Brainstem auditory evoked potentials in patients with delayed encephalopathy after acute carbon monoxide poisoning

Objective:To evaluate the changes of brainstem auditory evoked potential (BAEP) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods: BAEPs were performed in 32 controls and 40 patients. Wave Ⅰ , Ⅱ , Ⅲ ,Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies were measured, respectively. Results: Abnormalities of BAEPs in 13 patients (13/40, 32 ％). Among the13 abnormal BAEPs, 3 displayed prolongation of latency to waves in one side, no potential in another side; 5 displayed a similar abnormality which was bilateral prolongation of latency to waves ;and another 5 displayed unilateral latency delay. Compared wave Ⅰ , Ⅱ , Ⅲ , Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies in the patients and the controls, there were no significant differences (P＞0.05). Conclusion: BAEPs can be used for evaluating the diagnostic and prognostic values in the cases of delayed encephalopathy after acute carbon monoxide poisoning.

Characteristics of brainstem auditory evoked potentials of students studying folk dance

BACKGROUND: Previous experiments have demonstrated that brainstem auditory evoked potential is affected by exercise,exercise duration,and frequency. OBJECTIVE: Comparing the brainstem auditory evoked potential of students studying folk dance to students studying other subjects. DESIGN: Observational contrast study. SETTING: Physical Education College,Shandong Normal University PARTICIPANTS: Fifty-five female students were enrolled at Shandong Normal University between September and December in 2005,including 21 students that studied folk dance and 34 students that studied other subjects. The age of the folk dance students averaged (19 ± 1) years and dance training length was (6.0 ± 1.5) years. The students that studied other subjects had never taken part in dance training or other physical training,and their age averaged (22 ± 1) years,body height averaged (162 ± 5) cm,body mass averaged (51 ± 6) kg. All subjects had no prior ear disease or history of other neurological disorders. All students provided informed consent for the experimental project. METHODS: The neural electricity tester,NDI-200 (Shanghai Poseidon Medical Electronic Instrument Factory) was used to examine and record Brainstem Auditory Evoked Potential values of the subjects during silence,as well as to transversally analyze the Brainstem Auditory Evoked Potential values. The electrode positions were cleaned and degreased with soapy water,followed by ethanol. The selected bipolar electrodes were situated on the head: recording electrodes were placed at the Baihui acupoint,and the reference electrode was placed at the mastoid of the measured ear,with grounding electrodes in the center of the forehead. Brainstem Auditory Evoked Potential values were elicited by monaural stimulation of a "click" though an earphone; the other ear was sheltered by the white noise. The click intensity was 102 db,the stimulation frequency was 30 Hz,the bandpass filters were 1 000-3 000 Hz,the sensitivity was 5 μV,and a total of 2 000 sweeps were averaged. Waveform identification and analysis: various components of the Brainstem Auditory Evoked Potential values were identified,and the peak latencies and peak-peak values were analyzed. MAIN OUTCOME MEASURES: Latency of Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ and Peak-Peak Value of Ⅰ,Ⅲ,Ⅴ were measured. RESULTS: Fifty-five subjects were enrolled in the final analysis,without any loss. Compared to the students who studied other subjects ①Ⅰ-Ⅴ peak latencies (PL): Ⅳ PL of the right ear of the folk dance students was obviously longer (P < 0.05); ②Ⅰ,Ⅲ,Ⅴ peak-peak values: Ⅰ peak-peak values of the right ear were obviously higher (P < 0.05). CONCUSION: ① PL of the right ear of the folk dance students was obviously longer,which indicates that dancing results in a stronger sensibility to auditory stimuli. ②P?eak-peak values were obviously higher,which indicates that long-term exercise enhances the music senses and synchrony of auditory nerve impulses.

Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

BACKGROUND:Brainstem auditory evoked potential(BAEP) has been widely used to evaluate the functional integrity and development of injured auditory system and brain,especially to objectively evaluate the function of auditory system and brain stem of very young babies,such as neonates and sick babies. OBJECTIVE:To observe the changes of BAEP of neonates with hyperbilirubinemia,and to investigate the relationship of bilirubin concentration and BAEP. DESIGN:An observation experiment. SETTING:Department of Pediatrics,the 309 Clinical Division,General Hospital of Chinese PLA. PARTICIPANTS:Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born,who received the treatment in the Department of Pediatrics,the 309 Clinical Division,General Hospital of Chinese PLA between January 2004 and May 2007,were recruited in this study. The involved neonates,31 boys and 27 girls,had gestational age of 37 to 46 weeks. They had no history of birth asphyxia,and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value,the neonates were assigned into 3 groups:low-concentration bilirubin group(n =16),moderate-concentration bilirubin group(n =27) and high-concentration bilirubin group(n =15). According to mean daily bilirubin increase,the subjects were sub-assigned into bilirubin rapid increase group(n =39) and bilirubin slow increase group(n =19). METHODS:After admission,all the neonates received drug treatment. Meanwhile,their 116 ears were examined with a myoelectricity evoked potential equipment(KEYPOINT) in latency,wave duration,amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES:① Abnormal rate and abnormal type of BAEP. ② Latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ,and Ⅰ to Ⅴ. RESULTS:Fifty-eight neonates with mild or moderate hyperbilirubinemia were involved in the final analysis. ①Abnormal type and abnormal rate of BAEP of neonates with hyperbilirubinemia:Among the 116 ears,unilateral or bilateral waves Ⅰ,Ⅲ,Ⅴ still existed. The latency of waves Ⅰ,Ⅲ and Ⅴ was +2.5 s longer than the normal level in 8,4 and 15 ears,respectively. The wave duration of waves Ⅰ to Ⅲ and waves Ⅲ to Ⅴ was +2.5 s longer than the normal level in 6 and 14 ears,respectively. The wave duration of waves Ⅲ to Ⅴ was longer than that of ipsilateral waves Ⅰ to Ⅲ in 24 ears. The latency difference of wave Ⅴ between two ears was larger than 0.4 ms in 31 neonates with hyperbilirubinemia;The amplitude of wave Ⅴ to that of ipsilateral wave I was lower than 0.5 in 29 neonates. Totally 52 ears were abnormal,and the abnormal rate was 44.8%. One to two months later,98% abnormal neonates with hyperbilirubinemia recovered. The abnormal rate in the low-,moderate-,and high-concentration bilirubin groups was 37.5%,44.4% and 53.3%,respectively. ② Comparison of latency and wave duration of each wave of BAEP:Latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ and Ⅲ to Ⅴ were gradually prolonged in low-,moderate-,and high-concentration bilirubin groups,but significant difference did not exist between two groups(P > 0.05). ③ There were no significant differences in latency of waves Ⅰ,Ⅲ and Ⅴ,and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ and Ⅰ to Ⅴ between bilirubin rapid increase group and bilirubin slow increase group(P > 0.05). CONCLUSION:Auditory acuity and brainstem of neonates with mild or moderate hyperbilirubinemia are damaged to some extent. High-concentration bilirubin causes BAEP abnormality easily. Bilirubin increase and its concentration change are not consistent with nervous lesion degree.

Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder

BACKGROUND: Electroencephalogram (EEG) and brainstem auditory evoked potential (BAEP) are objective non-invasive means of measuring brain electrophysiology. OBJECTIVE: To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder. DESIGN, TIME AND SETTING: This case analysis study was performed at the Rehabilitation Center of Hunan Children’s Hospital from January 2002 to January 2006. PARTICIPANTS: A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1–6 months were enrolled for this study. METHODS: EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale. MAIN OUTCOME MEASURES: (1) The rate of abnormal EEG and BAEP, (2) correlation of abnormalities of EEG and BAEP with associated injuries, (3) correlation of abnormalities of EEG and BAEP with high risk factors. RESULTS: The rate of abnormal EEG was 68.6% (407/593 patients), and was increased in patients who also had mental retardation (P < 0.05). The rate of abnormal BAEP was 21.4% (127/593 patients). These 127 patients included 67 patients (52.8%) with peripheral auditory damage and 60 patients (47.2%) with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation (P < 0.01). Logistic regression analysis showed that asphyxia (P < 0.05), jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder. Intracranial hemorrhage, jaundice (P < 0.05), low birth weight and intrauterine infection (P < 0.05) were closely correlated with abnormal BAEP in patients with central coordination disorder. CONCLUSION: Central coordination disorder is often associated with abnormal EEG and BAEP. The rate of EEG or BAEP abnormality is positively associated with the size of the brain injury. Asphyxia is a high risk factor for abnormal EEG in central coordination disorder. Jaundice and intrauterine infection are high risk factors for abnormal BAEP in central coordination disorder.

Otoacoustic Emissions and Evoked Potentials in Infants after Breast-Feeding Jaundice——Hearing Dysfunction in Breast-Feeding Jaundice

We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.

