5页
目的 采用功能性磁共振成像(functional magnetic resonance image, fMRI)技术观察针刺太冲穴所激活脑区的性别差异,以阐明针刺效应性别差异的机制。方法 女性组选取25例青年女性志愿者,男性组选取30例青年男性志愿者,针刺志愿者左侧太... 目的 采用功能性磁共振成像(functional magnetic resonance image, fMRI)技术观察针刺太冲穴所激活脑区的性别差异,以阐明针刺效应性别差异的机制。方法 女性组选取25例青年女性志愿者,男性组选取30例青年男性志愿者,针刺志愿者左侧太冲穴并收集fMRI数据。结果 女性组针刺太冲穴激活的脑区有左侧小脑下部、右侧缘上回、左侧中央后回。男性组针刺太冲穴激活的脑区有右侧缘上回、左侧中央盖沟、右侧中央旁小叶。与女性组比较,男性组更广泛地激活了右侧缘上回、右侧中央沟盖。结论 针刺受试者太冲穴激活脑区并不完全对称,针刺效应在大脑具有偏侧性,针刺太冲穴时大脑活动反应存在性别差异。 展开更多
关键词 太冲穴 功能性磁共振成像 任务态 脑区 性别差异
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