The human brain is smaller than you might expect:One of them,dripping with formaldehyde,fits in a single gloved hand of a lab supervisor.Soon,this rubbery organ will be frozen solid,coated in glue,and then sliced into...The human brain is smaller than you might expect:One of them,dripping with formaldehyde,fits in a single gloved hand of a lab supervisor.Soon,this rubbery organ will be frozen solid,coated in glue,and then sliced into several thousand wispy slivers,each just 60 micrometers thick.A custom apparatus will scan those sections using 3D polarized light imaging(3DPLI)to measure the spatial orientation of nerve fibers at the micrometer level.The scans will be gathered into展开更多
The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slo...The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slowness and paucity of voluntary movement（bradykinesia）.展开更多
文摘The human brain is smaller than you might expect:One of them,dripping with formaldehyde,fits in a single gloved hand of a lab supervisor.Soon,this rubbery organ will be frozen solid,coated in glue,and then sliced into several thousand wispy slivers,each just 60 micrometers thick.A custom apparatus will scan those sections using 3D polarized light imaging(3DPLI)to measure the spatial orientation of nerve fibers at the micrometer level.The scans will be gathered into
基金supported by grants from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare (HI15C1928)the National Research Foundation of Korea (NRF-2017R1A2B4002675)
文摘The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slowness and paucity of voluntary movement（bradykinesia）.