家兔椎基底动脉供血不足动物模型的BAEP变化

目的 为了探讨家兔椎基底动脉缺血后的脑干听觉诱发电位 (brainstem auditory evoked poten-tials,BAEP)变化及其在临床工作中的意义。方法 通过结扎家兔单侧椎动脉从而造成脑干缺血 ,并连续记录结扎后一小时内的 BAEP的变化过程。结果 、 、 潜伏期逐渐延长 ,以 波延长最明显 , ～ 、 ～ 、 ～ 峰间期均明显延长 , 波、 波波幅改变无统计意义。结论 本实验表明在椎基底动脉供血不全时 BAEP有显著异常 ,可作为椎基底动脉梗死溶栓治疗后脑干功能变化的观察指标。

电刺激双耳后乳突部治疗椎动脉型颈椎病的TCD和BAEP观察

目的:观察电刺激治疗椎动脉型颈椎病患者的经颅多普勒超声(TCD)和脑干听觉诱发电位(BAEP)变化,从血流速度及神经电生理角度探讨电刺激双耳后乳突部的作用机制。方法:将40例椎动脉型颈椎病患者随机分为电刺激组和常规组,电刺激组20例,常规组20例,与30例健康人对照组比较。治疗前及治疗2周后检查TCD及BAEP,观察电刺激治疗对椎动脉型颈椎病患者血流速度及脑电生理的影响。结果:治疗前电刺激组与常规组椎基底动脉(VBA)流速明显低于对照组(P<0.05)。TCD异常的比例为75%(30/40例),以VBA流速降低为主要特点。BAEP异常的比例为77.5%(31/40例),以脑干型异常为主。治疗后两组血流速度均有改善,与常规组比较,电刺激组椎动脉流速改善更显著(P<0.05)。治疗后两组神经传导功能均有改善,与常规组相比,电刺激组Ⅴ波的峰潜伏期(PL)、Ⅲ-Ⅴ和Ⅰ-Ⅴ波的峰间潜伏期改善更显著(P<0.05)。结论:电刺激双耳后乳突部可改善椎动脉型颈椎病椎基循环的血流速度及脑干神经传导功能。

闭合性颅脑损伤后大鼠BAEP及脑损伤的动态变化

目的观察大鼠闭合性弥漫性颅脑损伤后脑干听觉诱发电位(BAEP)的动态改变及脑组织病理学变化,探讨BAEP在颅脑损伤后评估听觉功能障碍的价值。方法使用自制弹簧式小型生物打击机打击大鼠颅顶部,制造闭合性弥漫性轻型颅脑损伤模型。观察对照组以及伤后15min和1,3,6,12h及1,2,4,7,10,14,21d等时间点大鼠脑组织病理学改变,干/湿法检测脑组织含水量。分别于伤前、伤后各时间点以50Hz刺激率记录大鼠BAEP,对其结果进行比较。结果损伤后15min,BAEP的Ⅰ～Ⅴ、Ⅲ～ⅤIPL即较损伤前延长(P<0.05),至6～12h,Ⅲ、ⅤPL较损伤前延长。损伤后1～2d,Ⅲ、ⅤPL和Ⅰ～Ⅲ、Ⅰ～Ⅴ、Ⅲ～ⅤIPL均较损伤前显著延长(P<0.001),14d后BAEP逐渐恢复正常。伤后15min脑组织含水量开始升高,伤后1d达高峰,持续至4d后逐渐下降,至10d后降至正常水平。结论BAEP可作为闭合性弥漫性轻型颅脑损伤后听觉功能障碍的客观评价指标。

重症肌无力患者IgG脑室内注射对大鼠EEG及BAEP的影响

目的 观察重症肌无力 (myasthenia gravis,MG)患者 Ig G(ACh RAb)经大鼠脑室内注入对其脑电图 (elec-troencephalography,EEG)及脑干听觉诱发电位 (brain stem auditory evoked potential,BAEP)的影响 ,并探讨ACh RAb影响大鼠中枢神经系统 (CNS)的机制。方法 将从确诊的、ACh RAb阳性的 MG患者血清中提纯的Ig G(ACh RAb) ,注射到实验组大鼠侧脑室 ,对照组大鼠则注射健康人 Ig G,观察大鼠行为学、 BAEP、 EEG改变。结果 实验组大鼠术后出现类似于实验性自身免疫性 MG的行为学改变 ,部分大鼠出现癫痫发作 ;BAEP峰间潜伏期 (IPLs)延长 ;EEG异常 ,即δ、θ增多与痫性波发放增加。结论 MG ACh RAb可致大鼠 CNS损害 ,ACh RAb与大鼠 CNS神经元型乙酰胆碱受体结合 ,可能是其病理生理机制。

BAEP、BR及MEP联合检测在脑死亡诊断中的应用

目的探讨神经电生理在脑死亡判定中的应用价值。方法通过瞬间反射(BR)、脑干听觉诱发电位(BAEP)、运动诱发电位(MEP)三项联合检查对22例脑死亡患者进行评定,并与GCS评分结果进行比较。结果BAEP、BR和MEP三项联合检查对脑死亡判断准确率为100%,与GCS评分比较差异显著(P<0.05)。结论BAEP、BR和MEP三项联合检测对评价脑死亡患者的脑功能状态、预测预后提供了客观可靠的依据。

BAEP和TCD联合评价后循环缺血患者临床病情

目的评价脑干听觉诱发电位(BAEP)及经颅多普勒(TCD)检查的临床价值。方法对124例经临床确诊的后循环缺血患者依据临床症状及CT、MRI检查结果分为梗死亚组(53例)和非梗死亚组(71例),均进行BAEP及经颅多普勒检查,并与健康对照组(60例)进行对比。结果 124例后循环缺血患者中,BAEP异常113例,异常率91.11%。与对照组比较,后循环缺血患者的Ⅴ波峰潜伏期和Ⅲ～Ⅴ波的峰间潜伏期均延长,差异有统计学意义(P<0.05)。梗死亚组与非梗死亚组比较,Ⅴ波峰潜伏期、Ⅲ～Ⅴ波峰间潜伏期亦延长,差异有统计学意义(P<0.05)。124例后循环缺血患者中,TCD异常79例,异常率63.7%,其中梗死亚组异常率(77.3%)高于非梗死亚组(53.5%),差异有统计学意义(P<0.05)。结论联合应用BAEP和TCD可为后循环缺血的病情评估提供重要的参考。

轻型和中型脑损伤的BAEP对比分析

目的探讨轻型和中型脑损伤的脑干听觉诱发电位(Brain Auditory Evoked Potential,BAEP)特征。方法对性别、年龄和受伤时间匹配的19例轻型和20例中型脑损伤伤者进行脑干听觉诱发电位检测,比较两者之间的电生理特征。结果轻型和中型脑损伤的脑干段电反应异常率、绝对潜伏期(Peak Latency,PL)、峰间期(Interpeak Latency,IPL)以及BAEP分型差异均无显著性意义。结论轻型和中型脑损伤伤者不仅存在脑干功能障碍,而且具有相同的电生理特征。

BAEP转颈试验在后循环缺血诊断中的应用

目的:探讨脑干听觉诱发电位(BAEP)转颈试验对后循环缺血的诊断意义。方法:对60例后循环缺血眩晕间歇期患者分别作 BAEP常规检测和转颈试验,并与40例正常人对照。结果:后循环缺血组BAEP常规检测阳性率26．7％,转颈试验阳性率91．7％,与对照组比较均有极显著差异。结论:转颈试验可提高BAEP的阳性率,对后循环缺血诊断有重要参考意义。

椎基底动脉供血不足BAEP检查结果分析

目的：探讨脑干听觉诱发电位（ＢＡＥＰ）在椎基底动脉供血不足（ＶＢＩ）诊断中的意义。方法：对１０９例ＶＢＩ患者做常规ＢＡＥＰ检查，并对其结果按年龄、病程进行分析。结果：１０９例中异常８１例（７４３％），异常表现为各主波的潜伏期和波间期延长。其中病程＜２年者异常率为４０６％（１３／３２例），２～５年者为８７８％（３６／４１），＞５年者为８８９％（３２／３６）。结论：ＶＢＩ患者的ＢＡＥＰ异常率有随病程延长而增高的倾向。ＢＡＥＰ对ＶＢＩ缓解期病例的诊断有一定参考意义。

BAEP与MRA在椎基底动系统TIA中的应用研究

目的:探讨脑干听觉诱发电位(BAEP)及磁共振血管成像(MRA)检查对椎基底动脉系统TIA的早期诊断价值。方法:对60例椎基底动脉系统TIA患者进行BAEP和MRA检查。BAEP异常患者治疗1周后复查,分析其前后变化。同时选取36例健康人行BAEP检查作对照。结果:治疗前患者组BAEP异常44例(73.3%),MRA异常35例(58.3%);治疗后患者组BAEP异常14例(23.3%)。对照组两项检查均正常。结论:BAEP、MRA对椎基底动脉系统TIA早期诊断具有重要价值,二者联合检测有助于缺血定位。

椎基底动脉供血不足的TCD BAEP与EEG分析研究

目的探讨脑干听觉诱发电位(BAEP)、脑电图(EEG)及经颅多普勒超声(TCD)检查对椎基底动脉供血不足(VBI)的诊断价值。方法对40例临床确诊的VBI患者进行BAEP、EEG及TCD检测。结果 VBI患者BAEP、EEG及TCD检查的异常率分别为65%、32.5%及72.5%。结论 BAEP、EEG及TCD检查从不同角度反映了VBI的病理生理基础,对VBI的诊断有参考意义。

VBI性眩晕患者的BAEP、TCD、CDFI的对照研究

目的 :探讨脑干听觉诱发电位 (BAEP) ,经颅多普勒超声 (TCD) ,彩色多普勒超声 (CDFI)对椎基底动脉供血不足 (VBI)的诊断价值。方法 :对 6 6例临床确诊的VBI性眩晕患者进行BAEP ,TCD ,CDFI检测。结果 :VBI患者上述三项检查的异常率分别为 70 % ,79% ,82 %。BAEP提示 :内耳型 8例 ,脑干型 31例 ,混合型 7例。TCD提示 :单血管流速异常 30例 ,多血管流速异常 2 2例 ;低流速 38例 ,高流速14例 ;伴有阻力指数 (RI)异常 2 2例。CDFI提示 :单侧异常 33例 ,双侧异常 2 1例 ,既有椎动脉形态学异常又伴有血流参数异常的 36例 ,单纯血流参数异常的 18例。结论 :此三项检查均是较理想的非创伤性检查 ,有助于VBI早期定位和定性诊断。

海风藤对犬脑干缺血后BAEP的影响

目的观察海风藤对犬脑干缺血后脑干听觉诱发电位（ＢＡＥＰ）的影响。方法建立犬脑干缺血模型，给药组和对照组各２０只犬，分别于阻断基底动脉前３ｈ向十二指肠注入海风藤溶液（按０．３ｇ／ｋｇ）和等体积生理盐水，于缺血前和缺血后０．５、３、６和１２ｈ分别记录ＢＡＥＰ。结果给药组ＢＡＥＰ的Ⅰ、Ⅲ、Ⅴ波潜伏期和Ⅰ－Ⅲ、Ⅲ－Ⅴ、Ⅰ－Ⅴ波峰间期明显缩短。结论海风藤可改善犬脑干对缺血的耐受程度，减小半暗带的范围，减轻病变的程度。

高压氧治疗一氧化碳中毒疗效的BAEP评估

目的:探讨高压氧治疗一氧化碳中毒的疗效。方法:收集29例一氧化碳中毒患者,对高压氧治疗前后的脑干听觉诱发电位(BAEP)异常率进行统计学比较。结果:高压氧治疗前后BAEP的总异常率、Ⅰ波与Ⅴ波异常率、Ⅰ～Ⅴ峰间期异常率比较,差异有统计学意义(P<0.01)。结论:急性一氧化碳中毒患者经高压氧治疗后,BAEP异常率降低,高压氧治疗一氧化碳中毒有效。

TSEP和BAEP监测在三叉神经痛微血管减压术中的应用价值

目的：探讨三叉神经痛微血管减压术（MVD）中联合应用三叉神经诱发电位（TSEP）、脑干听觉诱发电位（BAEP）监测的价值。方法：2007年2月至2009年11月我院采用MVD治疗58例三叉神经痛病人，以术中使用电生理监测的30例患者为试验组，未使用这两种电生理监测的28例患者为对照组，对比分析两组有效率（三叉神经痛症状缓解或消失）及眩晕、听力下降等并发症的发生率。结果：试验组术后有效率为93％（28例），发生眩晕1例（3％）和听力下降1例（3％）；对照组术后有效率为68％（19例），发生眩晕8例（29％）和听力下降9例（32％）。两组MVD治疗疗效差异及并发症发生率比较差异均有统计学意义（P〈0．05）。结论：三叉神经痛MVD中，联合应用TSEP和BAEP作术中监测能较好地控制并发症的发生及提高三叉神经MVD的治疗效果。